Gabriella Spengler

Summary

Affiliation: Semmelweis University
Country: Hungary

Publications

  1. ncbi request reprint The mechanism of plasmid curing in bacteria
    Gabriella Spengler
    Institute of Medical Microbiology and Immunobiology, Albert Szent Gyorgyi Medical Centre, University of Szeged, Szeged, Hungary
    Curr Drug Targets 7:823-41. 2006
  2. ncbi request reprint Synergistic interaction between proton pump inhibitors and resistance modifiers: promoting effects of antibiotics and plasmid curing
    Kristina Wolfart
    Department of Medical Microbiology, University of Szeged, 6720 Szeged, Dom ter 10, Hungary
    In Vivo 20:367-72. 2006
  3. ncbi request reprint The antimotility action of a trifluoromethyl ketone on some gram-negative bacteria
    Gabriella Spengler
    Departament of Medical Microbiology and Immunobiology, Albert Szent Gyorgyi Medical Centre, Faculty of Medicine, University of Szeged, Dom ter 10, H 6720 Szeged, Hungary
    Acta Microbiol Immunol Hung 51:351-8. 2004
  4. ncbi request reprint Infectious plasmid resistance and efflux pump mediated resistance
    J Molnar
    Department of Medical Microbiology and Immunobiology, Faculty of General Medicine, University of Szeged, Dom ter 10, H 6720 Szeged, Hungary
    Acta Microbiol Immunol Hung 51:333-49. 2004
  5. ncbi request reprint Activity of fourteen new hydantoin compounds on the human ABCB1 efflux pump
    Ana Martins
    Institute of Pharmacognosy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary
    In Vivo 26:293-7. 2012
  6. ncbi request reprint Thioridazine induces apoptosis of multidrug-resistant mouse lymphoma cells transfected with the human ABCB1 and inhibits the expression of P-glycoprotein
    Gabriella Spengler
    Institute of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, Hungary
    Anticancer Res 31:4201-5. 2011
  7. ncbi request reprint Modulation of multidrug efflux pump activity by new hydantoin derivatives on colon adenocarcinoma cells without inducing apoptosis
    Gabriella Spengler
    Institute of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dom ter 10, H 6720 Szeged, Hungary
    Anticancer Res 31:3285-8. 2011
  8. ncbi request reprint Multidrug resistance reversal by 3-formylchromones in human colon cancer and human mdr1 gene-transfected mouse lymphoma cells
    Zoltán Baráth
    Institute of Medical Microbiology and Immunobiology, Faculty of General Medicine, University of Szeged, Szeged, Hungary
    In Vivo 20:645-9. 2006
  9. ncbi request reprint Inhibitory action of a new proton pump inhibitor, trifluoromethyl ketone derivative, against the motility of clarithromycin-susceptible and-resistant Helicobacter pylori
    Gabriella Spengler
    Department of Medical Microbiology and Immunobiology, Albert Szent Gyorgyi Medical Centre, Faculty of Medicine, University of Szeged, Szeged, Hungary
    Int J Antimicrob Agents 23:631-3. 2004
  10. ncbi request reprint Multidrug resistance reversing activity of newly developed phenothiazines on P-glycoprotein (ABCB1)-related resistance of mouse T-lymphoma cells
    Gabriella Spengler
    Institute of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dom ter 10, H 6720 Szeged, Hungary
    Anticancer Res 34:1737-41. 2014

Collaborators

Detail Information

Publications17

  1. ncbi request reprint The mechanism of plasmid curing in bacteria
    Gabriella Spengler
    Institute of Medical Microbiology and Immunobiology, Albert Szent Gyorgyi Medical Centre, University of Szeged, Szeged, Hungary
    Curr Drug Targets 7:823-41. 2006
    ..Plasmid elimination in vitro provides a method of isolating plasmid free bacteria for biotechnology without any risk of inducing mutations...
  2. ncbi request reprint Synergistic interaction between proton pump inhibitors and resistance modifiers: promoting effects of antibiotics and plasmid curing
    Kristina Wolfart
    Department of Medical Microbiology, University of Szeged, 6720 Szeged, Dom ter 10, Hungary
    In Vivo 20:367-72. 2006
    ..coli and that it was this pump which, when inhibited by TF14, allowed more PMZ to reach its plasmid elimination target...
  3. ncbi request reprint The antimotility action of a trifluoromethyl ketone on some gram-negative bacteria
    Gabriella Spengler
    Departament of Medical Microbiology and Immunobiology, Albert Szent Gyorgyi Medical Centre, Faculty of Medicine, University of Szeged, Dom ter 10, H 6720 Szeged, Hungary
    Acta Microbiol Immunol Hung 51:351-8. 2004
    ..We suppose that the inhibiton of bacterial motility is related to the virulence of bacteria: consequently the pathogenicity can be reduced in the presence of TF18...
  4. ncbi request reprint Infectious plasmid resistance and efflux pump mediated resistance
    J Molnar
    Department of Medical Microbiology and Immunobiology, Faculty of General Medicine, University of Szeged, Dom ter 10, H 6720 Szeged, Hungary
    Acta Microbiol Immunol Hung 51:333-49. 2004
    ..Inhibition of the conjugational transfer of antibiotic resistance plasmids can be exploited to reduce the spreading of these plasmids in ecosystems...
  5. ncbi request reprint Activity of fourteen new hydantoin compounds on the human ABCB1 efflux pump
    Ana Martins
    Institute of Pharmacognosy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary
    In Vivo 26:293-7. 2012
    ..The overexpression of an ABC transporter, the ABCB1, is often associated with MDR in cancer. Previously it was observed that hydantoin compounds can modulate the activity of the ABCB1 pump...
  6. ncbi request reprint Thioridazine induces apoptosis of multidrug-resistant mouse lymphoma cells transfected with the human ABCB1 and inhibits the expression of P-glycoprotein
    Gabriella Spengler
    Institute of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, Hungary
    Anticancer Res 31:4201-5. 2011
    ....
  7. ncbi request reprint Modulation of multidrug efflux pump activity by new hydantoin derivatives on colon adenocarcinoma cells without inducing apoptosis
    Gabriella Spengler
    Institute of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dom ter 10, H 6720 Szeged, Hungary
    Anticancer Res 31:3285-8. 2011
    ..Previously, we demonstrated that eight hydantoin derivatives inhibited the P-glycoprotein (ABCB1) efflux pump of mouse T-lymphoma cells, as well as acting synergistically with the anticancer drug doxorubicin...
  8. ncbi request reprint Multidrug resistance reversal by 3-formylchromones in human colon cancer and human mdr1 gene-transfected mouse lymphoma cells
    Zoltán Baráth
    Institute of Medical Microbiology and Immunobiology, Faculty of General Medicine, University of Szeged, Szeged, Hungary
    In Vivo 20:645-9. 2006
    ..The log P values can provide an adequate explanation for the selective cytotoxicity against cancer cells...
  9. ncbi request reprint Inhibitory action of a new proton pump inhibitor, trifluoromethyl ketone derivative, against the motility of clarithromycin-susceptible and-resistant Helicobacter pylori
    Gabriella Spengler
    Department of Medical Microbiology and Immunobiology, Albert Szent Gyorgyi Medical Centre, Faculty of Medicine, University of Szeged, Szeged, Hungary
    Int J Antimicrob Agents 23:631-3. 2004
    ..Based on the results, it is supposed that TF18 works as an uncoupler similar to the 'clutch' in a biological motor, in which counterclockwise rotation is more sensitive to the effect of TF18 than the clockwise rotation...
  10. ncbi request reprint Multidrug resistance reversing activity of newly developed phenothiazines on P-glycoprotein (ABCB1)-related resistance of mouse T-lymphoma cells
    Gabriella Spengler
    Institute of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dom ter 10, H 6720 Szeged, Hungary
    Anticancer Res 34:1737-41. 2014
    ..Phenothiazines have anticancer properties and are able to reverse the multidrug resistance of neoplastic cells by inhibiting the ATP-binding cassette, sub-family B (MDR/TAP), member 1 protein (ABCB1 or P-glycoprotein) activity...
  11. ncbi request reprint Effect of thioridazine stereoisomers on the drug accumulation of mouse lymphoma and human prostate cancer cell lines in vitro
    Akos Csonka
    D Sc, Institute of Medical Microbiology and Immunobiology, University of Szeged H 6720 Szeged, Hungary
    In Vivo 27:815-20. 2013
    ..Cancer cells become refractory to chemotherapy as a consequence of their overexpression of multidrug transporters...
  12. ncbi request reprint Enhancement of plasmid curing by 9-aminoacridine and two phenothiazines in the presence of proton pump inhibitor 1-(2-benzoxazolyl)-3,3,3-trifluoro-2-propanone
    Gabriella Spengler
    Department of Microbiology, Institute of Medical Microbiology, Albert Szent Gyorgyi Medical University, Szeged, Hungary
    Int J Antimicrob Agents 22:223-7. 2003
    ....
  13. ncbi request reprint Bacterial models for tumor development. Mini-review
    Nora Gyemant
    Department of Medical Microbiology and Immunobiology, Faculty of Medicine, Szent Györgyi Albert Medical Centre, University of Szeged, Dom ter 10, H 6720 Szeged, Hungary
    Acta Microbiol Immunol Hung 51:321-32. 2004
    ..The frequency of transformation is the rate-limiting step, but the co-transmission of the DNA-protein complex is common in the three systems...
  14. ncbi request reprint Coumarin derivatives with tumor-specific cytotoxicity and multidrug resistance reversal activity
    Masami Kawase
    Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan
    In Vivo 19:705-11. 2005
    ..A deeper understanding of the relationship between their structures and their potency will contribute to the design of optimal agents...
  15. ncbi request reprint [Attempts to reduce drug resistance of bacteria and cancer cells]
    Gabriella Spengler
    Szegedi Tudomanyegyetem, Altalános Orvostudományi Kar Orvosi Mikrobiológiai és Immunbiológiai Intézet Szeged
    Orv Hetil 148:1037-40. 2007
  16. ncbi request reprint The interaction between resistance modifiers such as pyrido[3,2-g]quinoline, aza-oxafluorene and pregnane derivatives with DNA, plasmid DNA and tRNA
    Derek Sharples
    School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, UK
    Eur J Med Chem 40:195-202. 2005
    ..Complex formation with MDR1 p-glycoprotein and drug accumulation increased in cancer cells. Both plasmid DNA and p-gp complex formation were related to the chemical structures of the resistance modifiers...
  17. ncbi request reprint Effects of a series of dihydroanthracene derivatives on drug efflux in multidrug resistant cancer cells
    Sandrine Alibert
    GERCTOP UMR CNRS 6009, Faculte de Pharmacie, Universite de la Mediterranee, 27, Bd Jean Moulin, 13385 cedex 05, Marseille, France
    Eur J Med Chem 38:253-63. 2003
    ..Structure activity relationships and molecular modeling studies allowed to define topological display of pharmacophoric groups for these reversal agents...