Zsolt Kovacs

Summary

Affiliation: University of West Hungary
Country: Hungary

Publications

  1. ncbi The antiepileptic potential of nucleosides
    Z Kovacs
    Department of Zoology, University of West Hungary, Savaria Campus, Szombathely, Károlyi Gáspár tér 4, 9700 Hungary
    Curr Med Chem 21:788-821. 2014
  2. ncbi 5'-nucleotidases, nucleosides and their distribution in the brain: pathological and therapeutic implications
    Zsolt Kovacs
    Department of Zoology, University of West Hungary, Savaria Campus, Szombathely, Károlyi Gáspár tér 4, 9700 Hungary
    Curr Med Chem 20:4217-40. 2013
  3. doi Uridine modulates neuronal activity and inhibits spike-wave discharges of absence epileptic Long Evans and Wistar Albino Glaxo/Rijswijk rats
    Zsolt Kovacs
    Department of Zoology, University of West Hungary, Savaria Campus, Károlyi Gáspár tér 4, Szombathely 9700, Hungary
    Brain Res Bull 97:16-23. 2013
  4. doi Neonatal tricyclic antidepressant clomipramine treatment reduces the spike-wave discharge activity of the adult WAG/Rij rat
    Zsolt Kovacs
    Department of Zoology, University of West Hungary, Savaria Campus, Károlyi Gáspár tér 4, Szombathely 9700, Hungary
    Brain Res Bull 89:102-7. 2012
  5. doi Doxycycline could aggravate the absence-like epileptic seizures of WAG/Rij rats via matrix metalloproteinase inhibition
    Zsolt Kovacs
    Department of Zoology, University of West Hungary, Savaria Campus, Szombathely, Hungary
    Neurochem Int 59:563-6. 2011
  6. doi Intracerebroventricularly administered lipopolysaccharide enhances spike-wave discharges in freely moving WAG/Rij rats
    Zsolt Kovacs
    Department of Zoology, University of West Hungary, Savaria Campus, Szombathely, Károlyi Gáspár tér 4, 9700, Hungary
    Brain Res Bull 85:410-6. 2011
  7. ncbi Area, age and gender dependence of the nucleoside system in the brain: a review of current literature
    Zsolt Kovacs
    Department of Zoology, University of West Hungary, Savaria Campus, Szombathely, Károlyi Gáspár tér 4, 9700 Hungary
    Curr Top Med Chem 11:1012-33. 2011
  8. doi The effect of intraperitoneally administered dimethyl sulfoxide on absence-like epileptic activity of freely moving WAG/Rij rats
    Zsolt Kovacs
    Department of Zoology, University of West Hungary, Savaria Campus, Károlyi Gáspár tér 4, 9700 Szombathely, Hungary
    J Neurosci Methods 197:133-6. 2011
  9. doi Nucleoside map of the human central nervous system
    Zsolt Kovacs
    Department of Zoology, University of West Hungary, Savaria Campus, Károlyi Gáspár tér 4, 9700, Szombathely, Hungary
    Neurochem Res 35:452-64. 2010
  10. doi Clomipramine increases the incidence and duration of spike-wave discharges in freely moving WAG/Rij rats
    Zsolt Kovacs
    Department of Zoology, University of West Hungary Savaria Campus, Szombathely, Károlyi Gáspár tér 4, 9700 Hungary
    Epilepsy Res 90:167-70. 2010

Detail Information

Publications13

  1. ncbi The antiepileptic potential of nucleosides
    Z Kovacs
    Department of Zoology, University of West Hungary, Savaria Campus, Szombathely, Károlyi Gáspár tér 4, 9700 Hungary
    Curr Med Chem 21:788-821. 2014
    ..Therefore, the aim of this review article is to summarize our present knowledge about the nucleoside system as a promising target in the treatment of epilepsy. ..
  2. ncbi 5'-nucleotidases, nucleosides and their distribution in the brain: pathological and therapeutic implications
    Zsolt Kovacs
    Department of Zoology, University of West Hungary, Savaria Campus, Szombathely, Károlyi Gáspár tér 4, 9700 Hungary
    Curr Med Chem 20:4217-40. 2013
    ..The present article describes the regionally different activities of the nucleoside system, demonstrates the associations between these activities and 5'NT activity and discusses the therapeutic implications of these associations. ..
  3. doi Uridine modulates neuronal activity and inhibits spike-wave discharges of absence epileptic Long Evans and Wistar Albino Glaxo/Rijswijk rats
    Zsolt Kovacs
    Department of Zoology, University of West Hungary, Savaria Campus, Károlyi Gáspár tér 4, Szombathely 9700, Hungary
    Brain Res Bull 97:16-23. 2013
    ..The present results suggest that Urd-sensitive neurons in the thalamus and the cerebral cortex may play a role in the antiepileptic action of Urd possibly via modulation of thalamocortical neuronal circuits. ..
  4. doi Neonatal tricyclic antidepressant clomipramine treatment reduces the spike-wave discharge activity of the adult WAG/Rij rat
    Zsolt Kovacs
    Department of Zoology, University of West Hungary, Savaria Campus, Károlyi Gáspár tér 4, Szombathely 9700, Hungary
    Brain Res Bull 89:102-7. 2012
    ..We concluded that neonatal clomipramine treatment produced aggravation of depression-like symptoms while decreased the SWD activity in the adult (8 months old) WAG/Rij rat...
  5. doi Doxycycline could aggravate the absence-like epileptic seizures of WAG/Rij rats via matrix metalloproteinase inhibition
    Zsolt Kovacs
    Department of Zoology, University of West Hungary, Savaria Campus, Szombathely, Hungary
    Neurochem Int 59:563-6. 2011
    ....
  6. doi Intracerebroventricularly administered lipopolysaccharide enhances spike-wave discharges in freely moving WAG/Rij rats
    Zsolt Kovacs
    Department of Zoology, University of West Hungary, Savaria Campus, Szombathely, Károlyi Gáspár tér 4, 9700, Hungary
    Brain Res Bull 85:410-6. 2011
    ..Our results show that centrally injected LPS, likewise the peripheral injection, can increase the number and duration of SWDs in the WAG/Rij rat, and the effect invoke inflammatory cytokines as well as excitatory neurotransmitters...
  7. ncbi Area, age and gender dependence of the nucleoside system in the brain: a review of current literature
    Zsolt Kovacs
    Department of Zoology, University of West Hungary, Savaria Campus, Szombathely, Károlyi Gáspár tér 4, 9700 Hungary
    Curr Top Med Chem 11:1012-33. 2011
    ....
  8. doi The effect of intraperitoneally administered dimethyl sulfoxide on absence-like epileptic activity of freely moving WAG/Rij rats
    Zsolt Kovacs
    Department of Zoology, University of West Hungary, Savaria Campus, Károlyi Gáspár tér 4, 9700 Szombathely, Hungary
    J Neurosci Methods 197:133-6. 2011
    ..We revealed that low doses of DMSO decreased whereas high doses of DMSO increased the absence-like epileptic activity of WAG/Rij rats...
  9. doi Nucleoside map of the human central nervous system
    Zsolt Kovacs
    Department of Zoology, University of West Hungary, Savaria Campus, Károlyi Gáspár tér 4, 9700, Szombathely, Hungary
    Neurochem Res 35:452-64. 2010
    ..The regional differences in nucleoside levels in the CNS may reflect the distinct physiological functions adopted by these compounds in different brain areas...
  10. doi Clomipramine increases the incidence and duration of spike-wave discharges in freely moving WAG/Rij rats
    Zsolt Kovacs
    Department of Zoology, University of West Hungary Savaria Campus, Szombathely, Károlyi Gáspár tér 4, 9700 Hungary
    Epilepsy Res 90:167-70. 2010
    ..We investigated whether the single injection of monoamine reuptake inhibitor clomipramine has an acute effect on spike-wave discharge (SWD) activity in Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats...
  11. ncbi Post mortem degradation of nucleosides in the brain: comparison of human and rat brains for estimation of in vivo concentration of nucleosides
    Zsolt Kovacs
    Department of Zoology, Berzsenyi Dániel College, Szombathely, Károlyi Gáspár tér 4, 9700, Hungary
    J Neurosci Methods 148:88-93. 2005
    ..We also report a method how to validate human neurosurgical brain samples in terms of sample preparation and statistical analysis...
  12. ncbi Suppression of spike-wave discharge activity and c-fos expression by 2-methyl-4-oxo-3H-quinazoline-3-acetyl piperidine (Q5) in vivo
    Zsolt Kovacs
    Department of Zoology, Berzsenyi Dániel College, Szombathely, Hungary
    Neurosci Lett 423:73-7. 2007
    ..Thus, our in vivo results demonstrate that in addition to the prevention of absence seizures, Q5 effectively suppresses neuronal activation in various stress- and pain-sensitive brain areas...
  13. doi Gender- and age-dependent changes in nucleoside levels in the cerebral cortex and white matter of the human brain
    Zsolt Kovacs
    Department of Zoology, University of West Hungary, Savaria Campus, 9700, Szombathely, Hungary
    Brain Res Bull 81:579-84. 2010
    ....