Research Topics
Genomes and Genes | Janos KappelmayerSummaryAffiliation: University of Debrecen Country: Hungary Publications
| Collaborators
|
Detail Information
Publications
Monocytes express tissue factor in young patients with cerebral ischemiaJ Kappelmayer
Department of Clinical Chemistry, University Medical School, Debrecen, Hungary
Cerebrovasc Dis 8:235-9. 1998..05). In conclusion, in cerebral ischemia TF expression on monocytes suggests enhanced activation of blood coagulation and subsequent fibrinolysis...- Flow cytometric detection of intracellular myeloperoxidase, CD3 and CD79a. Interaction between monoclonal antibody clones, fluorochromes and sample preparation protocolsJ Kappelmayer
Department of Clinical Biochemistry and Molecular Pathology, University Medical School of Debrecen, P O Box 40, Nagyerdei krt 98, H 4012 Debrecen, Hungary
J Immunol Methods 242:53-65. 2000..Thus, combined selection of fixation/permeabilization kits and monoclonal antibody reagents against CD3, CD79a and MPO is required for obtaining optimal cytoplasmic detection of these antigens... - Identification of P-selectin glycoprotein ligand-1 as a useful marker in acute myeloid leukaemiasJ Kappelmayer
Department of Clinical Biochemistry and Molecular Pathology, Medical and Health Sciences Centre, University of Debrecen, PO Box 40, Debrecen, Hungary H 4012
Br J Haematol 115:903-9. 2001.... - "Pros and cons" on how to measure multidrug resistance in leukemiasJanos Kappelmayer
Department of Clinical Biochemistry and Molecular Pathology, Budapest, Hungary
Leuk Lymphoma 43:711-7. 2002..Thus, we believe that functional assays when carried out in a standardized way and particularly combined with labeling for various surface markers can be recommended as a front-line test in MDR measurement... - Progress in defining multidrug resistance in leukemiaJanos Kappelmayer
Department of Clinical Biochemistry and Molecular Pathology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary H 4032
Expert Rev Mol Diagn 4:209-17. 2004..The authors believe that a standardized MDR assay, as well as a suitable monitoring test, may become a prognostic marker in several types of leukemia... - The emerging value of P-selectin as a disease markerJanos Kappelmayer
Department of Clinical Biochemistry and Molecular Pathology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
Clin Chem Lab Med 42:475-86. 2004..Such results bear clinical significance since P-selectin has been implicated in the pathogenesis of wide-spread disorders including coronary artery disease, stroke, diabetes and malignancy... - Progesterone administration fails to protect albino male rats against photostress-induced retinal degenerationI Kaldi
Department of Ophthalmology, Kenezy Hospital, Debrecen, Hungary
Eur J Ophthalmol 14:306-14. 2004..The aim of this study was to test the protective effect of female sexual hormones against photostress-induced photoreceptor apoptosis... 
Expression of coagulation factor XIII subunit A in acute promyelocytic leukemiaAgnes Simon
Department of Laboratory Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
Cytometry B Clin Cytom 82:209-16. 2012..This novel expression site of FXIII-A in AML M3 can be considered as a leukemia associated immunophenotype and may have pathophysiological significance...- Binding of plasma factor XIII to thrombin-receptor activated human plateletsBela Nagy
Department of Clinical Biochemistry and Molecular Pathology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
Thromb Haemost 102:83-9. 2009..We conclude that FXIII-A(2)B(2) of plasma origin binds to thrombin-receptor activated platelets via GPIIb/IIIa receptor-bound fibrinogen with gamma'-chain and is not capable of direct platelet binding... - Three novel mutations in the glycoprotein IIb gene in a patient with type II Glanzmann thrombastheniaGergely Losonczy
Clinical Research Center, Thrombosis and Hemostasis Research Group of the Hungarian Academy of Sciences, University of Debrecen, Debrecen, Hungary
Haematologica 92:698-701. 2007..The p.His782Asn mutation compromised transport of the pro-GPIIb/IIIa complex from the endoplasmic reticulum to the Golgi, hindering its maturation and surface expression... - A coagulation factor becomes useful in the study of acute leukemias: studies with blood coagulation factor XIIIFlora Kiss
Department of Clinical Biochemistry and Molecular Pathology, University of Debrecen, Hungary
Cytometry A 73:194-201. 2008..These data provide evidence that FXIII-A is a sufficiently sensitive marker in differentiating myeloblasts and monoblasts and is suitable for identifying leukemia-associated phenotypes in ALL... - Effects of ad hoc clopidogrel loading versus pre-treatment on P-selectin expression after coronary stent implantationTibor Szuk
Institute of Cardiology, Debrecen, Hungary
Platelets 17:344-6. 2006..Aspirin non-responsiveness did not influence the results. These data point to the beneficial effect of clopidogrel treatment in reducing platelet reactivity during stenting... - Alfacalcidol treatment restores derailed immune-regulation in patients with undifferentiated connective tissue diseaseEva Zold
Division of Clinical Immunology, 3rd Department of Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
Autoimmun Rev 10:155-62. 2011.... - Laboratory evaluation of a flow cytometric BCR-ABL immunobead assayZsuzsanna Hevessy
Department of Laboratory Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
Clin Chem Lab Med 50:689-92. 2012..A new flow cytometric (FC) BCR-ABL immunobead assay has been developed recently. Here we present the laboratory evaluation of the commercially available kit... - Increased levels of platelet activation markers are positively associated with carotid wall thickness and other atherosclerotic risk factors in obese patientsEva Csongradi
1st Department of Medicine, Medical and Health Science Center, University of Debrecen, Hungary
Thromb Haemost 106:683-92. 2011..009). In conclusion, P-selectin and PMP levels showed positive associations with abnormal carotid IMT and other risk factors in obesity suggesting a critical role of enhanced platelet reactivity in atherosclerotic wall alteration... - Anthracycline antibiotics induce acute renal tubular toxicity in children with cancerEdit Bardi
Department of Pediatrics, Medical and Health Science Center, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
Pathol Oncol Res 13:249-53. 2007..The damage was clinically mild and only a minor proportion of patients can be expected to develop long-lasting tubulopathy with negative impact on the quality of life... - Variant translocations of 11q23 in infant acute lymphoblastic leukemia (ALL): do outcomes differ from t(4;11)?Zsuzsanna Jakab
Department of Pediatrics, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
Med Pediatr Oncol 39:63-5. 2002 - Detection of mutations by flow cytometric melting point analysis of PCR productsLaszlo Imre
Department of Biophysics and Cell Biology, Medical and Health Science Center, University of Debrecen, Hungary
Cytometry A 79:720-6. 2011..In general, the method described herein is offered for the diagnosis of any pathological condition where the length of a genomic or cDNA sequence is expected to be different from that of the normal allele... - Late effects on renal glomerular and tubular function in childhood cancer survivorsEdit Bardi
Department of Pediatrics, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
Pediatr Blood Cancer 43:668-73. 2004..Late nephrotoxicity among childhood cancer survivors is poorly documented... - Lack of P-selectin glycoprotein ligand-1 protects mice from thrombosis after collagen/epinephrine challengeKornél Miszti-Blasius
Department of Clinical Biochemistry and Molecular Pathology, Hungary
Thromb Res 127:228-34. 2011..Our aim was to establish the role of PSGL-1 in thrombus formation by evaluating the response to thrombotic stimuli in wild type and PSGL-1 knockout mice... - Rapid-onset heparin-induced thrombocytopenia without previous heparin exposureZsolt Oláh
2nd Department of Medicine, University of Debrecen, Debrecen, Hungary
Platelets 23:495-8. 2012..Furthermore, transient presence of anti-phospholipid antibodies can cause a differential diagnostic problem in the cases of HIT... - Monitoring of mycophenolic acid and kidney function during combined immunosuppressive therapyAnna V Olah
Department of Clinical Biochemistry and Molecular Pathology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
Clin Chem Lab Med 49:1849-53. 2011..Still, there is no consensus considering the recommended dosing and the therapeutic range of MPA... - Classical and atypical neuroblastoma--case reportsLaszlo Csathy
Department of Clinical Biochemistry and Molecular Pathology, Medical and Health Science Center, University of Debrecen, Hungary
Cytometry B Clin Cytom 80:134-6. 2011..In most cases the primary tumor can be identified, but in this particular case only bone marrow involvement could be detected using flow cytometry, as such making it a powerful tool for diagnosis and disease monitoring... - Protein phosphatase inhibitor calyculin-A modulates activation markers in TRAP-stimulated human plateletsZsuzsa Simon
Department of Clinical Biochemistry and Molecular Pathology, Hungarian Academy of Sciences, Research Center for Molecular Medicine, Medical and Health Science Center, University of Debrecen, Hungary
Platelets 21:555-62. 2010..In conclusion, PP1 and PP2A-catalyzed dephosphorylation processes have crucial roles in PMP formation and in the regulation of alpha-granule and lysosome secretion in human platelets... - Platelet-derived microparticle levels are significantly elevated in patients treated by elective stenting compared to subjects with diagnostic catheterization aloneBela Nagy
Department of Clinical Biochemistry and Molecular Pathology, University of Debrecen, Hungary
Platelets 21:147-51. 2010..We suggest that the observed cellular changes are early and sensitive markers to detect the platelet-activating effect of stent implantation... - Coagulation factor XIII-A. A flow cytometric intracellular marker in the classification of acute myeloid leukemiasJanos Kappelmayer
Department of Clinical Biochemistry and Molecular Pathology, Medical and Health Science Centre, University of Debrecen, Hungary
Thromb Haemost 94:454-9. 2005..FXIII-A can be considered as a reliable intracytoplasmic marker for the monocytic and megakaryocytic series and its presence is highly predictive for mono- and megakaryocytic AML and for CMML... - Acute phase proteins in the diagnosis and prediction of cirrhosis associated bacterial infectionsMaria Papp
2nd Department of Medicine, Division of Gastroenterology, University of Debrecen, Debrecen, Hungary
Liver Int 32:603-11. 2012..Bacterial infections are common cause of morbidity and mortality in patients with cirrhosis. The early diagnosis of these infections is rather difficult... - Pgp and FLT3: identification and modulation of two proteins that lead to chemotherapy resistance in acute myeloid leukemiaJanos Kappelmayer
Department of Clinical Biochemistry and Molecular Pathology, Medical and Health Science Center, University of Debrecen, Hungary
Curr Med Chem 14:519-30. 2007..This review focuses on the pathophysiological phenomena and the detection methods of Pgp and FLT3 as well as on novel therapeutic strategies that are offered by their inhibition... - The immunoregulatory role of vitamins A, D and E in patients with primary Sjogren's syndromePeter Szodoray
3rd Department of Medicine, Division of Clinical Immunology, Medical and Health Science Centre, University of Debrecen, Moricz Zs Str 22, 4032 Debrecen, Hungary
Rheumatology (Oxford) 49:211-7. 2010..The aim of the present study was to investigate the immunomodulating role of fat-soluble vitamins in 25 patients with primary SS (pSS) and 15 healthy individuals... - Investigation of Thr715Pro P-selectin gene polymorphism and soluble P-selectin levels in type 2 diabetes mellitusBela Nagy
Department of Clinical Biochemistry and Molecular Pathology, Medical and Health Science Center, University of Debrecen, Nagyerdei krt 98, 4032 Hungary
Thromb Haemost 98:186-91. 2007..We suggest that in type 2 DM individuals, the significantly elevated sP-selectin levels are not due to the Thr715Pro P-selectin gene polymorphism... - Early relapse after rituximab chemoimmunotherapyFlora Kiss
Department of Clinical Biochemistry and Molecular Pathology, Medical and Health Sicence Center, University of Debrecen, Debrecen, Hungary
Pediatr Blood Cancer 50:372-5. 2008..Rituximab eliminated the CD20-positive subpopulation, but not the more immature leukemic cells. The patient died with fulminant aspergillosis before hematopoietic stem cell transplantation could be performed... - Detection of internal tandem duplications in the FLT3 gene by different electrophoretic methodsTamás Bubán
Institute of Internal Medicine, 1st Department of Internal Medicine, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary
Clin Chem Lab Med 50:301-10. 2012..In acute myeloid leukemia (AML), the internal tandem duplication (ITD) in the juxtamembrane domain of the FLT3 (Fms-like tyrosine kinase 3) gene is one of the most frequent genetic alterations associated with poor prognosis... - Differential effect of corticosteroids on serum cystatin C in thrombocytopenic purpura and leukemiaEdit Bardi
Departments of Pediatric Hematology and Oncology, University of Debrecen, Debrecen, Hungary
Pathol Oncol Res 16:453-6. 2010..04). Although the concentration of cysC may be slightly and reversibly influenced by corticosteroid treatment, cysC is sensitive to detect early and moderate deterioration of GFR in children with cancer... - Stem cell therapy: a promising and prospective approach in the treatment of patients with severe Buerger's diseaseZoltan Boda
2nd Department of Medicine, University of Debrecen, Debrecen, Hungary
Clin Appl Thromb Hemost 15:552-60. 2009..Severe adverse events were not observed. We conclude that ABMSCT with isolated CD34+ cells is safe, effective, and results in sustained clinical benefit for patients with SPAD... - [Activity of natural coagulation inhibitor proteins in the acute phase of ischaemic stroke]Laszlo Olah
Debreceni Egyetem, Orvos és Egészségtudományi Centrum, Neurológiai Klinika, Debrecen
Ideggyogy Sz 58:33-9. 2005..The authors' aim was to investigate whether the decreased activity of natural anticoagulants is accompanied by worsening of symptoms in ischaemic stroke... - [Autologous bone marrow-derived stem cell therapy in patients with severe peripheral arterial disorder]Zoltan Boda
Debreceni Egyetem, Orvos és Egészségtudományi Centrum, Altalános Orvostudományi Kar II Belgyógyászati Klinika, Haemostasis Tanszék Debrecen Nagyerdei krt 98 4012
Orv Hetil 149:531-40. 2008..Autologous bone marrow-derived stem cell transplantation is an arising therapy modality with an option of building new blood vessels through endothelial stem and/or progenitor cells... - Elevated human epididymis protein 4 concentrations in chronic kidney diseaseBela Nagy
Department of Laboratory Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
Ann Clin Biochem 49:377-80. 2012..However, it is unknown if the levels of HE4 and CA125 may be altered in subjects who have impaired renal function with no ovarian disorders... - Early-onset carotid atherosclerosis is associated with increased intima-media thickness and elevated serum levels of inflammatory markersMaria T Magyar
Department of Neurology, University of Debrecen, Health Science and Medical Center, Debrecen, Hungary
Stroke 34:58-63. 2003..Several factors have been held responsible for the development of atherosclerosis. To avoid the masking effect of age, we evaluated correlates of carotid atherosclerosis in patients <55 years of age... - A novel homozygous mutation (1619delC) in GPIIb gene associated with Glanzmann thrombasthenia, the decay of GPIIb-mRNA and the synthesis of a truncated GPIIb unable to form complex with GPIIIaGergely Losonczy
Clinical Research Center, University of Debrecen, Medical and Health Science Center, Hungary
Thromb Haemost 93:904-9. 2005.... - Increased platelet glycoprotein Ib receptor number, enhanced platelet adhesion and severe cerebral ischaemia in a patient with polycythaemia veraJudit Toth
Clinical Research Center, University of Debrecen, Debrecen, Hungary
Platelets 20:282-7. 2009..Similar results with pathological findings have not been published in PV until now. Our result undersigns the necessity of antiplatelet therapy of PV patients, even at normal platelet count... - Distribution of CFTR mutations in Eastern Hungarians: relevance to genetic testing and to the introduction of newborn screening for cystic fibrosisGergely Ivády
Department of Clinical Biochemistry and Molecular Pathology, University of Debrecen, Hungary
J Cyst Fibros 10:217-20. 2011..Due to the homogeneity of the Hungarian population our data are generally applicable to other regions of the country, including the sizeable diaspora... - ["Turnaround time": a new parameter for the characterization of the overall efficacy of laboratory diagnostic processes]Peter Antal-Szalmas
Debreceni Egyetem Orvos és Egészségtudományi Centrum, Klinikai Biokémiai és Molekuláris Patológiai Intézet, Debrecen, Hungary
Orv Hetil 148:1317-27. 2007..It characterizes the efficacy of the result generation process very well, and therefore, is considered as an important parameter of laboratory quality control... - Increased mean platelet volume in primary Raynaud's phenomenonAmir Houshang Shemirani
Clinical Research Center, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
Platelets 23:312-6. 2012..3, 95% CI: 4.85-26.12, p<0.001) were found to be independently associated with PRP. In conclusion, increased MPV is independently related to PRP, and its level was not influenced by age, gender, and the duration of PRP... - Cystatin C is a suitable marker of glomerular function in children with cancerEdit Bardi
Department of Pediatrics, Medical and Health Science Center, University of Debrecen, Hungary
Pediatr Nephrol 19:1145-7. 2004..CysC increased significantly after cisplatin, methotrexate, cyclophosphamide, ifosfamide, and multimodality treatment. Our results suggest that cysC measurement can be used to characterize glomerular function in children with cancer... - Synthesis and anticoagulant activity of bioisosteric sulfonic-Acid analogues of the antithrombin-binding pentasaccharide domain of heparinMihály Herczeg
Research Group for Carbohydrates of the Hungarian Academy of Sciences, University of Debrecen, 4010, Debrecen, P O Box 94, Hungary
Chemistry 18:10643-52. 2012..The difference in the biological activity of the disulfonic- and trisulfonic-acid counterparts could be explained by the different conformation of their L-iduronic-acid residues... - Long-lasting partial remission by Interferon-alpha treatment in a child with essential thrombocythemiaIstvan Szegedi
Department of Pediatrics, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
Pediatr Blood Cancer 49:744-7. 2007..After 65 months of in vivo IFN treatment, the patient experienced a sustained partial remission with platelet counts varying between 400 and 600 x 10(3)/microl... 
Vitamin D deficiency in undifferentiated connective tissue diseaseEva Zold
Division of Clinical Immunology, 3rd Department of Medicine, Medical and Health Science Center, University of Debrecen, Moricz Zs, Str, 22, Debrecen, 4032, Hungary
Arthritis Res Ther 10:R123. 2008..The aim of the present study was to investigate the prevalence of vitamin D insufficiency in patients with undifferentiated connective tissue disease (UCTD)...