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Genomes and Genes | University of SzegedSummaryOrganization: University of Szeged Country: Hungary Top Publications
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Putting together rather than taking apartJanos Szabad
Department of Biology, University of Szeged, Hungary
EMBO Rep 11:904-6. 2010..The EMBO workshop was held between 16 and 20 August and brought together a multidisciplinary group of scientists who use systems approaches to understand how the size and shape of multicellular organisms and organs are determined...
[A concise history of the Wolff-Parkinson-White syndrome]Tamas Fazekas
1st Department of Internal Medicine, Szeged University Medical School, Hungary
Orvostort Kozl 51:5-22. 2006..Our current knowledge and day-to-day clinical practice is the result of marvelous contributions from numerous dedicated scientists in diverse disciplines in many countries...
Capillary electrophoresis tandem mass spectrometry of bromine-containing charged derivatives of peptidesGyörgyi Ferenc
Department of Medicinal Chemistry, University of Szeged, Dom ter 8, H 6720 Szeged, Hungary
J Chromatogr A 1159:119-24. 2007..By eliminating the non-doubled peaks, clear and easily interpretable MS/MS spectra can be produced that contain only the labeled fragments...
New steroid-fused P-heterocycles. Part II. Synthesis and conformational study of oxazaphosphorino[16,17-e]estrone derivativesEva Frank
Department of Organic Chemistry, University of Szeged, Hungary
Steroids 72:446-58. 2007....
Reventilation with room air or 100% oxygen after asphyxia differentially affects cerebral neuropathology in newborn pigsFerenc Domoki
Department of Physiology, Faculty of Medicine, University of Szeged, Szeged, and Department of Pathology, University Teaching Hospital, Kecskemet, Hungary
Acta Paediatr 95:1109-15. 2006..To test if reventilation with room air (RA) or 100% oxygen (O2) after asphyxia would differentially affect neuronal damage in different brain areas of newborn pigs...
Stereoselective synthesis of some 17beta-dihydrooxazinyl steroids, as novel presumed inhibitors of 17alpha-hydroxylase-C17,20-lyaseJanos Wolfling
Department of Organic Chemistry, University of Szeged, Dom ter 8, H 6720 Szeged, Hungary
Steroids 71:809-16. 2006..The inhibitory effects of these compounds on rat testicular C(17,20)-lyase were investigated with an in vitro radioincubation technique...
Candidate susceptibility genes in Alzheimer's disease are at high risk for being forgotten-- they don't give peace of mindAndrás Palotás
Alzheimer s Disease Research Center, Department of Psychiatry, Albert Szent Gyorgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H 6720 Szeged, Pécsi u 4, Hungary
Curr Drug Metab 7:273-93. 2006..Over the past decades, a number of candidate genes have been identified as disease modifiers with conflicting results. This study reviews susceptibility genes that are associated with increased risk of developing AD...
Autoimmune pancreatitis: functional and morphological recovery after steroid therapyLaszlo Czako
First Department of Medicine, University of Szeged, PO Box 469, H 6701 Szeged, Hungary
World J Gastroenterol 12:1810-2. 2006..However, in contrast with chronic pancreatitis, its symptoms and morphologic and laboratory alterations are completely reversed by oral steroid therapy...
3,4-Methylenedioxymethamphetamine (MDMA), but not morphine, alters APP processing in the rat brainJanos Kalman
Department of Psychiatry and Alzheimer s Disease Research Centre, Albert Szent Györgyi Center for Medical and Pharmaceutical Sciences, Faculty of Medicine, University of Szeged, Szeged, Hungary
Int J Neuropsychopharmacol 10:183-90. 2007..These results indicate that the chronic use of 'ecstasy', but not morphine, may be harmful via a novel mode of action, i.e. by altering the APP expression and processing in the brain...
Efficient and specific targeting of Polycomb group proteins requires cooperative interaction between Grainyhead and PleiohomeoticAndras Blastyak
Hungarian Academy of Sciences, Biological Research Center, Institute of Genetics, Temesvari krt 62, P O B 521, H 6701 Szeged, Hungary
Mol Cell Biol 26:1434-44. 2006....
Molecular investigation of genetic elements contributing to metronidazole resistance in Bacteroides strainsJózsef Sóki
Instutute of Clinical Microbiology, University of Szeged, H 6725 Szeged, Somogyi Béla tér 1, Hungary
J Antimicrob Chemother 57:212-20. 2006....
[Cholesterol and Alzheimer's disease]Janos Kalman
Szegedi Tudomanyegyetem, Pszichiatriai Klinika, Alzheimer kór Kutatócsoport, Szeged
Orv Hetil 146:1903-11. 2005..New, promising cholesterol metabolism related therapeutic approaches are discussed, but it is emphasized that the clinical evidences regarding their efficacy in Alzheimer's disease are still missing...
Detection of nanobacteria-like particles in human atherosclerotic plaquesL G Puskas
Laboratory of Functional Genomics, Biological Research Center, Hungarian Academy of Sciences, P O Box 521, H 6701 Szeged, Hungary
Acta Biol Hung 56:233-45. 2005..Identification of nanobacteria-like particles at the lesion supports, but does not by itself prove the hypothesis that these agents contribute to the pathogenesis of atherosclerosis, especially vascular calcifications...
Evolutionary relationships among Aspergillus terreus isolates and their relativesJanos Varga
Department of Microbiology, Faculty of Sciences, University of Szeged, P O Box 533, H 6701, Szeged, Hungary
Antonie Van Leeuwenhoek 88:141-50. 2005..flavipes isolates are more closely related to A. terreus than A. carneus isolates. Our data suggest that sections Terrei and Flavipedes should be merged. However, further loci should be analysed to draw more definite conclusions...
Evaluation of oxidative stress markers after vaginal delivery or Caesarean sectionZsuzsanna Hracsko
Department of Biochemistry and Molecular Biology, University of Szeged, H 6701 Szeged, Hungary
In Vivo 21:703-6. 2007..The effects of vaginal delivery (VD) and of cesarean section (CS) on the markers of oxidative stress were investigated...
Regeneration of reinnervated rat soleus muscle is accompanied by fiber transition toward a faster phenotypeLuca Mendler
Institute of Biochemistry, Faculty of General Medicine, University of Szeged, Dom ter 9, 6720 Szeged, Hungary
J Histochem Cytochem 56:111-23. 2008....
Applicability of a new gastric tonometric probe in infants requiring intensive careGyula Tálosi
Department of Pediatrics, Albert Szent Gyorgyi Medical and Pharmaceutical Center, University of Szeged, Szeged, Hungary
Med Sci Monit 14:PI32-7. 2008..The aims of this paper are to describe the technique of application of a recently developed gastric tonometric probe especially suitable for performing measurements on neonates and infants and to present the first human results...
[Evaluation of the mitral valve by transthoracic real-time three-dimensional echocardiography]Attila Nemes
Erasmus MC, Thoraxcentrum, Kardiológiai Klinika, Rotterdam
Orv Hetil 151:854-63. 2010..The aim of this review is to demonstrate the role of one of the newest echocardiographic developments, the transthoracic real-time three-dimensional echocardiography in the evaluation of mitral valve...
Familiar ochronotic arthropathy-caused by a gene mutation traced three hundred yearsKalman Toth
Department of Orthopedics, Faculty of Medicine, University of Szeged, 6725, Semmelweis Street 6, Szeged, Hungary
Joint Bone Spine 77:355-7. 2010..Therefore genetic counselling is highly recommended to minimize the risk factors...
Prevalence, nucleotide sequence and expression studies of two proteins of a 5.6kb, class III, Bacteroides plasmid frequently found in clinical isolates from European countriesJózsef Sóki
Institute of Clinical Microbiology, Albert Szent Gyorgyi Clinical Center, Faculty of General Medicine, University of Szeged, Semmelweis u 6, H 6725 Szeged, Hungary
Plasmid 63:86-97. 2010..Four additional ORFs (orf1-4) were identified. Orf1 was predicted to code a lipoprotein. In expression studies in an Escherichia coli host, Orf1 behaved as a periplasmic protein...
Syntheses, transformations and pharmaceutical applications of kynurenic acid derivativesF Fulop
Institute of Pharmaceutical Chemistry and Research Group for Stereochemistry, Hungarian Academy of Sciences, University of Szeged, H 6720 Szeged, Eotvos u 6, Hungary
Curr Med Chem 16:4828-42. 2009..The syntheses and transformations of 4-hydroxyquinoline-2-carboxylic acid, kynurenic acid, are reviewed, and special attention is paid to the pharmacological activities and pharmaceutical applications of its derivatives...
Perceptual and motor factors of implicit skill learningDezso Nemeth
Institute of Psychology, University of Szeged, Szeged, 6722 Hungary
Neuroreport 20:1654-8. 2009..Our results showed that motor and perceptual factors influenced skill learning to a similar extent...
Two subgroups of schizophrenia identified by systematic cognitive neuropsychiatric mappingIstvan Szendi
Department of Psychiatry, University of Szeged, 6 Semmelweis str, 6725, Szeged, Hungary
Eur Arch Psychiatry Clin Neurosci 260:257-66. 2010..The patterns of cognitive dysfunctions and neurological developmental anomalies equally indicate that there may be hemispherical differences between the patients belonging to the different clusters...
Rare extraintestinal infection caused by toxin-producing Clostridium difficileEdit Urban
Institute of Clinical Microbiology, Faculty of Medicine, University of Szeged, Hungary
Anaerobe 16:301-3. 2010..On the basis of antibiotic susceptibility testing, the isolated strain was susceptible to most antimicrobials, except from cefoxitin, thus cefuroxime was changed to imipenem...
[The mechanism of peripheral and central sensitization in migraine. A literature review]Janos Tajti
Szegedi Tudományegyetem Neurológiai Klinika, Szeged
Neuropsychopharmacol Hung 11:15-21. 2009..This process is explained clinically by face and scalp ollodynia and by neck stiffness (extracranial tenderness)...
Secretory phospholipase A2 inhibitor PX-18 preserves microvascular reactivity after cerebral ischemia in pigletsFerenc Domoki
Department of Physiology, Faculty of Medicine, University of Szeged, H 6720 Szeged, Dom ter 10, Hungary
Microvasc Res 78:212-7. 2009..In conclusion, inhibition of sPLA(2) by PX-18 improves neurovascular function both at the neuronal and the microvascular level following I/R. This effect of PX-18 likely contributes to its neuroprotective effect...
Identification of two phospholipid hydroperoxide glutathione peroxidase (gpx4) genes in common carpEdit Hermesz
Department of Biochemistry and Molecular Biology, Faculty of Science, University of Szeged, Szeged, Hungary
Comp Biochem Physiol C Toxicol Pharmacol 150:101-6. 2009..Cold shock and Cd(2+) exposure influenced the gpx4a expression to only a slight extent, whereas gpx4b was greatly down-regulated following Cd(2+) exposure...
Hungarian hospital antibiotic consumption at the regional level, 1996-2005R Benko
Dept of Clinical Pharmacy, University of Szeged, Hungary
Infection 37:133-7. 2009..This study was designed to explore regional variations and investigate determinants of antibiotic consumption in hospital care in Hungary...
Interaction of tomato lectin with ABC transporter in cancer cells: glycosylation confers functional conformation of P-gpJoseph Molnar
Department of Medical Microbiology and Immunbiology, Faculty of Medicine, University of Szeged, Dom ter 10, H 6720 Szeged, Hungary
Acta Histochem 111:329-33. 2009..Our results indicate that the polylactosamine chains of P-gp are part of the functionally active protein conformation...
Lung volumes and respiratory mechanics in elastase-induced emphysema in miceZ Hantos
Dept of Medical Informatics, Univ of Szeged, Koranyi fasor 9, H 6720 Szeged, Hungary
J Appl Physiol 105:1864-72. 2008..These findings emphasize the importance of absolute lung volumes and indicate that tissue destruction was not associated with airway dysfunction in this mouse model of emphysema...
Relationship between breath-hold time and physical performance in patients with cystic fibrosisMaria Barnai
Department of Physiotherapy, Faculty of Health Science, University of Szeged, Hungary
Eur J Appl Physiol 95:172-8. 2005..53 + 0.42 x BHT and WC at the AT (watt/kg) = 0.56 + 0.38 x BHT Our results suggest that the voluntary breath-hold time might be a useful index for prediction of the exercise tolerance of CF patients...
Reactions of some cucurbitaceous species Tozucchini yellow mosaic virus (ZYMV)R Csorba
Szeged University, College of Agriculture, Department of Plant Production and Horticulture, Hódmezõvásárhely, Hungary
Commun Agric Appl Biol Sci 69:499-506. 2004..Our results might have significant role in the field of research of host range, virus resistance and virus differentiation...
Occurrence of metronidazole and imipenem resistance among Bacteroides fragilis group clinical isolates in HungaryE Nagy
Institute of Clinical Microbiology, Faculty of Medicine, University of Szeged, Hungary
Acta Biol Hung 52:271-80. 2001..In the 2 B. fragilis isolates with increased MICs to metronidazole, the nim gene could be detected by PCR. The IS1186 element was found in these isolates upregulating the metronidazole resistance gene...
Tissue-specific expression of two metallothionein genes in common carp during cadmium exposure and temperature shockE Hermesz
University of Szeged, Faculty of Science, Department of Biochemistry, P O Box 533, H 6701, Szeged, Hungary
Comp Biochem Physiol C Toxicol Pharmacol 128:457-65. 2001..Cold stress resulted in a significantly higher induction of MT-1 than of MT-2, while heat shock had no effect on the expression of either gene...
Auto-inhibition of Ca(2+)/calmodulin-dependent protein kinase II by its ATP-binding domainI Lengyel
Institute of Biochemistry, Biological Research Center, Szeged, Hungary
J Neurochem 76:1066-72. 2001..Thus the molecular interactions involving the ATP-binding domain appears to play a role in the regulation of nonphosphorylated CaMPK-II activity...
Effects of dopamine and dopamine-active compounds on oxytocin and vasopressin production in rat neurohypophyseal tissue culturesM Galfi
Department of Biology, University of Sciences, Faculty of Juhász Gyula Teachers College, Szeged, Hungary
Regul Pept 98:49-54. 2001..The results indicate that NH hormone production can be directly influenced by the DA-ergic system. The DA-ergic control of NH hormone secretion in rats can occur independently of the hypothalamus, at the level of the posterior pituitary...
Water enema CT examination of rectum cancer by reduced amount of waterA Palko
Department of Radiology, Faculty of General Medicine, University of Szeged, Hungary
Rofo 172:901-4. 2000..To define whether volume of water, administered during water enema CT (WE-CT) for local staging of rectal cancer, may be reduced without compromising the diagnostic value of the examination...
Acute 4-aminopyridine seizures increase the regional cerebral blood flow in the thalamus and neocortex, but not in the entire allocortex of the mouse brainA Mihaly
Department of Anatomy, Faculty of Medicine, Albert Szent Györgyi Health Science Center, University of Szeged, Hungary
Acta Physiol Hung 87:43-52. 2000..The primary involvement of the neocortex and thalamus points to the importance of thalamocortical circuits in the precipitation and maintenance of experimental 4-aminopyridine convulsions...
Alicyclic beta-amino acids: useful synthons in drug researchF Fulop
Institute of Pharmaceutical Chemistry, University of Szeged, Hungary
Farmaco 55:181-3. 2000..The syntheses, transformations and some of the biological features of 2-aminocyclopentanecarboxylic acid and related alicyclic beta-amino acids are discussed...
Fetal renal artery flow and renal echogenicity in the chronically hypoxic stateA Suranyi
Department of Pediatrics, Albert Szent Gyorgyi Medical University, Szeged, Hungary
Pediatr Nephrol 14:393-9. 2000....
Effects of N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine on the blood-brain barrier permeability in the ratM A Deli
Laboratory of Molecular Neurobiology, Institute of Biophysics, Biological Research Centre of the Hungarian Academy of Sciences, Temesvari korut 62, H 6701, Szeged, Hungary
Eur J Pharmacol 387:63-72. 2000..In conclusion, DPPE induced an increased permeability in the rat, which supports a role for histamine, as an intracellular messenger, in the regulation of the blood-brain barrier characteristics...
Markerless gene replacement in Escherichia coli stimulated by a double-strand break in the chromosomeG Posfai
Institute of Biochemistry, Biological Research Center, H 6701 Szeged, Hungary
Nucleic Acids Res 27:4409-15. 1999..Use of the method was demonstrated by constructing a 17-bp and a 62-kb deletion in the MG1655 chromosome. Cleavage of the chromosome induces the SOS response but does not lead to an increased mutation rate...
Role of nitric oxide and TPEN, a potent metal chelator, in ischaemic and reperfused rat isolated heartsP Ferdinandy
Department of Biochemistry, A Szent Gyorgyi Medical School, Hungary
Clin Exp Pharmacol Physiol 25:496-502. 1998..6. The results show that TPEN exerts beneficial effects on postischaemic cardiac function and dysrhythmias in relation to inhibition of the accumulation of NO in ischaemic/reperfused myocardium...
Structural factors controlling ligand binding to myoglobin: a kinetic hole-burning studyP Ormos
Institute of Biophysics, Biological Research Centre of the Hungarian Academy of Sciences, P O Box 521 H 6701 Szeged, Hungary
Proc Natl Acad Sci U S A 95:6762-7. 1998..We give evidence that this coordinate, contrary to widespread belief, is not the iron displacement from the mean heme plane...
Digital communication with fetal monitorsZ Bozoki
Department of Obstetrics and Gynecology, Albert Szent Gyorgyi Medical University, World Health Organization Collaborating Center of Research in Human Reproduction, Szeged, Hungary
Obstet Gynecol 90:837-9. 1997..Fetal heart rate (FHR) values in the averaged format that are provided by commercial computed cardiotocography analysis systems may be unsuitable for special analysis purposes...
Double-stranded rna elements and virus-like particles in AspergilliJ Varga
Department of Microbiology, Faculty of Sciences, University of Szeged, Hungary
Acta Biol Hung 52:355-63. 2001..The presence of virus-like particles in these and other Aspergilli was also examined by electron microscopy. Most infected Aspergillus isolates examined were found to carry virus-like particles in the size range 36-40 nm...
High-performance liquid chromatographic enantioseparation of bicyclic 1,3-amino alcoholsA Peter
Department of Inorganic and Analytical Chemistry, University of Szeged, Hungary
J Chromatogr A 919:79-86. 2001..The order of elution of the enantiomers was determined by both direct and indirect methods...
Breeding of mycoparasitic Trichoderma strains for heavy metal resistanceL Kredics
Hungarian Academy of Sciences and University of Szeged, Microbiological Research Group, Hungary
Lett Appl Microbiol 33:112-6. 2001....
[Fetal renal ultrasound investigation in toxaemic pregnancies]Andrea Surányi
Szegedi Tudomanyegyetem, Szent Györgyi Albert Orvos és Gyógyszerésztudományi Centrum, Általános Orvostudományi Kar, Szülészeti és Nőgyógyászati Klinika, Szeged
Orv Hetil 145:1511-6. 2004..A relationship was sought between renal hyperechogenicity and the hypoxic state of fetuses...
Y-chromosome STR haplotype in Szekely populationZsuzsanna Beer
Department of Forensic Medicine, University of Szeged, Kossuth L sgt 40, Szeged 6740, Hungary
Forensic Sci Int 139:155-8. 2004..Ninety different haplotypes were obtained from 99 unrelated Szekely males...
The roles of different regions of the CycH protein in c-type cytochrome biogenesis in Sinorhizobium melilotiG Cinege
Institute of Genetics, Biological Research Centre, Hungarian Academy of Sciences, PO Box 521, 6701 Szeged, Hungary
Mol Genet Genomics 271:171-9. 2004..In contrast, only the full-length protein confers the ability to fix nitrogen...
Inhibitory effect of galanin on dopamine induced increased oxytocin secretion in rat neurohypophyseal tissue culturesM Galfi
Department of Biology, Faculty of Juhász Gyula Teacher Training College, University of Szeged, Szeged, Hungary
Regul Pept 116:35-41. 2003..The results indicate that OT release from the NH is directly influenced by the GAL-ergic system. The GAL-ergic control of OT secretion from NH tissue in rats can occur at the level of the posterior pituitary...
A novel and convenient method for the synthesis of free 5'-thiol modified oligonucleotidesZ Kupihar
Nucleic Acids Laboratory, Department of Medicinal Chemistry, University of Szeged, Szeged, Hungary
Nucleosides Nucleotides Nucleic Acids 22:1297-9. 2003..The synthesis of free 5'-thiol-modified oligonucleotides using a 4,4',4''-trimethoxytrityl (TMTr)-protected linker and standard Poly-Pak purification has been described...
[Imaging of dopamine transporter with Tc99m-Trodat-SPECT in movement disorders]Balázs Kanyó
Szegedi Tudomanyegyetem, Nukleáris Medicina Intézet, H 6720 Szeged, Koranyi fasor 8
Ideggyogy Sz 56:231-40. 2003..99mTc-TRODAT-1 is a new, technetium based radiopharmaceutical that selectively binds to the dopamine transporters. The aim of the study was to evaluate the dopamine transporter status in movement disorders...
The new injury severity score is a better predictor of extended hospitalization and intensive care unit admission than the injury severity score in patients with multiple orthopaedic injuriesZsolt J Balogh
Department of Traumatology, Albert Szent Gyorgyi Medical and Pharmaceutical Center, University of Szeged, Szeged, Hungary
J Orthop Trauma 17:508-12. 2003....
Expression and function of Toll-like receptors 2 and 4 in human keratinocytesAndor Pivarcsi
Department of Dermatology and Allergology, University of Szeged, and Dermatological Research Group of the Hungarian Academy of Sciences, 6701 Szeged, Hungary
Int Immunol 15:721-30. 2003..Our findings stress the importance of the role of keratinocytes as a component of innate immunity...
The role of innate immunity in the pathogenesis of acneA Koreck
Department of Dermatology and Allergology, University of Szeged, Hungary
Dermatology 206:96-105. 2003..The elements of the skin immune system are involved in the development of both noninflammatory and inflammatory acne lesions...
Should all sexually active young women in Hungary be screened for Chlamydia trachomatis?Tibor Nyari
Department of Medical Informatics, University of Szeged, P O Box 427, H 6720, Szeged, Hungary
Eur J Obstet Gynecol Reprod Biol 106:55-9. 2003..Cost-effectiveness analysis was carried out to develop screening strategy for Chlamydia trachomatis to assess the possibility of preventing pelvic inflammatory disease and its sequelae...
Differential regulation of the two metallothionein genes in common carpEdit Hermesz
Department of Biochemistry, Faculty of Science, University of Szeged, Hungary
Acta Biol Hung 53:343-50. 2002..Arsenic affected mostly the MT-2 expression, while the level of the MT-1 transcript did not change significantly in either organ...
[Dose-dependent effect of pancreatin replacement upon the pancreatic function in the period after pancreatic surgery]G Farkas
Szegedi Tudományegyetem Altalános Orvosi Kar, Sebészeti Klinika, 6720 Szeged, Pécsi út 4
Magy Seb 54:347-50. 2001..Disturbance of the exocrine function can persist for several weeks following pancreatic surgery. Active proteases in the duodenal lumen may help to recover exocrine function, but the effect can depend on dosage...
Continuous enteral feeding has an attenuating effect on the exocrine pancreas in ratsT Wittmann
First Department of Medicine, University of Szeged, Hungary
Pancreas 23:329-34. 2001..Its effects on the exocrine pancreas, however, remain only partially investigated...
The photocycle of bacteriorhodopsin at high pH and ionic strength. I. Effects of pH and buffer on the absorption kineticsG I Groma
Department of Chemistry and Biochemistry, University of California, Santa Cruz 95064, USA
Biochim Biophys Acta 1319:59-68. 1997..Unexpected differences were found in the kinetic parameters in CHES and borate buffers...
