Laszlo Fesus

Summary

Affiliation: University of Debrecen
Country: Hungary

Publications

  1. ncbi request reprint Transglutaminase 2: an enigmatic enzyme with diverse functions
    Laszlo Fesus
    Dept of Biochemistry and Molecular Biology, Faculty of Medicine, Medical and Health Science Center, University of Debrecen, H 4012, Debrecen, Hungary
    Trends Biochem Sci 27:534-9. 2002
  2. ncbi request reprint Transglutaminase 2 in the balance of cell death and survival
    Laszlo Fesus
    Department of Biochemistry and Molecular Biology, Faculty of Medicine and Signaling and Apoptosis Research Group of the Hungarian Academy of Sciences, Research Center for Molecular Medicine, University of Debrecen, Debrecen, Hungary
    FEBS Lett 579:3297-302. 2005
  3. ncbi request reprint Ligation of retinoic acid receptor alpha regulates negative selection of thymocytes by inhibiting both DNA binding of nur77 and synthesis of bim
    Eva Szegezdi
    Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary
    J Immunol 170:3577-84. 2003
  4. doi request reprint Over-expression of integrin beta3 can partially overcome the defect of integrin beta3 signaling in transglutaminase 2 null macrophages
    Beáta Tóth
    Department of Biochemistry and Molecular Biology, Apoptosis and Genomics Research Group, Hungarian Academy of Sciences, University of Debrecen, Nagyerdei krt 98, Debrecen H 4012, Hungary
    Immunol Lett 126:22-8. 2009
  5. doi request reprint PPARγ modulated inflammatory response of human dendritic cell subsets to engulfed apoptotic neutrophils
    Gyöngyike Majai
    Research Center for Molecular Medicine, University of Debrecen, Egyetem ter 1, Debrecen, Hungary
    J Leukoc Biol 88:981-91. 2010
  6. pmc A single conformational transglutaminase 2 epitope contributed by three domains is critical for celiac antibody binding and effects
    Zsófia Simon-Vecsei
    Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, Nagyerdei krt 98, Debrecen H 4032, Hungary
    Proc Natl Acad Sci U S A 109:431-6. 2012
  7. doi request reprint The glucocorticoid dexamethasone programs human dendritic cells for enhanced phagocytosis of apoptotic neutrophils and inflammatory response
    Judit Hodrea
    Department of Biochemistry and Molecular Biology, Signaling and Apoptosis and Genomics Research Group of the Hungarian Academy of Sciences, University of Debrecen, Debrecen, Hungary
    J Leukoc Biol 91:127-36. 2012
  8. ncbi request reprint Adenosine A2A receptor-mediated cell death of mouse thymocytes involves adenylate cyclase and Bim and is negatively regulated by Nur77
    Ildiko Kiss
    Department of Biochemistry and Molecular Biology, Signaling and Apoptosis Research Group, Hungarian Academy of Sciences, Research Center of Molecular Medicine, University of Debrecen
    Eur J Immunol 36:1559-71. 2006
  9. doi request reprint Transglutaminase 2 is needed for the formation of an efficient phagocyte portal in macrophages engulfing apoptotic cells
    Beáta Tóth
    Department of Biochemistry and Molecular Biology, Apoptosis and Genomics Research Group, Hungarian Academy of Sciences, Debrecen, Hungary
    J Immunol 182:2084-92. 2009
  10. ncbi request reprint Ligation of RARgamma inhibits proliferation of phytohaemagglutinin-stimulated T-cells via down-regulating JAK3 protein levels
    Katalin Ludanyi
    Department of Biochemistry and Molecular Biology, Research Center of Molecular Medicine, University Medical School of Debrecen, Nagyerdei krt 98, H 4012 Debrecen, Hungary
    Immunol Lett 98:103-13. 2005

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Transglutaminase 2: an enigmatic enzyme with diverse functions
    Laszlo Fesus
    Dept of Biochemistry and Molecular Biology, Faculty of Medicine, Medical and Health Science Center, University of Debrecen, H 4012, Debrecen, Hungary
    Trends Biochem Sci 27:534-9. 2002
    ..An important role for the enzyme in the pathogenesis of coeliac disease, fibrosis and neurodegenerative disorders has also been demonstrated, making TG2 an important therapeutic target...
  2. ncbi request reprint Transglutaminase 2 in the balance of cell death and survival
    Laszlo Fesus
    Department of Biochemistry and Molecular Biology, Faculty of Medicine and Signaling and Apoptosis Research Group of the Hungarian Academy of Sciences, Research Center for Molecular Medicine, University of Debrecen, Debrecen, Hungary
    FEBS Lett 579:3297-302. 2005
    ..This function of TG2 is partially achieved by being expressed and activated also in macrophages digesting apoptotic cells and mediating a crosstalk between dying and phagocytic cells...
  3. ncbi request reprint Ligation of retinoic acid receptor alpha regulates negative selection of thymocytes by inhibiting both DNA binding of nur77 and synthesis of bim
    Eva Szegezdi
    Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary
    J Immunol 170:3577-84. 2003
    ..Our data imply that retinoids are able to inhibit negative selection in vivo as well, and they interfere with multiple steps of the T cell selection signal pathway...
  4. doi request reprint Over-expression of integrin beta3 can partially overcome the defect of integrin beta3 signaling in transglutaminase 2 null macrophages
    Beáta Tóth
    Department of Biochemistry and Molecular Biology, Apoptosis and Genomics Research Group, Hungarian Academy of Sciences, University of Debrecen, Nagyerdei krt 98, Debrecen H 4012, Hungary
    Immunol Lett 126:22-8. 2009
    ..Our data provide a proof for the concept that the function of TG2 is to stabilize accumulated integrin beta(3) concentration in the phagocytic cup...
  5. doi request reprint PPARγ modulated inflammatory response of human dendritic cell subsets to engulfed apoptotic neutrophils
    Gyöngyike Majai
    Research Center for Molecular Medicine, University of Debrecen, Egyetem ter 1, Debrecen, Hungary
    J Leukoc Biol 88:981-91. 2010
    ..These results demonstrate that DCs are able to respond to allogeneic, apoptotic neutrophils with inflammatory cytokines and T cell responses in a subtype-specific manner that is modulated by the anti-inflammatory effects of PPARγ...
  6. pmc A single conformational transglutaminase 2 epitope contributed by three domains is critical for celiac antibody binding and effects
    Zsófia Simon-Vecsei
    Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, Nagyerdei krt 98, Debrecen H 4032, Hungary
    Proc Natl Acad Sci U S A 109:431-6. 2012
    ..Such antibodies or similar specific competitors will be useful in further functional studies and in exploring whether interference with celiac antibody actions leads to therapeutic benefits...
  7. doi request reprint The glucocorticoid dexamethasone programs human dendritic cells for enhanced phagocytosis of apoptotic neutrophils and inflammatory response
    Judit Hodrea
    Department of Biochemistry and Molecular Biology, Signaling and Apoptosis and Genomics Research Group of the Hungarian Academy of Sciences, University of Debrecen, Debrecen, Hungary
    J Leukoc Biol 91:127-36. 2012
    ..Furthermore, the Dex-treated DCs could activate autologous T lymphocytes toward Th1 effector cells, and this was enhanced by their exposure to allogeneic apoptotic neutrophils...
  8. ncbi request reprint Adenosine A2A receptor-mediated cell death of mouse thymocytes involves adenylate cyclase and Bim and is negatively regulated by Nur77
    Ildiko Kiss
    Department of Biochemistry and Molecular Biology, Signaling and Apoptosis Research Group, Hungarian Academy of Sciences, Research Center of Molecular Medicine, University of Debrecen
    Eur J Immunol 36:1559-71. 2006
    ..Collectively our data demonstrate that adenosine-induced cell death involves signaling pathways originally found in negative selection of thymocytes and suggest a determining role of Bim and a regulatory role for Nur77...
  9. doi request reprint Transglutaminase 2 is needed for the formation of an efficient phagocyte portal in macrophages engulfing apoptotic cells
    Beáta Tóth
    Department of Biochemistry and Molecular Biology, Apoptosis and Genomics Research Group, Hungarian Academy of Sciences, Debrecen, Hungary
    J Immunol 182:2084-92. 2009
    ..As a result, the formation of the engulfing portals, as well as the portals formed, is much less efficient. We propose that TG2 has a novel function to stabilize efficient phagocytic portals...
  10. ncbi request reprint Ligation of RARgamma inhibits proliferation of phytohaemagglutinin-stimulated T-cells via down-regulating JAK3 protein levels
    Katalin Ludanyi
    Department of Biochemistry and Molecular Biology, Research Center of Molecular Medicine, University Medical School of Debrecen, Nagyerdei krt 98, H 4012 Debrecen, Hungary
    Immunol Lett 98:103-13. 2005
    ....
  11. doi request reprint Tissue transglutaminase contributes to the all-trans-retinoic acid-induced differentiation syndrome phenotype in the NB4 model of acute promyelocytic leukemia
    Krisztián Csomós
    Signalling and Apoptosis Research Group of Hungarian Academy of Sciences, Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary
    Blood 116:3933-43. 2010
    ..Based on our results, we propose that reduced expression of TG2 in differentiating APL cells may suppress effector functions of neutrophil granulocytes and attenuate the ATRA-induced inflammatory phenotype of differentiation syndrome...
  12. ncbi request reprint Tissue transglutaminase (TG2) acting as G protein protects hepatocytes against Fas-mediated cell death in mice
    Zsolt Sarang
    Department of Biochemistry and Molecular Biology, Signaling and Apoptosis Research Group, Hungarian Academy of Sciences, Research Center of Molecular Medicine, University of Debrecen, Debrecen, Hungary
    Hepatology 42:578-87. 2005
    ....
  13. doi request reprint Retinoids produced by macrophages engulfing apoptotic cells contribute to the appearance of transglutaminase 2 in apoptotic thymocytes
    Eva Garabuczi
    Department of Biochemistry and Molecular Biology, Apoptosis and Genomics Research Group of the Hungarian Academy of Sciences, Research Center of Molecular Medicine, University Medical School of Debrecen, Nagyerdei krt 98, Debrecen 4012, Hungary
    Amino Acids 44:235-44. 2013
    ..Our data reveal a new crosstalk between macrophages and apoptotic cells, in which apoptotic cell uptake-induced retinoid synthesis in macrophages enhances TG2 expression in the dying thymocytes...
  14. pmc Differentiation and glucocorticoid regulated apopto-phagocytic gene expression patterns in human macrophages. Role of Mertk in enhanced phagocytosis
    Gábor Zahuczky
    Apoptosis and Genomics Research Group, Department of Biochemistry and Molecular Biology, Hungarian Academy of Sciences, University of Debrecen, Debrecen, Hungary
    PLoS ONE 6:e21349. 2011
    ..However, the additional role of other glucocorticoid induced elements must be also considered since the presence of autologous serum during phagocytosis could almost completely compensate for the blocked function of Mertk...
  15. doi request reprint Transglutaminase 2 is expressed and active on the surface of human monocyte-derived dendritic cells and macrophages
    Judit Hodrea
    Department of Biochemistry and Molecular Biology, Hungarian Academy of Sciences, University of Debrecen, Debrecen, Hungary
    Immunol Lett 130:74-81. 2010
    ..Bacterial lipopolysaccharide (LPS) increased the level of TG2 on the surface of maturing DCs, supporting the hypothesis that an unspecific inflammatory process in the gut may expose more transglutaminase activity...
  16. doi request reprint Functional significance of five noncanonical Ca2+-binding sites of human transglutaminase 2 characterized by site-directed mutagenesis
    Robert Kiraly
    Apoptosis and Genomics Research Group of Hungarian Academy of Sciences, Debrecen, Hungary
    FEBS J 276:7083-96. 2009
    ..It can be concluded that five of the Ca(2+)-binding sites of TG2 influence its transglutaminase activity, two sites are involved in the regulation of GTPase activity, and one determines antigenicity for autoantibodies in celiac patients...
  17. doi request reprint Transglutaminase 2 null macrophages respond to lipopolysaccharide stimulation by elevated proinflammatory cytokine production due to an enhanced αvβ3 integrin-induced Src tyrosine kinase signaling
    Zsolt Sarang
    Department of Biochemistry and Molecular Biology, Signaling and Apoptosis Research Group, Hungarian Academy of Sciences, Research Center of Molecular Medicine, University of Debrecen, Nagyerdei krt 98, H 4012 Debrecen, Hungary
    Immunol Lett 138:71-8. 2011
    ..Our data suggest that TG2 null macrophages bear a proinflammatory phenotype, which might contribute to the enhanced susceptibility of these mice to develop autoimmunity and atherosclerosis...
  18. pmc Cultivation and characterization of cornea limbal epithelial stem cells on lens capsule in animal material-free medium
    Reka Albert
    Department of Ophthalmology, Medical and Health Science Center, University of Debrecen, Hungary
    PLoS ONE 7:e47187. 2012
    ....
  19. pmc Involvement of adenosine A2A receptors in engulfment-dependent apoptotic cell suppression of inflammation
    Krisztina Köröskényi
    Department of Biochemistry and Molecular Biology, Signaling and Apoptosis Research Group, Hungarian Academy of Sciences, Research Center of Molecular Medicine, University of Debrecen, Debrecen H 4012, Hungary
    J Immunol 186:7144-55. 2011
    ..Altogether, our data indicate that adenosine is one of the soluble mediators released by macrophages that mediate engulfment-dependent apoptotic cell suppression of inflammation...
  20. doi request reprint Altered sialylation on the cell-surface proteins of dexamethasone-treated human macrophages contributes to augmented uptake of apoptotic neutrophils
    Andras Madi
    Apoptosis and Genomics Research Group of the Hungarian Academy of Sciences, Research Centre for Molecular Medicine, Medical Faculty, University of Debrecen, Nagyerdei krt 98, H 4032 Debrecen, Hungary
    Immunol Lett 135:88-95. 2011
    ..Our results suggest that dexamethasone treatment leads to decreased number of sialic acids on the surfaces of human macrophages promoting recognition and uptake of apoptotic cells...
  21. ncbi request reprint Retinoid receptor-activating ligands are produced within the mouse thymus during postnatal development
    Ildiko Kiss
    Department of Biochemistry and Molecular Biology, Signaling and Apoptosis Research Group, Hungarian Academy of Sciences, Research Center of Molecular Medicine, University of Debrecen, Debrecen, Hungary
    Eur J Immunol 38:147-55. 2008
    ....
  22. doi request reprint Identification of a specific one amino acid change in recombinant human transglutaminase 2 that regulates its activity and calcium sensitivity
    Kajal Kanchan
    Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, Nagyerdei krt 98, Debrecen H 4032, Hungary
    Biochem J 455:261-72. 2013
    ..The results of the present study suggest that Val224 increases TG2 activity by modulating its calcium-binding affinity enabling transamidation reactions inside cells. ..
  23. ncbi request reprint High-throughput scintillation proximity assay for transglutaminase activity measurement
    Andras Madi
    Research Center for Molecular Medicine, Medical and Health Science Center, University of Debrecen, H 4012 Debrecen, Nagyerdei krt 98, Hungary
    Anal Biochem 343:256-62. 2005
    ..The assay is sensitive, specific, linear at concentrations of tissue transglutaminase between 0.05 and 1.6m U/ml, and suitable for high-throughput measurements...
  24. pmc ATP release from dying autophagic cells and their phagocytosis are crucial for inflammasome activation in macrophages
    Gizem Ayna
    Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    PLoS ONE 7:e40069. 2012
    ..These findings demonstrate that NALP3 performs key upstream functions in inflammasome activation in mouse macrophages engulfing dying autophagic cells, and that these functions lead to pro-inflammatory responses...
  25. ncbi request reprint PPARgamma-dependent regulation of human macrophages in phagocytosis of apoptotic cells
    Gyöngyike Majai
    Department of Biochemistry and Molecular Biology, Signalling and Apoptosis Research Group of the Hungarian Academy of Sciences, Research Centre for Molecular Medicine, University of Debrecen, Medical and Health Science Centre, Debrecen, Hungary
    Eur J Immunol 37:1343-54. 2007
    ....
  26. doi request reprint Novel role of ICAM3 and LFA-1 in the clearance of apoptotic neutrophils by human macrophages
    Endre Kristóf
    Department of Biochemistry and Molecular Biology, Stem Cells, Apoptosis and Genomics Research Group of the Hungarian Academy of Sciences, University of Debrecen, Egyetem ter 1, Debrecen, 4010, Hungary
    Apoptosis 18:1235-51. 2013
    ..We propose that ICAM3 and LFA-1 act as recognition receptors in the phagocytosis portals of macrophages for engulfment of apoptotic neutrophils. ..
  27. ncbi request reprint Structure-function relationships of transglutaminases--a contemporary view
    Zoltan Nemes
    Departments of Biochemistry and Molecular Biology, Hungarian Academy of Sciences, Research Center for Molecular Medicine, University of Debrecen, Debrecen, Hungary
    Prog Exp Tumor Res 38:19-36. 2005
  28. ncbi request reprint Amine donor protein substrates for transglutaminase activity in Caenorhabditis elegans
    Andras Madi
    Signalling and Apoptosis Research Group of the Hungarian Academy of Sciences, University of Debrecen, Debrecen, Hungary
    Biochem Biophys Res Commun 315:1064-9. 2004
    ..We also purified and identified streptavidin-binding proteins of the worm...
  29. ncbi request reprint Substrate preference of transglutaminase 2 revealed by logistic regression analysis and intrinsic disorder examination
    Eva Csosz
    Department of Biochemistry and Molecular Biology, University of Debrecen, Egyetem ter 1, Life Science Building, 4010 Debrecen, Hungary
    J Mol Biol 383:390-402. 2008
    ..The collected structural data have provided novel understanding of how this versatile enzyme selects its substrates in various cell compartments and tissues...
  30. ncbi request reprint Tissue-transglutaminase contributes to neutrophil granulocyte differentiation and functions
    Zoltan Balajthy
    Department of Biochemistry and Molecular Biology, University of Debrecen, Medical and Health Science Center, H 4012 Debrecen, Nagyerdei krt 98, Hungary
    Blood 108:2045-54. 2006
    ..These results clearly suggest that TG2 may modulate the expression of genes related to neutrophil functions and is involved in several intracellular and extracellular functions of extravasating neutrophil...
  31. ncbi request reprint Tools for the detection and quantitation of protein transglutamination
    Zoltan Nemes
    Department of Psychiatry, Medical and Health Sciences Center, University of Debrecen, H 4012 Debrecen, Hungary
    Anal Biochem 342:1-10. 2005
  32. ncbi request reprint Competitive enzyme-linked immonosorbent assay for N epsilon gamma-glutamyl lysine
    Monika Sarvari
    Department of Biochemistry and Molecular Biology, University of Debrecen Medical and Health Sciences Center, H 4012 Debrecen, Hungary
    Anal Biochem 311:187-90. 2002
  33. doi request reprint Protein transamidation by transglutaminase 2 in cells: a disputed Ca2+-dependent action of a multifunctional protein
    Robert Kiraly
    Department of Biochemistry and Molecular Biology, Apoptosis and Genomics Group of the Hungarian Academy of Sciences, University of Debrecen, Debrecen, Hungary
    FEBS J 278:4717-39. 2011
    ....
  34. ncbi request reprint Phagocytosis of cells dying through autophagy evokes a pro-inflammatory response in macrophages
    Goran Petrovski
    Department of Biochemistry, Hungarian Academy of Sciences Research Center for Molecular Medicine, University of Debrecen, Debrecen, Hungary
    Autophagy 3:509-11. 2007
    ..Phagocytic uptake of cells dying through autophagy by macrophages leads to a pro-inflammatory response characterized by the induction and secretion of IL-6, TNFalpha, IL-8 and IL-10...
  35. doi request reprint Clearance of dying ARPE-19 cells by professional and nonprofessional phagocytes in vitro- implications for age-related macular degeneration (AMD)
    Goran Petrovski
    Department of Ophthalmology, Medical and Health Science Center, University of Debrecen, Hungary
    Acta Ophthalmol 89:e30-4. 2011
    ..The dynamics and influence of different treatments on this clearance process can be studied in vitro using human ARPE-19 cells and macrophages as phagocytes modelling dry and wet type of AMD, respectively...
  36. ncbi request reprint Inflammation and the apopto-phagocytic system
    Gyöngyike Majai
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, Signalling and Apoptosis Research Group of the Hungarian Academy of Sciences, Faculty of Medicine, Medical and Health Science Center, University of Debrecen, Hungary
    Immunol Lett 104:94-101. 2006
    ..Both professional and "amateur" cells can engulf apoptotic cells and mediate an anti-inflammatory action. Disturbance of these processes have significant roles in development of autoimmune diseases and highly malignant tumors...
  37. doi request reprint Polymorphism of transglutaminase 2: unusually low frequency of genomic variants with deficient functions
    Robert Kiraly
    Department of Biochemistry and Molecular Biology, Apoptosis and Genomics Research Group of Hungarian Academy of Sciences, Medical and Health Science Center, University of Debrecen, Egyetem ter 1, Debrecen 4012, Hungary
    Amino Acids 44:215-25. 2013
    ..Further studies are required to clarify the pathologic significance of these rare TGM2 alleles in the human population...
  38. doi request reprint Cellular biochemistry of the multifunctional transglutaminase 2: challenging issues and novel concepts
    Laszlo Fesus
    Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary
    FEBS J 278:4703. 2011
    ..Decades after its discovery, this enigmatic protein still intrigues researchers. Some of the most recent and compelling findings concerning TG2 are reviewed in four minireivews in this issue of FEBS Journal...
  39. ncbi request reprint Phagocytosis of cells dying through autophagy induces inflammasome activation and IL-1β release in human macrophages
    Goran Petrovski
    Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary corrected
    Autophagy 7:321-30. 2011
    ..Thus, autophagic death of malignant cells and their clearance may lead to immunogenic response...
  40. pmc Transglutaminase 2-/- mice reveal a phagocytosis-associated crosstalk between macrophages and apoptotic cells
    Zsuzsa Szondy
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, Institute of Immunology, University of Debrecen, Debrecen H 4012, Hungary
    Proc Natl Acad Sci U S A 100:7812-7. 2003
    ..These findings have broad implications not only for diseases linked to inflammation and autoimmunity but also for understanding the interrelationship between the apoptosis and phagocytosis process...
  41. ncbi request reprint Deoxy-adenosine-monophosphate (dAMP) di-n-butylester induces apoptosis by increasing the dATP level in HL-60 cells
    Klára Katona
    Department of Biochemistry and Molecular Biology, Medical and Health Science Center, Research Center for Molecular Medicine, University of Debrecen, Nagyerdei krt 98 P O Box 6, 4012 Debrecen, Hungary
    Cancer Lett 235:281-90. 2006
    ..Our results indicate that use of dAMP derivatives with masked phosphate may be a feasible approach for pharmacological elevation of intracellular dATP and induction of apoptosis...
  42. doi request reprint In vitro and in vivo activity of 4-thio-uridylate against JY cells, a model for human acute lymphoid leukemia
    Erika Berényi
    Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, 98 Nagyerdei krt, Debrecen 4032, Hungary
    Biochem Biophys Res Commun 410:682-7. 2011
    ..These results suggest that s(4)UMP alone or in combination with other clinically approved anti-leukemic remedies should be further explored as a potential novel therapeutic agent...
  43. doi request reprint Deamidated gliadin peptides form epitopes that transglutaminase antibodies recognize
    Ilma R Korponay-Szabo
    Departments of Pediatrics, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    J Pediatr Gastroenterol Nutr 46:253-61. 2008
    ..We investigated whether deamidated gliadin antigens are structurally similar to transglutaminase 2 or could mimic transglutaminase epitopes...
  44. ncbi request reprint Retinoids induce Fas(CD95) ligand cell surface expression via RARgamma and nur77 in T cells
    Beáta Tóth
    Department of Biochemistry and Molecular Biology, Research Center of Molecular Medicine, University Medical School of Debrecen, Debrecen, Hungary
    Eur J Immunol 34:827-36. 2004
    ..It is proposed that therapeutically administered RA might induce apoptosis in Fas-sensitive cells via induction of FasL expression in activated Tcells...
  45. pmc Transglutaminase-mediated intramolecular cross-linking of membrane-bound alpha-synuclein promotes amyloid formation in Lewy bodies
    Zoltan Nemes
    Department of Psychiatry, Signaling and Apoptosis Research Group, Hungarian Academy of Sciences, Research Center for Molecular Medicine, University of Debrecen, Debrecen H 4012, Hungary
    J Biol Chem 284:27252-64. 2009
    ..Our findings reveal the pivotal role of membrane attachment and transglutaminase-mediated intermolecular cross-linking for the propagative misfolding and aggregation of alpha-synuclein...
  46. doi request reprint Autophagy shapes inflammation
    Laszlo Fesus
    Department of Biochemistry and Molecular Biology, The Apoptosis and Genomics Research Group of the Hungarian Academy of Sciences, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    Antioxid Redox Signal 14:2233-43. 2011
    ..The intertwining regulatory connections between inflammation and immunity extend to pathologic conditions including chronic inflammatory diseases, autoimmunity and cancer...
  47. ncbi request reprint Potent inhibition of HIV-1 entry by (s4dU)35
    Andras Horvath
    Department of Biochemistry and Molecular Biology, University of Debrecen, H 4012 Debrecen, Nagyerdei krt 98, Hungary
    Virology 334:214-23. 2005
    ..Our studies identify (s(4)dU)(35) as a potential novel HIV entry inhibitor that may have utility as either a systemic antiretroviral or as a preventing agent for HIV transmission...
  48. doi request reprint Transdab wiki: the interactive transglutaminase substrate database on web 2.0 surface
    Eva Csosz
    Department of Biochemistry and Molecular Biology, University of Debrecen, Egyetem ter 1, Life Science Building, 4010, Debrecen, Hungary
    Amino Acids 36:615-7. 2009
    ..The scientific community is invited to edit the database and besides providing up-to-date information, this wiki should serve as a platform for valuable discussions...
  49. doi request reprint Methods to analyze transglutamination of proteins involved in apoptosis
    Zoltan Nemes
    Department of Psychiatry and Biochemistry, Hungarian Academy of Sciences, Research Center for Molecular Medicine, University of Debrecen Medical and Health Sciences Center, Debrecen, Hungary
    Methods Mol Biol 559:107-16. 2009
    ..In the techniques described below, we rely on the increasing availability and user-friendliness of mass spectrometric equipments...
  50. ncbi request reprint Thioredoxin motif of Caenorhabditis elegans PDI-3 provides Cys and His catalytic residues for transglutaminase activity
    Bernadett Blasko
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, Medical and Health Science Center, University of Debrecen, POB 6, Hungary
    Biochem Biophys Res Commun 303:1142-7. 2003
    ....
  51. ncbi request reprint "Tissue" transglutaminase in AIDS
    Alessandra Amendola
    I N M I L Spallanzani, I R C C S, Rome, Italy
    J Immunol Methods 265:145-59. 2002
    ....