Zoltan Szekanecz

Summary

Affiliation: University of Debrecen
Country: Hungary

Publications

  1. ncbi request reprint Immunoperoxidase histochemistry for the detection of cellular adhesion molecule, cytokine, and chemokine expression in the arthritic synovium
    Zoltan Szekanecz
    University of Debrecen, Hungary
    Methods Mol Biol 225:283-90. 2003
  2. ncbi request reprint Gastrointestinal manifestations in Hungarian scleroderma patients
    Szilvia Szamosi
    Division of Rheumatology, Third Department of Medicine, Institute for Medicine, Medical and Health Science Center, University of Debrecen, 22 Moricz Street, Debrecen 4004, Hungary
    Rheumatol Int 26:1120-4. 2006
  3. ncbi request reprint Associations between serum anti-CCP antibody, rheumatoid factor levels and HLA-DR4 expression in Hungarian patients with rheumatoid arthritis
    Aniko Kapitany
    Laboratory of Immunology, Third Department of Medicine, University of Debrecen Medical Centre, Debrecen, Hungary
    Isr Med Assoc J 10:32-6. 2008
  4. doi request reprint Effects of rituximab treatment on endothelial dysfunction, carotid atherosclerosis, and lipid profile in rheumatoid arthritis
    György Kerekes
    Cardiovascular Unit, Third Department of Medicine, University of Debrecen Medical and Health Science Center, Moricz Zs Krt 22, 4032, Debrecen, Hungary
    Clin Rheumatol 28:705-10. 2009
  5. pmc New insights in synovial angiogenesis
    Zoltan Szekanecz
    Department of Rheumatology, Institute of Medicine, University of Debrecen Medical and Health Sciences Center, 98, Nagyerdei street, Debrecen, H 4032, Hungary
    Joint Bone Spine 77:13-9. 2010
  6. doi request reprint Superior performance of the CCP3.1 test compared to CCP2 and MCV in the rheumatoid factor-negative RA population
    Zoltan Szekanecz
    Department of Rheumatology, Institute of Medicine, University of Debrecen Medical and Health Science Center, Nagyerdei str 98, Debrecen, 4032, Hungary
    Immunol Res 56:439-43. 2013
  7. doi request reprint Pharmacogenetics and pharmacogenomics in rheumatology
    Zoltan Szekanecz
    Department of Rheumatology, Institute of Medicine, University of Debrecen Medical and Health Science Center, Nagyerdei Street 98, 4032, Debrecen, Hungary
    Immunol Res 56:325-33. 2013
  8. pmc Angiogenesis in rheumatoid arthritis
    Zoltan Szekanecz
    Department of Rheumatology, Institute of Medicine, University of Debrecen Medical and Health Sciences Center, Debrecen, H 4032, Hungary
    Autoimmunity 42:563-73. 2009
  9. doi request reprint Vascular effects of biologic agents in RA and spondyloarthropathies
    Zoltan Szekanecz
    Department of Rheumatology Institute of Medicine, University of Debrecen Medical and Health Science Center, Debrecen, Hungary
    Nat Rev Rheumatol 5:677-84. 2009
  10. ncbi request reprint Chemokine and chemokine receptor blockade in arthritis, a prototype of immune-mediated inflammatory diseases
    Z Szekanecz
    Department of Rheumatology, Institute of Medicine, University of Debrecen Medical and Health Sciences Center, Debrecen, H 4004, Hungary
    Neth J Med 69:356-66. 2011

Collaborators

Detail Information

Publications73

  1. ncbi request reprint Immunoperoxidase histochemistry for the detection of cellular adhesion molecule, cytokine, and chemokine expression in the arthritic synovium
    Zoltan Szekanecz
    University of Debrecen, Hungary
    Methods Mol Biol 225:283-90. 2003
  2. ncbi request reprint Gastrointestinal manifestations in Hungarian scleroderma patients
    Szilvia Szamosi
    Division of Rheumatology, Third Department of Medicine, Institute for Medicine, Medical and Health Science Center, University of Debrecen, 22 Moricz Street, Debrecen 4004, Hungary
    Rheumatol Int 26:1120-4. 2006
    ..Our results support that GI manifestations are rather common in SSc. Apart from the esophagus, other GI complications in SSc are usually mild, however, early recognition is necessary to improve quality of life...
  3. ncbi request reprint Associations between serum anti-CCP antibody, rheumatoid factor levels and HLA-DR4 expression in Hungarian patients with rheumatoid arthritis
    Aniko Kapitany
    Laboratory of Immunology, Third Department of Medicine, University of Debrecen Medical Centre, Debrecen, Hungary
    Isr Med Assoc J 10:32-6. 2008
    ..However, there is little information regarding a relationship between quantitative anti-CCP production (serum anti-CCP concentrations) and the shared epitope...
  4. doi request reprint Effects of rituximab treatment on endothelial dysfunction, carotid atherosclerosis, and lipid profile in rheumatoid arthritis
    György Kerekes
    Cardiovascular Unit, Third Department of Medicine, University of Debrecen Medical and Health Science Center, Moricz Zs Krt 22, 4032, Debrecen, Hungary
    Clin Rheumatol 28:705-10. 2009
    ..RTX may also decrease ccIMT; however, longer follow-up is needed to assess the prolonged effects of RTX on vascular function and lipid profile in RA patients...
  5. pmc New insights in synovial angiogenesis
    Zoltan Szekanecz
    Department of Rheumatology, Institute of Medicine, University of Debrecen Medical and Health Sciences Center, 98, Nagyerdei street, Debrecen, H 4032, Hungary
    Joint Bone Spine 77:13-9. 2010
    ..A complete review of antiangiogenic drugs used in animal models of arthritis or human RA is available in a table...
  6. doi request reprint Superior performance of the CCP3.1 test compared to CCP2 and MCV in the rheumatoid factor-negative RA population
    Zoltan Szekanecz
    Department of Rheumatology, Institute of Medicine, University of Debrecen Medical and Health Science Center, Nagyerdei str 98, Debrecen, 4032, Hungary
    Immunol Res 56:439-43. 2013
    ..131). In conclusion, the CCP3.1 assay can significantly increase the sensitivity of ACPA testing in RF-negative RA, as well as in the total RA population...
  7. doi request reprint Pharmacogenetics and pharmacogenomics in rheumatology
    Zoltan Szekanecz
    Department of Rheumatology, Institute of Medicine, University of Debrecen Medical and Health Science Center, Nagyerdei Street 98, 4032, Debrecen, Hungary
    Immunol Res 56:325-33. 2013
    ..More, focused studies carried out in larger patient cohorts, using pre-selected genes, may be needed in order to determine the future of pharmacogenetics and pharmacogenomics as tools for personalized medicine in rheumatology...
  8. pmc Angiogenesis in rheumatoid arthritis
    Zoltan Szekanecz
    Department of Rheumatology, Institute of Medicine, University of Debrecen Medical and Health Sciences Center, Debrecen, H 4032, Hungary
    Autoimmunity 42:563-73. 2009
    ..In addition, some naturally produced or synthetic compounds including angiostatin, endostatin, paclitaxel, fumagillin analogues, 2-methoxyestradiol and thalidomide may be included in the management of RA...
  9. doi request reprint Vascular effects of biologic agents in RA and spondyloarthropathies
    Zoltan Szekanecz
    Department of Rheumatology Institute of Medicine, University of Debrecen Medical and Health Science Center, Debrecen, Hungary
    Nat Rev Rheumatol 5:677-84. 2009
    ..Preliminary data suggest that rituximab also improves endothelial function and dyslipidemia. Further studies are needed to determine the net effects of biologic agents on the vasculature...
  10. ncbi request reprint Chemokine and chemokine receptor blockade in arthritis, a prototype of immune-mediated inflammatory diseases
    Z Szekanecz
    Department of Rheumatology, Institute of Medicine, University of Debrecen Medical and Health Sciences Center, Debrecen, H 4004, Hungary
    Neth J Med 69:356-66. 2011
    ..Therefore, modulation of receptor occupancy may be a feasible option to increase the efficacy of chemokine receptor targeting...
  11. doi request reprint Angiogenesis and vasculogenesis in rheumatoid arthritis
    Zoltan Szekanecz
    Department of Rheumatology, Institute of Medicine, University of Debrecen Medical and Health Sciences Center, Hungary
    Curr Opin Rheumatol 22:299-306. 2010
    ..Current understanding of the role of angiogenesis and vasculogenesis in rheumatoid arthritis (RA) and possibilities of therapeutic intervention should be summarized...
  12. doi request reprint Malignancies in autoimmune rheumatic diseases - a mini-review
    Zoltan Szekanecz
    Department of Rheumatology, Institute of Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    Gerontology 57:3-10. 2011
    ..Tumor-associated antigens may be produced by inflammatory cells and their production may be increased in rheumatoid arthritis and other autoimmune diseases...
  13. doi request reprint Biologics - beyond the joints
    Zoltan Szekanecz
    Department of Rheumatology, Institute of Medicine, University of Debrecen Medical and Health Science Center, Hungary
    Autoimmun Rev 9:820-4. 2010
    ..At present, we do not always have sufficient evidence to confirm these differences, therefore, more information should be obtained from large trials and long-term observational studies...
  14. ncbi request reprint Increased production of the soluble tumor-associated antigens CA19-9, CA125, and CA15-3 in rheumatoid arthritis: potential adhesion molecules in synovial inflammation?
    Eva Szekanecz
    Department of Oncology, University of Debrecen Medical and Health Science Center, Debrecen, Hungary
    Ann N Y Acad Sci 1108:359-71. 2007
    ..CEA, CA19-9, CA125, and CA15-3 contain carbohydrate motifs and thus they may be involved in synovitis-associated adhesive events. Furthermore, some TAAs, such as CEA, may also correlate with prognostic factors, such as serum RF levels...
  15. doi request reprint New classification of the shared epitope in rheumatoid arthritis: impact on the production of various anti-citrullinated protein antibodies
    Agnes Gyetvai
    Laboratory of Immunology, 3rd Department of Medicine, University of Debrecen Medical and Health Science Center, 98 Nagyerdei Street, Debrecen, H 4012, Hungary
    Rheumatology (Oxford) 49:25-33. 2010
    ..Instead of comparing allele-carriers to non-carriers, we studied each allele group individually, using the X/X (non-SE) genotype as reference...
  16. doi request reprint Comparative assessment of vascular function in autoimmune rheumatic diseases: considerations of prevention and treatment
    Pal Soltesz
    University of Debrecen Medical and Health Sciences Center, Institute of Medicine, Third Department of Medicine, Angiology and Intensive Care Unit, Debrecen, Hungary
    Autoimmun Rev 10:416-25. 2011
    ..The official EULAR recommendations on the assessment and management of cardiovascular disease in arthritides have just been published, and similar recommendations in connective tissue diseases are to be developed soon...
  17. ncbi request reprint Association of systemic and thyroid autoimmune diseases
    Edit Biro
    3rd Department of Medicine, University of Debrecen Medical and Health Sciences Center, 22 Moricz Street, 4004 Debrecen, Hungary
    Clin Rheumatol 25:240-5. 2006
    ..In this study, we wished to determine the association of Hashimoto's thyroiditis (HT) and Graves' disease (GD) with systemic autoimmune diseases...
  18. doi request reprint Anti-citrullinated protein antibodies in rheumatoid arthritis: as good as it gets?
    Zoltan Szekanecz
    Division of Rheumatology, 3rd Department of Medicine, Medical and Health Science Center, University of Debrecen, 22 Moricz Street, Debrecen, H 4004, Hungary
    Clin Rev Allergy Immunol 34:26-31. 2008
    ..The family of ACPAs is expected to expand; there is an increasing need for developing new diagnostic strategies after careful evaluation of the characteristics of the available assays...
  19. ncbi request reprint Effects of adalimumab treatment on vascular disease associated with early rheumatoid arthritis
    György Kerekes
    Cardiovascular Unit, Third Department of Medicine, University of Debrecen Medical and Health Science Center, Debrecen, Hungary
    Isr Med Assoc J 13:147-52. 2011
    ..Tumor necrosis factor-alpha (TNFa) inhibitors may influence flow-mediated vasodilation (FMD) of the brachial artery, common carotid intima-media thickness (ccIMT) and arterial stiffness indicated by pulse-wave velocity (PWV) in RA...
  20. doi request reprint A comparative study of arterial stiffness, flow-mediated vasodilation of the brachial artery, and the thickness of the carotid artery intima-media in patients with systemic autoimmune diseases
    Pal Soltesz
    Cardiovascular Unit, Institute of Medicine, Third Department of Medicine, University of Debrecen Medical and Health Science Center, Debrecen, 4032, Hungary
    Clin Rheumatol 28:655-62. 2009
    ..Assessment of arterial stiffness, FMD, and ccIMT are reproducible and reliable noninvasive techniques for the complex assessment of vascular abnormalities in patients at high risk...
  21. doi request reprint Assessment of subclinical vascular disease associated with ankylosing spondylitis
    Nóra Bodnár
    Department of Rheumatology, Institute of Medicine, Hungary
    J Rheumatol 38:723-9. 2011
    ..We assessed endothelial dysfunction, carotid atherosclerosis, and aortic stiffness in AS in context with clinical and laboratory measurements...
  22. doi request reprint Longterm effects of rituximab on B cell counts and autoantibody production in rheumatoid arthritis: use of high-sensitivity flow cytometry for more sensitive assessment of B cell depletion
    Andrea Váncsa
    Department of Rheumatology, Division of Hematology, Institute of Medicine, University of Debrecen Medical and Health Sciences Center, Debrecen, Hungary
    J Rheumatol 40:565-71. 2013
    ..To assess the efficacy and safety of longterm rituximab (RTX) therapy for rheumatoid arthritis (RA) and study correlations among B cell depletion, clinical response, and autoantibody production...
  23. doi request reprint Combined plasmapheresis and high-dose intravenous immunoglobulin treatment in systemic sclerosis for 12 months: follow-up of immunopathological and clinical effects
    Zoltan Szekanecz
    Department of Rheumatology, University of Debrecen Medical Center, 22 Moricz Street, Debrecen 4004, Hungary
    Clin Rheumatol 28:347-50. 2009
    ....
  24. doi request reprint Effects of biologics on vascular function and atherosclerosis associated with rheumatoid arthritis
    György Kerekes
    Cardiovascular Unit, Third Department of Medicine, University of Debrecen Medical and Health Science Center, Debrecen, Hungary
    Ann N Y Acad Sci 1173:814-21. 2009
    ..Preliminary data suggest that rituximab may also improve endothelial function and dyslipidemia. Further studies are needed to determine the net effects of biologics on the vasculature...
  25. ncbi request reprint Accelerated atherosclerosis in rheumatoid arthritis
    Zoltan Szekanecz
    Division of Rheumatology, Third Department of Medicine, University of Debrecen Medical and Health Science Center, Debrecen, Hungary
    Ann N Y Acad Sci 1108:349-58. 2007
    ....
  26. ncbi request reprint Genetic control of experimental spondylarthropathy
    Zoltan Szabo
    University of Debrecen, Hungary
    Arthritis Rheum 52:2452-60. 2005
    ..To characterize experimentally induced spondylarthropathy (SpA) in arthritis-susceptible inbred mice and in their F(1) and F(2) hybrid generations of susceptible and resistant mouse strains...
  27. ncbi request reprint Clinical evaluation of anti-mutated citrullinated vimentin by ELISA in rheumatoid arthritis
    Lilla Soos
    Division of Rheumatology, Laboratory of Immunology, Department of Medicine, University of Debrecen, Medical and Health Science Center, Hungarian Academy of Sciences, Debrecen, Hungary
    J Rheumatol 34:1658-63. 2007
    ..We examined the diagnostic performance of the newly developed anti-mutated citrullinated vimentin (MCV) antibody assay...
  28. ncbi request reprint Disturbances in B- and T-cell homeostasis in rheumatoid arthritis: suggested relationships with antigen-driven immune responses
    Andrea Fekete
    Laboratory of Immunology, 3rd Department of Medicine, Medical and Health Science Center, University of Debrecen, 22 Moricz Street, H 4032 Debrecen, Hungary
    J Autoimmun 29:154-63. 2007
    ....
  29. ncbi request reprint Chemokines in rheumatic diseases
    Zoltan Szekanecz
    Division of Rheumatology, Third Department of Medicine, University of Debrecen Medical and Health Sciences Center, Debrecen, H 4004, Hungary
    Curr Drug Targets 7:91-102. 2006
    ....
  30. pmc Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets
    Bertalan Mesko
    Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary
    BMC Med Genomics 3:15. 2010
    ..The main focus of our work was the identification of novel markers that overlap among the 3 diseases or discriminate them from each other...
  31. pmc Chemokines and angiogenesis in rheumatoid arthritis
    Zoltan Szekanecz
    Division of Rheumatology, Third Department of Medicine, University of Debrecen Medical and Health Sciences Center, Debrecen, H 4004, Hungary
    Front Biosci (Elite Ed) 1:44-51. 2009
    ..Apart from discussing the pathogenic role of chemokines and chemokine receptors in arthritic vessel formation, authors also review the important relevance of chemokines and angiogenesis for therapeutic intervention...
  32. doi request reprint Intracytoplasmic cytokine expression and T cell subset distribution in the peripheral blood of patients with ankylosing spondylitis
    Sandor Szanto
    Division of Rheumatology, Third Department of Internal Medicine, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary
    J Rheumatol 35:2372-5. 2008
    ..To determine the role of inflammatory mediators in the pathogenesis of ankylosing spondylitis (AS), we investigated peripheral blood lymphocyte subsets and their intracellular cytokine production...
  33. ncbi request reprint Macrophages and their products in rheumatoid arthritis
    Zoltan Szekanecz
    Division of Rheumatology, Third Department of Medicine, University of Debrecen Medical and Health Sciences Center, Debrecen, Hungary
    Curr Opin Rheumatol 19:289-95. 2007
    ..Macrophages express adhesion molecules, chemokine receptors and other surface antigens. They also secrete a number of chemokines, cytokines, growth factors, proteases and other mediators...
  34. ncbi request reprint Increased arterial stiffness as the marker of vascular involvement in systemic sclerosis
    Orsolya Timar
    Third Department of Medicine, Cardiovascular Unit and Rheumatology Division, University of Debrecen Medical Center, Debrecen, Hungary
    J Rheumatol 35:1329-33. 2008
    ..Accelerated atherosclerosis and impaired flow-mediated vasodilation have been described in SSc. We evaluated arterial stiffness in patients with SSc compared to healthy controls...
  35. ncbi request reprint Mechanisms of Disease: angiogenesis in inflammatory diseases
    Zoltan Szekanecz
    Third Department of Medicine, Rheumatology Division, University of Debrecen Medical Center, 22 Moricz Zs Street, Debrecen, H 4012, Hungary
    Nat Clin Pract Rheumatol 3:635-43. 2007
    ..Furthermore, angiogenesis might be targeted by several specific approaches that could be therapeutically used to control inflammatory diseases...
  36. doi request reprint Anti-mutated citrullinated vimentin (anti-MCV) and anti-65 kDa heat shock protein (anti-hsp65): new biomarkers in ankylosing spondylitis
    Nóra Bodnár
    Department of Rheumatology, Institute of Medicine, Medical and Health Science Center, University of Debrecen, 98, Nagyerdei street, 4012 Debrecen, Hungary
    Joint Bone Spine 79:63-6. 2012
    ..As new laboratory biomarkers of AS are needed, we investigated the prevalence of anti-mutated citrullinated vimentin (MCV) and anti-hsp65 antibodies in AS...
  37. doi request reprint In vivo calcium and phosphate iontophoresis for the topical treatment of osteoporosis
    Izabella Gomez
    Department of Rheumatology, University of Debrecen Medical and Health Sciences Center, Debrecen, Hungary
    Phys Ther 92:289-97. 2012
    ..In addition to systemic treatment, osteoporosis may be treated topically by incorporating calcium and phosphate into the bone...
  38. ncbi request reprint Angiogenesis and chemokines in rheumatoid arthritis and other systemic inflammatory rheumatic diseases
    Edit Bodolay
    Division of Rheumatology, Third Department of Medicine, University of Debrecen Medical and Health Sciences Center, Debrecen, H 4004, Hungary
    J Cell Mol Med 6:357-76. 2002
    ....
  39. pmc Chemokines and chemokine receptors in arthritis
    Zoltan Szekanecz
    Division of Rheumatology, Third Department of Medicine, University of Debrecen Medical and Health Sciences Center, Debrecen, Hungary, Europe
    Front Biosci (Schol Ed) 2:153-67. 2010
    ..However, it is very likely that various specific chemokine and chemokine receptor antagonists will be developed and administered to RA patients...
  40. ncbi request reprint Catastrophic antiphospholipid syndrome (Asherson's syndrome) associated with cytokeratin 7-positive endometrial cancer
    Pal Soltesz
    Cardiovascular Unit, University of Debrecen Medical and Health Science Center, Debrecen, Hungary
    Isr Med Assoc J 9:891-3. 2007
  41. doi request reprint The genetic background of ankylosing spondylitis
    Aniko Vegvari
    Department of Rheumatology, Institute of Medicine, University of Debrecen Medical and Health Science Center, 22, Móricz street, Debrecen, H 4032, Hungary
    Joint Bone Spine 76:623-8. 2009
    ..Thus, AS is not a single-gene disease and the involvement of multiple non-MHC genes may account for the individual as well as geographical differences seen in AS...
  42. doi request reprint Plasma homocysteine levels, the prevalence of methylenetetrahydrofolate reductase gene C677T polymorphism and macrovascular disorders in systemic sclerosis: risk factors for accelerated macrovascular damage?
    Szilvia Szamosi
    Department of Rheumatology, University of Debrecen, Medical and Health Science Centre, Debrecen, Hungary
    Clin Rev Allergy Immunol 36:145-9. 2009
    ..Elevated Hcy levels may be associated with disease duration and the evolution of macrovascular disorders and pulmonary hypertension in SSc...
  43. doi request reprint Tumor-associated antigens in systemic sclerosis and systemic lupus erythematosus: associations with organ manifestations, immunolaboratory markers and disease activity indices
    Eva Szekanecz
    Department of Oncology, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary
    J Autoimmun 31:372-6. 2008
    ..Some of these TAAs contain sialylated carbohydrate motifs and they are involved in tumor-associated cell adhesion and metastasis...
  44. ncbi request reprint Chemokines and chemokine receptors in rheumatoid arthritis
    Zoltan Szekanecz
    Rheumatology Division, Third Department of Medicine, University of Debrecen Medical and Health Sciences Center, Debrecen H 4004, Hungary
    Semin Immunol 15:15-21. 2003
    ..Finally, potential strategies using anti-chemokine or anti-chemokine receptor biologicals in anti-rheumatic therapy are discussed...
  45. doi request reprint Improvement in pain intensity, spine stiffness, and mobility during a controlled individualized physiotherapy program in ankylosing spondylitis
    Zsuzsanna Némethné Gyurcsik
    Department of Physiotherapy, Faculty of Public Health, Medical and Health Sciences Center, University of Debrecen, Kassai u 26, 4028 Debrecen, Hungary
    Rheumatol Int 32:3931-6. 2012
    ..A complex, individualized physical therapy program may be useful and should be introduced to AS patients in order to maintain and increase spine mobility, preserve functional capacity, decrease the pain and stiffness...
  46. doi request reprint Malignancies associated with systemic sclerosis
    Eva Szekanecz
    Department of Oncology, Department of Rheumatology, University of Debrecen Medical and Health Sciences Center, Debrecen, Hungary
    Autoimmun Rev 11:852-5. 2012
    ..The adequate treatment and follow-up of scleroderma patients may help us to lower the risk of malignancies secondary to SSc...
  47. ncbi request reprint Angiogenesis in rheumatoid arthritis
    Zoltan Szekanecz
    Division of Rheumatology, Third Department of Medicine, University of Debrecen Medical and Health Sciences Center, Debrecen, H 4004, Hungary
    Front Biosci 10:1739-53. 2005
    ..In addition, further perspectives of anti-angiogenic therapy in arthritis are also discussed. Specific targeting of angiogenesis may be useful in the future management of various inflammatory, as well as malignant, diseases...
  48. ncbi request reprint Malignancies and soluble tumor antigens in rheumatic diseases
    Eva Szekanecz
    Department of Oncology, University of Debrecen, Medical and Health Science Center, Móricz, Hungary
    Autoimmun Rev 6:42-7. 2006
    ..Tumor-associated antigens may be produced by inflammatory cells and their production may be increased in RA and other autoimmune diseases...
  49. pmc Genetics of rheumatoid arthritis - a comprehensive review
    Julia Kurkó
    Department of Rheumatology, Institute of Medicine, University of Debrecen Medical and Health Science Center, Nagyerdei str 98, Debrecen, 4032, Hungary
    Clin Rev Allergy Immunol 45:170-9. 2013
    ..Finally, pharmacogenomics identified SNPs or multiple genetic signatures that may be associated with responses to traditional disease-modifying drugs and biologics...
  50. pmc Non-MHC risk alleles in rheumatoid arthritis and in the syntenic chromosome regions of corresponding animal models
    Timea Besenyei
    Department of Rheumatology, Faculty of Medicine, Medical and Health Science Centre, University of Debrecen, Debrecen 4012, Hungary
    Clin Dev Immunol 2012:284751. 2012
    ..Mouse GWAS appear to be far ahead of rat studies, and significantly more mouse QTLs correspond to human RA risk alleles...
  51. doi request reprint Validated methods for assessment of subclinical atherosclerosis in rheumatology
    György Kerekes
    Angiology and Intensive Care Unit, Third Department of Medicine, University of Debrecen Medical and Health Sciences Center, 98 Nagyerdei Street, Debrecen H 4032, Hungary
    Nat Rev Rheumatol 8:224-34. 2012
    ..The potential use of a multimarker approach to increase the diagnostic and prognostic value of these clinical assessments is also discussed...
  52. ncbi request reprint Association of HELLP syndrome with primary antiphospholipid syndrome--a case report
    Katalin Veres
    Cardiovascular Unit, 3rd Department of Internal Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    Clin Rheumatol 27:111-3. 2008
    ..There have been only few scattered reports in the literature on the association of HELLP syndrome and APS, which was successfully managed with the combination of various immunosuppressive and immunomodulatory treatment modalities...
  53. ncbi request reprint Endothelial cells in inflammation and angiogenesis
    Zoltan Szekanecz
    Division of Rheumatology, Third Department of Medicine, University of Debrecen Medical and Health Sciences Center, Debrecen H 4004, Hungary
    Curr Drug Targets Inflamm Allergy 4:319-23. 2005
    ..Specific targeting of pathological endothelial function including adhesion and angiogenesis, may be useful for the future management of various inflammatory diseases...
  54. doi request reprint Incidence of lymphoma in systemic sclerosis: a retrospective analysis of 218 Hungarian patients with systemic sclerosis
    Eva Szekanecz
    Department of Oncology, University of Debrecen Medical Center, Debrecen, Hungary
    Clin Rheumatol 27:1163-6. 2008
    ..In our three patients, B cell lymphoma developed within 2 years after the onset of SSc. Altered B cell function implicated in the pathogenesis of SSc may lead to the development of lymphoid malignancies...
  55. ncbi request reprint Therapeutic inhibition of leukocyte recruitment in inflammatory diseases
    Zoltan Szekanecz
    Division of Rheumatology, Third Department of Medicine, University of Debrecen Medical and Health Sciences Center, Debrecen, H 4004, Hungary
    Curr Opin Pharmacol 4:423-8. 2004
    ..In this review, the most recent advances in anti-chemokine and anti-adhesion therapeutic strategies are summarized...
  56. ncbi request reprint Cardiac manifestations in antiphospholipid syndrome
    Pal Soltesz
    Third Department of Medicine, Cardiovascular Unit, University Medical School of Debrecen, Debrecen, H 4004, Hungary
    Autoimmun Rev 6:379-86. 2007
    ....
  57. doi request reprint Increased production of asymmetric dimethylarginine (ADMA) in ankylosing spondylitis: association with other clinical and laboratory parameters
    Adam Kemeny-Beke
    Department of Ophthalmology, University of Debrecen, Medical and Health Science Center, Debrecen 4032, Hungary
    Joint Bone Spine 78:184-7. 2011
    ..Asymmetric dimethylarginine (ADMA) has been associated with atherosclerosis, vascular diseases and, recently, also with arthritis including rheumatoid arthritis (RA) and ankylosing spondylitis (AS)...
  58. ncbi request reprint Balneotherapy in elderly patients: effect on pain from degenerative knee and spine conditions and on quality of life
    Janos Gaal
    Department of Rheumatology, Kenézy Gyula County Hospital, Debrecen, Hungary
    Isr Med Assoc J 10:365-9. 2008
    ..Balneotherapy is an established treatment modality for musculoskeletal disease, but few studies have examined the efficacy of spa therapy in elderly patients with degenerative spine and joint diseases...
  59. doi request reprint Expression of bone morphogenetic protein 2, 4, 5, and 7 correlates with histological activity of otosclerotic foci
    Péter Csomor
    Department of Otolaryngology and Head and Neck Surgery, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    Acta Otolaryngol 132:624-31. 2012
    ..These results confirm that elevated expression levels of BMPs, members of the transforming growth factor (TGF)-β superfamily, contribute to the pathologically increased bone turnover in early, active stages of otosclerosis...
  60. pmc Angiogenesis and its targeting in rheumatoid arthritis
    Zoltan Szekanecz
    Department of Rheumatology, Institute of Medicine, University of Debrecen Medical and Health Sciences Center, Debrecen, H 4012 Hungary
    Vascul Pharmacol 51:1-7. 2009
    ..Potentially any angiostatic compound could be introduced to studies using animal models of arthritis or even to human rheumatoid arthritis trials...
  61. pmc Vascular involvement in rheumatic diseases: 'vascular rheumatology'
    Zoltan Szekanecz
    University of Debrecen Medical Center, Institute of Medicine, Department of Rheumatology, 22 Moricz Street, Debrecen, H 4032, Hungary
    Arthritis Res Ther 10:224. 2008
    ..Vasoprotective agents may help to prevent premature atherosclerosis and cardiovascular disease...
  62. pmc Capsular neuronal elements and their relation to pain reduction and functional improvement following total hip replacement
    Levente Gáspár
    Department of Orthopaedic Surgery, Medical Health and Science Center, University of Debrecen, Nagyerdei krt 98, 4012, Debrecen, Hungary
    Int Orthop 28:142-5. 2004
    ..Thus, other factors than capsular neurofilaments influence the scores of pain and disability in osteoarthritis...
  63. doi request reprint Clinical course, prognosis, and causes of death in mixed connective tissue disease
    Agota Hajas
    Division of Clinical Immunology, Department of Medicine, Medical and Health Science Centre, University of Debrecen, Debrecen, Hungary
    J Rheumatol 40:1134-42. 2013
    ..To study the survival rate and prognostic indicators of mixed connective tissue disease (MCTD) in a Hungarian population...
  64. doi request reprint Evaluation of tear osmolarity in non-Sjögren and Sjögren syndrome dry eye patients with the TearLab system
    Eszter Szalai
    Department of Ophthalmology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    Cornea 31:867-71. 2012
    ....
  65. doi request reprint Association of ANCA-associated vasculitis-rheumatoid arthritis overlap syndrome in four patients: rituximab may be the right choice?
    Maria Szilasi
    Department of Pulmonology, University of Debrecen Medical and Health Sciences Center, Debrecen, Hungary
    Autoimmunity 45:304-9. 2012
    ..There have been few reports on the association of rheumatoid arthritis (RA) with anti-neutrophil cytoplasmic antigen (ANCA)-associated systemic vasculitides...
  66. ncbi request reprint Meningitis in mixed connective tissue disease complicated by herpes virus infection: case report
    Edit Bodolay
    Division of Clinical Immunology, Third Department of Internal Medicine, University of Debrecen Medical and Health Science Center, 4004 Debrecen, Moricz Zs 22, Hungary
    Rheumatol Int 24:359-61. 2004
    ..The administration of corticosteroids resulted in rapid improvements in clinical symptoms and laboratory indicators...
  67. doi request reprint Otosclerosis: an autoimmune disease?
    Tamás Karosi
    Department of Otolaryngology and Head and Neck Surgery, University of Debrecen Medical and Health Science Center, Debrecen, Hungary
    Autoimmun Rev 9:95-101. 2009
    ..To review our current knowledge of the etiopathogenesis of otosclerotic bone remodeling including genetics, viral infection, autoimmunity and inflammation and to discuss disease pathogenesis with relevance for pharmacotherapy...
  68. ncbi request reprint Vitamin D receptor gene polymorphism in rheumatoid arthritis and associated osteoporosis
    Péter Rass
    Division of Rheumatology, Third Department of Medicine, University of Debrecen Medical and Health Science Center, 22 Moricz Street, 4004 Debrecen, Hungary
    Rheumatol Int 26:964-71. 2006
    ..The possible involvement of vitamin D and VDR gene polymorphisms in the development and progression of RA needs further elucidation...
  69. ncbi request reprint Vascular endothelium and immune responses: implications for inflammation and angiogenesis
    Zoltan Szekanecz
    Division of Rheumatology, Third Department of Medicine, University of Debrecen Medical and Health Sciences Center, 22 Moricz Street, Debrecen H 4004, Hungary
    Rheum Dis Clin North Am 30:97-114. 2004
    ..Specific targeting of pathologic endothelial function may be useful for the future management of various inflammatory diseases...
  70. doi request reprint Coexistence of ankylosing spondylitis and rheumatoid arthritis in a female patient
    Beáta Baksay
    Department of Rheumatology, Hospital of Hungarian State Railways, Verseghy str 6 8, Szolnok, Hungary
    Clin Rheumatol 30:1119-22. 2011
    ..In 2007, authors diagnosed seropositive RA. Therapy included anti-inflammatory therapy and traditional disease-modifying agents, eventually followed by biological therapy...
  71. ncbi request reprint Technique of synovial biopsy of metacarpophalangeal joints using the needle arthroscope
    Levente Gáspár
    Department of Orthopedics, Medical Health and Science CenterUniversity of Debrecen, Nagyerdei krt 98, 4012, Debrecen, Hungary
    Knee Surg Sports Traumatol Arthrosc 11:50-2. 2003
    ..The tight tension of the joint and traction of the finger is necessary for good visualization, but despite this visibility can be difficult. Needle biopsy is a useful method for the early diagnosis of rheumatoid arthritis...
  72. doi request reprint Development of natural calcium- and phosphate-donating microparticles and a new iontophoretic apparatus for the topical treatment of local osteoporosis. Preliminary in vitro and in vivo studies
    Lajos Pap
    University of Debrecen, Department of Inorganic and Analytical Chemistry, Debrecen, Hungary
    Joint Bone Spine 77:426-31. 2010
    ..We wished to develop a new iontophoretic device suitable for the treatment of local bone loss such as after fractures or in osteodystrophy...
  73. ncbi request reprint Serum cytokine levels and type 1 and type 2 intracellular T cell cytokine profiles in mixed connective tissue disease
    Edit Bodolay
    3rd Department of Internal Medicine, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary
    J Rheumatol 29:2136-42. 2002
    ..To determine serum cytokine concentrations and intracellular cytokine production of CD4+ and CD8+ T cells in 20 patients with mixed connective tissue disease (MCTD)...