Z Radak

Summary

Affiliation: Semmelweis University
Country: Hungary

Publications

  1. ncbi request reprint Attenuation of the development of murine solid leukemia tumor by physical exercise
    Zsolt Radak
    Laboratory of Exercise Physiology, School of Sport Sciences, Semmelweis University Budapest, Hungary
    Antioxid Redox Signal 4:213-9. 2002
  2. ncbi request reprint Exercise, oxidative stress and hormesis
    Zsolt Radak
    Institute of Sport Science, Faculty of Physical Education and Sport Science, Semmelweis University, Budapest, Hungary
    Ageing Res Rev 7:34-42. 2008
  3. ncbi request reprint Adaptation to exercise-induced oxidative stress: from muscle to brain
    Z Radak
    Lab Exercise Physiology, School of Sport Science, Semmelweis University, 1123 Budapest, Alkotas u 44, Hungary
    Exerc Immunol Rev 7:90-107. 2001
  4. ncbi request reprint Lung cancer in smoking patients inversely alters the activity of hOGG1 and hNTH1
    Zsolt Radak
    Laboratory of Exercise Physiology, School of Sport Science, Semmelweis University, Budapest, Hungary
    Cancer Lett 219:191-5. 2005
  5. ncbi request reprint The effects of training and detraining on memory, neurotrophins and oxidative stress markers in rat brain
    Zsolt Radak
    Institute of Sport Science, Faculty of Physical Education and Sport Sciences, Semmelweis University, Budapest, Hungary
    Neurochem Int 49:387-92. 2006
  6. doi request reprint Nitric oxide: is it the cause of muscle soreness?
    Zsolt Radak
    Semmelweis University, Research Institute of Sport Science, Budapest, Hungary
    Nitric Oxide 26:89-94. 2012
  7. ncbi request reprint 8-Oxoguanosine and uracil repair of nuclear and mitochondrial DNA in red and white skeletal muscle of exercise-trained old rats
    Zsolt Radak
    Institute of Sport Science, Faculty of Physical Education and Sport Science, Semmelweis University, Budapest, Hungary
    J Appl Physiol (1985) 102:1696-701. 2007
  8. ncbi request reprint Age-associated increase in oxidative stress and nuclear factor kappaB activation are attenuated in rat liver by regular exercise
    Zsolt Radak
    Laboratory of Exercise Physiology, School of Sport Science, Semmelweis University, Budapest, Hungary
    FASEB J 18:749-50. 2004
  9. ncbi request reprint Exercise and hormesis: oxidative stress-related adaptation for successful aging
    Zsolt Radak
    Exercise Physiology Laboratory, School of Sport Science, Semmelweis University, Budapest, Hungary
    Biogerontology 6:71-5. 2005
  10. pmc 8-Oxo-7,8-dihydroguanine: links to gene expression, aging, and defense against oxidative stress
    Zsolt Radak
    Research Institute of Sport Science, Faculty of Physical Education and Sport Science, Semmelweis University, Budapest, Hungary
    Free Radic Biol Med 49:587-96. 2010

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Attenuation of the development of murine solid leukemia tumor by physical exercise
    Zsolt Radak
    Laboratory of Exercise Physiology, School of Sport Sciences, Semmelweis University Budapest, Hungary
    Antioxid Redox Signal 4:213-9. 2002
    ..The present data suggest that exercise during leukemia attenuates the development of tumors in mice. The selective alteration of regulatory proteins might play a role in the beneficial effects of exercise during leukemia...
  2. ncbi request reprint Exercise, oxidative stress and hormesis
    Zsolt Radak
    Institute of Sport Science, Faculty of Physical Education and Sport Science, Semmelweis University, Budapest, Hungary
    Ageing Res Rev 7:34-42. 2008
    ..Based upon the genetic setup, regular moderate physical exercise/activity provides systemic beneficial effects, including improved physiological function, decreased incidence of disease and a higher quality of life...
  3. ncbi request reprint Adaptation to exercise-induced oxidative stress: from muscle to brain
    Z Radak
    Lab Exercise Physiology, School of Sport Science, Semmelweis University, 1123 Budapest, Alkotas u 44, Hungary
    Exerc Immunol Rev 7:90-107. 2001
    ..Regular exercise causes adaptation of the antioxidant and repair systems, which could result in a decreased base level of oxidative damage and increased resistance to oxidative stress...
  4. ncbi request reprint Lung cancer in smoking patients inversely alters the activity of hOGG1 and hNTH1
    Zsolt Radak
    Laboratory of Exercise Physiology, School of Sport Science, Semmelweis University, Budapest, Hungary
    Cancer Lett 219:191-5. 2005
    ..On the contrary, the activity of endonuclease III homologue, hNTH1, was lower in tumours compared to controls. These opposing alterations in DNA repair enzymes may affect cancer growth due to the increased formation of AP sites...
  5. ncbi request reprint The effects of training and detraining on memory, neurotrophins and oxidative stress markers in rat brain
    Zsolt Radak
    Institute of Sport Science, Faculty of Physical Education and Sport Sciences, Semmelweis University, Budapest, Hungary
    Neurochem Int 49:387-92. 2006
    ..It is suggested that exercise training is more likely to beneficially effect the production of reactive oxygen species and the related oxidative damage...
  6. doi request reprint Nitric oxide: is it the cause of muscle soreness?
    Zsolt Radak
    Semmelweis University, Research Institute of Sport Science, Budapest, Hungary
    Nitric Oxide 26:89-94. 2012
    ..The present mini-review attempts to elucidate the possible relationship between NO and DOMS, based upon current literature...
  7. ncbi request reprint 8-Oxoguanosine and uracil repair of nuclear and mitochondrial DNA in red and white skeletal muscle of exercise-trained old rats
    Zsolt Radak
    Institute of Sport Science, Faculty of Physical Education and Sport Science, Semmelweis University, Budapest, Hungary
    J Appl Physiol (1985) 102:1696-701. 2007
    ..These data provide evidence for differential regulation of UDG and OGG1 in maintaining fidelity of DNA in oxidatively stressed cells...
  8. ncbi request reprint Age-associated increase in oxidative stress and nuclear factor kappaB activation are attenuated in rat liver by regular exercise
    Zsolt Radak
    Laboratory of Exercise Physiology, School of Sport Science, Semmelweis University, Budapest, Hungary
    FASEB J 18:749-50. 2004
    ....
  9. ncbi request reprint Exercise and hormesis: oxidative stress-related adaptation for successful aging
    Zsolt Radak
    Exercise Physiology Laboratory, School of Sport Science, Semmelweis University, Budapest, Hungary
    Biogerontology 6:71-5. 2005
    ....
  10. pmc 8-Oxo-7,8-dihydroguanine: links to gene expression, aging, and defense against oxidative stress
    Zsolt Radak
    Research Institute of Sport Science, Faculty of Physical Education and Sport Science, Semmelweis University, Budapest, Hungary
    Free Radic Biol Med 49:587-96. 2010
    ....
  11. ncbi request reprint Exercise plays a preventive role against Alzheimer's disease
    Zsolt Radak
    Research Institute of Sport Science, Faculty of Physical Education and Sport Science, Semmelweis University, Budapest, Hungary
    J Alzheimers Dis 20:777-83. 2010
    ..Although extensive studies are required to understand the mechanism, it is clear that physical exercise is beneficial in the prevention of AD and other age-associated neurodegenerative disorders...
  12. pmc Exercise improves import of 8-oxoguanine DNA glycosylase into the mitochondrial matrix of skeletal muscle and enhances the relative activity
    Zsolt Radak
    Institute of Sport Science, Faculty of Physical Education and Sport Science, Semmelweis University, H 1123 Budapest, Hungary
    Free Radic Biol Med 46:238-43. 2009
    ....
  13. doi request reprint Systemic adaptation to oxidative challenge induced by regular exercise
    Zsolt Radak
    Laboratory of Exercise Physiology, School of Sport Science, Semmelweis University, Alkotas u 44, Budapest H 1123, Hungary
    Free Radic Biol Med 44:153-9. 2008
    ..Or in other words, it seems that the vulnerability of the body to oxidative stress and diseases is significantly enhanced in a sedentary compared to a physically active lifestyle...
  14. ncbi request reprint Effects of exercise on brain function: role of free radicals
    Zsolt Radak
    Institute of Sport Science, Faculty of Physical Education and Sport Science, Semmelweis University, Budapest, Hungary
    Appl Physiol Nutr Metab 32:942-6. 2007
    ..It appears that exercise-induced modulation of the redox state is an important means by which exercise benefits brain function, increases the resistance against oxidative stress, and facilitates recovery from oxidative stress...
  15. ncbi request reprint Super-marathon race increases serum and urinary nitrotyrosine and carbonyl levels
    Z Radak
    Faculty of Physical Education and Sport Sciences, Semmelweis University, Budapest, Hungary
    Eur J Clin Invest 33:726-30. 2003
    ..Increased levels of reactive oxygen and nitrogen species (RONS) are formed during exhaustive physical exercise and causes alterations to cellular proteins...
  16. pmc Age-dependent changes in 8-oxoguanine-DNA glycosylase activity are modulated by adaptive responses to physical exercise in human skeletal muscle
    Zsolt Radak
    Research Institute of Sport Science, Semmelweis University, Budapest H 1123, Hungary
    Free Radic Biol Med 51:417-23. 2011
    ....
  17. ncbi request reprint Regular training modulates the accumulation of reactive carbonyl derivatives in mitochondrial and cytosolic fractions of rat skeletal muscle
    Z Radak
    Department of Exercise Physiology, School of Sport Science, Semmelweis University Budapest, Hungary
    Arch Biochem Biophys 383:114-8. 2000
    ..Exercise training increases the accumulation of protein damage in mitochondria of skeletal muscle but cytosolic proteins are protected by increased activity of proteasome complex and possibly by other antioxidant enzymes...
  18. ncbi request reprint Single bout of exercise eliminates the immobilization-induced oxidative stress in rat brain
    Z Radak
    Laboratory of Exercises Physiology, School of Sport Science, Semmelwies University, HUPE Alkotas u 44, H 1123, Budapest, Hungary
    Neurochem Int 39:33-8. 2001
    ....
  19. ncbi request reprint Telomerase activity is not altered by regular strenuous exercise in skeletal muscle or by sarcoma in liver of rats
    Z Radak
    Laboratory of Exercise Physiology, School of Sport Sciences, Semmelweis University, Budapest, Hungary
    Redox Rep 6:99-103. 2001
    ..Exercise training during sarcoma significantly retards the development of tumors and could possibly serve as a positive adjunct to treatment...
  20. ncbi request reprint Exercise training decreases DNA damage and increases DNA repair and resistance against oxidative stress of proteins in aged rat skeletal muscle
    Zsolt Radak
    Laboratory of Exercise Physiology, School of Sport Sciences, Semmelweis University, Alkotas u 44, H 1123, Budapest, Hungary
    Pflugers Arch 445:273-8. 2002
    ..We suggest that regular exercise-induced adaptation attenuates the age-associated increase in 8-OHdG levels, and increases the activity of DNA repair and resistance against oxidative stress in proteins...
  21. ncbi request reprint The effect of exercise training on oxidative damage of lipids, proteins, and DNA in rat skeletal muscle: evidence for beneficial outcomes
    Z Radak
    Laboratory of Exercise Physiology, Hungarian University of Physical Education, Budapest
    Free Radic Biol Med 27:69-74. 1999
    ..05). The adaptive response against oxidative stress induced by moderate endurance exercise constitutes a beneficial effect of exercise...
  22. ncbi request reprint Regular exercise improves cognitive function and decreases oxidative damage in rat brain
    Z Radak
    Laboratory of Exercise Physiology, School of Sport Sciences, Semmelweis University, Budapest, Hungary
    Neurochem Int 38:17-23. 2001
    ..05) in the brain of young exercised animals. These data show that swimming training improves some cognitive functions in rats, with parallel attenuation of the accumulation of oxidatively damaged proteins...
  23. ncbi request reprint Muscle soreness-induced reduction in force generation is accompanied by increased nitric oxide content and DNA damage in human skeletal muscle
    Z Radak
    Laboratory of Exercise Physiology, Hungarian University of Physical Education, Budapest
    Free Radic Biol Med 26:1059-63. 1999
    ..This is the first demonstration that muscle soreness-induced decrease in maximal force generation is a result of an increase in muscular NO content and associated with enhanced formation of 8-OHdG in human skeletal muscle...
  24. pmc Aerobic endurance capacity affects spatial memory and SIRT1 is a potent modulator of 8-oxoguanine repair
    L Sarga
    Research Institute of Sport Science, Faculty of Physical Education and Sport Science, Semmelweis University, Budapest H 1123, Hungary Department of Microbiology and Immunology, Sealy Center for Molecular Medicine, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA
    Neuroscience 252:326-36. 2013
    ..These findings imply that high-running capacity is associated with increased hippocampal function, and SIRT1 level/activity and inversely correlates with AcOgg1 levels and thereby the repair of genomic 8-oxoG...
  25. pmc Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats
    Erika Koltai
    Research Institute of Sport Science, Faculty of Physical Education and Sport Science, Semmelweis University, Budapest, Hungary
    Mech Ageing Dev 131:21-8. 2010
    ..Regular exercise decelerates the deleterious effects of the aging process via SIRT1-dependent pathways through the stimulation of NAD(+) biosynthesis by NAMPT...
  26. doi request reprint Long-term exercise treatment reduces oxidative stress in the hippocampus of aging rats
    K Marosi
    Semmelweis University, Institute of Sport Science, Budapest, Hungary
    Neuroscience 226:21-8. 2012
    ..These results suggest that long-term physical exercise can comprises antioxidant properties and by this way protect neurons against oxidative stress at the early stage of aging...
  27. doi request reprint The effect of exercise and oxidant-antioxidant intervention on the levels of neurotrophins and free radicals in spinal cord of rats
    S Siamilis
    Faculty of Physical Education and Sport Science, Institute of Sport Science, Semmelweis University, Budapest, Hungary
    Spinal Cord 47:453-7. 2009
    ..This study was designed to investigate the effects of oxidant and antioxidant treatment, as well as regular exercise, on neurotrophin levels in the spinal cord of rats...
  28. doi request reprint The beneficial effects of nettle supplementation and exercise on brain lesion and memory in rat
    Anna Toldy
    Research Institute for Sport Sciences, Semmelweis University, 1123 Budapest, Hungary
    J Nutr Biochem 20:974-81. 2009
    ..The additive effect of the two treatments was more profound in the down-regulation of inflammatory transcription processes in NMDA lesion...
  29. doi request reprint The redox-associated adaptive response of brain to physical exercise
    Z Radak
    Faculty of Physical Education and Sport Sciences, Institute of Sport Science, Semmelweis University, Budapest, Hungary
    Free Radic Res 48:84-92. 2014
    ..Exercise is also effective in attenuating age-associated loss in brain function, which suggests that physical activity-related complex metabolic and redox changes are important for a healthy neural system...
  30. ncbi request reprint Changes in urine 8-hydroxydeoxyguanosine levels of super-marathon runners during a four-day race period
    Z Radak
    Lab Exercice Physiol, Hungarian University of Physical Education, Budapest
    Life Sci 66:1763-7. 2000
    ..However, repeated extreme exercise-induced oxidative stress does not propagate on increase of urinary 8-OHdG, but rather causes an adaptation leading to normalization of oxidative DNA damage...
  31. ncbi request reprint The effect of high altitude and caloric restriction on reactive carbonyl derivatives and activity of glutamine synthetase in rat brain
    Z Radak
    Laboratory of Exercise Physiology, Institute of Sport and Health Sciences, University of Tsukuba, Japan
    Life Sci 62:1317-22. 1998
    ..The data suggest that both HA and CR decreases the accumulation of RCD in the brain, however the mechanism of the decrease seems to be different during HA and CR...
  32. ncbi request reprint Marathon running alters the DNA base excision repair in human skeletal muscle
    Zsolt Radak
    Laboratory of Exercise Physiology, School of Sport Sciences, Semmelweis University, Alkotas u 44, H 1123, Budapest, Hungary
    Life Sci 72:1627-33. 2003
    ..The up-regulation of DNA repair enzymes might be an important part of the regular exercise induced adaptation process...
  33. ncbi request reprint High altitude and oxidative stress
    Agoston Dosek
    Institute of Sport Science, Faculty of Physical Education and Sport Science, Semmelweis University, Budapest, Hungary
    Respir Physiol Neurobiol 158:128-31. 2007
    ..Physical exercise or an enhanced level of physical activity at high altitude, exacerbates the extent of the oxidative challenge. Therefore, special attention is necessary to curb the degree of oxidative stress...
  34. ncbi request reprint Regular exercise reduces 8-oxodG in the nuclear and mitochondrial DNA and modulates the DNA repair activity in the liver of old rats
    Hideko Nakamoto
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Toho University, Miyama 2 2 1, Funabashi, Chiba 274 8510, Japan
    Exp Gerontol 42:287-95. 2007
    ..We suggest that the apparent beneficial outcomes in reducing the DNA damage by regular exercise can be interpreted in terms of hormetic effect by moderate oxidative stress and potential adaptation to stronger stresses...
  35. ncbi request reprint Endurance exercise increases the SIRT1 and peroxisome proliferator-activated receptor gamma coactivator-1alpha protein expressions in rat skeletal muscle
    Masataka Suwa
    Institute of Health Science, Kyushu University, Kasuga, Fukuoka 816 8580, Japan
    Metabolism 57:986-98. 2008
    ....
  36. ncbi request reprint Antioxidative effects of a new lychee fruit-derived polyphenol mixture, oligonol, converted into a low-molecular form in adipocytes
    Takuya Sakurai
    Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, Mitaka, Tokyo 181 8611, Japan
    Biosci Biotechnol Biochem 72:463-76. 2008
    ..These results suggest that Oligonol has antioxidative effects and that it attenuates HFD-induced dysregulated expression of genes for adipokines in adipocytes...
  37. ncbi request reprint Beneficial biochemical outcomes of late-onset dietary restriction in rodents
    Sataro Goto
    Tokyo Metropolitan Institute of Gerontology, Sakae cho 35 2, Itabashi ku, 173 0015 Tokyo, Japan
    Ann N Y Acad Sci 1100:431-41. 2007
    ..We argue, however, that application of late life DR/CR can be harmful if practiced in people who are already eating modestly...
  38. ncbi request reprint Serum brain-derived neurotrophic factor level is increased and associated with obesity in newly diagnosed female patients with type 2 diabetes mellitus
    Masataka Suwa
    Institute of Health Science, Kyushu University, Kasuga, Fukuoka 816 8580, Japan
    Metabolism 55:852-7. 2006
    ..In addition, the BDNF is related to the total and abdominal subcutaneous fat mass and energy metabolism in the newly diagnosed female patients with type 2 diabetes mellitus...