Laszlo Nagy

Summary

Affiliation: University of Debrecen
Country: Hungary

Publications

  1. pmc STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells
    Attila Szanto
    Department of Biochemistry and Molecular Biology, University of Debrecen, Medical and Health Science Center, Research Center for Molecular Medicine, Egyetem ter 1 Debrecen, H 4010, Hungary
    Immunity 33:699-712. 2010
  2. pmc PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation
    Tamas Varga
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Medical and Health Science Center, Hungary
    Biochim Biophys Acta 1812:1007-22. 2011
  3. doi request reprint Would eating carrots protect your liver? A new role involving NKT cells for retinoic acid in hepatitis
    Laszlo Nagy
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary
    Eur J Immunol 42:1677-80. 2012
  4. doi request reprint Nuclear hormone receptors enable macrophages and dendritic cells to sense their lipid environment and shape their immune response
    Laszlo Nagy
    Department of Biochemistry and Molecular Biology, University of Debrecen, Medical and Health Science Center, Egyetem ter 1, Debrecen, Hungary
    Physiol Rev 92:739-89. 2012
  5. doi request reprint Identification of novel markers of alternative activation and potential endogenous PPARγ ligand production mechanisms in human IL-4 stimulated differentiating macrophages
    Zsolt Czimmerer
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, Medical and Health Science Center, University of Debrecen, Life Science Building, Egyetem ter 1, Debrecen H 4012, Hungary
    Immunobiology 217:1301-14. 2012
  6. pmc Research resource: transcriptome profiling of genes regulated by RXR and its permissive and nonpermissive partners in differentiating monocyte-derived dendritic cells
    Lajos Szeles
    Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, Egyetem ter 1, H 4010 Debrecen, Hungary
    Mol Endocrinol 24:2218-31. 2010
  7. ncbi request reprint PPARγ-mediated and arachidonic acid-dependent signaling is involved in differentiation and lipid production of human sebocytes
    Anikó Dózsa
    1 Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary 2 Department of Dermatology, Health Care Center, Miskolc, Hungary
    J Invest Dermatol 134:910-20. 2014
  8. pmc Ligand binding shifts highly mobile retinoid X receptor to the chromatin-bound state in a coactivator-dependent manner, as revealed by single-cell imaging
    Peter Brazda
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Faculty of Medicine, Debrecen, Hungary
    Mol Cell Biol 34:1234-45. 2014
  9. pmc RDH10, RALDH2, and CRABP2 are required components of PPARγ-directed ATRA synthesis and signaling in human dendritic cells
    Adrienn Gyöngyösi
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary
    J Lipid Res 54:2458-74. 2013
  10. doi request reprint 1,25-dihydroxyvitamin D3 is an autonomous regulator of the transcriptional changes leading to a tolerogenic dendritic cell phenotype
    Lajos Szeles
    Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    J Immunol 182:2074-83. 2009

Detail Information

Publications56

  1. pmc STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells
    Attila Szanto
    Department of Biochemistry and Molecular Biology, University of Debrecen, Medical and Health Science Center, Research Center for Molecular Medicine, Egyetem ter 1 Debrecen, H 4010, Hungary
    Immunity 33:699-712. 2010
    ..This interaction, underpinning cell type-specific responses, represents a unique way of controlling nuclear receptor signaling by inflammatory molecules in immune cells...
  2. pmc PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation
    Tamas Varga
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Medical and Health Science Center, Hungary
    Biochim Biophys Acta 1812:1007-22. 2011
    ..This article is part of a Special Issue entitled: Translating nuclear receptors from health to disease...
  3. doi request reprint Would eating carrots protect your liver? A new role involving NKT cells for retinoic acid in hepatitis
    Laszlo Nagy
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary
    Eur J Immunol 42:1677-80. 2012
    ..Furthermore, the study by Lee et al. provides additional support for the concept of metabolic regulation of immune function...
  4. doi request reprint Nuclear hormone receptors enable macrophages and dendritic cells to sense their lipid environment and shape their immune response
    Laszlo Nagy
    Department of Biochemistry and Molecular Biology, University of Debrecen, Medical and Health Science Center, Egyetem ter 1, Debrecen, Hungary
    Physiol Rev 92:739-89. 2012
    ..We also show that these networks are implicated in various immune diseases and are amenable to therapeutic exploitation...
  5. doi request reprint Identification of novel markers of alternative activation and potential endogenous PPARγ ligand production mechanisms in human IL-4 stimulated differentiating macrophages
    Zsolt Czimmerer
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, Medical and Health Science Center, University of Debrecen, Life Science Building, Egyetem ter 1, Debrecen H 4012, Hungary
    Immunobiology 217:1301-14. 2012
    ..Our data suggest that global gene expression profiling, combined with computational transcription activity prediction, can lead to identification of transcriptional networks that underpin cellular subtype specification...
  6. pmc Research resource: transcriptome profiling of genes regulated by RXR and its permissive and nonpermissive partners in differentiating monocyte-derived dendritic cells
    Lajos Szeles
    Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, Egyetem ter 1, H 4010 Debrecen, Hungary
    Mol Endocrinol 24:2218-31. 2010
    ..These data suggested that RXR signaling in Mo-DCs was mediated via multiple permissive heterodimers and also by mechanism(s) independent of permissive heterodimers, and it was controlled in a cell-type and gene-specific manner...
  7. ncbi request reprint PPARγ-mediated and arachidonic acid-dependent signaling is involved in differentiation and lipid production of human sebocytes
    Anikó Dózsa
    1 Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary 2 Department of Dermatology, Health Care Center, Miskolc, Hungary
    J Invest Dermatol 134:910-20. 2014
    ..Collectively, our findings highlight the importance of endogenous ligand-activated PPARγ signaling in human sebocyte biology and suggest that PPARγ might be a promising candidate for the clinical management of SG disorders. ..
  8. pmc Ligand binding shifts highly mobile retinoid X receptor to the chromatin-bound state in a coactivator-dependent manner, as revealed by single-cell imaging
    Peter Brazda
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Faculty of Medicine, Debrecen, Hungary
    Mol Cell Biol 34:1234-45. 2014
    ..Our results support a model in which RXR has a distinct, highly dynamic nuclear behavior and follows hit-and-run kinetics upon activation...
  9. pmc RDH10, RALDH2, and CRABP2 are required components of PPARγ-directed ATRA synthesis and signaling in human dendritic cells
    Adrienn Gyöngyösi
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary
    J Lipid Res 54:2458-74. 2013
    ....
  10. doi request reprint 1,25-dihydroxyvitamin D3 is an autonomous regulator of the transcriptional changes leading to a tolerogenic dendritic cell phenotype
    Lajos Szeles
    Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    J Immunol 182:2074-83. 2009
    ....
  11. doi request reprint Activation of liver X receptor sensitizes human dendritic cells to inflammatory stimuli
    Daniel Torocsik
    Department of Biochemistry and Molecular Biology, University of Debrecen, Medical and Health Science Center, Hungary
    J Immunol 184:5456-65. 2010
    ..We propose that activation of LXR represents a novel lipid-signaling paradigm that alters the inflammatory response of human DCs...
  12. doi request reprint Chronic obstructive pulmonary disease-specific gene expression signatures of alveolar macrophages as well as peripheral blood monocytes overlap and correlate with lung function
    Szilard Poliska
    Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    Respiration 81:499-510. 2011
    ..Alveolar macrophages (AM) derived from peripheral monocytes (MO) appear to play a key role in initiating and/or sustaining disease progression...
  13. pmc PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells
    Istvan Szatmari
    Department of Biochemistry and Molecular Biology, University of Debrecen, Medical and Health Science Center, Debrecen H 4010, Hungary
    J Exp Med 203:2351-62. 2006
    ..The uncovered mechanisms allow the DCs to respond to altered lipid homeostasis by changing CD1 gene expression...
  14. doi request reprint Pro-inflammatory cytokines negatively regulate PPARγ mediated gene expression in both human and murine macrophages via multiple mechanisms
    Zsuzsanna S Nagy
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen Medical and Health Science Center, H 4032 Debrecen, Nagyerdei krt 98, Hungary
    Immunobiology 218:1336-44. 2013
    ..These findings support that inflammatory conditions skew the lipid sensing function of macrophages, further contributing to the vicious circle of metabolic disorders. ..
  15. doi request reprint Peroxisome proliferator-activated receptor γ-regulated cathepsin D is required for lipid antigen presentation by dendritic cells
    Britt Nakken
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Debrecen 4010, Hungary
    J Immunol 187:240-7. 2011
    ..These results reveal a novel mechanism of lipid Ag presentation and identify CatD as a key component of this machinery and firmly place PPARγ as the transcriptional regulator linking lipid metabolism and lipid Ag processing...
  16. doi request reprint Transient receptor potential vanilloid-1 signaling as a regulator of human sebocyte biology
    Balazs I Toth
    Department of Physiology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    J Invest Dermatol 129:329-39. 2009
    ....
  17. doi request reprint Factor XIII-A is involved in the regulation of gene expression in alternatively activated human macrophages
    Daniel Torocsik
    Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary
    Thromb Haemost 104:709-17. 2010
    ..Our findings suggest that functional impairment of macrophages at the level of gene expression regulation plays a role in the wound healing defects of FXIII-A-deficient patients...
  18. ncbi request reprint Differentiation of CD1a- and CD1a+ monocyte-derived dendritic cells is biased by lipid environment and PPARgamma
    Peter Gogolak
    Institute of Immunology, Department of Pathology, Research Center for Molecular Medicine, University of Debrecen, 98 Nagyerdei Blv Debrecen, H 4012 Hungary
    Blood 109:643-52. 2007
    ..The presence of CD1a-PPARgamma+ and CD1a+PPARgamma- DCs in lymph nodes and in pulmonary Langerhans cell histiocytosis confirms the functional relevance of these DC subsets in vivo...
  19. ncbi request reprint Genome-wide localization of histone 4 arginine 3 methylation in a differentiation primed myeloid leukemia cell line
    Balint L Balint
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Medical and Health Science Center, Nagyerdei krt 98 Debrecen, H 4012 Hungary
    Immunobiology 210:141-52. 2005
    ..A significant number of the genes in the proximity of the identified genomic loci are involved in signaling pathways and developmental processes including immune response of myeloid cells...
  20. doi request reprint Gene expression profiles in peripheral blood for the diagnosis of autoimmune diseases
    Bertalan Mesko
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Mediicne, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    Trends Mol Med 17:223-33. 2011
    ..A gene-disease interaction network in chronic inflammatory diseases, a general protocol for future studies and a decision tree for researchers are presented to facilitate standardization and adoption of this approach...
  21. ncbi request reprint Peroxisome proliferator-activated receptor gamma-regulated ABCG2 expression confers cytoprotection to human dendritic cells
    Istvan Szatmari
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Hungary
    J Biol Chem 281:23812-23. 2006
    ..The increased expression of the promiscuous ABCG2 transporter can significantly modify the xenobiotic and drug resistance of human myeloid dendritic cells...
  22. doi request reprint A novel method to predict regulatory regions based on histone mark landscapes in macrophages
    Gergely Nagy
    Department of Biochemistry and Molecular Biology, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary
    Immunobiology 218:1416-27. 2013
    ....
  23. doi request reprint Association of peroxisome proliferator-activated receptor gamma polymorphisms with inflammatory bowel disease in a Hungarian cohort
    Szilard Poliska
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Debrecen, Hungary
    Inflamm Bowel Dis 18:472-9. 2012
    ..Our aim was to examine the association of four polymorphisms of PPARγ in a well-characterized Hungarian IBD cohort...
  24. pmc Arginine methylation provides epigenetic transcription memory for retinoid-induced differentiation in myeloid cells
    Balint L Balint
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Medical and Health Science Center, Nagyerdei krt 98, Debrecen H 4012, Hungary
    Mol Cell Biol 25:5648-63. 2005
    ....
  25. ncbi request reprint PPARgamma regulates the function of human dendritic cells primarily by altering lipid metabolism
    Istvan Szatmari
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Medical and Health Science Center, Nagyerdei krt 98, Debrecen, Hungary
    Blood 110:3271-80. 2007
    ..Our data show that PPARgamma acts as a mostly positive transcriptional regulator in human developing DCs, acting primarily through controlling genes involved in lipid metabolism and via this, indirectly modifying the immune phenotype...
  26. pmc Carboxypeptidase-M is regulated by lipids and CSFs in macrophages and dendritic cells and expressed selectively in tissue granulomas and foam cells
    Ioannis Tsakiris
    Department of Pathology, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary
    Lab Invest 92:345-61. 2012
    ..Furthermore, the present data offer CPM for the first time to be a novel marker and cellular player in lipid uptake and/or metabolism of MAs by promoting foam cell formation...
  27. doi request reprint Tissue LyC6- macrophages are generated in the absence of circulating LyC6- monocytes and Nur77 in a model of muscle regeneration
    Tamas Varga
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, Medical and Health Science Center, University of Debrecen, Debrecen 4012, Hungary
    J Immunol 191:5695-701. 2013
    ..Lastly, our data show that in the used sterile inflammation model tissue LyC6(-) MFs are derived from LyC6(+) cells. ..
  28. ncbi request reprint PPARgamma in immunity and inflammation: cell types and diseases
    Lajos Szeles
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Medical and Health Science Center, Life Science Building, Egyetem ter 1 Debrecen, H 4010 Hungary
    Biochim Biophys Acta 1771:1014-30. 2007
    ....
  29. doi request reprint The role of lipid-activated nuclear receptors in shaping macrophage and dendritic cell function: From physiology to pathology
    Mate Kiss
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary
    J Allergy Clin Immunol 132:264-86. 2013
    ....
  30. pmc Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets
    Bertalan Mesko
    Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary
    BMC Med Genomics 3:15. 2010
    ..The main focus of our work was the identification of novel markers that overlap among the 3 diseases or discriminate them from each other...
  31. ncbi request reprint Roles for lipid-activated transcription factors in atherosclerosis
    Laszlo Nagy
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary
    Mol Nutr Food Res 49:1072-4. 2005
    ....
  32. doi request reprint Activation of retinoic acid receptor signaling coordinates lineage commitment of spontaneously differentiating mouse embryonic stem cells in embryoid bodies
    Zoltan Simandi
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    FEBS Lett 584:3123-30. 2010
    ..These data suggest that retinoid signaling not only promotes a particular pathway but also acts as a context dependent general coordinator of the differentiation states in embryonic stem cells...
  33. doi request reprint Oxysterol signaling links cholesterol metabolism and inflammation via the liver X receptor in macrophages
    Daniel Torocsik
    Department of Biochemistry and Molecular Biology, University of Debrecen, Medical and Health Science Center, Research Center for Molecular Medicine, Hungary
    Mol Aspects Med 30:134-52. 2009
    ..We also summarize data supporting the notion that LXR is also involved in the regulation of inflammatory processes. Finally, the in vivo consequences of LXR activation or deletion are discussed...
  34. ncbi request reprint Highly efficient differentiation of embryonic stem cells into adipocytes by ascorbic acid
    Ixchelt Cuaranta-Monroy
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Medical and Health Science Center, Egyetem ter 1, Debrecen H 4012, Hungary
    Stem Cell Res 13:88-97. 2014
    ..Moreover, the differentiated cells are in a monolayer, allowing a broad range of genome-wide studies in early and late stages of adipocyte differentiation to be performed. ..
  35. doi request reprint Pharmacogenetics and pharmacogenomics in rheumatology
    Zoltan Szekanecz
    Department of Rheumatology, Institute of Medicine, University of Debrecen Medical and Health Science Center, Nagyerdei Street 98, 4032, Debrecen, Hungary
    Immunol Res 56:325-33. 2013
    ..More, focused studies carried out in larger patient cohorts, using pre-selected genes, may be needed in order to determine the future of pharmacogenetics and pharmacogenomics as tools for personalized medicine in rheumatology...
  36. ncbi request reprint Retinoids potentiate peroxisome proliferator-activated receptor gamma action in differentiation, gene expression, and lipid metabolic processes in developing myeloid cells
    Attila Szanto
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, Medical and Health Science Center, University of Debrecen, 98 Nagyerdei krt, Debrecen, Hungary H 4012
    Mol Pharmacol 67:1935-43. 2005
    ..PPARgamma activity can be enhanced by retinoids at least in part via increasing PPARgamma expression level. These observations can be exploited to enhance therapeutically beneficial PPAR responses in myeloid cells...
  37. pmc Analyses of association between PPAR gamma and EPHX1 polymorphisms and susceptibility to COPD in a Hungarian cohort, a case-control study
    Andras Penyige
    Department of Human Genetics, University of Debrecen, Debrecen, Hungary
    BMC Med Genet 11:152. 2010
    ..Genetic association studies of new candidate genes in COPD may lead to improved understanding of the pathogenesis of the disease...
  38. pmc Nuclear receptor signalling in dendritic cells connects lipids, the genome and immune function
    Istvan Szatmari
    Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    EMBO J 27:2353-62. 2008
    ....
  39. ncbi request reprint Activation of PPARgamma specifies a dendritic cell subtype capable of enhanced induction of iNKT cell expansion
    Istvan Szatmari
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Medical and Health Science Center, Nagyerdei krt 98, H 4012, Hungary
    Immunity 21:95-106. 2004
    ....
  40. doi request reprint Nuclear receptor mediated mechanisms of macrophage cholesterol metabolism
    Zsuzsanna S Nagy
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen Medical and Health Science Center, H 4032 Debrecen, Nagyerdei krt 98, Hungary
    Mol Cell Endocrinol 368:85-98. 2013
    ..This review will summarize the most recent findings from this field narrowly focusing on the contribution of various nuclear receptors to macrophage cholesterol metabolism...
  41. doi request reprint Peripheral blood gene expression and IgG glycosylation profiles as markers of tocilizumab treatment in rheumatoid arthritis
    Bertalan Mesko
    Department of Biochemistry and Molecular Biology, Apoptosis and Genomics Research Group, Hungarian Academy of Sciences, Budapest, Hungary
    J Rheumatol 39:916-28. 2012
    ..It is not known if there are characteristic changes in gene expression and immunoglobulin G glycosylation during therapy or in response to treatment...
  42. ncbi request reprint PPARgamma, a lipid-activated transcription factor as a regulator of dendritic cell function
    Istvan Szatmari
    Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, H 4010, Hungary
    Ann N Y Acad Sci 1088:207-18. 2006
    ..It is also possible that this receptor is a relevant target for pharmacological intervention in immune diseases such as chronic inflammation and autoimmune conditions...
  43. pmc Transcriptional regulation of human CYP27 integrates retinoid, peroxisome proliferator-activated receptor, and liver X receptor signaling in macrophages
    Attila Szanto
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Hungary
    Mol Cell Biol 24:8154-66. 2004
    ..Our findings suggest that nuclear receptor-regulated CYP27 expression is likely to be a key integrator of retinoic acid receptor-PPARgamma-LXR signaling, relying on natural ligands and contributing to lipid metabolism in macrophages...
  44. doi request reprint [The place of functional genomics in oncological research]
    Balint L Balint
    Debreceni Egyetem Orvos és Egészségtudományi Centrum, Klinikai Genomikai és Személyreszabott Orvoslási Központ, Debrecen, Hungary
    Magy Onkol 57:21-5. 2013
    ..Based on the recent development in the field we summarize the challenges that have to be addressed in the next couple of years...
  45. doi request reprint Ethanol increases phosphate-mediated mineralization and osteoblastic transformation of vascular smooth muscle cells
    Melinda Oros
    Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    J Cell Mol Med 16:2219-26. 2012
    ..The observed effects of ethanol were not due to alterations of phosphate uptake by HSMCs. We conclude that ethanol enhances Pi-mediated human vascular smooth muscle calcification and transition of these cells into osteoblast-like cells...
  46. pmc Live-cell fluorescence correlation spectroscopy dissects the role of coregulator exchange and chromatin binding in retinoic acid receptor mobility
    Peter Brazda
    Department of Biochemistry and Molecular Biology, University of Debrecen, Medical and Health Science Centre, Egyetem ter 1 Debrecen, H 4010, Hungary
    J Cell Sci 124:3631-42. 2011
    ....
  47. ncbi request reprint Coagulation factor XIII-A. A flow cytometric intracellular marker in the classification of acute myeloid leukemias
    Janos Kappelmayer
    Department of Clinical Biochemistry and Molecular Pathology, Medical and Health Science Centre, University of Debrecen, Hungary
    Thromb Haemost 94:454-9. 2005
    ..FXIII-A can be considered as a reliable intracytoplasmic marker for the monocytic and megakaryocytic series and its presence is highly predictive for mono- and megakaryocytic AML and for CMML...
  48. doi request reprint The many faces of PPARgamma: anti-inflammatory by any means?
    Attila Szanto
    Department of Biochemistry and Molecular Biology, University of Debrecen, Medical and Health Science Center, Research Center for Molecular Medicine, Life Science Building, Egyetem ter 1, H 4032 Debrecen, Hungary
    Immunobiology 213:789-803. 2008
    ..The action of PPARgamma in acute and chronic inflammatory diseases and disease models will be presented...
  49. pmc Twenty years of nuclear receptors: Conference on Nuclear Receptors: from Chromatin to Disease
    Laszlo Nagy
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Medical and Health Science Center, Egyetem ter 1, H 4010 Debrecen, Hungary
    EMBO Rep 7:579-84. 2006
  50. ncbi request reprint Accelerated recovery of 5-fluorouracil-damaged bone marrow after rosiglitazone treatment
    Katayoun Djazayeri
    Department of Pharmacology and Pharmacotherapy, Medical and Health Science Center, University of Debrecen, Hungary
    Eur J Pharmacol 522:122-9. 2005
    ....
  51. doi request reprint The triad of success in personalised medicine: pharmacogenomics, biotechnology and regulatory issues from a Central European perspective
    Bertalan Mesko
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary
    N Biotechnol 29:741-50. 2012
    ..We propose that the synergy of these three issues: pharmacogenomics, biotechnology and regulatory issues should be considered a triad necessary to succeed in personalised medicine...
  52. pmc A versatile method to design stem-loop primer-based quantitative PCR assays for detecting small regulatory RNA molecules
    Zsolt Czimmerer
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen Medical and Health Science Center, Debrecen, Hungary
    PLoS ONE 8:e55168. 2013
    ..The assay design method is freely available for anyone who wishes to use a robust and flexible system for the quantitative analysis of matured regulatory RNA-s...
  53. doi request reprint Nuclear receptors as regulators of stem cell and cancer stem cell metabolism
    Zoltan Simandi
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Medical and Health Science Center, Egyetem ter 1, Debrecen H 4012, Hungary
    Semin Cell Dev Biol 24:716-23. 2013
    ..We also discuss the role of TR4, NGF1β, LXRβ and RARs in stemness. In addition, we summarize our current understanding of the potential roles of NRs in cancer stem cells. ..
  54. pmc Ribonucleoprotein-masked nicks at 50-kbp intervals in the eukaryotic genomic DNA
    Lorant Szekvolgyi
    Department of Biophysics and Cell Biology, Hungarian Academy of Sciences, Debrecen, Hungary
    Proc Natl Acad Sci U S A 104:14964-9. 2007
    ....
  55. ncbi request reprint Monoclonal antibody proteomics: discovery and prevalidation of chronic obstructive pulmonary disease biomarkers in a single step
    Eszter Csanky
    Department of Pulmonology, University of Debrecen, Debrecen, Hungary
    Electrophoresis 28:4401-6. 2007
    ....
  56. doi request reprint Endocannabinoids enhance lipid synthesis and apoptosis of human sebocytes via cannabinoid receptor-2-mediated signaling
    Nóra Dobrosi
    Department of Physiology, University of Debrecen, Medical and Health Science Center, 4032 Debrecen, Nagyerdei krt 98 PO Box 22, Hungary
    FASEB J 22:3685-95. 2008
    ..CB2 antagonists or agonists therefore deserve to be explored in the management of skin disorders characterized by sebaceous gland dysfunctions (e.g., acne vulgaris, seborrhea, dry skin)...