Research Topics
Species | Mark BarokSummaryAffiliation: University of Debrecen Country: Hungary Publications
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Detail Information
Publications
ErbB-directed immunotherapy: antibodies in current practice and promising new agentsElza Friedlander
Department of Biophysics and Cell Biology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
Immunol Lett 116:126-40. 2008..Recent data pertinent to the prevalent problem of clinical resistance to treatment with trastuzumab are also discussed...
Trastuzumab decreases the number of circulating and disseminated tumor cells despite trastuzumab resistance of the primary tumorMark Barok
Department of Biophysics and Cell Biology, University of Debrecen, 4012 Debrecen, Egyetem ter 1, Hungary
Cancer Lett 260:198-208. 2008..Thus, trastuzumab treatment might also be beneficial in the case of patients with breast cancer that is already trastuzumab resistant...- Characterization of a novel, trastuzumab resistant human breast cancer cell lineMark Barok
Department of Biophysics and Cell Biology, Faculty of Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
Front Biosci (Elite Ed) 2:627-40. 2010..Based on the experiments performed in SCID mice and the genotypic/phenotypic characteristics, this new in vivo breast cancer xenograft is a valuable model to investigate molecular mechanism of trastuzumab resistance... - Trastuzumab causes antibody-dependent cellular cytotoxicity-mediated growth inhibition of submacroscopic JIMT-1 breast cancer xenografts despite intrinsic drug resistanceMark Barok
Medical and Health Science Center, Department of Biophysics and Cell Biology, University of Debrecen, 1 Egyetem sqr, Debrecen 4010, Hungary
Mol Cancer Ther 6:2065-72. 2007..Thus, measuring the ADCC activity of patient's leukocytes against the tumor cells may be a relevant predictor of clinical trastuzumab responsiveness in vivo... - Hyaluronan-induced masking of ErbB2 and CD44-enhanced trastuzumab internalisation in trastuzumab resistant breast cancerZsuzsanna Pályi Krekk
Department of Biophysics and Cell Biology, Medical and Health Science Centre, University of Debrecen, 1 Egyetem Square, H 4010 Debrecen, Hungary
Eur J Cancer 43:2423-33. 2007..Our results point to the importance of the CD44-hyaluronan pathway in the escape of tumour cells from receptor-oriented therapy... - EGFR and ErbB2 are functionally coupled to CD44 and regulate shedding, internalization and motogenic effect of CD44Zsuzsanna Pályi-Krekk
Department of Biophysics and Cell Biology, Medical and Health Science Center, University of Debrecen, 1 Egyetem Square, H 4010 Debrecen, Hungary
Cancer Lett 263:231-42. 2008..Our experiments point to an unexpected, but potentially important mechanism of action of ErbB receptor-targeted monoclonal antibodies used in the treatment of cancer... - Die hard: are cancer stem cells the Bruce Willises of tumor biology?Akos Fabian
Department of Biophysics and Cell Biology, Research Center for Molecular Medicine, Medical and Health Science Center, University of Debrecen, Hungary
Cytometry A 75:67-74. 2009..Therefore, a model that describes cancer initiation and progression should combine elements of clonal evolution and CSC theory... - EGFR gene copy number alterations in primary cutaneous malignant melanomas are associated with poor prognosisZsuzsa Rakosy
Department of Preventive Medicine, Faculty of Public Health, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
Int J Cancer 121:1729-37. 2007..Further studies are required to clarify whether melanoma patients with EGFR alterations can benefit from anti-EGFR therapy...