Mark Barok

Summary

Affiliation: University of Debrecen
Country: Hungary

Publications

  1. doi request reprint ErbB-directed immunotherapy: antibodies in current practice and promising new agents
    Elza Friedlander
    Department of Biophysics and Cell Biology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    Immunol Lett 116:126-40. 2008
  2. ncbi request reprint Trastuzumab decreases the number of circulating and disseminated tumor cells despite trastuzumab resistance of the primary tumor
    Mark Barok
    Department of Biophysics and Cell Biology, University of Debrecen, 4012 Debrecen, Egyetem ter 1, Hungary
    Cancer Lett 260:198-208. 2008
  3. ncbi request reprint Characterization of a novel, trastuzumab resistant human breast cancer cell line
    Mark Barok
    Department of Biophysics and Cell Biology, Faculty of Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    Front Biosci (Elite Ed) 2:627-40. 2010
  4. ncbi request reprint Trastuzumab causes antibody-dependent cellular cytotoxicity-mediated growth inhibition of submacroscopic JIMT-1 breast cancer xenografts despite intrinsic drug resistance
    Mark Barok
    Medical and Health Science Center, Department of Biophysics and Cell Biology, University of Debrecen, 1 Egyetem sqr, Debrecen 4010, Hungary
    Mol Cancer Ther 6:2065-72. 2007
  5. ncbi request reprint Hyaluronan-induced masking of ErbB2 and CD44-enhanced trastuzumab internalisation in trastuzumab resistant breast cancer
    Zsuzsanna Pályi-Krekk
    Department of Biophysics and Cell Biology, Medical and Health Science Centre, University of Debrecen, 1 Egyetem Square, H 4010 Debrecen, Hungary
    Eur J Cancer 43:2423-33. 2007
  6. doi request reprint EGFR and ErbB2 are functionally coupled to CD44 and regulate shedding, internalization and motogenic effect of CD44
    Zsuzsanna Pályi-Krekk
    Department of Biophysics and Cell Biology, Medical and Health Science Center, University of Debrecen, 1 Egyetem Square, H 4010 Debrecen, Hungary
    Cancer Lett 263:231-42. 2008
  7. doi request reprint Die hard: are cancer stem cells the Bruce Willises of tumor biology?
    Akos Fabian
    Department of Biophysics and Cell Biology, Research Center for Molecular Medicine, Medical and Health Science Center, University of Debrecen, Hungary
    Cytometry A 75:67-74. 2009
  8. ncbi request reprint EGFR gene copy number alterations in primary cutaneous malignant melanomas are associated with poor prognosis
    Zsuzsa Rakosy
    Department of Preventive Medicine, Faculty of Public Health, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    Int J Cancer 121:1729-37. 2007

Collaborators

  • Gyorgy Vereb
  • Peter Nagy
  • John W Park
  • Hideyuki Saya
  • Janos Szollosi
  • Zsuzsanna Pályi-Krekk
  • Akos Fabian
  • Elza Friedlander
  • Zsuzsa Rakosy
  • Osamu Nagano
  • Tamas Kovacs
  • Jorma Isola
  • Zsuzsa Krekk
  • Zoltan Szentirmay
  • Mónika Gallai
  • Laura Vizkeleti
  • Zoltán Vokó
  • Margit Balazs
  • Szilvia Ecsedi
  • Roza Adany
  • Markku Tammi
  • Agnes Bégány

Detail Information

Publications8

  1. doi request reprint ErbB-directed immunotherapy: antibodies in current practice and promising new agents
    Elza Friedlander
    Department of Biophysics and Cell Biology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    Immunol Lett 116:126-40. 2008
    ..Recent data pertinent to the prevalent problem of clinical resistance to treatment with trastuzumab are also discussed...
  2. ncbi request reprint Trastuzumab decreases the number of circulating and disseminated tumor cells despite trastuzumab resistance of the primary tumor
    Mark Barok
    Department of Biophysics and Cell Biology, University of Debrecen, 4012 Debrecen, Egyetem ter 1, Hungary
    Cancer Lett 260:198-208. 2008
    ..Thus, trastuzumab treatment might also be beneficial in the case of patients with breast cancer that is already trastuzumab resistant...
  3. ncbi request reprint Characterization of a novel, trastuzumab resistant human breast cancer cell line
    Mark Barok
    Department of Biophysics and Cell Biology, Faculty of Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    Front Biosci (Elite Ed) 2:627-40. 2010
    ..Based on the experiments performed in SCID mice and the genotypic/phenotypic characteristics, this new in vivo breast cancer xenograft is a valuable model to investigate molecular mechanism of trastuzumab resistance...
  4. ncbi request reprint Trastuzumab causes antibody-dependent cellular cytotoxicity-mediated growth inhibition of submacroscopic JIMT-1 breast cancer xenografts despite intrinsic drug resistance
    Mark Barok
    Medical and Health Science Center, Department of Biophysics and Cell Biology, University of Debrecen, 1 Egyetem sqr, Debrecen 4010, Hungary
    Mol Cancer Ther 6:2065-72. 2007
    ..Thus, measuring the ADCC activity of patient's leukocytes against the tumor cells may be a relevant predictor of clinical trastuzumab responsiveness in vivo...
  5. ncbi request reprint Hyaluronan-induced masking of ErbB2 and CD44-enhanced trastuzumab internalisation in trastuzumab resistant breast cancer
    Zsuzsanna Pályi-Krekk
    Department of Biophysics and Cell Biology, Medical and Health Science Centre, University of Debrecen, 1 Egyetem Square, H 4010 Debrecen, Hungary
    Eur J Cancer 43:2423-33. 2007
    ..Our results point to the importance of the CD44-hyaluronan pathway in the escape of tumour cells from receptor-oriented therapy...
  6. doi request reprint EGFR and ErbB2 are functionally coupled to CD44 and regulate shedding, internalization and motogenic effect of CD44
    Zsuzsanna Pályi-Krekk
    Department of Biophysics and Cell Biology, Medical and Health Science Center, University of Debrecen, 1 Egyetem Square, H 4010 Debrecen, Hungary
    Cancer Lett 263:231-42. 2008
    ..Our experiments point to an unexpected, but potentially important mechanism of action of ErbB receptor-targeted monoclonal antibodies used in the treatment of cancer...
  7. doi request reprint Die hard: are cancer stem cells the Bruce Willises of tumor biology?
    Akos Fabian
    Department of Biophysics and Cell Biology, Research Center for Molecular Medicine, Medical and Health Science Center, University of Debrecen, Hungary
    Cytometry A 75:67-74. 2009
    ..Therefore, a model that describes cancer initiation and progression should combine elements of clonal evolution and CSC theory...
  8. ncbi request reprint EGFR gene copy number alterations in primary cutaneous malignant melanomas are associated with poor prognosis
    Zsuzsa Rakosy
    Department of Preventive Medicine, Faculty of Public Health, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    Int J Cancer 121:1729-37. 2007
    ..Further studies are required to clarify whether melanoma patients with EGFR alterations can benefit from anti-EGFR therapy...