Jozsef Mandl

Summary

Affiliation: Semmelweis University
Country: Hungary

Publications

  1. pmc Vitamin C: update on physiology and pharmacology
    J Mandl
    Department of Medical Chemistry, Molecular Biology and Patobiochemistry, Semmelweis University Budapest, Budapest, Hungary
    Br J Pharmacol 157:1097-110. 2009
  2. ncbi request reprint [Endoplasmic reticulum stress--common pathomechanism of different diseases?]
    Jozsef Mandl
    Semmelweis Egyetem Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet Budapest Pf 260 1444
    Orv Hetil 148:1779-85. 2007
  3. ncbi request reprint Role of ascorbate in oxidative protein folding
    Gabor Banhegyi
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Biofactors 17:37-46. 2003
  4. ncbi request reprint Scurvy leads to endoplasmic reticulum stress and apoptosis in the liver of Guinea pigs
    Eva Margittai
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Endoplasmic Reticulum Research Group of The Hungarian Academy of Science, Budapest, Hungary
    J Nutr 135:2530-4. 2005
  5. ncbi request reprint Glutathione transport in the endo/sarcoplasmic reticulum
    Miklos Csala
    Department of Medical Chemistry, Pathobiochemistry and Molecular Biology, Semmelweis University, H 1444, Budapest, POB 260, Hungary
    Biofactors 17:27-35. 2003
  6. ncbi request reprint Ascorbyl free radical and dehydroascorbate formation in rat liver endoplasmic reticulum
    András Szarka
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    J Bioenerg Biomembr 34:317-23. 2002
  7. ncbi request reprint FAD transport and FAD-dependent protein thiol oxidation in rat liver microsomes
    Marianne Varsányi
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, 1444 Budapest, Hungary
    J Biol Chem 279:3370-4. 2004
  8. doi request reprint Maintenance of luminal NADPH in the endoplasmic reticulum promotes the survival of human neutrophil granulocytes
    Tamas Kardon
    Semmelweis Egyetem Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézete and MTA SE Patobiokémiai Kutatócsoport, Budapest, Hungary
    FEBS Lett 582:1809-15. 2008
  9. ncbi request reprint Influence of BGP-15, a nicotinic amidoxime derivative, on the vascularization and growth of murine hepatoma xenografts
    Tamas Kardon
    Department of Medical Chemistry, Semmelweis University, 1444 Budapest P O B 260, Hungary
    Anticancer Res 26:1023-8. 2006
  10. ncbi request reprint Characterization of sulfate transport in the hepatic endoplasmic reticulum
    Miklos Csala
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Endoplasmic Reticulum Research Group of The Hungarian Academy of Sciences, H 1444, Budapest, P O Box 260, Hungary
    Arch Biochem Biophys 440:173-80. 2005

Collaborators

Detail Information

Publications36

  1. pmc Vitamin C: update on physiology and pharmacology
    J Mandl
    Department of Medical Chemistry, Molecular Biology and Patobiochemistry, Semmelweis University Budapest, Budapest, Hungary
    Br J Pharmacol 157:1097-110. 2009
    ..The increasing knowledge of the functions of ascorbate and of its molecular sites of action can mechanistically substantiate a place for ascorbate in the treatment of various diseases...
  2. ncbi request reprint [Endoplasmic reticulum stress--common pathomechanism of different diseases?]
    Jozsef Mandl
    Semmelweis Egyetem Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet Budapest Pf 260 1444
    Orv Hetil 148:1779-85. 2007
    ..Understanding of ER stress related events can open new perspectives to improve the current therapy...
  3. ncbi request reprint Role of ascorbate in oxidative protein folding
    Gabor Banhegyi
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Biofactors 17:37-46. 2003
    ..g. tocopherol, ubiquinone, and vitamin K) in the electron transfer chain responsible for oxidative protein folding in the ER...
  4. ncbi request reprint Scurvy leads to endoplasmic reticulum stress and apoptosis in the liver of Guinea pigs
    Eva Margittai
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Endoplasmic Reticulum Research Group of The Hungarian Academy of Science, Budapest, Hungary
    J Nutr 135:2530-4. 2005
    ..Therefore, persistent ascorbate deficiency leads to ER stress, unfolded protein response, and apoptosis in the liver, suggesting that insufficient protein processing participates in the pathology of scurvy...
  5. ncbi request reprint Glutathione transport in the endo/sarcoplasmic reticulum
    Miklos Csala
    Department of Medical Chemistry, Pathobiochemistry and Molecular Biology, Semmelweis University, H 1444, Budapest, POB 260, Hungary
    Biofactors 17:27-35. 2003
    ..These findings strongly suggest that the ryanodine receptor channel activity is directly associated with glutathione transport activity in the skeletal muscle sarcoplasmic reticulum membrane...
  6. ncbi request reprint Ascorbyl free radical and dehydroascorbate formation in rat liver endoplasmic reticulum
    András Szarka
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    J Bioenerg Biomembr 34:317-23. 2002
    ..The results indicate the presence of a primary enzymatic ascorbate oxidation in rat liver endoplasmic reticulum which is able to generate dehydroascorbate, an important source of the oxidizing environment in the endoplasmic reticulum...
  7. ncbi request reprint FAD transport and FAD-dependent protein thiol oxidation in rat liver microsomes
    Marianne Varsányi
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, 1444 Budapest, Hungary
    J Biol Chem 279:3370-4. 2004
    ..These findings support the notion that, similar to yeast, free FAD may have a decisive role in the mechanism of oxidative protein folding in the endoplasmic reticulum lumen of mammalian cells...
  8. doi request reprint Maintenance of luminal NADPH in the endoplasmic reticulum promotes the survival of human neutrophil granulocytes
    Tamas Kardon
    Semmelweis Egyetem Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézete and MTA SE Patobiokémiai Kutatócsoport, Budapest, Hungary
    FEBS Lett 582:1809-15. 2008
    ..In conclusion, the maintenance of the luminal NADPH pool is an important antiapoptotic factor in neutrophil granulocytes...
  9. ncbi request reprint Influence of BGP-15, a nicotinic amidoxime derivative, on the vascularization and growth of murine hepatoma xenografts
    Tamas Kardon
    Department of Medical Chemistry, Semmelweis University, 1444 Budapest P O B 260, Hungary
    Anticancer Res 26:1023-8. 2006
    ..Previous observations suggested that nicotinic amidoxime derivatives (i.e. BGP-15) might interfere with the induction of hypoxia-sensitive genes. Hence, the effect of BGP-15 on angiogenesis was studied in Hepa 1c1c7 tumor xenografts...
  10. ncbi request reprint Characterization of sulfate transport in the hepatic endoplasmic reticulum
    Miklos Csala
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Endoplasmic Reticulum Research Group of The Hungarian Academy of Sciences, H 1444, Budapest, P O Box 260, Hungary
    Arch Biochem Biophys 440:173-80. 2005
    ..Our results indicate that sulfate fluxes in the endoplasmic reticulum are mediated by a novel, S3483-sensitive transport pathway(s)...
  11. ncbi request reprint FAD oxidizes the ERO1-PDI electron transfer chain: the role of membrane integrity
    Eszter Papp
    Department of Medical Chemistry, Semmelweis University, H 1088 Budapest, Hungary
    Biochem Biophys Res Commun 338:938-45. 2005
    ..Our findings prompt further studies to elucidate the membrane-dependent steps of PDI oxidation and the role of FAD in redox folding...
  12. doi request reprint BGP-15 inhibits caspase-independent programmed cell death in acetaminophen-induced liver injury
    Gabor Nagy
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, HAS Pathobiochemistry Research Group, H 1444 Budapest POB 260, Hungary
    Toxicol Appl Pharmacol 243:96-103. 2010
    ..In addition, pharmacological inhibition of AIF translocation may effectively protect against or at least delay acetaminophen-induced programmed cell death...
  13. ncbi request reprint Inhibition of hepatic glucose 6-phosphatase system by the green tea flavanol epigallocatechin gallate
    Miklos Csala
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Pathobiochemistry Research Group of The Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary
    FEBS Lett 581:1693-8. 2007
    ..Indeed, EGCG was found to inhibit microsomal glucose efflux. Since G6Pase activity is depressed by glucose in a concentration-dependent manner, we concluded that EGCG inhibits G6Pase through an elevated luminal glucose level...
  14. ncbi request reprint A novel insulin sensitizer drug candidate-BGP-15-can prevent metabolic side effects of atypical antipsychotics
    Zsuzsanna Literati-Nagy
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry Semmelweis University Budapest, Budapest, Hungary
    Pathol Oncol Res 18:1071-6. 2012
    ..Data indicate that this rat model is suitable to analyze the metabolic side effects of AAPDs and the protective mechanism of BGP-15...
  15. ncbi request reprint Translocon pores in the endoplasmic reticulum are permeable to small anions
    Beáta Lizák
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, PO Box 260, 1444 Budapest, Hungary
    Am J Physiol Cell Physiol 291:C511-7. 2006
    ..This pathway can contribute to the nonspecific substrate supply of enzymes with intraluminal active centers...
  16. doi request reprint Inhibition of glycoprotein synthesis in the endoplasmic reticulum as a novel anticancer mechanism of (-)-epigallocatechin-3-gallate
    Laura Konta
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University and MTA SE Pathobiochemistry Research Group, Budapest, Hungary
    Biofactors 37:468-76. 2011
    ..This mechanism provides a novel therapeutic approach in dermatology and might play an important role in the antitumor effect or hepatotoxicity of EGCG...
  17. doi request reprint Crosstalk and barriers between the electron carriers of the endoplasmic reticulum
    Gabor Banhegyi
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Antioxid Redox Signal 16:772-80. 2012
    ..Spatial and kinetic barriers contribute to the generation and maintenance of this special redox environment...
  18. ncbi request reprint Glucuronide transport across the endoplasmic reticulum membrane is inhibited by epigallocatechin gallate and other green tea polyphenols
    Katalin Révész
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Endoplasmic Reticulum Research Group of The Hungarian Academy of Sciences, Semmelweis University, H 1444 Budapest, P O Box 260, Hungary
    Int J Biochem Cell Biol 39:922-30. 2007
    ..This phenomenon might potentially contribute to the cancer-preventing dietary or pharmacological effect attributed to these catechins...
  19. doi request reprint Redox-based endoplasmic reticulum dysfunction in neurological diseases
    Gabor Banhegyi
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    J Neurochem 107:20-34. 2008
    ..The redox changes in the endoplasmic reticulum are integral parts of the pathomechanism of neurological diseases, either as causative agents, or as complications...
  20. ncbi request reprint Stress on redox
    Gabor Banhegyi
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, 1444 Budapest, POB 260, Hungary
    FEBS Lett 581:3634-40. 2007
    ..The aim of this minireview is to summarize the luminal redox systems and the redox sensing mechanisms of the endoplasmic reticulum...
  21. doi request reprint Natural mutations lead to enhanced proteasomal degradation of human Ncb5or, a novel flavoheme reductase
    Fanni S Kálmán
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, POB 260, 1444 Budapest, Hungary
    Biochimie 95:1403-10. 2013
    ..These data provide first evidence for natural mutations in NCB5OR gene resulting in decreased protein levels and hence having potential implications in human pathology...
  22. doi request reprint Inhibition of microsomal cortisol production by (-)-epigallocatechin-3-gallate through a redox shift in the endoplasmic reticulum--a potential new target for treating obesity-related diseases
    Péter Szelényi
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Biofactors 39:534-41. 2013
    ....
  23. ncbi request reprint Role of glutathione in the regulation of liver metabolism
    Jozsef Mandl
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Biofactors 17:21-6. 2003
  24. doi request reprint Synergic insulin sensitizing effect of rimonabant and BGP-15 in Zucker-obese rats
    Zsuzsanna Literati-Nagy
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Pathol Oncol Res 19:571-5. 2013
    ....
  25. doi request reprint The endoplasmic reticulum as the extracellular space inside the cell: role in protein folding and glycosylation
    Miklos Csala
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Antioxid Redox Signal 16:1100-8. 2012
    ..Transport of the required intermediates across the ER membrane and maintenance of the luminal redox conditions and Ca(2+) ion concentration are indispensable for appropriate protein maturation...
  26. ncbi request reprint Evidence for multiple glucuronide transporters in rat liver microsomes
    Miklos Csala
    Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland
    Biochem Pharmacol 68:1353-62. 2004
    ..These data also indicate that the size and/or shape of the aglycone rather than the glucuronic acid moiety per se is an important determinant of transporter specificity...
  27. pmc Participation of low molecular weight electron carriers in oxidative protein folding
    Eva Margittai
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Int J Mol Sci 10:1346-59. 2009
    ..This review focuses on the participation of small molecular weight redox compounds in oxidative protein folding...
  28. ncbi request reprint Optimization of important early ADME(T) parameters of NADPH oxidase-4 inhibitor molecules
    Gabor Borbely
    Pathobiochemistry Research Group of Hungarian Academy of Sciences, Department of Medical Chemistry, Semmelweis University, Budapest, Hungary
    Med Chem 8:174-81. 2012
    ....
  29. doi request reprint Endoplasmic reticulum: nutrient sensor in physiology and pathology
    Jozsef Mandl
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Trends Endocrinol Metab 20:194-201. 2009
    ..This review highlights the recent evidence that the ER has a prominent role in cellular adaptation, as well as in the pathomechanism of type 2 diabetes...
  30. doi request reprint A cellular stress-directed bistable switch controls the crosstalk between autophagy and apoptosis
    Orsolya Kapuy
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Tuzoltó utca 37 47, Budapest, H 1094, Hungary
    Mol Biosyst 9:296-306. 2013
    ..The presence of an additional positive feedback loop between Bcl2 and caspases helps to maintain the caspases activation by making the switch irreversible. Our results provide a framework for further experiments and modelling...
  31. doi request reprint Luminal accumulation of newly synthesized morphine-3-glucuronide in rat liver microsomal vesicles
    Katalin Révész
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Biofactors 39:271-8. 2013
    ..Accumulation of bulky glucuronides in the ER lumen might also play an important role in their targeting and in the control of biliary excretion...
  32. pmc The HSP co-inducer BGP-15 can prevent the metabolic side effects of the atypical antipsychotics
    Zsuzsanna Literati-Nagy
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Cell Stress Chaperones 17:517-21. 2012
    ..Taken together, our results indicate that BGP-15 inhibits multiple metabolic side effects of atypical antipsychotics, and this effect is likely to be related to its HSP co-inducing ability...
  33. doi request reprint UVB induces a biphasic response of HIF-1alpha in cultured human keratinocytes
    Livius Wunderlich
    Department of Medical Chemistry, Semmelweis University, Budapest, Hungary
    Exp Dermatol 17:335-42. 2008
    ..It is concluded that changes in HIF-1alpha expression underlie the alterations in expression of VEGF upon UVB irradiation. Our findings indicate the involvement of PI3K in UVB-mediated HIF-1alpha upregulation...
  34. ncbi request reprint Acetaminophen induces ER dependent signaling in mouse liver
    Gabor Nagy
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, 1444 Budapest POB 260, Hungary
    Arch Biochem Biophys 459:273-9. 2007
    ..The results show that intraluminal redox imbalance of the ER and consequential activation of signaling processes and proapoptotic events are involved in hepatocellular damage caused by AAP overdose...
  35. ncbi request reprint Uncoupled redox systems in the lumen of the endoplasmic reticulum. Pyridine nucleotides stay reduced in an oxidative environment
    Simona Piccirella
    Department of Medical Chemistry, Molecular Biology, and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    J Biol Chem 281:4671-7. 2006
    ..The results demonstrated the separate existence of two redox systems in the endoplasmic reticulum lumen, which explains the contemporary functioning of oxidative folding and of powerful reductive reactions...
  36. ncbi request reprint Ethanol-dependent induction of bilirubin UDP-glucuronosyl-transferase in rat liver is mediated by Kupffer cells
    Tamas Kardon
    Department of Medical Chemistry, Semmelweis University, Budapest, Hungary
    Life Sci 70:1205-12. 2002
    ..These results suggest that Kupffer cells play a major role in the mediation of ethanol-stimulated induction of UGT1A1 in liver parenchymal cells...