Research Topics
Genomes and Genes | Laszlo FesusSummaryAffiliation: University of Debrecen Country: Hungary Publications
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Publications
Transglutaminase 2 in the balance of cell death and survivalLaszlo Fesus
Department of Biochemistry and Molecular Biology, Faculty of Medicine and Signaling and Apoptosis Research Group of the Hungarian Academy of Sciences, Research Center for Molecular Medicine, University of Debrecen, Debrecen, Hungary
FEBS Lett 579:3297-302. 2005..This function of TG2 is partially achieved by being expressed and activated also in macrophages digesting apoptotic cells and mediating a crosstalk between dying and phagocytic cells...- Transglutaminase 2: an enigmatic enzyme with diverse functionsLaszlo Fesus
Dept of Biochemistry and Molecular Biology, Faculty of Medicine, Medical and Health Science Center, University of Debrecen, H 4012, Debrecen, Hungary
Trends Biochem Sci 27:534-9. 2002..An important role for the enzyme in the pathogenesis of coeliac disease, fibrosis and neurodegenerative disorders has also been demonstrated, making TG2 an important therapeutic target... - Over-expression of integrin beta3 can partially overcome the defect of integrin beta3 signaling in transglutaminase 2 null macrophagesBeáta Tóth
Department of Biochemistry and Molecular Biology, Apoptosis and Genomics Research Group, Hungarian Academy of Sciences, University of Debrecen, Nagyerdei krt 98, Debrecen H 4012, Hungary
Immunol Lett 126:22-8. 2009..Our data provide a proof for the concept that the function of TG2 is to stabilize accumulated integrin beta(3) concentration in the phagocytic cup... - PPARγ modulated inflammatory response of human dendritic cell subsets to engulfed apoptotic neutrophilsGyöngyike Majai
Research Center for Molecular Medicine, University of Debrecen, Egyetem ter 1, Debrecen, Hungary
J Leukoc Biol 88:981-91. 2010..These results demonstrate that DCs are able to respond to allogeneic, apoptotic neutrophils with inflammatory cytokines and T cell responses in a subtype-specific manner that is modulated by the anti-inflammatory effects of PPARγ... - A single conformational transglutaminase 2 epitope contributed by three domains is critical for celiac antibody binding and effectsZsófia Simon-Vecsei
Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, Nagyerdei krt 98, Debrecen H 4032, Hungary
Proc Natl Acad Sci U S A 109:431-6. 2012..Such antibodies or similar specific competitors will be useful in further functional studies and in exploring whether interference with celiac antibody actions leads to therapeutic benefits... - Ligation of RARgamma inhibits proliferation of phytohaemagglutinin-stimulated T-cells via down-regulating JAK3 protein levelsKatalin Ludanyi
Department of Biochemistry and Molecular Biology, Research Center of Molecular Medicine, University Medical School of Debrecen, Nagyerdei krt 98, H 4012 Debrecen, Hungary
Immunol Lett 98:103-13. 2005.... - The glucocorticoid dexamethasone programs human dendritic cells for enhanced phagocytosis of apoptotic neutrophils and inflammatory responseJudit Hodrea
1 Medical and Health Science Center, University of Debrecen, Egyetem ter 1, H 4010, Debrecen, Hungary
J Leukoc Biol 91:127-36. 2012..Furthermore, the Dex-treated DCs could activate autologous T lymphocytes toward Th1 effector cells, and this was enhanced by their exposure to allogeneic apoptotic neutrophils... - Adenosine A2A receptor-mediated cell death of mouse thymocytes involves adenylate cyclase and Bim and is negatively regulated by Nur77Ildiko Kiss
Department of Biochemistry and Molecular Biology, Signaling and Apoptosis Research Group, Hungarian Academy of Sciences, Research Center of Molecular Medicine, University of Debrecen
Eur J Immunol 36:1559-71. 2006..Collectively our data demonstrate that adenosine-induced cell death involves signaling pathways originally found in negative selection of thymocytes and suggest a determining role of Bim and a regulatory role for Nur77... - Transglutaminase 2 is needed for the formation of an efficient phagocyte portal in macrophages engulfing apoptotic cellsBeáta Tóth
Department of Biochemistry and Molecular Biology, Apoptosis and Genomics Research Group, Hungarian Academy of Sciences, Debrecen, Hungary
J Immunol 182:2084-92. 2009..As a result, the formation of the engulfing portals, as well as the portals formed, is much less efficient. We propose that TG2 has a novel function to stabilize efficient phagocytic portals... - High-throughput scintillation proximity assay for transglutaminase activity measurementAndras Madi
Research Center for Molecular Medicine, Medical and Health Science Center, University of Debrecen, H 4012 Debrecen, Nagyerdei krt 98, Hungary
Anal Biochem 343:256-62. 2005..The assay is sensitive, specific, linear at concentrations of tissue transglutaminase between 0.05 and 1.6m U/ml, and suitable for high-throughput measurements... - Tissue transglutaminase (TG2) acting as G protein protects hepatocytes against Fas-mediated cell death in miceZsolt Sarang
Department of Biochemistry and Molecular Biology, Signaling and Apoptosis Research Group, Hungarian Academy of Sciences, Research Center of Molecular Medicine, University of Debrecen, Debrecen, Hungary
Hepatology 42:578-87. 2005.... - Tissue transglutaminase contributes to the all-trans-retinoic acid-induced differentiation syndrome phenotype in the NB4 model of acute promyelocytic leukemiaKrisztián Csomós
Signalling and Apoptosis Research Group of Hungarian Academy of Sciences, Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary
Blood 116:3933-43. 2010..Based on our results, we propose that reduced expression of TG2 in differentiating APL cells may suppress effector functions of neutrophil granulocytes and attenuate the ATRA-induced inflammatory phenotype of differentiation syndrome... - Transglutaminase 2 null macrophages respond to lipopolysaccharide stimulation by elevated proinflammatory cytokine production due to an enhanced αvβ3 integrin-induced Src tyrosine kinase signalingZsolt Sarang
Department of Biochemistry and Molecular Biology, Signaling and Apoptosis Research Group, Hungarian Academy of Sciences, Research Center of Molecular Medicine, University of Debrecen, Nagyerdei krt 98, H 4012 Debrecen, Hungary
Immunol Lett 138:71-8. 2011..Our data suggest that TG2 null macrophages bear a proinflammatory phenotype, which might contribute to the enhanced susceptibility of these mice to develop autoimmunity and atherosclerosis... - Differentiation and glucocorticoid regulated apopto-phagocytic gene expression patterns in human macrophages. Role of Mertk in enhanced phagocytosisGábor Zahuczky
Apoptosis and Genomics Research Group, Department of Biochemistry and Molecular Biology, Hungarian Academy of Sciences, University of Debrecen, Debrecen, Hungary
PLoS ONE 6:e21349. 2011..However, the additional role of other glucocorticoid induced elements must be also considered since the presence of autologous serum during phagocytosis could almost completely compensate for the blocked function of Mertk... - Transglutaminase 2 is expressed and active on the surface of human monocyte-derived dendritic cells and macrophagesJudit Hodrea
Department of Biochemistry and Molecular Biology, Hungarian Academy of Sciences, University of Debrecen, Debrecen, Hungary
Immunol Lett 130:74-81. 2010..Bacterial lipopolysaccharide (LPS) increased the level of TG2 on the surface of maturing DCs, supporting the hypothesis that an unspecific inflammatory process in the gut may expose more transglutaminase activity... - Functional significance of five noncanonical Ca2+-binding sites of human transglutaminase 2 characterized by site-directed mutagenesisRobert Kiraly
Apoptosis and Genomics Research Group of Hungarian Academy of Sciences, Debrecen, Hungary
FEBS J 276:7083-96. 2009..It can be concluded that five of the Ca(2+)-binding sites of TG2 influence its transglutaminase activity, two sites are involved in the regulation of GTPase activity, and one determines antigenicity for autoantibodies in celiac patients... - Involvement of adenosine A2A receptors in engulfment-dependent apoptotic cell suppression of inflammationKrisztina Köröskényi
Department of Biochemistry and Molecular Biology, Signaling and Apoptosis Research Group, Hungarian Academy of Sciences, Research Center of Molecular Medicine, University of Debrecen, Debrecen H 4012, Hungary
J Immunol 186:7144-55. 2011..Altogether, our data indicate that adenosine is one of the soluble mediators released by macrophages that mediate engulfment-dependent apoptotic cell suppression of inflammation... - Retinoid receptor-activating ligands are produced within the mouse thymus during postnatal developmentIldiko Kiss
Department of Biochemistry and Molecular Biology, Signaling and Apoptosis Research Group, Hungarian Academy of Sciences, Research Center of Molecular Medicine, University of Debrecen, Debrecen, Hungary
Eur J Immunol 38:147-55. 2008.... - Altered sialylation on the cell-surface proteins of dexamethasone-treated human macrophages contributes to augmented uptake of apoptotic neutrophilsAndras Madi
Apoptosis and Genomics Research Group of the Hungarian Academy of Sciences, Research Centre for Molecular Medicine, Medical Faculty, University of Debrecen, Nagyerdei krt 98, H 4032 Debrecen, Hungary
Immunol Lett 135:88-95. 2011..Our results suggest that dexamethasone treatment leads to decreased number of sialic acids on the surfaces of human macrophages promoting recognition and uptake of apoptotic cells... - Structure-function relationships of transglutaminases--a contemporary viewZoltan Nemes
Departments of Biochemistry and Molecular Biology, Hungarian Academy of Sciences, Research Center for Molecular Medicine, University of Debrecen, Debrecen, Hungary
Prog Exp Tumor Res 38:19-36. 2005 - PPARgamma-dependent regulation of human macrophages in phagocytosis of apoptotic cellsGyöngyike Majai
Department of Biochemistry and Molecular Biology, Signalling and Apoptosis Research Group of the Hungarian Academy of Sciences, Research Centre for Molecular Medicine, University of Debrecen, Medical and Health Science Centre, Debrecen, Hungary
Eur J Immunol 37:1343-54. 2007.... - Competitive enzyme-linked immonosorbent assay for N epsilon gamma-glutamyl lysineMonika Sarvari
Department of Biochemistry and Molecular Biology, University of Debrecen Medical and Health Sciences Center, H 4012 Debrecen, Hungary
Anal Biochem 311:187-90. 2002 - Substrate preference of transglutaminase 2 revealed by logistic regression analysis and intrinsic disorder examinationEva Csosz
Department of Biochemistry and Molecular Biology, University of Debrecen, Egyetem ter 1, Life Science Building, 4010 Debrecen, Hungary
J Mol Biol 383:390-402. 2008..The collected structural data have provided novel understanding of how this versatile enzyme selects its substrates in various cell compartments and tissues... - Amine donor protein substrates for transglutaminase activity in Caenorhabditis elegansAndras Madi
Signalling and Apoptosis Research Group of the Hungarian Academy of Sciences, University of Debrecen, Debrecen, Hungary
Biochem Biophys Res Commun 315:1064-9. 2004..We also purified and identified streptavidin-binding proteins of the worm... - Tissue-transglutaminase contributes to neutrophil granulocyte differentiation and functionsZoltan Balajthy
Department of Biochemistry and Molecular Biology, University of Debrecen, Medical and Health Science Center, H 4012 Debrecen, Nagyerdei krt 98, Hungary
Blood 108:2045-54. 2006..These results clearly suggest that TG2 may modulate the expression of genes related to neutrophil functions and is involved in several intracellular and extracellular functions of extravasating neutrophil... - Inflammation and the apopto-phagocytic systemGyöngyike Majai
Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, Signalling and Apoptosis Research Group of the Hungarian Academy of Sciences, Faculty of Medicine, Medical and Health Science Center, University of Debrecen, Hungary
Immunol Lett 104:94-101. 2006..Both professional and "amateur" cells can engulf apoptotic cells and mediate an anti-inflammatory action. Disturbance of these processes have significant roles in development of autoimmune diseases and highly malignant tumors... - Protein transamidation by transglutaminase 2 in cells: a disputed Ca(2+) -dependent action of a multifunctional proteinRobert Kiraly
Department of Biochemistry and Molecular Biology, Apoptosis and Genomics Group of the Hungarian Academy of Sciences, University of Debrecen, Hungary
FEBS J 278:4717-39. 2011.... - Phagocytosis of cells dying through autophagy evokes a pro-inflammatory response in macrophagesGoran Petrovski
Department of Biochemistry, Hungarian Academy of Sciences Research Center for Molecular Medicine, University of Debrecen, Debrecen, Hungary
Autophagy 3:509-11. 2007..Phagocytic uptake of cells dying through autophagy by macrophages leads to a pro-inflammatory response characterized by the induction and secretion of IL-6, TNFalpha, IL-8 and IL-10... - Clearance of dying ARPE-19 cells by professional and nonprofessional phagocytes in vitro- implications for age-related macular degeneration (AMD)Goran Petrovski
Department of Ophthalmology, Medical and Health Science Center, University of Debrecen, Hungary
Acta Ophthalmol 89:e30-4. 2011..The dynamics and influence of different treatments on this clearance process can be studied in vitro using human ARPE-19 cells and macrophages as phagocytes modelling dry and wet type of AMD, respectively... - Cultivation and characterization of cornea limbal epithelial stem cells on lens capsule in animal material-free mediumReka Albert
Department of Ophthalmology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary Stem Cells and Eye Research Laboratory, Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
PLoS ONE 7:e47187. 2012.... - Cellular biochemistry of the multifunctional transglutaminase 2: challenging issues and novel conceptsLaszlo Fesus
Department of Biochemistry and Molecular Biology, University of Debrecen, Hungary
FEBS J 278:4703. 2011..Decades after its discovery, this enigmatic protein still intrigues researchers. Some of the most recent and compelling findings concerning TG2 are reviewed in four minireivews in this issue of FEBS Journal... - Phagocytosis of cells dying through autophagy induces inflammasome activation and IL-1β release in human macrophagesGoran Petrovski
Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
Autophagy 7:321-30. 2011..Thus, autophagic death of malignant cells and their clearance may lead to immunogenic response... - Transglutaminase 2-/- mice reveal a phagocytosis-associated crosstalk between macrophages and apoptotic cellsZsuzsa Szondy
Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, Institute of Immunology, University of Debrecen, Debrecen H 4012, Hungary
Proc Natl Acad Sci U S A 100:7812-7. 2003..These findings have broad implications not only for diseases linked to inflammation and autoimmunity but also for understanding the interrelationship between the apoptosis and phagocytosis process... - Deoxy-adenosine-monophosphate (dAMP) di-n-butylester induces apoptosis by increasing the dATP level in HL-60 cellsKlára Katona
Department of Biochemistry and Molecular Biology, Medical and Health Science Center, Research Center for Molecular Medicine, University of Debrecen, Nagyerdei krt 98 P O Box 6, 4012 Debrecen, Hungary
Cancer Lett 235:281-90. 2006..Our results indicate that use of dAMP derivatives with masked phosphate may be a feasible approach for pharmacological elevation of intracellular dATP and induction of apoptosis... - Retinoids induce Fas(CD95) ligand cell surface expression via RARgamma and nur77 in T cellsBeáta Tóth
Department of Biochemistry and Molecular Biology, Research Center of Molecular Medicine, University Medical School of Debrecen, Debrecen, Hungary
Eur J Immunol 34:827-36. 2004..It is proposed that therapeutically administered RA might induce apoptosis in Fas-sensitive cells via induction of FasL expression in activated Tcells... - In vitro and in vivo activity of 4-thio-uridylate against JY cells, a model for human acute lymphoid leukemiaErika Berényi
Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, 98 Nagyerdei krt, Debrecen 4032, Hungary
Biochem Biophys Res Commun 410:682-7. 2011..These results suggest that s(4)UMP alone or in combination with other clinically approved anti-leukemic remedies should be further explored as a potential novel therapeutic agent... - Deamidated gliadin peptides form epitopes that transglutaminase antibodies recognizeIlma R Korponay-Szabo
Departments of Pediatrics, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
J Pediatr Gastroenterol Nutr 46:253-61. 2008..We investigated whether deamidated gliadin antigens are structurally similar to transglutaminase 2 or could mimic transglutaminase epitopes... - Autophagy shapes inflammationLaszlo Fesus
Department of Biochemistry and Molecular Biology, The Apoptosis and Genomics Research Group of the Hungarian Academy of Sciences, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
Antioxid Redox Signal 14:2233-43. 2011..The intertwining regulatory connections between inflammation and immunity extend to pathologic conditions including chronic inflammatory diseases, autoimmunity and cancer... - Transglutaminase-mediated intramolecular cross-linking of membrane-bound alpha-synuclein promotes amyloid formation in Lewy bodiesZoltan Nemes
Department of Psychiatry, Signaling and Apoptosis Research Group, Hungarian Academy of Sciences, Research Center for Molecular Medicine, University of Debrecen, Debrecen H 4012, Hungary
J Biol Chem 284:27252-64. 2009..Our findings reveal the pivotal role of membrane attachment and transglutaminase-mediated intermolecular cross-linking for the propagative misfolding and aggregation of alpha-synuclein... - ATP release from dying autophagic cells and their phagocytosis are crucial for inflammasome activation in macrophagesGizem Ayna
Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
PLoS ONE 7:e40069. 2012..These findings demonstrate that NALP3 performs key upstream functions in inflammasome activation in mouse macrophages engulfing dying autophagic cells, and that these functions lead to pro-inflammatory responses... - Potent inhibition of HIV-1 entry by (s4dU)35Andras Horvath
Department of Biochemistry and Molecular Biology, University of Debrecen, H 4012 Debrecen, Nagyerdei krt 98, Hungary
Virology 334:214-23. 2005..Our studies identify (s(4)dU)(35) as a potential novel HIV entry inhibitor that may have utility as either a systemic antiretroviral or as a preventing agent for HIV transmission... - Transdab wiki: the interactive transglutaminase substrate database on web 2.0 surfaceEva Csosz
Department of Biochemistry and Molecular Biology, University of Debrecen, Egyetem ter 1, Life Science Building, 4010, Debrecen, Hungary
Amino Acids 36:615-7. 2009..The scientific community is invited to edit the database and besides providing up-to-date information, this wiki should serve as a platform for valuable discussions... - Methods to analyze transglutamination of proteins involved in apoptosisZoltan Nemes
Department of Psychiatry and Biochemistry, Hungarian Academy of Sciences, Research Center for Molecular Medicine, University of Debrecen Medical and Health Sciences Center, Debrecen, Hungary
Methods Mol Biol 559:107-16. 2009..In the techniques described below, we rely on the increasing availability and user-friendliness of mass spectrometric equipments... - Thioredoxin motif of Caenorhabditis elegans PDI-3 provides Cys and His catalytic residues for transglutaminase activityBernadett Blasko
Department of Biochemistry and Molecular Biology, Faculty of Medicine, Medical and Health Science Center, University of Debrecen, POB 6, Hungary
Biochem Biophys Res Commun 303:1142-7. 2003.... - "Tissue" transglutaminase in AIDSAlessandra Amendola
I.N.M.I. L. Spallanzani, I.R.C.C.S, Rome, Italy
J Immunol Methods 265:145-59. 2002....