Research Topics
| Miklos TothSummaryAffiliation: Semmelweis University Country: Hungary Publications
| Collaborators
|
Detail Information
Publications
Development and surgical anatomy of the round window nicheMiklos Toth
Department of Human Morphology and Developmental Biology, Faculty of Medicine, Semmelweis University, Tuzolto u 58, 1094 Budapest, Hungary
Ann Anat 188:93-101. 2006....- Surgical anatomy of the cochlea for cochlear implantationMiklos Toth
Department of Human Morphology and Developmental Biology, Faculty of Medicine, Semmelweis University, Tuzolto u 58, H 1094 Budapest, Hungary
Ann Anat 188:363-70. 2006..The promontorial and muscular portions can be investigated from two directions: through the facial recess and through the external acoustic meatus... - Development of the protympanumMiklos Toth
Department of Human Morphology and Developmental Biology, Faculty of Medicine, Semmelweis University, Tuzolto u 58, 1094 Budapest, Hungary
Ann Anat 188:267-73. 2006..The presence of the ICA is necessary for the development of the carotid canal. If the artery takes an aberrant pathway in the tympanic cavity, or is absent, there is no sign of the carotid canal... 
BclI polymorphism of the glucocorticoid receptor gene is associated with decreased bone mineral density in patients with endogenous hypercortisolismAgnes Szappanos
Second Department of Medicine, Semmelweis University, 46 Szentkiralyi, Budapest, Hungary
Clin Endocrinol (Oxf) 71:636-43. 2009..We investigated the impact of glucocorticoid receptor (GR) gene polymorphisms, including the BclI, N363S, ER22/23EK and A3669G variants on bone turnover and/or mineral density (BMD) in patients with endogenous glucocorticoid excess...- Involvement of endogenous ouabain-like compound in the cardiac hypertrophic process in vivoReka Skoumal
1st Department of Medicine, Semmelweis University, Budapest H 1083, Hungary Szentágothai János Knowledge Center, Semmelweis University, Budapest H 1085, Hungary
Life Sci 80:1303-10. 2007..6-fold vs. 9.6-fold, P<0.01). These data show that OLC as an adrenal-derived factor may be required for the induction LV ANP gene expression during the hypertrophic process... - MEN1 gene mutations in Hungarian patients with multiple endocrine neoplasia type 1Katalin Balogh
2nd Department of Medicine, Faculty of Medicine, Semmelweis Unievrsity, Budapest, Hungary
Clin Endocrinol (Oxf) 67:727-34. 2007..The aim of this study was to examine the prevalence and spectrum of MEN1 gene mutations in Hungarian patients with familial and sporadic MEN1 and in those with a MEN1-related state... - Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failureGabor Foldes
Ist Department of Medicine, Semmelweis University, Budapest, Hungary
Biochem Biophys Res Commun 308:480-5. 2003..Our results suggest that a new cardiac regulatory peptide, apelin, and APJ receptor may contribute to the pathophysiology of human CHF... - Genotype-phenotype correlations in Hungarian patients with hereditary medullary thyroid cancerAttila Patocs
2nd Department of Medicine, Faculty of Medicine, Semmelweis University, Szentkiralyi u. 46, 1088 Budapest, Hungary
Wien Klin Wochenschr 118:417-21. 2006..PHPT was present in one patient with mutation in exon 14 (Val804Met), whereas all other patients affected with mutations in exon 14 had hereditary MTC without PHPT and/or pheos... - [Malignant insulinoma]Miklos Toth
Semmelweis Egyetem, Általános Orvostudományi Kar, II Belgyógyászati Klinika, Budapest
Orv Hetil 152:398-402. 2011..The autopsy and the immunohistochemical investigations confirmed the diagnosis of insulin-producing, metastatic neuroendocrine carcinoma... - Overrepresentation of the N363S variant of the glucocorticoid receptor gene in patients with bilateral adrenal incidentalomasJudit Majnik
2nd Department of Medicine, Semmelweis University, Szentkiralyi 46, H 1088 Budapest, Hungary
J Clin Endocrinol Metab 91:2796-9. 2006..Some variants of the glucocorticoid receptor (GR) gene have been found to alter glucocorticoid sensitivity and have been associated with altered metabolic profiles... - [Treatment of iatrogenic Cushing syndrome: questions of glucocorticoid withdrawal]Peter Igaz
Semmelweis Egyetem, Általános Orvostudományi Kar, II Belgyógyászati Klinika, Budapest, Hungary
Orv Hetil 148:195-202. 2007..secondary adrenal insufficiency, iii. steroid withdrawal syndrome. Here, the authors summarize the most important aspects of this area based on their clinical experience and the available literature data... - [Evaluation of the accuracy of inferior petrosal sinus sampling in the differential diagnosis of ACTH-dependent Cushing's syndrome]Miklos Toth
Semmelweis Egyetem, Altalános Orvostudományi Kar II Belgyógyászati Klinika, Budapest
Orv Hetil 148:843-7. 2007..In addition to technical difficulties, the lower sensitivity can be accounted also for the highly selected nature of the patient group... 
Ser80Ile mutation and a concurrent Pro25Leu variant of the VHL gene in an extended Hungarian von Hippel-Lindau familyAttila Patocs
Molecular Medicine Research Group, Hungarian Academy of Sciences and Semmelweis University, Szentkiralyi 46, H 1088 Budapest, Hungary
BMC Med Genet 9:29. 2008..We concluded that the Pro25Leu variant is a rare, neutral variant, but the presence such a rare gene variant may make genetic counseling difficult...- Intraoperative determination of PTH concentrations in fine needle tissue aspirates to identify parathyroid tissue during parathyroidectomyJanos Horanyi
1st Department of Surgery, Semmelweis University, Ulloi út 78, 1082, Budapest, Hungary
World J Surg 34:538-43. 2010..We investigated the sensitivity and specificity of this method in a large cohort of consecutive patients who underwent parathyroidectomy in a tertiary referral center... - Chemical stabilization of tetrahydrobiopterin by L-ascorbic acid: contribution to placental endothelial nitric oxide synthase activityMiklos Toth
Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest 8, P O Box 260, H 1444, Hungary
Mol Hum Reprod 8:271-80. 2002..Moreover, we demonstrated that concentrations of ASC present in the placenta as a common vitamin C supply are sufficient to protect cellular free BH(4) and may contribute to the stimulation of placental eNOS activity... - Soluble semicarbazide-sensitive amine oxidase (SSAO) activity is related to oxidative stress and subchronic inflammation in streptozotocin-induced diabetic ratsGabor Mark Somfai
Faculty of Medicine, 2nd Department of Ophthalmology, Semmelweis University, Mária Str 39, H 1085 Budapest, Hungary
Neurochem Int 48:746-52. 2006..Our parsimonious conclusion is that there is a relation between the risk factors of AD and vascular dementia (diabetes, oxidative stress and chronic inflammation) and SSAO activity, which may originate from the vessel wall... - Cardiac gene expression of natriuretic substances is altered in streptozotocin-induced diabetes during angiotensin II-induced pressure overloadEva Ruzicska
2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
J Hypertens 22:1191-200. 2004.... - A rapid and simple method for detection of Asn363Ser polymorphism of the human glucocorticoid receptor geneJudit Majnik
Second Department of Medicine, Faculty of Medicine, Semmelweis University, Szentkiralyi 46, H 1088 Budapest, Hungary
J Steroid Biochem Mol Biol 92:465-8. 2004..The feasibility of these methods were tested in 301 patients, including 47 patients with postmenopausal osteoporosis in whom the frequency of Asn363Ser polymorphism was similar to that found in control subjects (4.3% versus 4.4%)... - [Role of novel G-protein-coupled receptors and their ligands in the cardiovascular system]Gabor Foldes
Semmelweis Egyetem, Általános Orvostudományi Kar, I Belgyógyászati Klinika, Budapest
Orv Hetil 145:561-6. 2004..Despite current drug therapies, cardiovascular disease remains the major cause of morbidity and mortality, which suggests that yet unknown transmitter systems might be also involved in this disease... - Insulin treatment decreases the antioxidant defense mechanism in experimental diabetesAniko Somogyi
2nd Department of Medicine, Semmelweis University, Budapest, Hungary
Med Sci Monit 11:BR206-11. 2005..Our aim was to determine the relationship between left ventricular hypertrophy and the total scavenger capacity (TSC) in diabetic rats... - [Clinical symptoms, diagnosis and treatment of multiple endocrine neoplasia type 1. Results of genetic screening in Hungarian patients]Katalin Balogh
Semmelweis Egyetem, Általános Orvostudományi Kar, II Sz Belgyógyászati Klinika, Budapest
Orv Hetil 146:2191-7. 2005..Also, genetic screening may be useful in cases when MEN1 syndrome is suspected, but the clinical manifestations do not fully establish the diagnosis of MEN1 syndrome... - Locally different role of atrial natriuretic peptide (ANP) in the pericardial fluidPal Soos
Department of Cardiovascular Surgery, Semmelweis University Budapest, Hungary
Life Sci 71:2563-73. 2002..Intrapericardial ANP may reflect the peptide concentration in the myocardial interstitium and may represent a paracrine regulatory mechanism, which seems independent of ANP-induced putative antiischemic influences... - [Diagnosis and treatment outcome in primary aldosteronism based on a retrospective analysis of 187 cases]Nikolette Szucs
Semmelweis Egyetem, Általános Orvostudományi Kar, II Belgyógyászati Klinika
Orv Hetil 147:51-9. 2006..The disease has been described by Jerome W. Conn in 1955; since that time there has been a great progress in the knowledge concerning the prevalence, diagnostics and treatment of the disease... - Evidence for a functional role of angiotensin II type 2 receptor in the cardiac hypertrophic process in vivo in the rat heartZoltan Lako-Futo
First Department of Medicine, Semmelweis University, and Molecular Genetic Research Group of the Hungarian Academy of Sciences, Budapest, Hungary
Circulation 108:2414-22. 2003..The precise function of angiotensin II type 2 receptor (AT2-R) in the mammalian heart in vivo is unknown. Here, we investigated the role of AT2-R in cardiac pressure overload... - Atherosclerotic risk factors and complications in patients with non-functioning adrenal adenomas treated with or without adrenalectomy: a long-term follow-up studyMarta Sereg
2nd Department of Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary
Eur J Endocrinol 160:647-55. 2009.... - Detection of the Bcl I polymorphism of the glucocorticoid receptor gene by single-tube allele-specific polymerase chain reactionPeter Gergics
2nd Department of Medicine, Faculty of Medicine, Semmelweis University, Szentkiralyi 46, Budapest H 1088, Hungary
J Steroid Biochem Mol Biol 100:161-6. 2006.... - Development of the anterior chordal canalMiklos Toth
Department of Human Morphology and Developmental Biology, Faculty of Medicine, Semmelweis University, Budapest, Hungary
Ann Anat 188:7-11. 2006..In case of an incomplete development the anterior chordal canal remains partially opened laterally which might allow the head of the mandibula to effect the chorda tympani mechanically causing Costen's syndrome... - Endothelin levels in experimental diabetes combined with cardiac hypertrophyReka Skoumal
First Department of Internal Medicine, Semmelweis University, Budapest, Hungary
J Cardiovasc Pharmacol 44:S195-7. 2004..The functional significance of altered endothelin responses to acute hemodynamic burden in experimental diabetes needs further investigation... - Cutoff values of midnight salivary cortisol for the diagnosis of overt hypercortisolism are highly influenced by methodsGabriella Beko
Central Isotope and Clinical Laboratory, Semmelweis University, Hungary
Clin Chim Acta 411:364-7. 2010.... - Germline VHL gene mutations in Hungarian families with von Hippel-Lindau disease and patients with apparently sporadic unilateral pheochromocytomasPeter Gergics
2nd Department of Medicine, Faculty of Medicine, Semmelweis University, 46 Szentkirályi Street, Budapest H 1088, Hungary
Eur J Endocrinol 161:495-502. 2009..Germline VHL gene alterations may be also present in patients with apparently sporadic pheochromocytoma (ASP), although a wide variation in mutation frequencies has been reported in different patient cohorts... - Spectrophotometric analysis of the protective effect of ascorbate against spontaneous oxidation of tetrahydrobiopterin in aqueous solution: kinetic characteristics and potentiation by catalase of ascorbate actionSándor Valent
Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, P O Box 260, H 1444 Budapest 8, Hungary
Int J Biochem Cell Biol 36:1266-80. 2004.... - Hormonal evaluation and mutation screening for steroid 21-hydroxylase deficiency in patients with unilateral and bilateral adrenal incidentalomasAttila Patocs
2nd Department of Medicine, Faculty of Medicine, Semmelweis University, H 1088 Budapest, Hungary
Eur J Endocrinol 147:349-55. 2002.... - Nuclear factor-kappaB signaling contributes to severe, but not moderate, angiotensin II-induced left ventricular remodelingBalazs Sarman
First Department of Medicine, Semmelweis University, Hungary
J Hypertens 25:1927-39. 2007..Here we characterize the importance of NF-kappaB signaling in moderate and severe left ventricular (LV) hypertrophy in rats with chronic pressure overload induced by angiotensin II (Ang II) infusion... - Parathyroid hormone-dependent hypercalcemiaJudit Toke
2nd Department of Medicine, Semmelweis University, Budapest, Hungary
Wien Klin Wochenschr 121:236-45. 2009.... - 11beta-hydroxysteroid dehydrogenase activity in acromegalic patients with normal or impaired carbohydrate metabolismAgnes Mondok
2nd Department of Medicine, Semmelweis University, Budapest, Hungary
Steroids 74:725-9. 2009..These findings indicate that disease activity exerts a significant impact on 11beta-HSD in acromegalic patients, which is further modified with altered carbohydrate homeostasis, frequently present in patients with active disease... - Expression of glucocorticoid receptor isoforms in human adrenocortical adenomasBelema Boyle
2nd Department of Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary
Steroids 75:695-700. 2010.... - Differences in the expression of histamine-related genes and proteins in normal human adrenal cortex and adrenocortical tumorsPeter M Szabó
2nd Department of Medicine, Faculty of Medicine, Semmelweis University, 1088 Budapest, Szentkiralyi str 46, Hungary
Virchows Arch 455:133-42. 2009..Adrenocortical tumorigenesis might, thus, be characterized by reduced histamine biosynthesis; furthermore, different adrenocortical tumor subtypes may show unique histamine receptor expression profiles...