Affiliation: University of Debrecen
Kiss B, TÃ³th K, Sarang Z, Garabuczi Ã, Szondy Z. Retinoids induce Nur77-dependent apoptosis in mouse thymocytes. Biochim Biophys Acta. 2015;1853:660-70 pubmed publisher
..The retinoid-induced apoptosis was dependent on both Caspase 8 and STAT1. Our data together indicate that retinoids induce a Nur77-dependent cell death program in thymocytes activating the mitochondrial pathway of apoptosis. ..
Garabuczi Ã, Sarang Z, Szondy Z. Glucocorticoids enhance prolonged clearance of apoptotic cells by upregulating liver X receptor, peroxisome proliferator-activated receptor-Î´ and UCP2. Biochim Biophys Acta. 2015;1853:573-82 pubmed publisher
..Our data indicate that retinoids could be considered as potential promoters of the efficacy of glucocorticoid treatment in inflammatory diseases. ..
Köröskényi K, Kiss B, Szondy Z. Adenosine A2A receptor signaling attenuates LPS-induced pro-inflammatory cytokine formation of mouse macrophages by inducing the expression of DUSP1. Biochim Biophys Acta. 2016;1863:1461-71 pubmed publisher
..Our data indicate that A2AR signaling regulates both basal and LPS-induced DUSP1 levels in macrophages via activating the adenylate cyclase pathway. ..
Sandor K, Dániel B, Kiss B, Kovács F, Szondy Z. Transcriptional control of transglutaminase 2 expression in mouse apoptotic thymocytes. Biochim Biophys Acta. 2016;1859:964-74 pubmed publisher
..Our study describes a novel strategy to identify and characterize the signal-specific functional enhancer set of a gene by integrating genome-wide datasets and measuring the production of enhancer specific RNA molecules. ..
Duró E, Pallai A, Köröskényi K, Sarang Z, Szondy Z. Adenosine A3 receptors negatively regulate the engulfment-dependent apoptotic cell suppression of inflammation. Immunol Lett. 2014;162:292-301 pubmed publisher
..Since during phagocytosis of apoptotic cells the expression of A2ARs increases, while that of A3Rs decreases, on long term adenosine suppresses the proinflammatory responses in engulfing macrophages. ..
Pallai A, Kiss B, Vereb G, Armaka M, Kollias G, Szekanecz Z, et al
. Transmembrane TNF-Î± Reverse Signaling Inhibits Lipopolysaccharide-Induced Proinflammatory Cytokine Formation in Macrophages by Inducing TGF-Î²: Therapeutic Implications. J Immunol. 2016;196:1146-57 pubmed publisher
..Additionally, none of the TNF-Î±-targeting molecules is expected to interfere with the immune-silencing effects of apoptotic cells. ..
SÃ¡ndor K, Pallai A, DurÃ³ E, Legendre P, Couillin I, SÃ¡ghy T, et al
. Adenosine produced from adenine nucleotides through an interaction between apoptotic cells and engulfing macrophages contributes to the appearance of transglutaminase 2 in dying thymocytes. Amino Acids. 2017;49:671-681 pubmed publisher
..Our data reveal a novel crosstalk between macrophages and apoptotic cells, in which apoptotic cell uptake-related adenosine production contributes to the appearance of TG2 in the dying thymocytes. ..
Szondy Z, Pallai A. Transmembrane TNF-alpha reverse signaling leading to TGF-beta production is selectively activated by TNF targeting molecules: Therapeutic implications. Pharmacol Res. 2017;115:124-132 pubmed publisher
..In this review we will focus on the potential contribution of the activation of the mTNF-? signaling pathway to the success of the anti-TNF therapy. ..
JoÃ³s G, JÃ¡kim J, Kiss B, Szamosi R, Papp T, Felszeghy S, et al
. Involvement of adenosine A3 receptors in the chemotactic navigation of macrophages towards apoptotic cells. Immunol Lett. 2017;183:62-72 pubmed publisher
..Interestingly, loss of A3Rs did not affect the in vivo clearance of apoptotic thymocytes in the dexamethasone-treated thymus. ..