Szabolcs Keri

..Recent evidence raised the possibility that low-dose antipsychotic treatment during the prodromal phase may prevent the development of full-blown psychosis...

..Persons at increased risk of psychosis should be offered long-term follow-up and care and an "open doors" policy in the case of worsening symptoms and crisis...

..These results suggest that the deficit of the M pathway is an endophenotype of fragile X syndrome...

..These results raise the possibility that there is a significant gene by environment interaction regarding SNP8NRG243177/rs6994992 and psychosocial stress...

..The aim of this study was to investigate whether recent evidence indeed suggests that cognitive dysfunctions are potent indicators of specific genetic traits that represent susceptibility for schizophrenia...

..In the isoluminant blue-on-yellow and high contrast achromatic conditions, there were no significant differences between the experimental groups. These results suggest that the deficit of M pathway is an endophenotype of schizophrenia...

..These results suggest that anterior cingulate dysfunction is a potential endophenotype of schizophrenia...

..High-dose first generation antipsychotics may disrupt BG-dependent learning by blocking dopaminergic neurotransmission in the nigro-stiratal system...

..Learning rate was normal in patients with schizophrenia. These results suggest that the DRD3 variant containing glycine is associated with more efficient striatal habit learning in healthy controls and patients with schizophrenia...

..The purpose of this study was to investigate the functional integrity of lateral connections in early visual areas of patients with schizophrenia and type I bipolar disorder with a history of psychosis...

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..Visual-perceptual and neuropsychological data did not correlate. In conclusion, M pathway dysfunction is a potential endophenotype of schizophrenia...

..These results suggest that the progressive developmental abnormality of motion-sensitive visual areas may be a characteristic feature of schizophrenia-vulnerability...

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..In this study, we investigated the recognition of complex social emotions and mental states in patients with alcoholism after long-term abstinence and healthy control subjects...

..However, the deficit was restricted to low spatial frequencies (0.5 cycles/degree), which suggests that this deficit is a trait marker of schizophrenia...

..Further studies are necessary to separately assess cortical and precortical stages of information-processing, and to exclude the possibility of general motivational and attentional impairments...

..In this paper, the authors review these vulnerability markers, providing a scientifically founded and clinically oriented framework for the prevention of schizophrenia...

..These results demonstrate that a copy number variation of the SNCA gene is associated with selective impairments on reinforcement learning in asymptomatic carriers without the motor symptoms of Parkinson disease...

..These results suggest that healthy persons with lower peripheral FMRP expression display a visual phenotype similar to that described in patients with FXS...

..This relationship was absent in the case of neutral (trust-unrelated) oxytocin level. These results suggest that the habituation of autonomic arousal is closely related to oxytocin released during trust-related social interactions...

..The classification performance and the severity of tics were independent of the explicit knowledge obtained during the test...

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..These results suggest that the hypodopaminergic state induced by antipsychotic medication may produce parkinsonian visual impairments in schizophrenia patients...

..The three control patients with damage to the parietal lobe displayed normal learning rates in PCL. These results suggest that separate frontostriatal mechanisms exist for attentional set shifting and habit learning...

..These findings are against the hypothesis of a pure generalized cognitive dysfunction in schizophrenia, providing preliminary evidence for intact neocortical mechanisms related to perceptual classification functions...

..These results suggest that the BM dysfunction is a trait marker of schizophrenia-spectrum disorders and may be present in the absence of working memory abnormalities...

..Instead, deficient cortical interactions of rapidly changing environmental signals may be involved...

..There was no significant correlation between the CS and the memory disturbances. The results suggest that early visual impairment and higher-level cognitive disturbances are independent in AD...

..Intriguingly, the highest creative achievements and creative-thinking scores were found in people who carried the T/T genotype, which was previously shown to be related to psychosis risk and altered prefrontal activation...

..These findings suggest that the perceptual learning of categories, but not free classification judgements are impaired in schizophrenia, and that this impairment is not due to pure attentional disturbances...

..Category learning tasks are suitable for mapping damaged brain systems in clinical populations...

..The aim of this study was to explore the relationship between this phenotype and neuregulin 1-related intracellular signaling processes...

..While cognitive functions have been widely studied, much less is known about implicit learning in depression...

..These results indicate that the deficit syndrome is associated with prominently impaired stimulus-response reinforcement learning, which may indicate abnormal functioning of basal ganglia circuits...

..These results suggest that the S/S genotype of the DRD3 is associated with worse therapeutic response and more severe executive dysfunctions in patients with schizophrenia...

..These results suggest that multiple-object tracking is impaired in schizophrenia, and that it is specifically associated with motion perception and spatial working memory...

..These results suggest that borderline patients are impaired in neuropsychological domains sensitive for frontal and temporal lobe functioning, and this deficit is related to impulsivity...

..These results suggest that the enduring negative symptoms of deficit patients may be related to decreased response to cognitive feedback and deficient basal ganglia functioning...

..In this naturalistic study the authors investigated the relationship between this polymorphism and the therapeutic response to atypical antipsychotics...

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..In conclusion, the detection of briefly presented, low-contrast visual stimuli was selectively impaired in multiple sclerosis. Lateral interactions between target and flankers robustly facilitated target detection in the patient group...

..We investigated delay discounting of reward and caudate volume in SNCA gene duplication carriers before and after the development of PD...

..In conclusion, NRG1-induced AKT phosphorylation is decreased in schizophrenia but not in other psychotic disorders. This peripheral marker is not related to neurocognitive functions...

..Previous studies indicated impaired perceptual organisation in schizophrenia. This study investigated lateral connection and attentional modulation in early visual cortex of schizophrenia patients...

..The purpose of this study was to investigate the possibility that cognitive deficits are associated with the emergence of unusual thoughts during a stressful family transaction...

..In this study, we tested the possibility that acquired equivalence learning is a sensitive marker of mild Alzheimer disease (AD)...

..These results raise the possibility for striatal contributions to visual categorization and may provide a novel protocol for further clinical studies...

..The aim of this study was to determine differences in subjective experience and social perception in young depressed patients with and without psychosis risk...

..The scotopic CS exhibited slower development than the photopic CS. These results suggest the late maturation of the magnocellular visual pathway...

..In contrast, MTL dysfunctions may result in a non-sequential learning of associations, which may indicate a loss of contextual information...

..These results suggest a close relationship between reinforcement learning and general psychosocial functioning in schizophrenia...

..Further studies are warranted to elucidate the significance of this finding in the pathophysiology of schizophrenia...

..This supports the hypothesis that corticostriatal circuits mediate perceptual feature weighting and integration in complex situations requiring categorical judgements...

..This suggests that ToM deficits are related to motion perception dysfunctions, which indicates a possible role of motion-sensitive areas in the pathophysiology of schizophrenia...

..These results suggest that schizophrenia patients are impaired in socioeconomic interactions requiring emotion recognition and decision-making, which may result in unstable behavioral strategies...

..These results suggest that patients with BPD exhibit less trust during interpersonal interactions, which may be related to stress-related paranoia, dissociation, identity disturbance, and problems in interpersonal relationships...

..Patients with major depressive disorder (MDD) show suboptimal decision-making strategy in experimental game situations. The influence of personality traits and genetic variations on decision-making is not known...

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..These results suggest that motion perception deficits are detectable in fragile X premutation carriers, and that the impairment of biological motion perception is associated with depressive symptoms...

..These results raise the possibility that the development of low spatial frequency processing may affect attentional mechanisms, which may have an impact on early contour integration...

..These results indicate that impaired AKT-related intracellular signaling is partly related to the developed illness and cannot fully be explained by the genetic background of schizophrenia...

..We found no significant difference between the patients and controls either before or after light therapy. These results raise the possibility that light therapy induces retinal sensitization in seasonal affective disorder...

..In the present study D2 receptor occupancy was investigated in quetiapine treated schizophrenic patients for the detection of a relationship between the scintigraphic pattern and clinical signs and symptoms...

..There were no such differences in the case of joy. These results indicate that the s-allele of the serotonin transporter gene is associated with a vulnerable cognitive style related to the appraisal of negative emotions...

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..25 and 0.5 cycles/degree). These results indicate the heightened sensitivity of magnocellular pathways in unmedicated first-episode schizophrenia, which may contribute to anomalous perceptual experiences and sensory overloading...

..These results suggest that early-stage perceptual dysfunctions, which may reflect the abnormality of precortical magnocellular visual pathways, are related to a specific group of abnormal neurological signs...

..Summing it up, the survey provides evidences for the introduction of the novel concept of parallel pathways into the diagnostic aspects of ophthalmology, neurology and psychiatry...

..This illustrates that the phenomenology of hallucinations not necessarily reflects the exact localization of cerebral pathology. Instead, the damaged area may serve as a focus of an abnormally activated neuronal network...

..These results suggest that, under scotopic conditions, human visuospatial processing is characteristically predominated by the functional activity of the magnocellular pathways...

..Impairments in emotional decision-making were not a pure consequence of executive dysfunctions...

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..Our results therefore suggest abnormal lateral interactions in early visual cortex of schizophrenia patients...

..These results indicate that retinal dysfunctions are specific for schizophrenia, as compared with bipolar disorder, and are confined to the acute stage of the illness...

..In this review, we discuss new results from the functional neuroanatomy of these brain circuits and outline their significance in the emergence of various psychopathological phenomena...

..Our results suggest a global impairment of the PFC in depression, which includes the dorsolateral and ventromedial regions...

..Our results indicate that somatosensory processing is altered after sleep deprivation...

..These results suggest that oxytocin specifically modulates the perception of socially relevant stimuli...

..At the end of this article we discuss this last theory in detail listing arguments for and against...

..These results suggest that decreased trust-related oxytocin release is related to the negative symptoms and may be associated with social withdrawal, isolation, and flattened affect in schizophrenia...

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..Data from functional neuroimaging indicated that the abnormal activation of the anterior insula might be a key factor during these processes, together with the cingulate cortex and the amygdala...

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