Research Topics
Genomes and GenesSpecies | Zsofia NemodaSummaryAffiliation: Semmelweis University Country: Hungary Publications
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Detail Information
Publications
Assessing genetic polymorphisms using DNA extracted from cells present in saliva samplesZsofia Nemoda
Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Tuzolto utca, Budapest, Hungary
BMC Med Res Methodol 11:170. 2011..In five studies we document the effects of sample volume, handling and storage conditions, type of collection device, and oral sampling location, on quantity, quality, and genetic assessment of DNA extracted from cells present in saliva...
Carboxylesterase 1 gene polymorphism and methylphenidate response in ADHDZsofia Nemoda
Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
Neuropharmacology 57:731-3. 2009..410 +/- 0.127 vs 0.572 +/- 0.153 mg/kg, t(1,88) = 2.33, p = 0.022). This result warrants for further investigations of the CES1 gene in larger ADHD samples...- Association between dopaminergic polymorphisms and borderline personality traits among at-risk young adults and psychiatric inpatientsZsofia Nemoda
Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
Behav Brain Funct 6:4. 2010..However, the efficacy of dopamine D2 receptor (DRD2) blocking antipsychotic drugs in BPD treatment also suggests involvement of the dopamine system in the neurobiology of BPD... - Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthoodZsofia Nemoda
Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
Neurosci Biobehav Rev 35:1665-86. 2011..The dopamine catabolizing enzyme genes, such as monoamine oxidase (MAO) A and catechol-O-methyltransferase (COMT) genes, have been linked to aggressive behaviors... - Catechol-O-methyltransferase Val158Met polymorphism is associated with methylphenidate response in ADHD childrenEva Kereszturi
Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
Am J Med Genet B Neuropsychiatr Genet 147:1431-5. 2008..015). This interaction might reflect the regulatory effect of COMT dominated prefrontal dopamine transmission on subcortical dopamine systems, which are the actual site of methylphenidate action... 
Dopaminergic candidate genes in Tourette syndrome: association between tic severity and 3' UTR polymorphism of the dopamine transporter geneZsanett Tarnok
Vadaskert Child and Adolescent Psychiatric Clinic, Budapest, Hungary
Am J Med Genet B Neuropsychiatr Genet 144:900-5. 2007..002). In summary, allele frequencies did not differ between cases and controls, but DAT1 genotype accounted for variations of tic severity within the TS group...- Analysis of a polymorphic microRNA target site in the purinergic receptor P2RX7 geneOmar Abdul Rahman
Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
Electrophoresis 31:1790-5. 2010..The developed genotyping method was applied in our depression-related association study... - Association between the 120-bp duplication of the dopamine D4 receptor gene and attention deficit hyperactivity disorder: genetic and molecular analysesEva Kereszturi
Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
Am J Med Genet B Neuropsychiatr Genet 144:231-6. 2007..These results suggest that the 1-repeat form of the 120-bp dup might be a risk factor of ADHD, especially in the homozygous form and/or in the context of certain haplotypes... - P2RX7 Gln460Arg polymorphism is associated with depression among diabetic patientsGeza Nagy
Semmelweis University, 2nd Department of Internal Medicine, Budapest, 1088, Szentkiralyi u 46, Hungary
Prog Neuropsychopharmacol Biol Psychiatry 32:1884-8. 2008..We assumed that genetic influence would be stronger on depressive symptoms in the "poor glycemic control" group (PC: HbA1C>7%) compared to the "good glycemic control" group (GC: HbA1C<or=7%)... - Association between depression and the Gln460Arg polymorphism of P2RX7 gene: a dimensional approachKrisztina Hejjas
Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
Am J Med Genet B Neuropsychiatr Genet 150:295-9. 2009..In conclusion, case-control analysis did not reveal significant results, but using a symptom severity scale we could support the association between depressive disorder and the G-allele of the Gln460Arg polymorphism in the P2RX7 gene... - Additive effects of serotonergic and dopaminergic polymorphisms on trait impulsivityGabor Varga
Institute of Psychology, Eotvos Lorand University, Budapest, Hungary
Am J Med Genet B Neuropsychiatr Genet 159:281-8. 2012..These results clearly suggest an additive effect of dopaminergic and serotonergic polymorphisms on trait impulsivity... - Infant genotype may moderate sensitivity to maternal affective communications: attachment disorganization, quality of care, and the DRD4 polymorphismJudit Gervai
Institute for Psychology, Hungarian Academy of Sciences, Budapest, Hungary
Soc Neurosci 2:307-19. 2007..Among carriers of the 7-repeat DRD4 allele, there was no relation between quality of maternal communication and infant disorganization. This interaction effect was independent of degree of social risk and maternal DRD4 genotype... - Linkage analysis and molecular haplotyping of the dopamine D4 receptor gene promoter regionEszter Szantai
Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, POB 260, Hungary 1444
Psychiatr Genet 15:259-70. 2005..Besides the accurate phenotype characterization, highly reliable genotyping methods are also of outstanding importance in these works... - [Analysis of the dopamine D4 receptor gene variants in attention deficit hyperactivity disorder]Eva Kereszturi
Semmelweis Egyetem, Orvosi Vegytani, Molekuláris Biológiai és Pathobiokémiai Intézet, Budapest
Neuropsychopharmacol Hung 9:11-8. 2007..01). These results of association and functional analyses suggest that the 1-repeat form of the 120 bp duplication might be a risk factor of ADHD... - Direct haplotype detection of adjacent polymorphic sites in the regulatory region of the dopamine D4 receptor (DRD4) geneZsolt Ronai
Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
Electrophoresis 23:1512-6. 2002..We have also demonstrated that the haplotypes of double heterozygotes for -521 C/T and for the 120 bp duplication can be clearly distinguished, that has only been possible previously by extensive pedigree analysis... - [Genetic factors in obsessive-compulsive disorder: summary of genetic studies]Eszter Kenézloi
Vadaskert Gyermekpszichiátriai Kóház és Szakambulancia, Budapest, Hungary
Psychiatr Hung 25:378-93. 2010..After an overview of the applied genetic methods, we will summarize the genetic results of the OCD literature, especially candidate gene association studies. Finally, we will outline the possible future trends in psychiatric genetics...