Eszter Farkas

Summary

Affiliation: University of Szeged
Country: Hungary

Publications

  1. ncbi request reprint Effects of cyclooxygenase (COX) inhibition on memory impairment and hippocampal damage in the early period of cerebral hypoperfusion in rats
    Adam Institoris
    Department of Physiology, School of Medicine, University of Szeged, H 6720 Szeged, Dom ter 10, Hungary
    Eur J Pharmacol 574:29-38. 2007
  2. ncbi request reprint Age-related microvascular degeneration in the human cerebral periventricular white matter
    Eszter Farkas
    Department of Anatomy, School of Medicine, University of Szeged, P O Box 427, 6701, Szeged, Hungary
    Acta Neuropathol 111:150-7. 2006
  3. ncbi request reprint Post-ischemic administration of diazoxide attenuates long-term microglial activation in the rat brain after permanent carotid artery occlusion
    Eszter Farkas
    Department of Anatomy, School of Medicine, University of Szeged, H 6701 Szeged, P O Box 427, Hungary
    Neurosci Lett 387:168-72. 2005
  4. ncbi request reprint Tumor necrosis factor-alpha increases cerebral blood flow and ultrastructural capillary damage through the release of nitric oxide in the rat brain
    Eszter Farkas
    Department of Anatomy, School of Medicine, University of Szeged, Szeged, Hungary
    Microvasc Res 72:113-9. 2006
  5. ncbi request reprint Diazoxide and dimethyl sulphoxide alleviate experimental cerebral hypoperfusion-induced white matter injury in the rat brain
    Eszter Farkas
    Department of Anatomy, School of Medicine, University of Szeged, P O Box 427, 6701 Szeged, Hungary
    Neurosci Lett 373:195-9. 2005
  6. ncbi request reprint Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases
    Eszter Farkas
    Department of Anatomy, School of Medicine, University of Szeged, H 6701 Szeged, P O Box 427, Hungary
    Brain Res Rev 54:162-80. 2007
  7. ncbi request reprint Diazoxide and dimethyl sulphoxide prevent cerebral hypoperfusion-related learning dysfunction and brain damage after carotid artery occlusion
    Eszter Farkas
    Department of Anatomy, School of Medicine, University of Szeged, P O Box 427, Szeged 6701, Hungary
    Brain Res 1008:252-60. 2004
  8. ncbi request reprint Experimental cerebral hypoperfusion induces white matter injury and microglial activation in the rat brain
    Eszter Farkas
    Department of Molecular Neurobiology, University of Groningen, The Netherlands
    Acta Neuropathol 108:57-64. 2004
  9. ncbi request reprint Chronic cerebral hypoperfusion-related neuropathologic changes and compromised cognitive status: window of treatment
    Eszter Farkas
    Group of Molecular Neurobiology, Department of Animal Physiology, University of Groningen, Groningen, The Netherlands
    Drugs Today (Barc) 38:365-76. 2002
  10. ncbi request reprint Systemic effects of dietary n-3 PUFA supplementation accompany changes of CNS parameters in cerebral hypoperfusion
    Eszter Farkas
    Department of Molecular Neurobiology, University of Groningen, Haren, The Netherlands
    Ann N Y Acad Sci 977:77-86. 2002

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Effects of cyclooxygenase (COX) inhibition on memory impairment and hippocampal damage in the early period of cerebral hypoperfusion in rats
    Adam Institoris
    Department of Physiology, School of Medicine, University of Szeged, H 6720 Szeged, Dom ter 10, Hungary
    Eur J Pharmacol 574:29-38. 2007
    ..In summary, NS-398 prevented the hypoperfusion-induced memory impairment, but not by protecting the hippocampal neurons...
  2. ncbi request reprint Age-related microvascular degeneration in the human cerebral periventricular white matter
    Eszter Farkas
    Department of Anatomy, School of Medicine, University of Szeged, P O Box 427, 6701, Szeged, Hungary
    Acta Neuropathol 111:150-7. 2006
    ..Finally, atherosclerosis in large, peripheral vessels is considered to be a predictive marker of microvascular pathology in the WM...
  3. ncbi request reprint Post-ischemic administration of diazoxide attenuates long-term microglial activation in the rat brain after permanent carotid artery occlusion
    Eszter Farkas
    Department of Anatomy, School of Medicine, University of Szeged, H 6701 Szeged, P O Box 427, Hungary
    Neurosci Lett 387:168-72. 2005
    ..These data provide evidence that post-treatment with diazoxide is not effective in impeding a long-term memory deficiency, but it can attenuate ischemia-induced microglial activation, independently of the solvent used...
  4. ncbi request reprint Tumor necrosis factor-alpha increases cerebral blood flow and ultrastructural capillary damage through the release of nitric oxide in the rat brain
    Eszter Farkas
    Department of Anatomy, School of Medicine, University of Szeged, Szeged, Hungary
    Microvasc Res 72:113-9. 2006
    ..Our data additionally demonstrate that the breakdown of the BBB by circulating TNFalpha may involve the astrocytic endfeet...
  5. ncbi request reprint Diazoxide and dimethyl sulphoxide alleviate experimental cerebral hypoperfusion-induced white matter injury in the rat brain
    Eszter Farkas
    Department of Anatomy, School of Medicine, University of Szeged, P O Box 427, 6701 Szeged, Hungary
    Neurosci Lett 373:195-9. 2005
    ..We conclude that diazoxide dissolved in DMSO can moderate ischemia-related neuroinflammation by suppressing glial reaction in selective cerebral WM areas...
  6. ncbi request reprint Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases
    Eszter Farkas
    Department of Anatomy, School of Medicine, University of Szeged, H 6701 Szeged, P O Box 427, Hungary
    Brain Res Rev 54:162-80. 2007
    ..Thorough characterization of the model suggests that 2VO in the rat is suitable for the development of potentially neuroprotective strategies in neurodegenerative diseases...
  7. ncbi request reprint Diazoxide and dimethyl sulphoxide prevent cerebral hypoperfusion-related learning dysfunction and brain damage after carotid artery occlusion
    Eszter Farkas
    Department of Anatomy, School of Medicine, University of Szeged, P O Box 427, Szeged 6701, Hungary
    Brain Res 1008:252-60. 2004
    ..Furthermore, we suggest that DMSO is a neuroprotective chemical in ischemic conditions, and it must be considerately used as a solvent for water-insoluble compounds in experimental animal models...
  8. ncbi request reprint Experimental cerebral hypoperfusion induces white matter injury and microglial activation in the rat brain
    Eszter Farkas
    Department of Molecular Neurobiology, University of Groningen, The Netherlands
    Acta Neuropathol 108:57-64. 2004
    ..Since the detected glial changes correspond with those reported in vascular and Alzheimer dementia, this model of cerebral hypoperfusion may serve to characterize the causal relationship between ischemia and white matter damage...
  9. ncbi request reprint Chronic cerebral hypoperfusion-related neuropathologic changes and compromised cognitive status: window of treatment
    Eszter Farkas
    Group of Molecular Neurobiology, Department of Animal Physiology, University of Groningen, Groningen, The Netherlands
    Drugs Today (Barc) 38:365-76. 2002
    ..The present review provides an overview of the actions of these compounds focusing on cerebral blood flow, neurodegeneration and cognitive decline...
  10. ncbi request reprint Systemic effects of dietary n-3 PUFA supplementation accompany changes of CNS parameters in cerebral hypoperfusion
    Eszter Farkas
    Department of Molecular Neurobiology, University of Groningen, Haren, The Netherlands
    Ann N Y Acad Sci 977:77-86. 2002
    ..The data draw attention to changes not only in the CNS, but also in the periphery as a consequence of chronic supplementation with n-3 PUFA-enriched diets...
  11. ncbi request reprint Dietary long chain PUFAs differentially affect hippocampal muscarinic 1 and serotonergic 1A receptors in experimental cerebral hypoperfusion
    Eszter Farkas
    Group of Molecular Neurobiology, Department of Animal Physiology, University of Groningen, Groningen, The Netherlands
    Brain Res 954:32-41. 2002
    ....
  12. ncbi request reprint The effect of pre- and posttreatment with diazoxide on the early phase of chronic cerebral hypoperfusion in the rat
    Eszter Farkas
    Department of Anatomy, School of Medicine, University of Szeged, H 6701 Szeged, PO Box 427, Hungary
    Brain Res 1087:168-74. 2006
    ..Thus, pretreatment with diazoxide offers therapeutical prospects for the treatment of cerebral ischemia...
  13. ncbi request reprint Pre-treatment and post-treatment with alpha-tocopherol attenuates hippocampal neuronal damage in experimental cerebral hypoperfusion
    Anita Annahazi
    Department of Physiology, School of Medicine, University of Szeged, Szeged, Hungary
    Eur J Pharmacol 571:120-8. 2007
    ..The data indicate that alpha-tocopherol, particularly when administered as post-treatment, is neuroprotective in chronic cerebral hypoperfusion...
  14. ncbi request reprint The effect of n-3 polyunsaturated fatty acid-rich diets on cognitive and cerebrovascular parameters in chronic cerebral hypoperfusion
    Martijn C de Wilde
    Department of Animal Physiology, Workgroup of Molecular Neurobiology, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    Brain Res 947:166-73. 2002
    ..The number of endothelial mitochondria, as well as the ratio of microvessels with degenerative pericytes appeared to be lower due to long chain n-3 PUFAs. These results may indicate an improved condition of the blood-brain barrier...
  15. doi request reprint Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampus
    Marietta Hugyecz
    Department of Physiology, Faculty of Medicine, University of Szeged, Szeged, Dom ter 10, H 6720, Hungary
    Brain Res 1404:31-8. 2011
    ..Both RSG and H(2)-RA prevented the changes of enzyme and connexin levels. Considering the lack of harmful side effects, inhalation of H(2)-RA can be a promising approach to reduce neuronal damage after TGCI...
  16. ncbi request reprint Dietary fatty acids alter blood pressure, behavior and brain membrane composition of hypertensive rats
    Martijn C de Wilde
    Department of Molecular Neurobiology, University of Groningen, Haren 9750 AA, The Netherlands
    Brain Res 988:9-19. 2003
    ..Furthermore, we consider a potential role of metabolically generated MUFAs in the beneficial effects of PUFA supplementation...
  17. doi request reprint Effects of early aging and cerebral hypoperfusion on spreading depression in rats
    Eszter Farkas
    Department of Medical Informatics, Faculty of Medicine, University of Szeged, H 6720 Szeged, Koranyi fasor 9, Hungary
    Neurobiol Aging 32:1707-15. 2011
    ..9±2.1 vs. 32.8±12.6% × min in Young). These data suggest reduced sensitivity of the cortex to CSD elicitation with early aging, and a less responsive cerebrovascular system with chronic hypoperfusion...
  18. doi request reprint Changes in pro-oxidant and antioxidant enzyme levels during cerebral hypoperfusion in rats
    Éva Mracskó
    Department of Physiology, Faculty of Medicine, University of Szeged, Szeged, Dom ter 10, H 6720, Hungary
    Brain Res 1321:13-9. 2010
    ..One year following 2VO onset, the eNOS expression was upregulated, which may strengthen the adaptation of the brain to cerebral ischemia...
  19. ncbi request reprint Beta-amyloid peptide-induced blood-brain barrier disruption facilitates T-cell entry into the rat brain
    Ibolya G Farkas
    Department of Anatomy, Histology and Embryology, University of Szeged, Hungary
    Acta Histochem 105:115-25. 2003
    ..Our study demonstrates that A beta and TNFalpha induce enhanced T-lymphocyte migration towards the brain. This effect may be attributed at least partly to dysfunctioning of the BBB, but other mechanisms are also possible...
  20. ncbi request reprint Ageing-related decline in adenosine A1 receptor binding in the rat brain: an autoradiographic study
    Peter Meerlo
    Department of Molecular Neurobiology, Graduate School of Behavioral and Cognitive Neurosciences, University of Groningen, Groningen, The Netherlands
    J Neurosci Res 78:742-8. 2004
    ..Since particularly in rats many studies have used animals at the age of 24 months or even less, the ageing-related decline in adenosine A1 signaling might have been underestimated...
  21. doi request reprint Capillary injury in the ischemic brain of hyperlipidemic, apolipoprotein B-100 transgenic mice
    Zoltan Sule
    Department of Anatomy, Faculty of Medicine, University of Szeged, Kossuth Lajos sgt 40, H 6724 Szeged, Hungary
    Life Sci 84:935-9. 2009
    ..Our aim was to investigate whether the expression of human apoB-100 in transgenic mice and/or a high-cholesterol diet cause cerebral microvascular lesions, and whether these conditions augment ischemia-related capillary damage...
  22. ncbi request reprint Diazoxide preserves hypercapnia-induced arteriolar vasodilation after global cerebral ischemia in piglets
    Ferenc Domoki
    Dept of Physiology, Faculty of Medicine, Univ of Szeged, Szeged, Dom ter 10, H 6720 Hungary
    Am J Physiol Heart Circ Physiol 289:H368-73. 2005
    ..In summary, preservation of arteriolar dilator responsiveness by Diaz may contribute to neuroprotection...
  23. doi request reprint Multi-modal imaging of anoxic depolarization and hemodynamic changes induced by cardiac arrest in the rat cerebral cortex
    Eszter Farkas
    Department of Medical Informatics, Faculty of Medicine, University of Szeged, H 6720 Szeged, Koranyi fasor 9, Hungary
    Neuroimage 51:734-42. 2010
    ....
  24. pmc Resveratrol preserves cerebrovascular density and cognitive function in aging mice
    Charlotte A Oomen
    Department of Molecular Neurobiology, Center for Behavior and Neuroscience, University of Groningen Groningen, The Netherlands
    Front Aging Neurosci 1:4. 2009
    ..Via this mechanism resveratrol can contribute to the preservation of cognitive function during aging...
  25. pmc Direct, live imaging of cortical spreading depression and anoxic depolarisation using a fluorescent, voltage-sensitive dye
    Eszter Farkas
    Division of Pharmacology, School of Life Sciences, University of Bradford, Bradford, UK
    J Cereb Blood Flow Metab 28:251-62. 2008
    ..In conclusion, this method provides the imaging equivalent of electrical extracellular DC potential recording, with the SD and AD negative shifts translating directly to fluorescence increase...