Anna Sebestyen

Summary

Affiliation: Semmelweis University
Country: Hungary

Publications

  1. doi request reprint Activity and complexes of mTOR in diffuse large B-cell lymphomas--a tissue microarray study
    Anna Sebestyen
    1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
    Mod Pathol 25:1623-8. 2012
  2. ncbi request reprint Cytokine regulation of syndecan expression in cells of liver origin
    A Sebestyen
    1st Institute of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
    Cytokine 12:1557-60. 2000
  3. ncbi request reprint Smad4-independent, PP2A-dependent apoptotic effect of exogenous transforming growth factor beta 1 in lymphoma cells
    Anna Sebestyen
    Semmelweis University, I Department of Pathology and Experimental Cancer Research, 1085 Budapest, Ulloi ut 26, Hungary
    Exp Cell Res 313:3167-74. 2007
  4. ncbi request reprint TGF beta 1 kills lymphoma cells using mitochondrial apoptotic pathway with the help of caspase-8
    Gabor Barna
    1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
    Anticancer Res 22:3867-72. 2002
  5. pmc Characteristic mTOR activity in Hodgkin-lymphomas offers a potential therapeutic target in high risk disease--a combined tissue microarray, in vitro and in vivo study
    Agnes Márk
    1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Ulloi ut 26, Budapest 1085, Hungary
    BMC Cancer 13:250. 2013
  6. pmc Mammalian target of rapamycin (mTOR) activity dependent phospho-protein expression in childhood acute lymphoblastic leukemia (ALL)
    Karolina Nemes
    2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
    PLoS ONE 8:e59335. 2013
  7. ncbi request reprint Different ways to induce apoptosis by fenretinide and all-trans-retinoic acid in human B lymphoma cells
    Gabor Barna
    First Department of Pathology and Experimental Cancer Research, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    Anticancer Res 25:4179-85. 2005
  8. doi request reprint Mitotic lymphoma cells are characterized by high expression of phosphorylated ribosomal S6 protein
    Gábor Egervári
    1st Institute of Pathology and Experimental Cancer Research, Semmelweis University, 1085 Üllői út 26, Budapest, Hungary
    Histochem Cell Biol 135:409-17. 2011
  9. ncbi request reprint Smad signal and TGFbeta induced apoptosis in human lymphoma cells
    Anna Sebestyen
    Ist Department of Pathology and Experimental Cancer Research, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary
    Cytokine 30:228-35. 2005
  10. ncbi request reprint Proteasome inhibitors abolish cell death downstream of caspase activation during anti-microtubule drug-induced apoptosis in leukemia cells
    Katalin Nagy
    First Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
    Anticancer Res 25:3321-6. 2005

Collaborators

Detail Information

Publications19

  1. doi request reprint Activity and complexes of mTOR in diffuse large B-cell lymphomas--a tissue microarray study
    Anna Sebestyen
    1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
    Mod Pathol 25:1623-8. 2012
    ..Taken together, mTOR inhibitors may be useful in addition to regular therapy in diffuse large B-cell lymphomas, however, patient and inhibitor selection criteria must be carefully considered...
  2. ncbi request reprint Cytokine regulation of syndecan expression in cells of liver origin
    A Sebestyen
    1st Institute of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
    Cytokine 12:1557-60. 2000
    ..Their action was target cell specific resulting in either up- or downregulation except TGF-beta1 that was stimulatory in all cell types examined...
  3. ncbi request reprint Smad4-independent, PP2A-dependent apoptotic effect of exogenous transforming growth factor beta 1 in lymphoma cells
    Anna Sebestyen
    Semmelweis University, I Department of Pathology and Experimental Cancer Research, 1085 Budapest, Ulloi ut 26, Hungary
    Exp Cell Res 313:3167-74. 2007
    ..Further studies are needed to clarify the possible role and involvement of Smad4-independent effects of TGFb in normal and malignant lymphoid cells and in cells of the tumor microenvironment...
  4. ncbi request reprint TGF beta 1 kills lymphoma cells using mitochondrial apoptotic pathway with the help of caspase-8
    Gabor Barna
    1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
    Anticancer Res 22:3867-72. 2002
    ..There is a time-gat between the early activation of Smad-dependent TIEG and the accumulation of ROS, therefore other participants that start the increase in mitochondrial membrane permeability should be identified...
  5. pmc Characteristic mTOR activity in Hodgkin-lymphomas offers a potential therapeutic target in high risk disease--a combined tissue microarray, in vitro and in vivo study
    Agnes Márk
    1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Ulloi ut 26, Budapest 1085, Hungary
    BMC Cancer 13:250. 2013
    ..However, the pathological characterization of mTOR activity in lymphomas is still incomplete...
  6. pmc Mammalian target of rapamycin (mTOR) activity dependent phospho-protein expression in childhood acute lymphoblastic leukemia (ALL)
    Karolina Nemes
    2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
    PLoS ONE 8:e59335. 2013
    ..Determining mTOR activity in leukemic cells may also be a useful tool for selecting patients who may benefit from future mTOR inhibitor treatments...
  7. ncbi request reprint Different ways to induce apoptosis by fenretinide and all-trans-retinoic acid in human B lymphoma cells
    Gabor Barna
    First Department of Pathology and Experimental Cancer Research, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    Anticancer Res 25:4179-85. 2005
    ..Our results suggest that natural (ATRA) and synthetic (4HPR) retinoids induce different apoptotic pathways in B lymphoma cells, which is particularly relevant for their potential use in leukemia treatment...
  8. doi request reprint Mitotic lymphoma cells are characterized by high expression of phosphorylated ribosomal S6 protein
    Gábor Egervári
    1st Institute of Pathology and Experimental Cancer Research, Semmelweis University, 1085 Üllői út 26, Budapest, Hungary
    Histochem Cell Biol 135:409-17. 2011
    ..These observations may have practical implications as they raise the possibility to consider p70S6K and/or S6 as a potential therapeutic target-besides mTOR-in certain lymphomas and perhaps in clinical immunosuppression...
  9. ncbi request reprint Smad signal and TGFbeta induced apoptosis in human lymphoma cells
    Anna Sebestyen
    Ist Department of Pathology and Experimental Cancer Research, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary
    Cytokine 30:228-35. 2005
    ..This findings indicates that the lost sensitivity of lymphoma cells toward a physiological regulatory factor could be reversed...
  10. ncbi request reprint Proteasome inhibitors abolish cell death downstream of caspase activation during anti-microtubule drug-induced apoptosis in leukemia cells
    Katalin Nagy
    First Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
    Anticancer Res 25:3321-6. 2005
    ..Anti-microtubule drugs and proteasome inhibitors are currently among the most intensively studied anti-tumor agents, however little is known about their pharmacological interactions at the cellular level...
  11. ncbi request reprint Antiproliferative and apoptotic effects of mycophenolic acid in human B-cell non-Hodgkin lymphomas
    Gyula Végso
    Semmelweis University, Department of Transplantation and Surgery, Budapest, Hungary
    Leuk Res 31:1003-8. 2007
    ..Xenografted lymphoma cells remained sensitive to MPA. Our results suggest that MPA may be recommended as an additional component of lymphoma chemotherapeutical regimens, with special considerations to post-transplant lymphomas...
  12. doi request reprint Heparin can liberate high molecular weight DNA from secondary necrotic cells
    Gabor Barna
    Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
    Cell Biol Int 36:1281-6. 2012
    ..Thus, the results suggest that heparin treatment helps in the clearance of cell debris and decreases the immunogenity of secondary necrotic cells...
  13. doi request reprint Effect of somatostatin analogue octreotide in medulloblastoma in xenograft and cell culture study
    Peter Hauser
    2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
    Pediatr Hematol Oncol 26:363-74. 2009
    ....
  14. doi request reprint ROR1 expression is not a unique marker of CLL
    Gabor Barna
    Faculty of Medicine, 1st Department of Pathology and Experimental Cancer Research, Budapest, Hungary
    Hematol Oncol 29:17-21. 2011
    ..Copyright © 2010 John Wiley & Sons, Ltd...
  15. doi request reprint Expression of TGFbeta1 and its signaling components by peripheral lymphocytes in systemic lupus erythematosus
    Eszter Kohut
    I Department of Pathology and Experimental Cancer Research, Semmelweis University, Ulloi ut 26, 1085 Budapest, Hungary
    Pathol Oncol Res 15:251-6. 2009
    ....
  16. doi request reprint The activated targets of mTOR signaling pathway are characteristic for PDGFRA mutant and wild-type rather than KIT mutant GISTs
    Zoltan Sapi
    1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
    Diagn Mol Pathol 20:22-33. 2011
    ....
  17. ncbi request reprint Mevastatin-induced apoptosis and growth suppression in U266 myeloma cells
    Judit Jánosi
    Department of Haematology, National Medical Center, Budapest, Hungary
    Anticancer Res 24:1817-22. 2004
    ..Mevastatin also stimulated shedding of syndecan-1 from the surface of myeloma cells. The apoptosis inducing effect of mevastatin could be considered as a potential participant in a complex antitumor protocol...
  18. ncbi request reprint Proteoglycans and tumor progression: Janus-faced molecules with contradictory functions in cancer
    Jozsef Timar
    Department of Tumor Progression, National Institute of Oncology, Budapest, Hungary
    Semin Cancer Biol 12:173-86. 2002
    ..Experimental data suggest that tumor cell surface heparan sulfate (PG) may provide a target for specific anti-metastatic interventions...
  19. doi request reprint Lymphoproliferative disorders after solid organ transplantation-classification, incidence, risk factors, early detection and treatment options
    Gyula Végso
    Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary
    Pathol Oncol Res 17:443-54. 2011
    ..g. interleukin-2 inhibitors). Early detection is especially important for high risk-e.g. EBV-negative-patients, where the appearance of EBV-DNA and the increase in its titer may help...