Zsolt Kovacs


Affiliation: University of West Hungary
Country: Hungary


  1. Kovács Z, Czurkó A, Kékesi K, Juhász G. Intracerebroventricularly administered lipopolysaccharide enhances spike-wave discharges in freely moving WAG/Rij rats. Brain Res Bull. 2011;85:410-6 pubmed publisher
    ..Our results show that centrally injected LPS, likewise the peripheral injection, can increase the number and duration of SWDs in the WAG/Rij rat, and the effect invoke inflammatory cytokines as well as excitatory neurotransmitters. ..
  2. Kovacs Z, Kekesi K, Juhasz G, Barna J, Héja L, Lakatos R, et al. Non-adenosine nucleoside inosine, guanosine and uridine as promising antiepileptic drugs: a summary of current literature. Mini Rev Med Chem. 2015;14:1033-42 pubmed
    ..Finally, we discuss some non-Ado nucleoside derivatives and their structures, which may be candidates as potential antiepileptic agents. ..
  3. Kovacs Z, Kardos J, Kekesi K, Juhasz G, Lakatos R, Héja L. Effects of nucleosides on glia - neuron interactions open up new vistas in the development of more effective antiepileptic drugs. Curr Med Chem. 2015;22:1500-14 pubmed
    ..In this review article we focus on the role of Ado and Urd in glia-neuron interactions, placing emphasis on their implications for the treatment of epilepsy. ..
  4. Kovács Z, Kékesi K, Juhász G, Dobolyi A. Modulatory effects of inosine, guanosine and uridine on lipopolysaccharide-evoked increase in spike-wave discharge activity in Wistar Albino Glaxo/Rijswijk rats. Brain Res Bull. 2015;118:46-57 pubmed publisher
    ..Our results suggest that different nucleosides have diverse effects on LPS-induced changes in absence epileptic activity. ..
  5. Kovacs Z, Czurkó A, Kekesi K, Juhasz G. The effect of intraperitoneally administered dimethyl sulfoxide on absence-like epileptic activity of freely moving WAG/Rij rats. J Neurosci Methods. 2011;197:133-6 pubmed publisher
    ..We revealed that low doses of DMSO decreased whereas high doses of DMSO increased the absence-like epileptic activity of WAG/Rij rats. ..
  6. Kovacs Z, Juhasz G, Palkovits M, Dobolyi A, Kekesi K. Area, age and gender dependence of the nucleoside system in the brain: a review of current literature. Curr Top Med Chem. 2011;11:1012-33 pubmed
  7. Kovacs Z, Dobolyi A, Kekesi K, Juhasz G. 5'-nucleotidases, nucleosides and their distribution in the brain: pathological and therapeutic implications. Curr Med Chem. 2013;20:4217-40 pubmed
    ..The present article describes the regionally different activities of the nucleoside system, demonstrates the associations between these activities and 5'NT activity and discusses the therapeutic implications of these associations. ..
  8. Völgyi K, Juhász G, Kovacs Z, Penke B. Dysfunction of Endoplasmic Reticulum (ER) and Mitochondria (MT) in Alzheimer's Disease: The Role of the ER-MT Cross-Talk. Curr Alzheimer Res. 2015;12:655-72 pubmed
    ..Another targets are the UPR cascade proteins (PERK, IRE1, ATF6) and receptors involved in Ca(2+) -level stabilization of the ER (Ryr, IP3R). ..
  9. Kovacs Z, Kékesi K, Juhasz G, Dobolyi A. The antiepileptic potential of nucleosides. Curr Med Chem. 2014;21:788-821 pubmed
    ..Therefore, the aim of this review article is to summarize our present knowledge about the nucleoside system as a promising target in the treatment of epilepsy. ..

More Information


  1. Kovács Z, Kékesi K, Dobolyi Ã, Lakatos R, Juhász G. Absence epileptic activity changing effects of non-adenosine nucleoside inosine, guanosine and uridine in Wistar Albino Glaxo Rijswijk rats. Neuroscience. 2015;300:593-608 pubmed publisher
    ..We strengthened that Urd can decrease absence epileptic activity. Our results suggest that Guo, Urd and their analogs could be potentially effective drugs for treatment of human absence epilepsy. ..
  2. Lakatos R, Dobolyi Ã, Todorov M, Kékesi K, Juhász G, Aleksza M, et al. Guanosine may increase absence epileptic activity by means of A2A adenosine receptors in Wistar Albino Glaxo Rijswijk rats. Brain Res Bull. 2016;124:172-81 pubmed publisher
    ..p. 100mg/kg Guo alone. The results suggest that i.p. 100mg/kg Guo can increase SWD number by means of the adenosinergic system. ..
  3. Kovacs Z, Lakatos R, Barna J, Dobolyi A. Absence epileptic activity in Wistar Albino Glaxo Rijswijk rat mothers. Brain Res. 2017;1657:368-376 pubmed publisher
    ..In conclusion, we first identified periods within the reproductive cycle with increased absence epileptic activity, implying that more attention should be devoted to epileptic activity changes in mothers. ..