Miklos Toth

Summary

Affiliation: Semmelweis University
Country: Hungary

Publications

  1. ncbi request reprint Development and surgical anatomy of the round window niche
    Miklos Toth
    Department of Human Morphology and Developmental Biology, Faculty of Medicine, Semmelweis University, Tuzolto u 58, 1094 Budapest, Hungary
    Ann Anat 188:93-101. 2006
  2. ncbi request reprint Surgical anatomy of the cochlea for cochlear implantation
    Miklos Toth
    Department of Human Morphology and Developmental Biology, Faculty of Medicine, Semmelweis University, Tuzolto u 58, H 1094 Budapest, Hungary
    Ann Anat 188:363-70. 2006
  3. ncbi request reprint Development of the protympanum
    Miklos Toth
    Department of Human Morphology and Developmental Biology, Faculty of Medicine, Semmelweis University, Tuzolto u 58, 1094 Budapest, Hungary
    Ann Anat 188:267-73. 2006
  4. doi request reprint BclI polymorphism of the glucocorticoid receptor gene is associated with decreased bone mineral density in patients with endogenous hypercortisolism
    Agnes Szappanos
    Second Department of Medicine, Semmelweis University, 46 Szentkiralyi, Budapest, Hungary
    Clin Endocrinol (Oxf) 71:636-43. 2009
  5. ncbi request reprint Involvement of endogenous ouabain-like compound in the cardiac hypertrophic process in vivo
    Reka Skoumal
    1st Department of Medicine, Semmelweis University, Budapest H 1083, Hungary Szentágothai János Knowledge Center, Semmelweis University, Budapest H 1085, Hungary
    Life Sci 80:1303-10. 2007
  6. ncbi request reprint MEN1 gene mutations in Hungarian patients with multiple endocrine neoplasia type 1
    Katalin Balogh
    2nd Department of Medicine, Faculty of Medicine, Semmelweis Unievrsity, Budapest, Hungary
    Clin Endocrinol (Oxf) 67:727-34. 2007
  7. ncbi request reprint Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure
    Gabor Foldes
    Ist Department of Medicine, Semmelweis University, Budapest, Hungary
    Biochem Biophys Res Commun 308:480-5. 2003
  8. ncbi request reprint Genotype-phenotype correlations in Hungarian patients with hereditary medullary thyroid cancer
    Attila Patocs
    2nd Department of Medicine, Faculty of Medicine, Semmelweis University, Szentkiralyi u 46, 1088 Budapest, Hungary
    Wien Klin Wochenschr 118:417-21. 2006
  9. doi request reprint [Malignant insulinoma]
    Miklos Toth
    Semmelweis Egyetem, Általános Orvostudományi Kar, II Belgyógyászati Klinika, Budapest
    Orv Hetil 152:398-402. 2011
  10. ncbi request reprint Overrepresentation of the N363S variant of the glucocorticoid receptor gene in patients with bilateral adrenal incidentalomas
    Judit Majnik
    2nd Department of Medicine, Semmelweis University, Szentkiralyi 46, H 1088 Budapest, Hungary
    J Clin Endocrinol Metab 91:2796-9. 2006

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Development and surgical anatomy of the round window niche
    Miklos Toth
    Department of Human Morphology and Developmental Biology, Faculty of Medicine, Semmelweis University, Tuzolto u 58, 1094 Budapest, Hungary
    Ann Anat 188:93-101. 2006
    ....
  2. ncbi request reprint Surgical anatomy of the cochlea for cochlear implantation
    Miklos Toth
    Department of Human Morphology and Developmental Biology, Faculty of Medicine, Semmelweis University, Tuzolto u 58, H 1094 Budapest, Hungary
    Ann Anat 188:363-70. 2006
    ..The promontorial and muscular portions can be investigated from two directions: through the facial recess and through the external acoustic meatus...
  3. ncbi request reprint Development of the protympanum
    Miklos Toth
    Department of Human Morphology and Developmental Biology, Faculty of Medicine, Semmelweis University, Tuzolto u 58, 1094 Budapest, Hungary
    Ann Anat 188:267-73. 2006
    ..The presence of the ICA is necessary for the development of the carotid canal. If the artery takes an aberrant pathway in the tympanic cavity, or is absent, there is no sign of the carotid canal...
  4. doi request reprint BclI polymorphism of the glucocorticoid receptor gene is associated with decreased bone mineral density in patients with endogenous hypercortisolism
    Agnes Szappanos
    Second Department of Medicine, Semmelweis University, 46 Szentkiralyi, Budapest, Hungary
    Clin Endocrinol (Oxf) 71:636-43. 2009
    ..We investigated the impact of glucocorticoid receptor (GR) gene polymorphisms, including the BclI, N363S, ER22/23EK and A3669G variants on bone turnover and/or mineral density (BMD) in patients with endogenous glucocorticoid excess...
  5. ncbi request reprint Involvement of endogenous ouabain-like compound in the cardiac hypertrophic process in vivo
    Reka Skoumal
    1st Department of Medicine, Semmelweis University, Budapest H 1083, Hungary Szentágothai János Knowledge Center, Semmelweis University, Budapest H 1085, Hungary
    Life Sci 80:1303-10. 2007
    ..6-fold vs. 9.6-fold, P<0.01). These data show that OLC as an adrenal-derived factor may be required for the induction LV ANP gene expression during the hypertrophic process...
  6. ncbi request reprint MEN1 gene mutations in Hungarian patients with multiple endocrine neoplasia type 1
    Katalin Balogh
    2nd Department of Medicine, Faculty of Medicine, Semmelweis Unievrsity, Budapest, Hungary
    Clin Endocrinol (Oxf) 67:727-34. 2007
    ..The aim of this study was to examine the prevalence and spectrum of MEN1 gene mutations in Hungarian patients with familial and sporadic MEN1 and in those with a MEN1-related state...
  7. ncbi request reprint Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure
    Gabor Foldes
    Ist Department of Medicine, Semmelweis University, Budapest, Hungary
    Biochem Biophys Res Commun 308:480-5. 2003
    ..Our results suggest that a new cardiac regulatory peptide, apelin, and APJ receptor may contribute to the pathophysiology of human CHF...
  8. ncbi request reprint Genotype-phenotype correlations in Hungarian patients with hereditary medullary thyroid cancer
    Attila Patocs
    2nd Department of Medicine, Faculty of Medicine, Semmelweis University, Szentkiralyi u 46, 1088 Budapest, Hungary
    Wien Klin Wochenschr 118:417-21. 2006
    ..PHPT was present in one patient with mutation in exon 14 (Val804Met), whereas all other patients affected with mutations in exon 14 had hereditary MTC without PHPT and/or pheos...
  9. doi request reprint [Malignant insulinoma]
    Miklos Toth
    Semmelweis Egyetem, Általános Orvostudományi Kar, II Belgyógyászati Klinika, Budapest
    Orv Hetil 152:398-402. 2011
    ..The autopsy and the immunohistochemical investigations confirmed the diagnosis of insulin-producing, metastatic neuroendocrine carcinoma...
  10. ncbi request reprint Overrepresentation of the N363S variant of the glucocorticoid receptor gene in patients with bilateral adrenal incidentalomas
    Judit Majnik
    2nd Department of Medicine, Semmelweis University, Szentkiralyi 46, H 1088 Budapest, Hungary
    J Clin Endocrinol Metab 91:2796-9. 2006
    ..Some variants of the glucocorticoid receptor (GR) gene have been found to alter glucocorticoid sensitivity and have been associated with altered metabolic profiles...
  11. ncbi request reprint [Treatment of iatrogenic Cushing syndrome: questions of glucocorticoid withdrawal]
    Peter Igaz
    Semmelweis Egyetem, Általános Orvostudományi Kar, II Belgyógyászati Klinika, Budapest, Hungary
    Orv Hetil 148:195-202. 2007
    ..secondary adrenal insufficiency, iii. steroid withdrawal syndrome. Here, the authors summarize the most important aspects of this area based on their clinical experience and the available literature data...
  12. ncbi request reprint [Evaluation of the accuracy of inferior petrosal sinus sampling in the differential diagnosis of ACTH-dependent Cushing's syndrome]
    Miklos Toth
    Semmelweis Egyetem, Altalános Orvostudományi Kar II Belgyógyászati Klinika, Budapest
    Orv Hetil 148:843-7. 2007
    ..In addition to technical difficulties, the lower sensitivity can be accounted also for the highly selected nature of the patient group...
  13. pmc Ser80Ile mutation and a concurrent Pro25Leu variant of the VHL gene in an extended Hungarian von Hippel-Lindau family
    Attila Patocs
    Molecular Medicine Research Group, Hungarian Academy of Sciences and Semmelweis University, Szentkiralyi 46, H 1088 Budapest, Hungary
    BMC Med Genet 9:29. 2008
    ..We concluded that the Pro25Leu variant is a rare, neutral variant, but the presence such a rare gene variant may make genetic counseling difficult...
  14. doi request reprint Intraoperative determination of PTH concentrations in fine needle tissue aspirates to identify parathyroid tissue during parathyroidectomy
    Janos Horanyi
    1st Department of Surgery, Semmelweis University, Ulloi út 78, 1082, Budapest, Hungary
    World J Surg 34:538-43. 2010
    ..We investigated the sensitivity and specificity of this method in a large cohort of consecutive patients who underwent parathyroidectomy in a tertiary referral center...
  15. ncbi request reprint Chemical stabilization of tetrahydrobiopterin by L-ascorbic acid: contribution to placental endothelial nitric oxide synthase activity
    Miklos Toth
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest 8, P O Box 260, H 1444, Hungary
    Mol Hum Reprod 8:271-80. 2002
    ..Moreover, we demonstrated that concentrations of ASC present in the placenta as a common vitamin C supply are sufficient to protect cellular free BH(4) and may contribute to the stimulation of placental eNOS activity...
  16. ncbi request reprint Soluble semicarbazide-sensitive amine oxidase (SSAO) activity is related to oxidative stress and subchronic inflammation in streptozotocin-induced diabetic rats
    Gabor Mark Somfai
    Faculty of Medicine, 2nd Department of Ophthalmology, Semmelweis University, Mária Str 39, H 1085 Budapest, Hungary
    Neurochem Int 48:746-52. 2006
    ..Our parsimonious conclusion is that there is a relation between the risk factors of AD and vascular dementia (diabetes, oxidative stress and chronic inflammation) and SSAO activity, which may originate from the vessel wall...
  17. ncbi request reprint Cardiac gene expression of natriuretic substances is altered in streptozotocin-induced diabetes during angiotensin II-induced pressure overload
    Eva Ruzicska
    2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
    J Hypertens 22:1191-200. 2004
    ....
  18. ncbi request reprint A rapid and simple method for detection of Asn363Ser polymorphism of the human glucocorticoid receptor gene
    Judit Majnik
    Second Department of Medicine, Faculty of Medicine, Semmelweis University, Szentkiralyi 46, H 1088 Budapest, Hungary
    J Steroid Biochem Mol Biol 92:465-8. 2004
    ..The feasibility of these methods were tested in 301 patients, including 47 patients with postmenopausal osteoporosis in whom the frequency of Asn363Ser polymorphism was similar to that found in control subjects (4.3% versus 4.4%)...
  19. ncbi request reprint [Role of novel G-protein-coupled receptors and their ligands in the cardiovascular system]
    Gabor Foldes
    Semmelweis Egyetem, Általános Orvostudományi Kar, I Belgyógyászati Klinika, Budapest
    Orv Hetil 145:561-6. 2004
    ..Despite current drug therapies, cardiovascular disease remains the major cause of morbidity and mortality, which suggests that yet unknown transmitter systems might be also involved in this disease...
  20. ncbi request reprint Insulin treatment decreases the antioxidant defense mechanism in experimental diabetes
    Aniko Somogyi
    2nd Department of Medicine, Semmelweis University, Budapest, Hungary
    Med Sci Monit 11:BR206-11. 2005
    ..Our aim was to determine the relationship between left ventricular hypertrophy and the total scavenger capacity (TSC) in diabetic rats...
  21. ncbi request reprint [Clinical symptoms, diagnosis and treatment of multiple endocrine neoplasia type 1. Results of genetic screening in Hungarian patients]
    Katalin Balogh
    Semmelweis Egyetem, Általános Orvostudományi Kar, II Sz Belgyógyászati Klinika, Budapest
    Orv Hetil 146:2191-7. 2005
    ..Also, genetic screening may be useful in cases when MEN1 syndrome is suspected, but the clinical manifestations do not fully establish the diagnosis of MEN1 syndrome...
  22. ncbi request reprint Locally different role of atrial natriuretic peptide (ANP) in the pericardial fluid
    Pal Soos
    Department of Cardiovascular Surgery, Semmelweis University Budapest, Hungary
    Life Sci 71:2563-73. 2002
    ..Intrapericardial ANP may reflect the peptide concentration in the myocardial interstitium and may represent a paracrine regulatory mechanism, which seems independent of ANP-induced putative antiischemic influences...
  23. ncbi request reprint [Diagnosis and treatment outcome in primary aldosteronism based on a retrospective analysis of 187 cases]
    Nikolette Szucs
    Semmelweis Egyetem, Általános Orvostudományi Kar, II Belgyógyászati Klinika
    Orv Hetil 147:51-9. 2006
    ..The disease has been described by Jerome W. Conn in 1955; since that time there has been a great progress in the knowledge concerning the prevalence, diagnostics and treatment of the disease...
  24. ncbi request reprint Evidence for a functional role of angiotensin II type 2 receptor in the cardiac hypertrophic process in vivo in the rat heart
    Zoltan Lako-Futo
    First Department of Medicine, Semmelweis University, and Molecular Genetic Research Group of the Hungarian Academy of Sciences, Budapest, Hungary
    Circulation 108:2414-22. 2003
    ..The precise function of angiotensin II type 2 receptor (AT2-R) in the mammalian heart in vivo is unknown. Here, we investigated the role of AT2-R in cardiac pressure overload...
  25. doi request reprint Atherosclerotic risk factors and complications in patients with non-functioning adrenal adenomas treated with or without adrenalectomy: a long-term follow-up study
    Marta Sereg
    2nd Department of Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    Eur J Endocrinol 160:647-55. 2009
    ....
  26. ncbi request reprint Detection of the Bcl I polymorphism of the glucocorticoid receptor gene by single-tube allele-specific polymerase chain reaction
    Peter Gergics
    2nd Department of Medicine, Faculty of Medicine, Semmelweis University, Szentkiralyi 46, Budapest H 1088, Hungary
    J Steroid Biochem Mol Biol 100:161-6. 2006
    ....
  27. ncbi request reprint Development of the anterior chordal canal
    Miklos Toth
    Department of Human Morphology and Developmental Biology, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    Ann Anat 188:7-11. 2006
    ..In case of an incomplete development the anterior chordal canal remains partially opened laterally which might allow the head of the mandibula to effect the chorda tympani mechanically causing Costen's syndrome...
  28. ncbi request reprint Endothelin levels in experimental diabetes combined with cardiac hypertrophy
    Reka Skoumal
    First Department of Internal Medicine, Semmelweis University, Budapest, Hungary
    J Cardiovasc Pharmacol 44:S195-7. 2004
    ..The functional significance of altered endothelin responses to acute hemodynamic burden in experimental diabetes needs further investigation...
  29. doi request reprint Cutoff values of midnight salivary cortisol for the diagnosis of overt hypercortisolism are highly influenced by methods
    Gabriella Beko
    Central Isotope and Clinical Laboratory, Semmelweis University, Hungary
    Clin Chim Acta 411:364-7. 2010
    ....
  30. doi request reprint Germline VHL gene mutations in Hungarian families with von Hippel-Lindau disease and patients with apparently sporadic unilateral pheochromocytomas
    Peter Gergics
    2nd Department of Medicine, Faculty of Medicine, Semmelweis University, 46 Szentkirályi Street, Budapest H 1088, Hungary
    Eur J Endocrinol 161:495-502. 2009
    ..Germline VHL gene alterations may be also present in patients with apparently sporadic pheochromocytoma (ASP), although a wide variation in mutation frequencies has been reported in different patient cohorts...
  31. ncbi request reprint Spectrophotometric analysis of the protective effect of ascorbate against spontaneous oxidation of tetrahydrobiopterin in aqueous solution: kinetic characteristics and potentiation by catalase of ascorbate action
    Sándor Valent
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, P O Box 260, H 1444 Budapest 8, Hungary
    Int J Biochem Cell Biol 36:1266-80. 2004
    ....
  32. ncbi request reprint Hormonal evaluation and mutation screening for steroid 21-hydroxylase deficiency in patients with unilateral and bilateral adrenal incidentalomas
    Attila Patocs
    2nd Department of Medicine, Faculty of Medicine, Semmelweis University, H 1088 Budapest, Hungary
    Eur J Endocrinol 147:349-55. 2002
    ....
  33. ncbi request reprint Nuclear factor-kappaB signaling contributes to severe, but not moderate, angiotensin II-induced left ventricular remodeling
    Balazs Sarman
    First Department of Medicine, Semmelweis University, Hungary
    J Hypertens 25:1927-39. 2007
    ..Here we characterize the importance of NF-kappaB signaling in moderate and severe left ventricular (LV) hypertrophy in rats with chronic pressure overload induced by angiotensin II (Ang II) infusion...
  34. doi request reprint Parathyroid hormone-dependent hypercalcemia
    Judit Toke
    2nd Department of Medicine, Semmelweis University, Budapest, Hungary
    Wien Klin Wochenschr 121:236-45. 2009
    ....
  35. doi request reprint 11beta-hydroxysteroid dehydrogenase activity in acromegalic patients with normal or impaired carbohydrate metabolism
    Agnes Mondok
    2nd Department of Medicine, Semmelweis University, Budapest, Hungary
    Steroids 74:725-9. 2009
    ..These findings indicate that disease activity exerts a significant impact on 11beta-HSD in acromegalic patients, which is further modified with altered carbohydrate homeostasis, frequently present in patients with active disease...
  36. doi request reprint Expression of glucocorticoid receptor isoforms in human adrenocortical adenomas
    Belema Boyle
    2nd Department of Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    Steroids 75:695-700. 2010
    ....
  37. doi request reprint Differences in the expression of histamine-related genes and proteins in normal human adrenal cortex and adrenocortical tumors
    Peter M Szabó
    2nd Department of Medicine, Faculty of Medicine, Semmelweis University, 1088 Budapest, Szentkiralyi str 46, Hungary
    Virchows Arch 455:133-42. 2009
    ..Adrenocortical tumorigenesis might, thus, be characterized by reduced histamine biosynthesis; furthermore, different adrenocortical tumor subtypes may show unique histamine receptor expression profiles...