Research Topics
Genomes and Genes | Peter VarnaiSummaryAffiliation: Semmelweis University Country: Hungary Publications
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Detail Information
Publications
STIM and Orai: the long-awaited constituents of store-operated calcium entryPeter Varnai
Department of Physiology, Semmelweis University Faculty of Medicine, H 1088, Puskin u 9, Budapest, Hungary
Trends Pharmacol Sci 30:118-28. 2009..Here, we briefly summarize recent developments in this exciting area of Ca(2+) signaling...- Mapping of the localization of type 1 angiotensin receptor in membrane microdomains using bioluminescence resonance energy transfer-based sensorsAndras Balla
Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary
J Biol Chem 287:9090-9. 2012.... 
Allosteric interactions within the AT₁ angiotensin receptor homodimer: role of the conserved DRY motifBence Szalai
Department of Physiology, Semmelweis University, Faculty of Medicine, Budapest, Hungary
Biochem Pharmacol 84:477-85. 2012..These data suggest that allosteric interactions in the homodimers of AT₁R significantly affect the function of the non-stimulated protomer, and the conserved DRY motif has a crucial role in these interactions...- Acute depletion of plasma membrane phosphatidylinositol 4,5-bisphosphate impairs specific steps in endocytosis of the G-protein-coupled receptorDániel J Tóth
Department of Physiology, Semmelweis University, Faculty of Medicine, Budapest, Hungary
J Cell Sci 125:2185-97. 2012..Our data suggest that in the absence of PtdIns(4,5)P(2), these receptors move into clathrin-coated membrane structures, but these are not cleaved efficiently and hence cannot reach the early endosomal compartment... 
Endocytosis of the AT1A angiotensin receptor is independent of ubiquitylation of its cytoplasmic serine/threonine-rich regionBalázs Mihalik
Department of Physiology, Faculty of Medicine, Semmelweis University, P O Box 259, H 1444 Budapest, Hungary
Int J Biochem Cell Biol 35:992-1002. 2003....- The effect of OPA1 on mitochondrial Ca²⁺ signalingLászló Fülöp
Department of Physiology, Faculty of Medicine, Semmelweis University, Hungarian Academy of Sciences, Budapest, Hungary
PLoS ONE 6:e25199. 2011..Altogether, our observations reveal the significance of OPA1 in the control of mitochondrial Ca²⁺ metabolism... - Mechanisms of angiotensin II-mediated regulation of aldosterone synthase expression in H295R human adrenocortical and rat adrenal glomerulosa cellsMaria Szekeres
Department of Physiology, Semmelweis University, Faculty of Medicine, Budapest, Hungary
Mol Cell Endocrinol 302:244-53. 2009.... - Visualization and manipulation of phosphoinositide dynamics in live cells using engineered protein domainsPeter Varnai
Endocrinology and Reproduction Research Branch, NICHD, National Institutes of Health, Bldg 49, Rm 6A35, 49 Convent Drive, Bethesda, MD, USA
Pflugers Arch 455:69-82. 2007..In this review, we will summarize our efforts to improve our tools in studying phosphoinositide dynamics and discuss our views on the values of these methods compared to other options currently used or being explored... - Chronic repeated restraint stress increases prolactin-releasing peptide/tyrosine-hydroxylase ratio with gender-related differences in the rat brainZsuzsanna E Toth
Neuromorphological and Neuroendocrine Research Laboratory, Department of Anatomy, Histology and Embryology of the Semmelweis University and the Hungarian Academy of Sciences, Budapest, Hungary
J Neurochem 104:653-66. 2008.... - Calcium entry is regulated by Zn2+ in relation to extracellular ionic environment in human airway epithelial cellsDóra Hargitai
Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary
Respir Physiol Neurobiol 170:67-75. 2010..In conclusion, Ca(2+) entry is finely regulated by external ionic environment. Therefore, we speculate that properly compiled aerosols could influence efficacy of zinc-based therapy in CF... - Demonstration of angiotensin II-induced Ras activation in the trans-Golgi network and endoplasmic reticulum using bioluminescence resonance energy transfer-based biosensorsAndras Balla
Department of Physiology, Faculty of Medicine, Semmelweis University, H 1444 Budapest, Hungary
J Biol Chem 286:5319-27. 2011..These data suggest that AngII can stimulate Ras activity in the TGN and ER with a G protein-dependent mechanism, which does not require β-arrestin-mediated signaling, receptor internalization, and EGF receptor transactivation... - Relating underrepresented genomic DNA patterns and tiRNAs: the rule behind the observation and beyondMiklos Cserzo
Department of Physiology, Semmelweis University, Budapest, Tuzolto Street, 37 47, 1094, Hungary, EU
Biol Direct 5:56. 2010..The exact role of these molecules in gene expression control is mostly unknown at present, while their importance is generally recognized... - Redox state of the endoplasmic reticulum is controlled by Ero1L-alpha and intraluminal calciumBalázs Enyedi
Department of Physiology, Semmelweis University, Faculty of Medicine, Budapest, Hungary
Antioxid Redox Signal 13:721-9. 2010..We also found that calcium mobilization from intracellular stores induces a decrease in ER H(2)O(2) level, suggesting a complex interplay between redox and calcium signaling in the mammalian ER... - Live cell imaging of phosphoinositides with expressed inositide binding protein domainsPeter Varnai
Department of Physiology, Semmelweis University Faculty of Medicine, Budapest, H 1088 Budapest, Puskin utca 9, Hungary, Bethesda, MD 20892, USA
Methods 46:167-76. 2008.... - Paracrine transactivation of the CB1 cannabinoid receptor by AT1 angiotensin and other Gq/11 protein-coupled receptorsGabor Turu
Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary
J Biol Chem 284:16914-21. 2009..These data suggest that, in addition to their retrograde neurotransmitter role, endocannabinoids have much broader paracrine mediator functions during activation of G(q/11)-coupled receptors...