Research Topics
Species | Jozsef MandlSummaryAffiliation: Semmelweis University Country: Hungary Publications
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Publications
[Endoplasmic reticulum stress--common pathomechanism of different diseases?]Jozsef Mandl
Semmelweis Egyetem Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet Budapest Pf 260 1444
Orv Hetil 148:1779-85. 2007..Understanding of ER stress related events can open new perspectives to improve the current therapy...
Vitamin C: update on physiology and pharmacologyJ Mandl
Department of Medical Chemistry, Molecular Biology and Patobiochemistry, Semmelweis University Budapest, Budapest, Hungary
Br J Pharmacol 157:1097-110. 2009..The increasing knowledge of the functions of ascorbate and of its molecular sites of action can mechanistically substantiate a place for ascorbate in the treatment of various diseases...- Role of ascorbate in oxidative protein foldingGabor Banhegyi
Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
Biofactors 17:37-46. 2003..g. tocopherol, ubiquinone, and vitamin K) in the electron transfer chain responsible for oxidative protein folding in the ER... - Glutathione transport in the endo/sarcoplasmic reticulumMiklos Csala
Department of Medical Chemistry, Pathobiochemistry and Molecular Biology, Semmelweis University, H 1444, Budapest, POB 260, Hungary
Biofactors 17:27-35. 2003..These findings strongly suggest that the ryanodine receptor channel activity is directly associated with glutathione transport activity in the skeletal muscle sarcoplasmic reticulum membrane... - Ascorbyl free radical and dehydroascorbate formation in rat liver endoplasmic reticulumAndrás Szarka
Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
J Bioenerg Biomembr 34:317-23. 2002..The results indicate the presence of a primary enzymatic ascorbate oxidation in rat liver endoplasmic reticulum which is able to generate dehydroascorbate, an important source of the oxidizing environment in the endoplasmic reticulum... - Characterization of sulfate transport in the hepatic endoplasmic reticulumMiklos Csala
Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Endoplasmic Reticulum Research Group of The Hungarian Academy of Sciences, H 1444, Budapest, P O Box 260, Hungary
Arch Biochem Biophys 440:173-80. 2005..Our results indicate that sulfate fluxes in the endoplasmic reticulum are mediated by a novel, S3483-sensitive transport pathway(s)... 
Maintenance of luminal NADPH in the endoplasmic reticulum promotes the survival of human neutrophil granulocytesTamas Kardon
Semmelweis Egyetem Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézete and MTA SE Patobiokémiai Kutatócsoport, Budapest, Hungary
FEBS Lett 582:1809-15. 2008..In conclusion, the maintenance of the luminal NADPH pool is an important antiapoptotic factor in neutrophil granulocytes...- FAD transport and FAD-dependent protein thiol oxidation in rat liver microsomesMarianne Varsányi
Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, 1444 Budapest, Hungary
J Biol Chem 279:3370-4. 2004..These findings support the notion that, similar to yeast, free FAD may have a decisive role in the mechanism of oxidative protein folding in the endoplasmic reticulum lumen of mammalian cells... - Inhibition of hepatic glucose 6-phosphatase system by the green tea flavanol epigallocatechin gallateMiklos Csala
Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Pathobiochemistry Research Group of The Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary
FEBS Lett 581:1693-8. 2007..Indeed, EGCG was found to inhibit microsomal glucose efflux. Since G6Pase activity is depressed by glucose in a concentration-dependent manner, we concluded that EGCG inhibits G6Pase through an elevated luminal glucose level... - BGP-15 inhibits caspase-independent programmed cell death in acetaminophen-induced liver injuryGabor Nagy
Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, HAS Pathobiochemistry Research Group, H 1444 Budapest POB 260, Hungary
Toxicol Appl Pharmacol 243:96-103. 2010..In addition, pharmacological inhibition of AIF translocation may effectively protect against or at least delay acetaminophen-induced programmed cell death... - Translocon pores in the endoplasmic reticulum are permeable to small anionsBeáta Lizák
Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, PO Box 260, 1444 Budapest, Hungary
Am J Physiol Cell Physiol 291:C511-7. 2006..This pathway can contribute to the nonspecific substrate supply of enzymes with intraluminal active centers... - Influence of BGP-15, a nicotinic amidoxime derivative, on the vascularization and growth of murine hepatoma xenograftsTamas Kardon
Department of Medical Chemistry, Semmelweis University, 1444 Budapest P O B 260, Hungary
Anticancer Res 26:1023-8. 2006..Previous observations suggested that nicotinic amidoxime derivatives (i.e. BGP-15) might interfere with the induction of hypoxia-sensitive genes. Hence, the effect of BGP-15 on angiogenesis was studied in Hepa 1c1c7 tumor xenografts... - Crosstalk and barriers between the electron carriers of the endoplasmic reticulumGabor Banhegyi
Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
Antioxid Redox Signal 16:772-80. 2012..RECENT ADVANCES: The ER redox has usually been considered from the perspective of oxidative protein folding, one of the major functions of the ER. Thus, the lumen has been described as a relatively oxidizing subcellular compartment... - Inhibition of glycoprotein synthesis in the endoplasmic reticulum as a novel anticancer mechanism of (-)-epigallocatechin-3-gallateLaura Konta
Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University and MTA SE Pathobiochemistry Research Group, Budapest, Hungary
Biofactors 37:468-76. 2011..This mechanism provides a novel therapeutic approach in dermatology and might play an important role in the antitumor effect or hepatotoxicity of EGCG... - Stress on redoxGabor Banhegyi
Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, 1444 Budapest, POB 260, Hungary
FEBS Lett 581:3634-40. 2007..The aim of this minireview is to summarize the luminal redox systems and the redox sensing mechanisms of the endoplasmic reticulum... - Glucuronide transport across the endoplasmic reticulum membrane is inhibited by epigallocatechin gallate and other green tea polyphenolsKatalin Révész
Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Endoplasmic Reticulum Research Group of The Hungarian Academy of Sciences, Semmelweis University, H 1444 Budapest, P O Box 260, Hungary
Int J Biochem Cell Biol 39:922-30. 2007..This phenomenon might potentially contribute to the cancer-preventing dietary or pharmacological effect attributed to these catechins... - Redox-based endoplasmic reticulum dysfunction in neurological diseasesGabor Banhegyi
Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
J Neurochem 107:20-34. 2008..The redox changes in the endoplasmic reticulum are integral parts of the pathomechanism of neurological diseases, either as causative agents, or as complications... - Role of glutathione in the regulation of liver metabolismJozsef Mandl
Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
Biofactors 17:21-6. 2003 - The endoplasmic reticulum as the extracellular space inside the cell: role in protein folding and glycosylationMiklos Csala
Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
Antioxid Redox Signal 16:1100-8. 2012..RECENT ADVANCES: Cooperation of enzymes and transporters to maintain a thiol-oxidizing milieu in the ER lumen has been recently elucidated. Ca(2+)-dependence of certain ER chaperones is a subject of intensive research... - A novel insulin sensitizer drug candidate-BGP-15-can prevent metabolic side effects of atypical antipsychoticsZsuzsanna Literati-Nagy
Department of Medical Chemistry, Molecular Biology and Pathobiochemistry Semmelweis University Budapest, Budapest, Hungary
Pathol Oncol Res 18:1071-6. 2012..Data indicate that this rat model is suitable to analyze the metabolic side effects of AAPDs and the protective mechanism of BGP-15... - Evidence for multiple glucuronide transporters in rat liver microsomesMiklos Csala
Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland
Biochem Pharmacol 68:1353-62. 2004..These data also indicate that the size and/or shape of the aglycone rather than the glucuronic acid moiety per se is an important determinant of transporter specificity... - Optimization of important early ADME(T) parameters of NADPH oxidase-4 inhibitor moleculesGabor Borbely
Pathobiochemistry Research Group of Hungarian Academy of Sciences, Department of Medical Chemistry, Semmelweis University, Budapest, Hungary
Med Chem 8:174-81. 2012.... - Endoplasmic reticulum: nutrient sensor in physiology and pathologyJozsef Mandl
Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
Trends Endocrinol Metab 20:194-201. 2009..This review highlights the recent evidence that the ER has a prominent role in cellular adaptation, as well as in the pathomechanism of type 2 diabetes... - The HSP co-inducer BGP-15 can prevent the metabolic side effects of the atypical antipsychoticsZsuzsanna Literati-Nagy
Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
Cell Stress Chaperones 17:517-21. 2012..Taken together, our results indicate that BGP-15 inhibits multiple metabolic side effects of atypical antipsychotics, and this effect is likely to be related to its HSP co-inducing ability... - UVB induces a biphasic response of HIF-1alpha in cultured human keratinocytesLivius Wunderlich
Department of Medical Chemistry, Semmelweis University, Budapest, Hungary
Exp Dermatol 17:335-42. 2008..It is concluded that changes in HIF-1alpha expression underlie the alterations in expression of VEGF upon UVB irradiation. Our findings indicate the involvement of PI3K in UVB-mediated HIF-1alpha upregulation... - Acetaminophen induces ER dependent signaling in mouse liverGabor Nagy
Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, 1444 Budapest POB 260, Hungary
Arch Biochem Biophys 459:273-9. 2007..The results show that intraluminal redox imbalance of the ER and consequential activation of signaling processes and proapoptotic events are involved in hepatocellular damage caused by AAP overdose... - A cellular stress-directed bistable switch controls the crosstalk between autophagy and apoptosisOrsolya Kapuy
Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Tuzoltó utca 37 47, Budapest, H 1094, Hungary
Mol Biosyst 9:296-306. 2013..The presence of an additional positive feedback loop between Bcl2 and caspases helps to maintain the caspases activation by making the switch irreversible. Our results provide a framework for further experiments and modelling... - Uncoupled redox systems in the lumen of the endoplasmic reticulum. Pyridine nucleotides stay reduced in an oxidative environmentSimona Piccirella
Department of Medical Chemistry, Molecular Biology, and Pathobiochemistry, Semmelweis University, Budapest, Hungary
J Biol Chem 281:4671-7. 2006..The results demonstrated the separate existence of two redox systems in the endoplasmic reticulum lumen, which explains the contemporary functioning of oxidative folding and of powerful reductive reactions... - Ethanol-dependent induction of bilirubin UDP-glucuronosyl-transferase in rat liver is mediated by Kupffer cellsTamas Kardon
Department of Medical Chemistry, Semmelweis University, Budapest, Hungary
Life Sci 70:1205-12. 2002..These results suggest that Kupffer cells play a major role in the mediation of ethanol-stimulated induction of UGT1A1 in liver parenchymal cells... - Scurvy leads to endoplasmic reticulum stress and apoptosis in the liver of Guinea pigsEva Margittai
Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Endoplasmic Reticulum Research Group of The Hungarian Academy of Science, Budapest, Hungary
J Nutr 135:2530-4. 2005..Therefore, persistent ascorbate deficiency leads to ER stress, unfolded protein response, and apoptosis in the liver, suggesting that insufficient protein processing participates in the pathology of scurvy... - FAD oxidizes the ERO1-PDI electron transfer chain: the role of membrane integrityEszter Papp
Department of Medical Chemistry, Semmelweis University, H-1088 Budapest, Hungary
Biochem Biophys Res Commun 338:938-45. 2005..Our findings prompt further studies to elucidate the membrane-dependent steps of PDI oxidation and the role of FAD in redox folding...