Research Topics
| Eszter FarkasSummaryAffiliation: University of Szeged Country: Hungary Publications
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Detail Information
Publications
Effects of cyclooxygenase (COX) inhibition on memory impairment and hippocampal damage in the early period of cerebral hypoperfusion in ratsAdam Institoris
Department of Physiology, School of Medicine, University of Szeged, H 6720 Szeged, Dom ter 10, Hungary
Eur J Pharmacol 574:29-38. 2007..In summary, NS-398 prevented the hypoperfusion-induced memory impairment, but not by protecting the hippocampal neurons...- Age-related microvascular degeneration in the human cerebral periventricular white matterEszter Farkas
Department of Anatomy, School of Medicine, University of Szeged, P O Box 427, 6701, Szeged, Hungary
Acta Neuropathol 111:150-7. 2006..Finally, atherosclerosis in large, peripheral vessels is considered to be a predictive marker of microvascular pathology in the WM... - Post-ischemic administration of diazoxide attenuates long-term microglial activation in the rat brain after permanent carotid artery occlusionEszter Farkas
Department of Anatomy, School of Medicine, University of Szeged, H 6701 Szeged, P O Box 427, Hungary
Neurosci Lett 387:168-72. 2005..These data provide evidence that post-treatment with diazoxide is not effective in impeding a long-term memory deficiency, but it can attenuate ischemia-induced microglial activation, independently of the solvent used... - Tumor necrosis factor-alpha increases cerebral blood flow and ultrastructural capillary damage through the release of nitric oxide in the rat brainEszter Farkas
Department of Anatomy, School of Medicine, University of Szeged, Szeged, Hungary
Microvasc Res 72:113-9. 2006..Our data additionally demonstrate that the breakdown of the BBB by circulating TNFalpha may involve the astrocytic endfeet... - Diazoxide and dimethyl sulphoxide alleviate experimental cerebral hypoperfusion-induced white matter injury in the rat brainEszter Farkas
Department of Anatomy, School of Medicine, University of Szeged, P O Box 427, 6701 Szeged, Hungary
Neurosci Lett 373:195-9. 2005..We conclude that diazoxide dissolved in DMSO can moderate ischemia-related neuroinflammation by suppressing glial reaction in selective cerebral WM areas... - Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseasesEszter Farkas
Department of Anatomy, School of Medicine, University of Szeged, H 6701 Szeged, P O Box 427, Hungary
Brain Res Rev 54:162-80. 2007..Thorough characterization of the model suggests that 2VO in the rat is suitable for the development of potentially neuroprotective strategies in neurodegenerative diseases... - Diazoxide and dimethyl sulphoxide prevent cerebral hypoperfusion-related learning dysfunction and brain damage after carotid artery occlusionEszter Farkas
Department of Anatomy, School of Medicine, University of Szeged, P O Box 427, Szeged 6701, Hungary
Brain Res 1008:252-60. 2004..Furthermore, we suggest that DMSO is a neuroprotective chemical in ischemic conditions, and it must be considerately used as a solvent for water-insoluble compounds in experimental animal models... - Experimental cerebral hypoperfusion induces white matter injury and microglial activation in the rat brainEszter Farkas
Department of Molecular Neurobiology, University of Groningen, The Netherlands
Acta Neuropathol 108:57-64. 2004..Since the detected glial changes correspond with those reported in vascular and Alzheimer dementia, this model of cerebral hypoperfusion may serve to characterize the causal relationship between ischemia and white matter damage... - Chronic cerebral hypoperfusion-related neuropathologic changes and compromised cognitive status: window of treatmentEszter Farkas
Group of Molecular Neurobiology, Department of Animal Physiology, University of Groningen, Groningen, The Netherlands
Drugs Today (Barc) 38:365-76. 2002..The present review provides an overview of the actions of these compounds focusing on cerebral blood flow, neurodegeneration and cognitive decline... - Systemic effects of dietary n-3 PUFA supplementation accompany changes of CNS parameters in cerebral hypoperfusionEszter Farkas
Department of Molecular Neurobiology, University of Groningen, Haren, The Netherlands
Ann N Y Acad Sci 977:77-86. 2002..The data draw attention to changes not only in the CNS, but also in the periphery as a consequence of chronic supplementation with n-3 PUFA-enriched diets... - Dietary long chain PUFAs differentially affect hippocampal muscarinic 1 and serotonergic 1A receptors in experimental cerebral hypoperfusionEszter Farkas
Group of Molecular Neurobiology, Department of Animal Physiology, University of Groningen, Groningen, The Netherlands
Brain Res 954:32-41. 2002.... - The effect of pre- and posttreatment with diazoxide on the early phase of chronic cerebral hypoperfusion in the ratEszter Farkas
Department of Anatomy, School of Medicine, University of Szeged, H 6701 Szeged, PO Box 427, Hungary
Brain Res 1087:168-74. 2006..Thus, pretreatment with diazoxide offers therapeutical prospects for the treatment of cerebral ischemia... - Pre-treatment and post-treatment with alpha-tocopherol attenuates hippocampal neuronal damage in experimental cerebral hypoperfusionAnita Annahazi
Department of Physiology, School of Medicine, University of Szeged, Szeged, Hungary
Eur J Pharmacol 571:120-8. 2007..The data indicate that alpha-tocopherol, particularly when administered as post-treatment, is neuroprotective in chronic cerebral hypoperfusion... - The effect of n-3 polyunsaturated fatty acid-rich diets on cognitive and cerebrovascular parameters in chronic cerebral hypoperfusionMartijn C de Wilde
Department of Animal Physiology, Workgroup of Molecular Neurobiology, University of Groningen, P.O. Box 14, 9750 AA Haren, The Netherlands
Brain Res 947:166-73. 2002..The number of endothelial mitochondria, as well as the ratio of microvessels with degenerative pericytes appeared to be lower due to long chain n-3 PUFAs. These results may indicate an improved condition of the blood-brain barrier... 
Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampusMarietta Hugyecz
Department of Physiology, Faculty of Medicine, University of Szeged, Szeged, Dom ter 10, H 6720, Hungary
Brain Res 1404:31-8. 2011..Both RSG and H(2)-RA prevented the changes of enzyme and connexin levels. Considering the lack of harmful side effects, inhalation of H(2)-RA can be a promising approach to reduce neuronal damage after TGCI...- Dietary fatty acids alter blood pressure, behavior and brain membrane composition of hypertensive ratsMartijn C de Wilde
Department of Molecular Neurobiology, University of Groningen, Haren 9750 AA, The Netherlands
Brain Res 988:9-19. 2003..Furthermore, we consider a potential role of metabolically generated MUFAs in the beneficial effects of PUFA supplementation... - Effects of early aging and cerebral hypoperfusion on spreading depression in ratsEszter Farkas
Department of Medical Informatics, Faculty of Medicine, University of Szeged, H 6720 Szeged, Koranyi fasor 9, Hungary
Neurobiol Aging 32:1707-15. 2011..9±2.1 vs. 32.8±12.6% × min in Young). These data suggest reduced sensitivity of the cortex to CSD elicitation with early aging, and a less responsive cerebrovascular system with chronic hypoperfusion... - Changes in pro-oxidant and antioxidant enzyme levels during cerebral hypoperfusion in ratsÉva Mracskó
Department of Physiology, Faculty of Medicine, University of Szeged, Szeged, Dom ter 10, H 6720, Hungary
Brain Res 1321:13-9. 2010..One year following 2VO onset, the eNOS expression was upregulated, which may strengthen the adaptation of the brain to cerebral ischemia... - Beta-amyloid peptide-induced blood-brain barrier disruption facilitates T-cell entry into the rat brainIbolya G Farkas
Department of Anatomy, Histology and Embryology, University of Szeged, Hungary
Acta Histochem 105:115-25. 2003..Our study demonstrates that A beta and TNFalpha induce enhanced T-lymphocyte migration towards the brain. This effect may be attributed at least partly to dysfunctioning of the BBB, but other mechanisms are also possible... - Ageing-related decline in adenosine A1 receptor binding in the rat brain: an autoradiographic studyPeter Meerlo
Department of Molecular Neurobiology, Graduate School of Behavioral and Cognitive Neurosciences, University of Groningen, Groningen, The Netherlands
J Neurosci Res 78:742-8. 2004..Since particularly in rats many studies have used animals at the age of 24 months or even less, the ageing-related decline in adenosine A1 signaling might have been underestimated... - Capillary injury in the ischemic brain of hyperlipidemic, apolipoprotein B-100 transgenic miceZoltan Sule
Department of Anatomy, Faculty of Medicine, University of Szeged, Kossuth Lajos sgt 40, H 6724 Szeged, Hungary
Life Sci 84:935-9. 2009..Our aim was to investigate whether the expression of human apoB-100 in transgenic mice and/or a high-cholesterol diet cause cerebral microvascular lesions, and whether these conditions augment ischemia-related capillary damage... - Diazoxide preserves hypercapnia-induced arteriolar vasodilation after global cerebral ischemia in pigletsFerenc Domoki
Dept of Physiology, Faculty of Medicine, Univ of Szeged, Szeged, Dom ter 10, H 6720 Hungary
Am J Physiol Heart Circ Physiol 289:H368-73. 2005..In summary, preservation of arteriolar dilator responsiveness by Diaz may contribute to neuroprotection... - Multi-modal imaging of anoxic depolarization and hemodynamic changes induced by cardiac arrest in the rat cerebral cortexEszter Farkas
Department of Medical Informatics, Faculty of Medicine, University of Szeged, H 6720 Szeged, Koranyi fasor 9, Hungary
Neuroimage 51:734-42. 2010.... 
Resveratrol preserves cerebrovascular density and cognitive function in aging miceCharlotte A Oomen
Department of Molecular Neurobiology, Center for Behavior and Neuroscience, University of Groningen Groningen, The Netherlands
Front Aging Neurosci 1:4. 2009..Via this mechanism resveratrol can contribute to the preservation of cognitive function during aging...- Direct, live imaging of cortical spreading depression and anoxic depolarisation using a fluorescent, voltage-sensitive dyeEszter Farkas
Division of Pharmacology, School of Life Sciences, University of Bradford, Bradford, UK
J Cereb Blood Flow Metab 28:251-62. 2008..In conclusion, this method provides the imaging equivalent of electrical extracellular DC potential recording, with the SD and AD negative shifts translating directly to fluorescence increase...