Peter Varnai

Summary

Affiliation: Semmelweis University
Country: Hungary

Publications

  1. pmc STIM and Orai: the long-awaited constituents of store-operated calcium entry
    Peter Varnai
    Department of Physiology, Semmelweis University Faculty of Medicine, H 1088, Puskin u 9, Budapest, Hungary
    Trends Pharmacol Sci 30:118-28. 2009
  2. ncbi request reprint Mitochondrial Ca2+ uptake with and without the formation of high-Ca2+ microdomains
    Gergo Szanda
    Department of Physiology, Faculty of Medicine, Semmelweis University and Laboratory of Cellular and Molecular Physiology, Hungarian Academy of Sciences, Budapest, Hungary
    Cell Calcium 40:527-37. 2006
  3. pmc Mapping of the localization of type 1 angiotensin receptor in membrane microdomains using bioluminescence resonance energy transfer-based sensors
    Andras Balla
    Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    J Biol Chem 287:9090-9. 2012
  4. doi request reprint Allosteric interactions within the AT₁ angiotensin receptor homodimer: role of the conserved DRY motif
    Bence Szalai
    Department of Physiology, Semmelweis University, Faculty of Medicine, Budapest, Hungary
    Biochem Pharmacol 84:477-85. 2012
  5. pmc Acute depletion of plasma membrane phosphatidylinositol 4,5-bisphosphate impairs specific steps in endocytosis of the G-protein-coupled receptor
    Dániel J Tóth
    Department of Physiology, Semmelweis University, Faculty of Medicine, Budapest, Hungary
    J Cell Sci 125:2185-97. 2012
  6. ncbi request reprint Endocytosis of the AT1A angiotensin receptor is independent of ubiquitylation of its cytoplasmic serine/threonine-rich region
    Balázs Mihalik
    Department of Physiology, Faculty of Medicine, Semmelweis University, P O Box 259, H 1444 Budapest, Hungary
    Int J Biochem Cell Biol 35:992-1002. 2003
  7. pmc The effect of OPA1 on mitochondrial Ca²⁺ signaling
    László Fülöp
    Department of Physiology, Faculty of Medicine, Semmelweis University, Hungarian Academy of Sciences, Budapest, Hungary
    PLoS ONE 6:e25199. 2011
  8. ncbi request reprint Mechanisms of angiotensin II-mediated regulation of aldosterone synthase expression in H295R human adrenocortical and rat adrenal glomerulosa cells
    Maria Szekeres
    Department of Physiology, Semmelweis University, Faculty of Medicine, Budapest, Hungary
    Mol Cell Endocrinol 302:244-53. 2009
  9. ncbi request reprint Visualization and manipulation of phosphoinositide dynamics in live cells using engineered protein domains
    Peter Varnai
    Endocrinology and Reproduction Research Branch, NICHD, National Institutes of Health, Bldg 49, Rm 6A35, 49 Convent Drive, Bethesda, MD, USA
    Pflugers Arch 455:69-82. 2007
  10. doi request reprint Chronic repeated restraint stress increases prolactin-releasing peptide/tyrosine-hydroxylase ratio with gender-related differences in the rat brain
    Zsuzsanna E Toth
    Neuromorphological and Neuroendocrine Research Laboratory, Department of Anatomy, Histology and Embryology of the Semmelweis University and the Hungarian Academy of Sciences, Budapest, Hungary
    J Neurochem 104:653-66. 2008

Collaborators

Detail Information

Publications16

  1. pmc STIM and Orai: the long-awaited constituents of store-operated calcium entry
    Peter Varnai
    Department of Physiology, Semmelweis University Faculty of Medicine, H 1088, Puskin u 9, Budapest, Hungary
    Trends Pharmacol Sci 30:118-28. 2009
    ..Here, we briefly summarize recent developments in this exciting area of Ca(2+) signaling...
  2. ncbi request reprint Mitochondrial Ca2+ uptake with and without the formation of high-Ca2+ microdomains
    Gergo Szanda
    Department of Physiology, Faculty of Medicine, Semmelweis University and Laboratory of Cellular and Molecular Physiology, Hungarian Academy of Sciences, Budapest, Hungary
    Cell Calcium 40:527-37. 2006
    ..The results presented here provide evidence that mitochondrial Ca(2+) uptake may occur both with and without the formation of HCMDs within the same cell...
  3. pmc Mapping of the localization of type 1 angiotensin receptor in membrane microdomains using bioluminescence resonance energy transfer-based sensors
    Andras Balla
    Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    J Biol Chem 287:9090-9. 2012
    ....
  4. doi request reprint Allosteric interactions within the AT₁ angiotensin receptor homodimer: role of the conserved DRY motif
    Bence Szalai
    Department of Physiology, Semmelweis University, Faculty of Medicine, Budapest, Hungary
    Biochem Pharmacol 84:477-85. 2012
    ..These data suggest that allosteric interactions in the homodimers of AT₁R significantly affect the function of the non-stimulated protomer, and the conserved DRY motif has a crucial role in these interactions...
  5. pmc Acute depletion of plasma membrane phosphatidylinositol 4,5-bisphosphate impairs specific steps in endocytosis of the G-protein-coupled receptor
    Dániel J Tóth
    Department of Physiology, Semmelweis University, Faculty of Medicine, Budapest, Hungary
    J Cell Sci 125:2185-97. 2012
    ..Our data suggest that in the absence of PtdIns(4,5)P(2), these receptors move into clathrin-coated membrane structures, but these are not cleaved efficiently and hence cannot reach the early endosomal compartment...
  6. ncbi request reprint Endocytosis of the AT1A angiotensin receptor is independent of ubiquitylation of its cytoplasmic serine/threonine-rich region
    Balázs Mihalik
    Department of Physiology, Faculty of Medicine, Semmelweis University, P O Box 259, H 1444 Budapest, Hungary
    Int J Biochem Cell Biol 35:992-1002. 2003
    ....
  7. pmc The effect of OPA1 on mitochondrial Ca²⁺ signaling
    László Fülöp
    Department of Physiology, Faculty of Medicine, Semmelweis University, Hungarian Academy of Sciences, Budapest, Hungary
    PLoS ONE 6:e25199. 2011
    ..Altogether, our observations reveal the significance of OPA1 in the control of mitochondrial Ca²⁺ metabolism...
  8. ncbi request reprint Mechanisms of angiotensin II-mediated regulation of aldosterone synthase expression in H295R human adrenocortical and rat adrenal glomerulosa cells
    Maria Szekeres
    Department of Physiology, Semmelweis University, Faculty of Medicine, Budapest, Hungary
    Mol Cell Endocrinol 302:244-53. 2009
    ....
  9. ncbi request reprint Visualization and manipulation of phosphoinositide dynamics in live cells using engineered protein domains
    Peter Varnai
    Endocrinology and Reproduction Research Branch, NICHD, National Institutes of Health, Bldg 49, Rm 6A35, 49 Convent Drive, Bethesda, MD, USA
    Pflugers Arch 455:69-82. 2007
    ..In this review, we will summarize our efforts to improve our tools in studying phosphoinositide dynamics and discuss our views on the values of these methods compared to other options currently used or being explored...
  10. doi request reprint Chronic repeated restraint stress increases prolactin-releasing peptide/tyrosine-hydroxylase ratio with gender-related differences in the rat brain
    Zsuzsanna E Toth
    Neuromorphological and Neuroendocrine Research Laboratory, Department of Anatomy, Histology and Embryology of the Semmelweis University and the Hungarian Academy of Sciences, Budapest, Hungary
    J Neurochem 104:653-66. 2008
    ....
  11. doi request reprint Calcium entry is regulated by Zn2+ in relation to extracellular ionic environment in human airway epithelial cells
    Dóra Hargitai
    Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary
    Respir Physiol Neurobiol 170:67-75. 2010
    ..In conclusion, Ca(2+) entry is finely regulated by external ionic environment. Therefore, we speculate that properly compiled aerosols could influence efficacy of zinc-based therapy in CF...
  12. pmc Demonstration of angiotensin II-induced Ras activation in the trans-Golgi network and endoplasmic reticulum using bioluminescence resonance energy transfer-based biosensors
    Andras Balla
    Department of Physiology, Faculty of Medicine, Semmelweis University, H 1444 Budapest, Hungary
    J Biol Chem 286:5319-27. 2011
    ..These data suggest that AngII can stimulate Ras activity in the TGN and ER with a G protein-dependent mechanism, which does not require β-arrestin-mediated signaling, receptor internalization, and EGF receptor transactivation...
  13. pmc Relating underrepresented genomic DNA patterns and tiRNAs: the rule behind the observation and beyond
    Miklos Cserzo
    Department of Physiology, Semmelweis University, Budapest, Tuzolto Street, 37 47, 1094, Hungary, EU
    Biol Direct 5:56. 2010
    ..The exact role of these molecules in gene expression control is mostly unknown at present, while their importance is generally recognized...
  14. doi request reprint Redox state of the endoplasmic reticulum is controlled by Ero1L-alpha and intraluminal calcium
    Balázs Enyedi
    Department of Physiology, Semmelweis University, Faculty of Medicine, Budapest, Hungary
    Antioxid Redox Signal 13:721-9. 2010
    ..We also found that calcium mobilization from intracellular stores induces a decrease in ER H(2)O(2) level, suggesting a complex interplay between redox and calcium signaling in the mammalian ER...
  15. pmc Live cell imaging of phosphoinositides with expressed inositide binding protein domains
    Peter Varnai
    Department of Physiology, Semmelweis University Faculty of Medicine, Budapest, H 1088 Budapest, Puskin utca 9, Hungary, Bethesda, MD 20892, USA
    Methods 46:167-76. 2008
    ....
  16. pmc Paracrine transactivation of the CB1 cannabinoid receptor by AT1 angiotensin and other Gq/11 protein-coupled receptors
    Gabor Turu
    Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    J Biol Chem 284:16914-21. 2009
    ..These data suggest that, in addition to their retrograde neurotransmitter role, endocannabinoids have much broader paracrine mediator functions during activation of G(q/11)-coupled receptors...