Research Topics
Genomes and Genes | Laszlo NagySummaryAffiliation: University of Debrecen Country: Hungary Publications
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Publications
Would eating carrots protect your liver? A new role involving NKT cells for retinoic acid in hepatitisLaszlo Nagy
Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary
Eur J Immunol 42:1677-80. 2012..Furthermore, the study by Lee et al. provides additional support for the concept of metabolic regulation of immune function...- Nuclear hormone receptors enable macrophages and dendritic cells to sense their lipid environment and shape their immune responseLaszlo Nagy
Department of Biochemistry and Molecular Biology, University of Debrecen, Medical and Health Science Center, Egyetem ter 1, Debrecen, Hungary
Physiol Rev 92:739-89. 2012..We also show that these networks are implicated in various immune diseases and are amenable to therapeutic exploitation... 
Research resource: transcriptome profiling of genes regulated by RXR and its permissive and nonpermissive partners in differentiating monocyte-derived dendritic cellsLajos Szeles
Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, Egyetem ter 1, H 4010 Debrecen, Hungary
Mol Endocrinol 24:2218-31. 2010..These data suggested that RXR signaling in Mo-DCs was mediated via multiple permissive heterodimers and also by mechanism(s) independent of permissive heterodimers, and it was controlled in a cell-type and gene-specific manner...- Chronic obstructive pulmonary disease-specific gene expression signatures of alveolar macrophages as well as peripheral blood monocytes overlap and correlate with lung functionSzilard Poliska
Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
Respiration 81:499-510. 2011..Alveolar macrophages (AM) derived from peripheral monocytes (MO) appear to play a key role in initiating and/or sustaining disease progression... - Activation of liver X receptor sensitizes human dendritic cells to inflammatory stimuliDaniel Torocsik
Department of Biochemistry and Molecular Biology, University of Debrecen, Medical and Health Science Center, Hungary
J Immunol 184:5456-65. 2010..We propose that activation of LXR represents a novel lipid-signaling paradigm that alters the inflammatory response of human DCs... - Peroxisome proliferator-activated receptor γ-regulated cathepsin D is required for lipid antigen presentation by dendritic cellsBritt Nakken
Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Debrecen 4010, Hungary
J Immunol 187:240-7. 2011..These results reveal a novel mechanism of lipid Ag presentation and identify CatD as a key component of this machinery and firmly place PPARγ as the transcriptional regulator linking lipid metabolism and lipid Ag processing... - 1,25-dihydroxyvitamin D3 is an autonomous regulator of the transcriptional changes leading to a tolerogenic dendritic cell phenotypeLajos Szeles
Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
J Immunol 182:2074-83. 2009.... - STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cellsAttila Szanto
Department of Biochemistry and Molecular Biology, University of Debrecen, Medical and Health Science Center, Research Center for Molecular Medicine, Egyetem ter 1 Debrecen, H 4010, Hungary
Immunity 33:699-712. 2010..This interaction, underpinning cell type-specific responses, represents a unique way of controlling nuclear receptor signaling by inflammatory molecules in immune cells... - Transient receptor potential vanilloid-1 signaling as a regulator of human sebocyte biologyBalazs I Toth
Department of Physiology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
J Invest Dermatol 129:329-39. 2009.... - PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cellsIstvan Szatmari
Department of Biochemistry and Molecular Biology, University of Debrecen, Medical and Health Science Center, Debrecen H 4010, Hungary
J Exp Med 203:2351-62. 2006..The uncovered mechanisms allow the DCs to respond to altered lipid homeostasis by changing CD1 gene expression... - Factor XIII-A is involved in the regulation of gene expression in alternatively activated human macrophagesDaniel Torocsik
Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary
Thromb Haemost 104:709-17. 2010..Our findings suggest that functional impairment of macrophages at the level of gene expression regulation plays a role in the wound healing defects of FXIII-A-deficient patients... 
Differentiation of CD1a- and CD1a+ monocyte-derived dendritic cells is biased by lipid environment and PPARgammaPeter Gogolak
Institute of Immunology, Department of Pathology, Research Center for Molecular Medicine, University of Debrecen, 98 Nagyerdei Blv Debrecen, H 4012 Hungary
Blood 109:643-52. 2007..The presence of CD1a-PPARgamma+ and CD1a+PPARgamma- DCs in lymph nodes and in pulmonary Langerhans cell histiocytosis confirms the functional relevance of these DC subsets in vivo...- Genome-wide localization of histone 4 arginine 3 methylation in a differentiation primed myeloid leukemia cell lineBalint L Balint
Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Medical and Health Science Center, Nagyerdei krt. 98. Debrecen, H-4012 Hungary
Immunobiology 210:141-52. 2005..A significant number of the genes in the proximity of the identified genomic loci are involved in signaling pathways and developmental processes including immune response of myeloid cells... - Gene expression profiles in peripheral blood for the diagnosis of autoimmune diseasesBertalan Mesko
Department of Biochemistry and Molecular Biology, Research Center for Molecular Mediicne, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
Trends Mol Med 17:223-33. 2011..A gene-disease interaction network in chronic inflammatory diseases, a general protocol for future studies and a decision tree for researchers are presented to facilitate standardization and adoption of this approach... - Association of peroxisome proliferator-activated receptor gamma polymorphisms with inflammatory bowel disease in a Hungarian cohortSzilard Poliska
Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Debrecen, Hungary
Inflamm Bowel Dis 18:472-9. 2012..Our aim was to examine the association of four polymorphisms of PPARγ in a well-characterized Hungarian IBD cohort... - PPARgamma regulates the function of human dendritic cells primarily by altering lipid metabolismIstvan Szatmari
Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Medical and Health Science Center, Nagyerdei krt 98, Debrecen, Hungary
Blood 110:3271-80. 2007..Our data show that PPARgamma acts as a mostly positive transcriptional regulator in human developing DCs, acting primarily through controlling genes involved in lipid metabolism and via this, indirectly modifying the immune phenotype... - Arginine methylation provides epigenetic transcription memory for retinoid-induced differentiation in myeloid cellsBalint L Balint
Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Medical and Health Science Center, Nagyerdei krt. 98, Debrecen H-4012, Hungary
Mol Cell Biol 25:5648-63. 2005.... - Carboxypeptidase-M is regulated by lipids and CSFs in macrophages and dendritic cells and expressed selectively in tissue granulomas and foam cellsIoannis Tsakiris
Department of Pathology, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary
Lab Invest 92:345-61. 2012..Furthermore, the present data offer CPM for the first time to be a novel marker and cellular player in lipid uptake and/or metabolism of MAs by promoting foam cell formation... - Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targetsBertalan Mesko
Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary
BMC Med Genomics 3:15. 2010..The main focus of our work was the identification of novel markers that overlap among the 3 diseases or discriminate them from each other... - Activation of retinoic acid receptor signaling coordinates lineage commitment of spontaneously differentiating mouse embryonic stem cells in embryoid bodiesZoltan Simandi
Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
FEBS Lett 584:3123-30. 2010..These data suggest that retinoid signaling not only promotes a particular pathway but also acts as a context dependent general coordinator of the differentiation states in embryonic stem cells... - Oxysterol signaling links cholesterol metabolism and inflammation via the liver X receptor in macrophagesDaniel Torocsik
Department of Biochemistry and Molecular Biology, University of Debrecen, Medical and Health Science Center, Research Center for Molecular Medicine, Hungary
Mol Aspects Med 30:134-52. 2009..We also summarize data supporting the notion that LXR is also involved in the regulation of inflammatory processes. Finally, the in vivo consequences of LXR activation or deletion are discussed... - Roles for lipid-activated transcription factors in atherosclerosisLaszlo Nagy
Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary
Mol Nutr Food Res 49:1072-4. 2005.... - Retinoids potentiate peroxisome proliferator-activated receptor gamma action in differentiation, gene expression, and lipid metabolic processes in developing myeloid cellsAttila Szanto
Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, Medical and Health Science Center, University of Debrecen, 98 Nagyerdei krt, Debrecen, Hungary H-4012
Mol Pharmacol 67:1935-43. 2005..PPARgamma activity can be enhanced by retinoids at least in part via increasing PPARgamma expression level. These observations can be exploited to enhance therapeutically beneficial PPAR responses in myeloid cells... - Peroxisome proliferator-activated receptor gamma-regulated ABCG2 expression confers cytoprotection to human dendritic cellsIstvan Szatmari
Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Hungary
J Biol Chem 281:23812-23. 2006..The increased expression of the promiscuous ABCG2 transporter can significantly modify the xenobiotic and drug resistance of human myeloid dendritic cells... - Nuclear receptor signalling in dendritic cells connects lipids, the genome and immune functionIstvan Szatmari
Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
EMBO J 27:2353-62. 2008.... - PPARgamma in immunity and inflammation: cell types and diseasesLajos Szeles
Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Medical and Health Science Center, Life Science Building, Egyetem ter 1 Debrecen, H 4010 Hungary
Biochim Biophys Acta 1771:1014-30. 2007.... - Analyses of association between PPAR gamma and EPHX1 polymorphisms and susceptibility to COPD in a Hungarian cohort, a case-control studyAndras Penyige
Department of Human Genetics, University of Debrecen, Debrecen, Hungary
BMC Med Genet 11:152. 2010..Genetic association studies of new candidate genes in COPD may lead to improved understanding of the pathogenesis of the disease... - PPARgamma, a lipid-activated transcription factor as a regulator of dendritic cell functionIstvan Szatmari
Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, H-4010, Hungary
Ann N Y Acad Sci 1088:207-18. 2006..It is also possible that this receptor is a relevant target for pharmacological intervention in immune diseases such as chronic inflammation and autoimmune conditions... - Ethanol increases phosphate-mediated mineralization and osteoblastic transformation of vascular smooth muscle cellsMelinda Oros
Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
J Cell Mol Med 16:2219-26. 2012..The observed effects of ethanol were not due to alterations of phosphate uptake by HSMCs. We conclude that ethanol enhances Pi-mediated human vascular smooth muscle calcification and transition of these cells into osteoblast-like cells... - Identification of novel markers of alternative activation and potential endogenous PPARγ ligand production mechanisms in human IL-4 stimulated differentiating macrophagesZsolt Czimmerer
Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, Medical and Health Science Center, University of Debrecen, Life Science Building, Egyetem ter 1, Debrecen H 4012, Hungary
Immunobiology 217:1301-14. 2012..Our data suggest that global gene expression profiling, combined with computational transcription activity prediction, can lead to identification of transcriptional networks that underpin cellular subtype specification... - Activation of PPARgamma specifies a dendritic cell subtype capable of enhanced induction of iNKT cell expansionIstvan Szatmari
Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Medical and Health Science Center, Nagyerdei krt. 98, H-4012, Hungary
Immunity 21:95-106. 2004.... - Peripheral blood gene expression and IgG glycosylation profiles as markers of tocilizumab treatment in rheumatoid arthritisBertalan Mesko
Department of Biochemistry and Molecular Biology, Apoptosis and Genomics Research Group, Hungarian Academy of Sciences, Budapest, Hungary
J Rheumatol 39:916-28. 2012..It is not known if there are characteristic changes in gene expression and immunoglobulin G glycosylation during therapy or in response to treatment... - Live-cell fluorescence correlation spectroscopy dissects the role of coregulator exchange and chromatin binding in retinoic acid receptor mobilityPeter Brazda
Department of Biochemistry and Molecular Biology, University of Debrecen, Medical and Health Science Centre, Egyetem ter 1 Debrecen, H 4010, Hungary
J Cell Sci 124:3631-42. 2011.... - Coagulation factor XIII-A. A flow cytometric intracellular marker in the classification of acute myeloid leukemiasJanos Kappelmayer
Department of Clinical Biochemistry and Molecular Pathology, Medical and Health Science Centre, University of Debrecen, Hungary
Thromb Haemost 94:454-9. 2005..FXIII-A can be considered as a reliable intracytoplasmic marker for the monocytic and megakaryocytic series and its presence is highly predictive for mono- and megakaryocytic AML and for CMML... - The many faces of PPARgamma: anti-inflammatory by any means?Attila Szanto
Department of Biochemistry and Molecular Biology, University of Debrecen, Medical and Health Science Center, Research Center for Molecular Medicine, Life Science Building, Egyetem ter 1, H 4032 Debrecen, Hungary
Immunobiology 213:789-803. 2008..The action of PPARgamma in acute and chronic inflammatory diseases and disease models will be presented... - Transcriptional regulation of human CYP27 integrates retinoid, peroxisome proliferator-activated receptor, and liver X receptor signaling in macrophagesAttila Szanto
Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Hungary
Mol Cell Biol 24:8154-66. 2004..Our findings suggest that nuclear receptor-regulated CYP27 expression is likely to be a key integrator of retinoic acid receptor-PPARgamma-LXR signaling, relying on natural ligands and contributing to lipid metabolism in macrophages... - Twenty years of nuclear receptors: Conference on Nuclear Receptors: from Chromatin to DiseaseLaszlo Nagy
Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Medical and Health Science Center, Egyetem ter 1, H-4010 Debrecen, Hungary
EMBO Rep 7:579-84. 2006 - PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammationTamas Varga
Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Medical and Health Science Center, Hungary
Biochim Biophys Acta 1812:1007-22. 2011..This article is part of a Special Issue entitled: Translating nuclear receptors from health to disease... - The triad of success in personalised medicine: pharmacogenomics, biotechnology and regulatory issues from a Central European perspectiveBertalan Mesko
Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary
N Biotechnol 29:741-50. 2012..We propose that the synergy of these three issues: pharmacogenomics, biotechnology and regulatory issues should be considered a triad necessary to succeed in personalised medicine... - Monoclonal antibody proteomics: discovery and prevalidation of chronic obstructive pulmonary disease biomarkers in a single stepEszter Csanky
Department of Pulmonology, University of Debrecen, Debrecen, Hungary
Electrophoresis 28:4401-6. 2007.... - Ribonucleoprotein-masked nicks at 50-kbp intervals in the eukaryotic genomic DNALorant Szekvolgyi
Department of Biophysics and Cell Biology, Hungarian Academy of Sciences, Debrecen, Hungary
Proc Natl Acad Sci U S A 104:14964-9. 2007.... - Endocannabinoids enhance lipid synthesis and apoptosis of human sebocytes via cannabinoid receptor-2-mediated signalingNóra Dobrosi
Department of Physiology, University of Debrecen, Medical and Health Science Center, 4032 Debrecen, Nagyerdei krt 98 PO Box 22, Hungary
FASEB J 22:3685-95. 2008..CB2 antagonists or agonists therefore deserve to be explored in the management of skin disorders characterized by sebaceous gland dysfunctions (e.g., acne vulgaris, seborrhea, dry skin)...