Research Topics
Genomes and Genes | Ferenc SiposSummaryAffiliation: Semmelweis University Country: Hungary Publications
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Publications
The possible role of isolated lymphoid follicles in colonic mucosal repairFerenc Sipos
2nd Department of Internal Medicine, Cell Analysis Laboratory, Semmelweis University, 1088, Budapest, Szentkiralyi Street 46, Hungary
Pathol Oncol Res 16:11-8. 2010..Our aim is to review the relation of ILFs to the different elements of colonic mucosal repair...
Regeneration associated growth factor receptor and epithelial marker expression in lymphoid aggregates of ulcerative colitisFerenc Sipos
2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
Scand J Gastroenterol 45:440-8. 2010....
[Use of DNA-chips technology in colorectal cancer]Ferenc Sipos
Semmelweis Egyetem, Általános Orvostudományi Kar, II Belgyógyászati Klinika, Budapest
Orv Hetil 145:993-9. 2004....
Elevated insulin-like growth factor 1 receptor, hepatocyte growth factor receptor and telomerase protein expression in mild ulcerative colitisFerenc Sipos
and Department of Internal Medicine, Semmelweis University, Budapest, Hungary
Scand J Gastroenterol 43:289-98. 2008..We assayed the expression alterations of regenerative signal receptors and cell-aging inhibitory systems within colonic crypts by considering the histological activity of the disease...
Growth in epithelial cell proliferation and apoptosis correlates specifically to the inflammation activity of inflammatory bowel diseases: ulcerative colitis shows specific p53- and EGFR expression alterationsFerenc Sipos
2nd Department of Medicine, Semmelweis University, Budapest, Hungary
Dis Colon Rectum 48:775-86. 2005..Epithelial cell turnover related differences between ulcerative colitis, Crohn's colitis, and aspecific colitis are not known yet...
Increase of α-SMA(+) and CK (+) cells as an early sign of epithelial-mesenchymal transition during colorectal carcinogenesisGábor Valcz
Cell Analysis Laboratory, 2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
Pathol Oncol Res 18:371-6. 2012..The negative correlation between E-cadherin and intraepithelial α-SMA expression suggests that EMT is facilitated by a loss of epithelial cell contact...
Diagnostic mRNA expression patterns of inflamed, benign, and malignant colorectal biopsy specimen and their correlation with peripheral blood resultsOrsolya Galamb
2nd Department of Medicine, Semmelweis University, Szentkiralyi str 46, 1088 Budapest, Hungary
Cancer Epidemiol Biomarkers Prev 17:2835-45. 2008..Our aim was to develop diagnostic mRNA expression patterns that may establish the basis of a new molecular biological diagnostic method...
Applicability of antibody and mRNA expression microarrays for identifying diagnostic and progression markers of early and late stage colorectal cancerSandor Spisak
2nd Department of Medicine, Semmelweis University, Budapest, Hungary
Dis Markers 28:1-14. 2010..Antibody microarrays may have a fundamental importance in testing of marker combinations and future application in diagnostics of tumorous diseases...
The influence of methylated septin 9 gene on RNA and protein level in colorectal cancerKinga Tóth
Semmelweis University, 2nd Department of Internal Medicine, Budapest, Hungary
Pathol Oncol Res 17:503-9. 2011..These changes can be reversed by demethylation agents converting this screening marker gene into therapeutic target...
Lymphoid aggregates may contribute to the migration and epithelial commitment of bone marrow-derived cells in colonic mucosaGábor Valcz
2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
J Clin Pathol 64:771-5. 2011..The aim was to study the role of lymphoid aggregates in the migration and transition of BMDCs in both healthy colons and non-specific colitis (NSC)...
Matrix metalloproteinase-9 expression in the normal mucosa-adenoma-dysplasia-adenocarcinoma sequence of the colonLaszlo Herszenyi
2nd Department of Medicine, Semmelweis University, 1088 Szentkirályi str 46, Budapest, Hungary
Pathol Oncol Res 14:31-7. 2008..We demonstrate a significantly higher expression of MMP-9 in adenoma with high grade dysplasia-CRC sequence as compared to normal tissue. The over-expression of MMP-9 strongly suggests its association with colorectal carcinogenesis...
Evaluation of malignant and benign gastric biopsy specimens by mRNA expression profile and multivariate statistical methodsOrsolya Galamb
2nd Department of Internal Medicine, University Semmelweis, Faculty of Medicine, Budapest, Hungary
Cytometry B Clin Cytom 72:299-309. 2007..mRNA expression array and multivariate statistical analysis of gastric biopsies can yield insight into the molecular biology basis of local alterations, supporting expression-based identification of morphological alterations...
mRNA expression, functional profiling and multivariate classification of colon biopsy specimen by cDNA overall glass microarrayOrsolya Galamb
2nd Department of Internal Medicine, University Semmelweis, Budapest, Hungary
World J Gastroenterol 12:6998-7006. 2006..To understand the local pathophysiological alterations and gene ontology-based functional classification of colonic biopsies into inflammatory and neoplastic diseases...
Increased p53 expression in the malignant transformation of Barrett's esophagus is accompanied by an upward shift of the proliferative compartmentIstvan Hritz
2nd Dept Medicine, Semmelweis University, 1088, Budapest, Szentkiralyi u 46, Hungary
Pathol Oncol Res 15:183-92. 2009..Quantification of these parameters in BE is thought to be useful to identify patients at higher risk for progression to adenocarcinoma...
The role of the bone marrow derived mesenchymal stem cells in colonic epithelial regenerationGábor Valcz
2nd Department of Internal Medicine, Cell Analysis Laboratory, Semmelweis University, Szentkiralyi Street 46, 1088 Budapest, Hungary
Pathol Oncol Res 17:11-6. 2011..In this review we summarize the current information about the role of BM-MSCs in the repair progress of injured colonic epithelium and their potential clinical applications...
Potential biomarkers of colorectal adenoma-dysplasia-carcinoma progression: mRNA expression profiling and in situ protein detection on TMAs reveal 15 sequentially upregulated and 2 downregulated genesOrsolya Galamb
2nd Department of Medicine, Semmelweis University, Szentkiralyi str 46, Budapest, Hungary
Cell Oncol 31:19-29. 2009..As most colorectal cancers (CRC) develop from villous adenomas, studying alterations in gene expression profiles across the colorectal adenoma-dysplasia-carcinoma sequence may yield potential biomarkers of disease progression...
Inflammation, adenoma and cancer: objective classification of colon biopsy specimens with gene expression signatureOrsolya Galamb
2nd Department of Medicine, Semmelweis University, Budapest, Hungary
Dis Markers 25:1-16. 2008..Our results provide further insight into the pathophysiological background of colonic diseases. The results set up data warehouse which can be mined further...
Elevated osteopontin expression and proliferative/apoptotic ratio in the colorectal adenoma-dysplasia-carcinoma sequenceGábor Valcz
2nd Department of Internal Medicine, Semmelweis University, Cell Analysis Laboratory, Szentkiralyi Street 46, 1088 Budapest, Hungary
Pathol Oncol Res 16:541-5. 2010..The significantly elevated OPN protein levels we found during normal epithelium to carcinoma progression may contribute to the increased fibroblast-myofibroblast transition determining stem cell niche in colorectal cancer...
Peripheral blood based discrimination of ulcerative colitis and Crohn's disease from non-IBD colitis by genome-wide gene expression profilingFerenc Sipos
2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
Dis Markers 30:1-17. 2011..Transcriptional profile alterations in peripheral blood can be located in diseased colon...
[Free circulating DNA based colorectal cancer screening from peripheral blood: the possibility of the methylated septin 9 gene marker]Kinga Tóth
Semmelweis Egyetem, Általános Orvostudományi Kar, II Belgyógyászati Klinika, Budapest
Orv Hetil 150:969-77. 2009..Nowadays intensive researches are going on about the relation between the septin 9 gene hypermethylation and colorectal cancer development...
Isolation of epsilon-haemoglobin-chain positive fetal cells with micromanipulation for prenatal diagnosisGyula Richard Nagy
Department of Obstetrics and Gynecology, Semmelweis University, Faculty of Medicine, Budapest, Hungary
Prenat Diagn 25:398-402. 2005..Here we report our first results...
[Appearing of bone marrow derived stem cells in healthy and regenerating colonic epithelium]Gábor Valcz
Semmelweis Egyetem, Általános Orvostudományi Kar, II Belgyógyászati Klinika, Budapest
Orv Hetil 150:1852-7. 2009..Samples from normal healthy individuals and from aspecific inflammation were used. The possible role of lymphoid aggregates in the epithelial regeneration was also studied...
[Tissue microarray (TMA) validated progression markers in colorectal cancer using antibody microarrays]Sandor Spisak
Semmelweis Egyetem, Általános Orvostudományi Kar, II Belgyógyászati Klinika, Budapest
Orv Hetil 150:1607-13. 2009..Using microarray systems, hundreds or thousands of parameters could be examined simultaneously for answering the mentioned questions...
Dysplasia-carcinoma transition specific transcripts in colonic biopsy samplesOrsolya Galamb
2nd Department of Medicine, Semmelweis University, Budapest, Hungary Molecular Medicine Research Unit, Hungarian Academy of Sciences, Budapest, Hungary
PLoS ONE 7:e48547. 2012....
Scanning fluorescent microscopy analysis is applicable for absolute and relative cell frequency determinationsJozsef Bocsi
1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
Cytometry A 61:1-8. 2004..Recently, we developed a scanning fluorescent microscopy (SFM) technique. This study compares SFM to LSC (two slide-based cytometry, SBC, techniques) and FCM, in experimental and clinical settings...
The behavior of matrix metalloproteinase-9 in lymphocytic colitis, collagenous colitis and ulcerative colitisGabor Lakatos
2nd Department of Medicine, Semmelweis University, Budapest, Hungary
Pathol Oncol Res 18:85-91. 2012..In contrast, the mucosal up-regulation of MMP-9 correlated with the severity of inflammation in UC. The increased MMP-9 expression could contribute to the severity of mucosal damage in active UC...
Physiological and pathological role of local and immigrating colonic stem cellsFerenc Sipos
Ferenc Sipos, Gábor Valcz, 2nd Department of Internal Medicine, Semmelweis University, 1088 Budapest, Hungary
World J Gastroenterol 18:295-301. 2012..This paper focuses on stem cell biology in the context of physiological and pathological processes in the human colon...
[Insulin-like growth factor receptor, hepatocyte-derived growth factor receptor and telomerase expression in ulcerative colitis]Ferenc Sipos
Semmelweis Egyetem, , , , Budapest
Orv Hetil 147:1835-41. 2006..This phenomenon let the genetically defected epithelial cells to pathologically survive and proliferate, so thus favours the development of tumors...
Helicobacter pylori and antrum erosion-specific gene expression patterns: the discriminative role of CXCL13 and VCAM1 transcriptsOrsolya Galamb
2nd Department of Medicine, Semmelweis University, Budapest, Hungary
Helicobacter 13:112-26. 2008..pylori-positive and H. pylori-negative gastric erosions and adjacent mucosa to explain the possible role and response to H. pylori infection and to get erosion-related mRNA expression patterns...
[Changes in the proliferation and apoptosis of colonic epithelial cells in correlation with histologic activity of ulcerative colitis]Ferenc Sipos
Semmelweis Egyetem, Budapest
Orv Hetil 143:2485-8. 2002....
Laser microdissection in translational and clinical researchAndras Ladanyi
Second Department of Medicine, Semmelweis University, Budapest, Hungary
Cytometry A 69:947-60. 2006..However, understanding the advantages and disadvantages of LMD technology and associated sample preparation procedures may aid in the earlier introduction of this method into the routine clinical diagnostics...
Molecular pathogenesis of Helicobacter pylori infection: the role of bacterial virulence factorsBela Molnar
Molecular Medicine Research Unit, Semmelweis University and the Hungarian Academy of Sciences, 2nd Department of Medicine, Budapest, Hungary
Dig Dis 28:604-8. 2010..The possible role of host counter responses and interactions with gastric epithelia and immune cells are also detailed...
The results of the expression array studies correlate and enhance the known genetic basis of gastric and colorectal cancerOrsolya Galamb
II Department of Medicine, Semmelweis University, Faculty of Medicine Budapest, Hungary
Cytometry B Clin Cytom 68:1-17. 2005....
Elevation in peripheral blood circulating tumor cell number correlates with macroscopic progression in UICC stage IV colorectal cancer patientsBela Molnar
II Department of Medicine, Semmelweis University, 1088 Budapest, Hungary
Dis Markers 24:141-50. 2008..Results are non-existent for the application of these techniques to the determination of progression and therapy response in Dukes stage D CRC patients...
[Stem cell theory of colorectal cancer and its connection with molecular-biological data]Krisztina Hagymasi
Semmelweis Egyetem, Altalános Orvostudományi Kar II Belgyógyászati Klinika, Budapest
Orv Hetil 148:779-85. 2007..The spread of dysplastic cells (bottom-up, top-down hypothesis) is also ambiguous...
Detection of Methylated SEPT9 in Plasma Is a Reliable Screening Method for Both Left- and Right-Sided Colon CancersKinga Tóth
2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
PLoS ONE 7:e46000. 2012..However, its relationship to cancer localization, guaiac-based fecal occult blood test (gFOBT) and carcinoembryonic antigen (CEA) have not been described...
[Isolation and therapeutic use of human stem cells]Ferenc Sipos
Semmelweis Egyetem, Általános Orvostudományi Kar, II Belgyógyászati Klinika, MTA SE, Gasztroenterológiai és Endokrinológiai Kutató Csoport
Orv Hetil 146:1327-33. 2005..The first therapeutic interventions have been already done in diseases such as myocardial infarction or diabetes mellitus, and led to promising results...
[Necessity of chip technology in stomach cancer]Orsolya Galamb
Semmelweis Egyetem Altalános Orvostudományi Kar, II Belgyógyászati Klinika, MTA Semmelweis Egyetem Gasztroenterológiai és Endokrinológiai Kutató Csoport, Budapest
Orv Hetil 145:939-47. 2004..All results show connection to and complete the already known molecular background of gastric cancer...
Genome-wide screening of genes regulated by DNA methylation in colon cancer developmentSandor Spisak
Molecular Medicine Research Unit, Hungarian Academy of Sciences, Budapest, Hungary
PLoS ONE 7:e46215. 2012..Activity of these genes possibly interferes with tumor progression, therefore genes identified can be key factors in the formation and in the progression of the disease...
The half-and-half nail: a new sign of Crohn's disease? Report of four casesTamas Zagoni
Laboratory of Endoscopy, 2nd Dept of Medicine, Semmelweis University, Szentkiralyi u 46, Budapest 1088, Hungary
Dis Colon Rectum 49:1071-3. 2006..The relationship of this symptom to clinical activity cannot yet be assessed and has only been observed in four cases...
Molecular detection of circulating cancer cells. Role in diagnosis, prognosis and follow-up of colon cancer patientsBela Molnar
Clinical Gastroenterology and Endocrinology Unit, Semmelweis University, Hungarian Academy of Sciences, Budapest, Hungary
Dig Dis 21:320-5. 2003..The circulating tumor cells of solid tumors, especially in colorectal cancer has been of great interest in medical research in the last and new century...
[The importance and use of laser microdissection in clinical research and diagnostic method development]Ferenc Sipos
Semmelweis Egyetem, Általános Orvostudományi Kar, II Belgyógyászati Klinika, MTA Gasztroenterológiai és Endokrinológiai kutatócsoport
Orv Hetil 145:1355-61. 2004..The aims of this study are to summarize current practical experiences and to foreshow the application possibilities of this quite new technique in clinical practice...
[Possibilities of investigation and clinical application of adult human stem cells]Orsolya Galamb
Semmelweis Egyetem, Általános Orvostudományi Kar, II sz Belgyógyászati Klinika MTA Semmelweis Egyetem Gasztroenterológiai és Endokrinológiai Kutató Csoport, Budapest
Orv Hetil 144:2263-70. 2003....
[Changes in cell kinetics and clinical course in inflammatory bowel diseases]Ferenc Sipos
, , Semmelweis Egyetem, Budapest
Orv Hetil 143:1175-81. 2002..Getting acquainted with and describing the changes of cell kinetics provide facilities to develop new and effective diagnostical methods and therapies...
Alterations of glutathione S-transferase and matrix metalloproteinase-9 expressions are early events in esophageal carcinogenesisLaszlo Herszenyi
2nd Department of Medicine, Semmelweis University, H 1088 Budapest, Szentkiralyi u 46, Hungary
World J Gastroenterol 13:676-82. 2007..To investigate the role of glutathione S-transferase (GST) and matrix metalloproteinase-9 (MMP-9) expressions in the development and progression of reflux esophagitis-Barrett's metaplasia-dysplasia-adenocarcinoma sequence in the esophagus...
Changes of the cytokine profile in inflammatory bowel diseasesGyorgyi Muzes
Györgyi Műzes, Ferenc Sipos, 2nd Department of Internal Medicine, Semmelweis University, 1088 Budapest, Hungary
World J Gastroenterol 18:5848-61. 2012..The better understanding of their production and functional activity may lead to the development of new therapeutic modalities...
Carcinoma arising in enterocutan fistulae of Crohn's disease patients: description of two casesTamas Zagoni
2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
Int J Colorectal Dis 21:461-4. 2006..We reported two cases of fistula cancers treated with infliximab. The short time-span between the administration of this drug and the diagnosis of cancer makes the correlation between the two unlikely...
Scanning fluorescent microscopy is an alternative for quantitative fluorescent cell analysisViktor Sebestyen Varga
Hungarian Academy of Sciences, Clinical Gastroenterology Research Unit, Budapest, Hungary
Cytometry A 60:53-62. 2004....
Regulatory T cells in inflammatory bowel diseases and colorectal cancerGyorgyi Muzes
Györgyi Műzes, Ferenc Sipos, 2nd Department of Internal Medicine, Semmelweis University, 1088 Budapest, Hungary
World J Gastroenterol 18:5688-94. 2012..In this paper, we aimed to review the current data surrounding the role of T(regs) in the pathogenesis of IBD, colitis-associated colon cancer and sporadic colorectal cancer...
Effect of ageing on colonic mucosal regenerationFerenc Sipos
Ferenc Sipos, Katalin Leiszter, 2nd Department of Internal Medicine, Semmelweis University, 1088 Budapest, Hungary
World J Gastroenterol 17:2981-6. 2011..Here, we aim to summarize the age-related microscopic and molecular changes of the human colon, as well as their role in altered mucosal healing...
[First attempts of detecting fetal cells in the maternal circulation]Gyula Richard Nagy
Semmelweis Egyetem, Általános Orvostudományi Kar, I Szülészeti és Nogyógyászati Klinika, Budapest
Orv Hetil 145:2231-6. 2004..In prenatal diagnosis there is great interest for noninvasive diagnostic methods. Authors report their first results in detecting fetal cells in the maternal circulation during pregnancy...
Anti-tumor immunity, autophagy and chemotherapyGyorgyi Muzes
Györgyi Műzes, Ferenc Sipos, 2nd Department of Internal Medicine, Semmelweis University, 1088 Budapest, Hungary
World J Gastroenterol 18:6537-40. 2012..Relation of autophagy to anticancer immune responses may indicate a novel aspect in cancer chemotherapy...
Epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions in the colonFerenc Sipos
Ferenc Sipos, Cell Analysis Laboratory, 2nd Department of Internal Medicine, Semmelweis University, 1088 Budapest, Hungary
World J Gastroenterol 18:601-8. 2012..The preliminary results of the current studies are promising, but more clinical investigations are needed to develop new and safe therapeutic strategies for diseases of the colon...
Identification and validation of colorectal neoplasia-specific methylation markers for accurate classification of diseaseFabian Model
Epigenomics, Inc, Suite 300, 1000 Seneca Street, Seattle, WA 98101, USA
Mol Cancer Res 5:153-63. 2007....
[Theoretical foundations of protein chips and their possible use in medical research and diagnostics]Sandor Spisak
Semmelweis Egyetem, Altalános Orvostudományi Kar II Belgyógyászati Klinika, MTA SE Molekuláris Medicina Kutatócsoport Budapest
Orv Hetil 148:1511-20. 2007....
[Identification of colorectal cancer, adenoma, and inflammatory bowel disease specific gene expression patterns using whole genomic oligonucleotide microarray system]Orsolya Galamb
Semmelweis Egyetem, Általános Orvostudományi Kar II Belgyógyászati Klinika Budapest
Orv Hetil 148:2067-79. 2007....
[Functional mRNA expression analysis and classification of colonic biopsy samples using overall cDNA microarray technique]Orsolya Galamb
Semmelweis Egyetem, Általános Orvostudományi Kar II Belgyógyászati Klinika Budapest
Orv Hetil 149:219-32. 2008....
