Peter Laszlo Lakatos

Summary

Affiliation: Semmelweis University
Country: Hungary

Publications

  1. doi request reprint Environmental factors affecting inflammatory bowel disease: have we made progress?
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, HU 1083 Budapest, Hungary
    Dig Dis 27:215-25. 2009
  2. pmc Current status of thiopurine analogues in the treatment in Crohn's disease
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, Koranyi, Budapest, Hungary
    World J Gastroenterol 17:4372-81. 2011
  3. doi request reprint Has there been a change in the natural history of Crohn's disease? Surgical rates and medical management in a population-based inception cohort from Western Hungary between 1977-2009
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, Budapest, Hungary
    Am J Gastroenterol 107:579-88. 2012
  4. pmc Efficacy and safety of infliximab induction therapy in Crohn's Disease in Central Europe--a Hungarian nationwide observational study
    Pal Miheller
    2nd Department of Medicine, Semmelweis University, Budapest, Hungary
    BMC Gastroenterol 9:66. 2009
  5. ncbi request reprint Is there a benefit from the concomitant use of immunosupression with anti-TNF in Crohn's disease; heads or tails?
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, Budapest, Hungary
    Rev Recent Clin Trials 4:152-8. 2009
  6. doi request reprint [Prediction of the disease course in inflammatory bowel diseases]
    Lajos Sandor Kiss
    Semmelweis Egyetem, Altalános Orvostudományi Kar I Belgyógyászati Klinika Budapest
    Orv Hetil 151:293-301. 2010
  7. ncbi request reprint [Double-balloon endoscopy for the diagnosis and treatment of small intestinal disease: an initial experience from 25 examinations]
    Peter Laszlo Lakatos
    Általános Orvostudományi Kar, I Belgyógyászati Klinika, Budapest
    Orv Hetil 147:1939-44. 2006
  8. ncbi request reprint Recent trends in the epidemiology of inflammatory bowel diseases: up or down?
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, Koranyi str 2 A, H 1083, Hungary
    World J Gastroenterol 12:6102-8. 2006
  9. ncbi request reprint Double-balloon endoscopy for small intestinal disease: a single-center experience in Hungary
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, Budapest, Hungary
    Med Sci Monit 16:MT22-27. 2010
  10. ncbi request reprint DLG5 R30Q is not associated with IBD in Hungarian IBD patients but predicts clinical response to steroids in Crohn's disease
    Peter Laszlo Lakatos
    First Department of Medicine, Semmelweis University, Budapest, Hungary
    Inflamm Bowel Dis 12:362-8. 2006

Detail Information

Publications79

  1. doi request reprint Environmental factors affecting inflammatory bowel disease: have we made progress?
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, HU 1083 Budapest, Hungary
    Dig Dis 27:215-25. 2009
    ..This review article focuses on the role of environmental factors in the pathogenesis and progression of IBDs...
  2. pmc Current status of thiopurine analogues in the treatment in Crohn's disease
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, Koranyi, Budapest, Hungary
    World J Gastroenterol 17:4372-81. 2011
    ..In this review, the authors try to highlight new evidence on the optimal timing, benefits, and risks of immunosuppressants alone, or in combination, in patients with Crohn's disease...
  3. doi request reprint Has there been a change in the natural history of Crohn's disease? Surgical rates and medical management in a population-based inception cohort from Western Hungary between 1977-2009
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, Budapest, Hungary
    Am J Gastroenterol 107:579-88. 2012
    ..The objective of this study was to analyze the evolution of the surgical rates and medical therapy in the population-based Veszprem province database...
  4. pmc Efficacy and safety of infliximab induction therapy in Crohn's Disease in Central Europe--a Hungarian nationwide observational study
    Pal Miheller
    2nd Department of Medicine, Semmelweis University, Budapest, Hungary
    BMC Gastroenterol 9:66. 2009
    ..Our objective in this study is to report the nationwide, multicenter experience with IFX induction therapy for CD in Hungary...
  5. ncbi request reprint Is there a benefit from the concomitant use of immunosupression with anti-TNF in Crohn's disease; heads or tails?
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, Budapest, Hungary
    Rev Recent Clin Trials 4:152-8. 2009
    ..The aim of this review is to summarize the benefits and risks for the use combination therapy with TNF-alpha inhibitors in the treatment of Crohn's disease...
  6. doi request reprint [Prediction of the disease course in inflammatory bowel diseases]
    Lajos Sandor Kiss
    Semmelweis Egyetem, Altalános Orvostudományi Kar I Belgyógyászati Klinika Budapest
    Orv Hetil 151:293-301. 2010
    ....
  7. ncbi request reprint [Double-balloon endoscopy for the diagnosis and treatment of small intestinal disease: an initial experience from 25 examinations]
    Peter Laszlo Lakatos
    Általános Orvostudományi Kar, I Belgyógyászati Klinika, Budapest
    Orv Hetil 147:1939-44. 2006
    ..Our aim was to report our early experience with the Fujinon EN-450 T5 therapeutic double-balloon endoscope...
  8. ncbi request reprint Recent trends in the epidemiology of inflammatory bowel diseases: up or down?
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, Koranyi str 2 A, H 1083, Hungary
    World J Gastroenterol 12:6102-8. 2006
    ..The quality of studies is also variable. Additional epidemiologic studies are needed to better define the burden of illness, explore the mechanism of association with environmental factors, and identify new risk factors...
  9. ncbi request reprint Double-balloon endoscopy for small intestinal disease: a single-center experience in Hungary
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, Budapest, Hungary
    Med Sci Monit 16:MT22-27. 2010
    ..We report on our experience with the Fujinon EN-450 T5 therapeutic double-balloon endoscope (DBE) and compare our findings with the results of earlier capsule endoscopy...
  10. ncbi request reprint DLG5 R30Q is not associated with IBD in Hungarian IBD patients but predicts clinical response to steroids in Crohn's disease
    Peter Laszlo Lakatos
    First Department of Medicine, Semmelweis University, Budapest, Hungary
    Inflamm Bowel Dis 12:362-8. 2006
    ..In view of the geographical differences in frequency of genetic markers and the absence of data in Central European patients, our aim was to determine the DLG5 R30Q variant in Hungarian IBD patients...
  11. ncbi request reprint Development of multiple myeloma in a patient with chronic hepatitis C: A case report and review of the literature
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, Koranyi str 2 A, H 1083, Hungary
    World J Gastroenterol 12:2297-300. 2006
    ..Although a pathogenic role of HCV infection in malignant lymphoproliferative disorders has not been established, NHL and possibly MM may develop in CHC patients, supporting a role of a complex follow-up in these patients...
  12. ncbi request reprint Is there an increased risk of lymphoma and malignancies under anti-TNF therapy in IBD?
    P L Lakatos
    1st Department of Medicine, Semmelweis University, Koranyi st 2 A, H 1083 Hungary
    Curr Drug Targets 11:179-86. 2010
    ..The aim of this review is to summarize the available evidence on the association between malignancy and anti-TNF treatment in IBD...
  13. doi request reprint Ulcerative proctitis: a review of pharmacotherapy and management
    Peter Laszlo Lakatos
    Semmelweis University, First Department of Medicine, H1083 Budapest, Koranyi S 2A, Hungary
    Expert Opin Pharmacother 9:741-9. 2008
    ..Ulcerative proctitis (UP) is a common presentation of ulcerative colitis (UC)...
  14. doi request reprint Interaction between seroreactivity to microbial antigens and genetics in Crohn's disease: is there a role for defensins?
    P L Lakatos
    1st Department of Medicine, Semmelweis University, Budapest, Hungary
    Tissue Antigens 71:552-9. 2008
    ..We found that variants in human beta-defensin 1 gene are inversely associated with antiglycan antibodies, further confirming an important role for innate immunity in the pathogenesis of CD...
  15. doi request reprint [Anti-TNF-alpha therapy in ulcerative colitis]
    Peter Laszlo Lakatos
    Semmelweis Egyetem, Általános Orvostudományi Kar I Belgyógyászati Klinika Budapest Korányi S u 2 A 1083
    Orv Hetil 149:921-7. 2008
    ..The aim of this paper is to review the rationale for the use of TNF-alpha inhibitors in the treatment of UC...
  16. pmc Perianal disease, small bowel disease, smoking, prior steroid or early azathioprine/biological therapy are predictors of disease behavior change in patients with Crohn's disease
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, Koranyi str 2 A, H 1083 Budapest, Hungary
    World J Gastroenterol 15:3504-10. 2009
    ..To assess the combined effect of disease phenotype, smoking and medical therapy [steroid, azathioprine (AZA), AZA/biological therapy] on the probability of disease behavior change in a Caucasian cohort of patients with Crohn's disease (CD)...
  17. pmc Use of new once-daily 5-aminosalicylic acid preparations in the treatment of ulcerative colitis: Is there anything new under the sun?
    Peter Laszlo Lakatos
    World J Gastroenterol 15:1799-804. 2009
    ..This editorial summarizes the available literature on the short- and medium-term efficacy and safety of the new once-daily mesalazine formulations...
  18. pmc Prevalence, predictors, and clinical consequences of medical adherence in IBD: how to improve it?
    Peter Laszlo Lakatos
    World J Gastroenterol 15:4234-9. 2009
    ..This editorial summarizes the available literature on frequency, predictors, clinical consequences, and strategies for improving medical adherence in patients with IBD...
  19. doi request reprint Pancreatic autoantibodies are associated with reactivity to microbial antibodies, penetrating disease behavior, perianal disease, and extraintestinal manifestations, but not with NOD2/CARD15 or TLR4 genotype in a Hungarian IBD cohort
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, Budapest, Hungary
    Inflamm Bowel Dis 15:365-74. 2009
    ..Our aim was to determine the accuracy of PAB and GAB autoantibodies as well as to study relevant phenotype-serotype associations...
  20. doi request reprint Once daily 5-aminosalicylic acid for the treatment of ulcerative colitis; are we there yet?
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, Koranyi S 2A, H 1083 Budapest, Hungary
    Pharmacol Res 58:190-5. 2008
    ..In this systematic review, the authors summarize the available literature on the short- and medium-term efficacy and safety of the new once daily mesalazine formulations...
  21. ncbi request reprint Double-balloon enteroscopy for the diagnosis and treatment of obscure bleeding, inflammatory bowel diseases and polyposis syndromes: we see more but do we know more?
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, Budapest, Hungary
    Hepatogastroenterology 55:133-7. 2008
    ..Our aim was to report our experience with the Fujinon EN-450 T5 therapeutic double-balloon endoscope (DBE) in the diagnosis of small bowel diseases...
  22. doi request reprint ATG16L1 and IL23 receptor (IL23R) genes are associated with disease susceptibility in Hungarian CD patients
    P L Lakatos
    1st Department of Medicine, Semmelweis University, Budapest, Hungary
    Dig Liver Dis 40:867-73. 2008
    ..The aims of this study were to investigate the association and examine genotype-phenotype relationships in a Hungarian IBD cohort...
  23. ncbi request reprint [Current concepts in the genetics of hereditary and sporadic colorectal cancer and the role of genetics in patient management. Hereditary colorectal cancers]
    Peter Laszlo Lakatos
    Semmelweis Egyetem, Általános Orvostudományi Kar, I Belgyógyászati Klinika, Budapest
    Orv Hetil 147:363-8. 2006
    ..Due to the high number of mutation genetic testing is difficult in HNPCC families and colonoscopic screening should be advised to affected families...
  24. ncbi request reprint [Current concepts in the genetics of hereditary and sporadic colorectal cancer and the role of genetics in clinical practice: sporadic and IBD-associated colorectal tumors, significance of genetic tests in diagnosis, prognosis and assessment of chemothera
    Peter Laszlo Lakatos
    Semmelweis Egyetem, Általános Orvostudományi Kar, I Belgyógyászati Klinika, Budapest
    Orv Hetil 147:449-55. 2006
    ..Similarly, genetic investigation may play an increasing role in the prediction of prognosis, therapy and complication of chemotherapy. A more distant goal may be the individualization of the therapy...
  25. ncbi request reprint Insulin-like growth factor I gene microsatellite repeat, collagen type Ialpha1 gene Sp1 polymorphism, and bone disease in primary biliary cirrhosis
    Peter Laszlo Lakatos
    First Department of Medicine, Semmelweis University, Budapest
    Eur J Gastroenterol Hepatol 16:753-9. 2004
    ..IGF-I treatment restored osteopenia and reduced fibrogenesis in experimental cirrhosis. We investigated IGF-I and COLIA1 gene polymorphisms and bone mineral density in Hungarian primary biliary cirrhosis patients...
  26. doi request reprint IBD in the elderly population: results from a population-based study in Western Hungary, 1977-2008
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, Budapest, Hungary
    J Crohns Colitis 5:5-13. 2011
    ....
  27. ncbi request reprint [Familial adenomatous polyposis coli--case report]
    Peter Laszlo Lakatos
    Semmelweis Egyetem, Általános Orvostudományi Kar, I Belgyógyászati Klinika, Budapest
    Orv Hetil 145:813-7. 2004
    ....
  28. ncbi request reprint [Decreased bone mineral density and gene polymorphism in primary biliary cirrhosis]
    Peter Laszlo Lakatos
    Semmelweis Egyetem, Általános Orvostudományi Kar, I sz Belgyógyászati Klinika, Budapest
    Orv Hetil 145:331-6. 2004
    ..IGF-I treatment restored osteopenia and reduced fibrogenesis in experimental cirrhosis. We investigated IGF-I and COLIA1 gene polymorphisms and BMD in Hungarian PBC patients...
  29. doi request reprint Risk of colorectal cancer and small bowel adenocarcinoma in Crohn's disease: a population-based study from western Hungary 1977-2008
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, Budapest, Hungary
    J Crohns Colitis 5:122-8. 2011
    ....
  30. doi request reprint Nutritional influences in selected gastrointestinal diseases
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, Budapest, Hungary
    Dig Dis 29:154-65. 2011
    ..g. recall bias, heterogeneity between collected data, lack of correction for covariates, difficulties in double blinding)...
  31. ncbi request reprint [Incidence and pathologic distribution of esophageal cancers at the gastro-esophageal junction between 1993-2003]
    Peter Laszlo Lakatos
    Semmelweis Egyetem, Általános Orvostudományi Kar, I Belgyógyászati Klinika, Budapest
    Orv Hetil 146:411-6. 2005
    ..As no Hungarian data is available, the authors' aim was to investigate the prevalence and histology of oesophageal and gastrooesophageal junction cancers in the last decade...
  32. ncbi request reprint Vitamin D receptor, oestrogen receptor-alpha gene and interleukin-1 receptor antagonist gene polymorphisms in Hungarian patients with primary biliary cirrhosis
    László P Lakatos
    1st Department of Internal Medicine, Semmelweis University, Koranyi str 2 A, H 1083 Budapest, Hungary
    Eur J Gastroenterol Hepatol 14:733-40. 2002
    ..We investigated the polymorphisms of the above genes and bone disease in Hungarian patients with primary biliary cirrhosis...
  33. doi request reprint Association of adherence to therapy and complementary and alternative medicine use with demographic factors and disease phenotype in patients with inflammatory bowel disease
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, Budapest, Hungary
    J Crohns Colitis 4:283-90. 2010
    ..Furthermore, a significant number of IBD patients fail to comply with treatment. The aim of our study was to evaluate the prevalence of non-adherence and the use of CAM in Hungarian patients with IBD...
  34. doi request reprint Serum lipopolysaccharide-binding protein and soluble CD14 are markers of disease activity in patients with Crohn's disease
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, Budapest, Hungary
    Inflamm Bowel Dis 17:767-77. 2011
    ....
  35. ncbi request reprint Clinical presentation of Crohn's disease. association between familial disease, smoking, disease phenotype, extraintestinal manifestations and need for surgery
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, Budapest
    Hepatogastroenterology 52:817-22. 2005
    ..It was also suggested that familial inflammatory bowel disease (IBD) is a homogenous subgroup, phenotypically different from sporadic disease. Our aim was to determine the clinical presentation in a large CD population...
  36. pmc Is the disease course predictable in inflammatory bowel diseases?
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, H 1083 Budapest, Koranyi S 2A, Hungary
    World J Gastroenterol 16:2591-9. 2010
    ..This review summarizes the available evidence on clinical, endoscopic variables and biomarkers in the prediction of short and long-term outcome in patients with inflammatory bowel diseases...
  37. ncbi request reprint Toll-like receptor 4 and NOD2/CARD15 mutations in Hungarian patients with Crohn's disease: phenotype-genotype correlations
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, Koranyi str 2 A, H 1083, Hungary
    World J Gastroenterol 11:1489-95. 2005
    ..To determine common NOD2/CARD15 mutations and TLR4 D299G polymorphism in Hungarian patients with CD...
  38. ncbi request reprint Mucocele of the appendix: an unusual cause of lower abdominal pain in a patient with ulcerative colitis. A case report and review of literature
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, Budapest, Hungary
    World J Gastroenterol 11:457-9. 2005
    ..Although primary adenocarcinoma of the appendix is uncommon, the authors emphasize that preoperative diagnosis of an underlying malignancy in a mucocele is important for patient management; however, it is difficult on imaging studies...
  39. ncbi request reprint Risk factors for ulcerative colitis-associated colorectal cancer in a Hungarian cohort of patients with ulcerative colitis: results of a population-based study
    Laszlo Lakatos
    1st Department of Medicine, Csolnoky F County Hospital, Veszprem, Hungary
    Inflamm Bowel Dis 12:205-11. 2006
    ..The risk depends primarily on the duration and extent of disease. The aim of this study was to identify the risk factors for and the epidemiology of CRC in Hungarian patients with UC...
  40. doi request reprint [The effect of early immunosuppressive therapy on the rate of resections performed in patients with Chron's disease, in Veszprém county, Hungary, a population-based cohort study]
    Petra Anna Golovics
    Semmelweis Egyetem, Általános Orvostudományi Kar I Belgyógyászati Klinika Budapest Korányi S u 2 A 1083
    Orv Hetil 153:541-52. 2012
    ..In contrast, surgery rates are still high and evidence about the the changes in the outcome of Crohn's disease over the past decades is scarce...
  41. doi request reprint [Predictors of efficacy, mucosal healing and dose intensification during the first year of adalimumab therapy in patients with luminal and fistulizing Crohn's disease. National data from Hungary]
    Lajos Sandor Kiss
    Semmelweis Egyetem, Altalános Orvostudományi Kar I Belgyógyászati Klinika Budapest
    Orv Hetil 152:1433-42. 2011
    ....
  42. ncbi request reprint [Change in location of colorectal cancer in Hungarian patients between 1993-2004]
    Peter Fuszek
    Általános Orvostudományi Kar, I Belgyógyászati Klinika, Budapest
    Orv Hetil 147:741-6. 2006
    ..Our aim was to investigate the prevalence, location and histology of colorectal cancers in the last twelve years in Hungarian patients...
  43. pmc Evolution of disease phenotype in adult and pediatric onset Crohn's disease in a population-based cohort
    Barbara Dorottya Lovász
    First Department of Medicine, Semmelweis University, H 1083 Budapest, Hungary
    World J Gastroenterol 19:2217-26. 2013
    ..To investigate the evolution of disease phenotype in adult and pediatric onset Crohn's disease (CD) populations, diagnosed between 1977 and 2008...
  44. ncbi request reprint [Significance of serum calcium levels in colorectal cancer]
    Peter Fuszek
    Semmelweis Egyetem, Általános Orvostudományi Kar, I Belgyógyászati Klinika, Budapest
    Orv Hetil 145:1561-5. 2004
    ..According to the most recent results, the serum calcium level is mainly determined by genetic factors. One of the key elements of this is calcium-sensing receptor...
  45. ncbi request reprint Novel mutations of the ATP7B gene among 109 Hungarian patients with Wilson's disease
    Aniko Folhoffer
    First Department of Internal Medicine, Semmelweis University, Budapest, Hungary
    Eur J Gastroenterol Hepatol 19:105-11. 2007
    ..The aim of the present study was to assess the impact of genetic testing for diagnosis of the disease in a large cohort (n=109) from Hungary...
  46. ncbi request reprint Serum leptin, soluble leptin receptor, free leptin index and bone mineral density in patients with primary biliary cirrhosis
    Ferenc Szalay
    1st Department of Medicine, Semmelweis University, Budapest, Hungary
    Eur J Gastroenterol Hepatol 17:923-8. 2005
    ..We investigated the relationship between serum leptin levels, soluble leptin receptor (sOB-R), free leptin index (FLI) and BMD in patients with primary biliary cirrhosis (PBC)...
  47. doi request reprint Early azathioprine/biological therapy is associated with decreased risk for first surgery and delays time to surgery but not reoperation in both smokers and nonsmokers with Crohn's disease, while smoking decreases the risk of colectomy in ulcerative colit
    Tamas Szamosi
    Department of Gastroenterology, State Health Centre, Budapest, Hungary
    Eur J Gastroenterol Hepatol 22:872-9. 2010
    ..Our aim was to assess the combined effect of disease phenotype, smoking, and immunomodulator [azathioprine (AZA), AZA/biological] treatment on the risk of intestinal resection/reoperation in CD and colectomy in UC...
  48. ncbi request reprint Location and age at onset of colorectal cancer in Hungarian patients between 1993 and 2004. The high number of advanced cases supports the need for a colorectal cancer screening program in Hungary
    Peter Fuszek
    First Department of Medicine, Semmelweis University, Budapest, Hungary
    Anticancer Res 26:527-31. 2006
    ..Our aim was to investigate the change in age at diagnosis, the gender, location and cancer stage of CRC cases over the last 12 years in a large number of Hungarian patients...
  49. doi request reprint The 3'UTR NFKBIA variant is associated with extensive colitis in Hungarian IBD patients
    Tamas Szamosi
    1st Department of Medicine, Semmelweis University, Koranyi st 2 A, 1083, Budapest, Hungary
    Dig Dis Sci 54:351-9. 2009
    ..The aim of our study was to investigate these two polymorphisms and patients' response to medical therapy and/or disease phenotype in Hungarian inflammatory bowel disease (IBD) patients...
  50. ncbi request reprint ATP-binding cassette transporter ABCG2 (BCRP) and ABCB1 (MDR1) variants are not associated with disease susceptibility, disease phenotype response to medical therapy or need for surgeryin Hungarian patients with inflammatory bowel diseases
    Simon Fischer
    1st Department of Medicine, Semmelweis University, Budapest, Hungary
    Scand J Gastroenterol 42:726-33. 2007
    ....
  51. pmc Common NOD2/CARD15 variants are not associated with susceptibility or the clinicopathologic characteristics of sporadic colorectal cancer in Hungarian patients
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, Budapest, Hungary
    BMC Cancer 7:54. 2007
    ..Recently, NOD2/CARD15 has been associated with a risk for CRC in some studies, which stemmed from ethnically diverse populations. Our aim was to identify common NOD2/CARD15 mutations in Hungarian patients with sporadic CRC...
  52. ncbi request reprint Striking elevation in incidence and prevalence of inflammatory bowel disease in a province of western Hungary between 1977-2001
    Laszlo Lakatos
    1st Department of Medicine, Csolnoky F Province Hospital, Veszprem, Hungary
    World J Gastroenterol 10:404-9. 2004
    ..An investigation into inflammatory bowel disease and colorectal cancer in Veszprem Province was conducted from 1977 to 2001...
  53. ncbi request reprint High serum osteoprotegerin and low RANKL in primary biliary cirrhosis
    Ferenc Szalay
    1st Department of Medicine, Semmelweis University, Koranyi st 2 A, H 1083 Budapest, Hungary
    J Hepatol 38:395-400. 2003
    ..Since osteoporosis is common in primary biliary cirrhosis (PBC), we investigated osteoprotegerin, RANKL and markers of bone turnover in PBC...
  54. pmc Is early limited surgery associated with a more benign disease course in Crohn's disease?
    Petra Anna Golovics
    Petra Anna Golovics, Barbara Dorottya Lovasz, Michael Mandel, Lajos Sandor Kiss, Zsuzsanna Vegh, Peter Laszlo Lakatos, First Department of Medicine, Semmelweis University, H 1083 Budapest, Hungary
    World J Gastroenterol 19:7701-10. 2013
    ..To analyze the difference in disease course and need for surgery in patients with Crohn's disease (CD)...
  55. ncbi request reprint Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors: pathogenic bacteria and altered bacterial sensing or changes in mucosal integrity take "toll" ?
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, Koranyi str 2 A, H 1083 Budapest, Hungary
    World J Gastroenterol 12:1829-41. 2006
    ..In the future, genetics may help more accurately diagnose and predict disease course in IBD...
  56. ncbi request reprint Association of extraintestinal manifestations of inflammatory bowel disease in a province of western Hungary with disease phenotype: results of a 25-year follow-up study
    Laszlo Lakatos
    1st Department of Medicine, Csolnoky F Province Hospital, Veszprem, Hungary
    World J Gastroenterol 9:2300-7. 2003
    ..IBD is a systemic disease associated with a large number of extraintestinal manifestations (EIMs). Our aim was to determine the prevalence of EIMs in a large IBD cohort in Veszprem Province in a 25-year follow-up study...
  57. pmc Low bone mass in microscopic colitis
    Katalin Lorinczy
    2nd Department of Medicine, Semmelweis University, Budapest, Hungary
    BMC Gastroenterol 11:58. 2011
    ..Microscopic colitis presents with similar symptoms to classic inflammatory bowel diseases. Osteoporosis is a common complication of Crohn's disease but there are no data concerning bone metabolism in microscopic colitis...
  58. ncbi request reprint [Gene therapy in liver diseases]
    Alajos Par
    Általános Orvostudományi Kar, I sz Belgyógyászati Klinika, Pecsi Tudomanyegyetem, Pecs
    Orv Hetil 143:125-9. 2002
    ..Due to the ongoing intensive genetic studies and if the existing problems being resolved in this field, we can predict that the early years of this millennium gene therapy will be a useful modality in the clinical hepatology as well...
  59. doi request reprint High-sensitivity C-reactive protein for identification of disease phenotype, active disease, and clinical relapses in Crohn's disease: a marker for patient classification?
    Lajos Sandor Kiss
    1st Department of Medicine, Semmelweis University, Budapest, Hungary
    Inflamm Bowel Dis 18:1647-54. 2012
    ..The authors' aim was to investigate whether high-sensitivity (hs)-CRP is useful for the identification disease phenotype, active disease, and relapse during follow-up, using a classification based on the hs-CRP value at diagnosis...
  60. pmc Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease
    Kriszta Molnar
    First Department of Pediatrics, Semmelweis University, H 1083 Budapest, Hungary
    World J Gastroenterol 18:3254-9. 2012
    ..To investigate intestinal alkaline phosphatase (iAP) in the intestinal mucosa of children with inflammatory bowel disease (IBD)...
  61. doi request reprint [Epidemiology, predictors and clinical aspects of loss of response to biological therapy]
    Katalin Lorinczy
    Semmelweis Egyetem, Általános Orvostudományi Kar, II Belgyógyászati Klinika, Budapest
    Orv Hetil 153:163-73. 2012
    ..In clinical practice, meticulous complex assessment of clinical symptoms, confirmation of active disease by endoscopic or radiological imaging, and excluding complications remain necessary...
  62. ncbi request reprint Relationship between serum calcium and CA 19-9 levels in colorectal cancer
    Peter Fuszek
    1st Department of Medicine, Faculty of Medicine, Semmelweis University, 1083 Budapest, Koronyi S u 2 a, Hungary
    World J Gastroenterol 10:1890-2. 2004
    ..To examine the calcium metabolism of colorectal cancer (CRC) in patients with colorectal cancer and control patients...
  63. doi request reprint Comparison of the effects of 1,25 dihydroxyvitamin D and 25 hydroxyvitamin D on bone pathology and disease activity in Crohn's disease patients
    Pal Miheller
    2nd Department of Medicine, Semmelweis University, Budapest, Hungary
    Inflamm Bowel Dis 15:1656-62. 2009
    ..Our work is a prospective study to compare the effects of aVD and pVD on bone metabolism and the clinical course of CD...
  64. doi request reprint Predictors of relapse in patients with ulcerative colitis in remission after one-year of infliximab therapy
    Klaudia Farkas
    1st Department of Medicine, University of Szeged, Szeged, Hungary
    Scand J Gastroenterol 48:1394-8. 2013
    ..Response to retreatment with infliximab was favorable in the majority of the patients who relapsed...
  65. ncbi request reprint [Genetic aspects of liver diseases]
    Alajos Par
    Általános Orvostudományi Kar, I Belgyógyászati Klinika, Pecsi Tudomanyegyetem, Pecs
    Orv Hetil 143:3-12. 2002
    ....
  66. doi request reprint Pregnancy outcome in patients with inflammatory bowel disease according to the activity of the disease and the medical treatment: a case-control study
    Tamas Molnar
    First Department of Medicine, University of Szeged, Szeged, Hungary
    Scand J Gastroenterol 45:1302-6. 2010
    ..The aim of our multicenter study was to compare the pregnancy outcomes and the data of infants in pregnancies before and after the diagnosis of IBD...
  67. doi request reprint Anti-TNF trough levels and detection of antibodies to anti-TNF in inflammatory bowel disease: are they ready for everyday clinical use?
    Pal Miheller
    Semmelweis University, 2nd Department of Medicine, H1088 Budapest, Szentkiralyi u 46, Hungary
    Expert Opin Biol Ther 12:179-92. 2012
    ..Some patients, however, experience lack- or loss of response (LOR) to treatment, and management of such patients is often empirical...
  68. doi request reprint Chronic hepatitis C virus infection associated with autonomic dysfunction
    Janos Osztovits
    1st Department of Internal Medicine, Semmelweis University, Budapest, Hungary
    Liver Int 29:1473-8. 2009
    ..To date, it is not known how chronic hepatitis C virus (HCV) infection affects the autonomic nervous system...
  69. doi request reprint Serologic antiglycan antibodies in inflammatory bowel disease
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, Budapest, Hungary
    Am J Gastroenterol 106:406-12. 2011
    ..Instruments for prediction of CD behavior are critical, as the use of immunomodulators and/or biologicals early in the disease course might be justified for patients with a high hazard for complicated disease behavior...
  70. ncbi request reprint Rising plasma nociceptin level during development of HCC: a case report
    Andrea Horvath
    MD, PhD, 1st Department of Medicine, Semmelweis University, Budapest, Hungary
    World J Gastroenterol 10:152-4. 2004
    ..High plasma nociceptin (N/OFQ) level has been shown in Wilson disease and in patients with acute and chronic pain...
  71. ncbi request reprint [ATP7B gene mutations in Hungarian patients with Wilson disease--case reports to illustrate the diverse clinical presentations]
    Aniko Folhoffer
    Semmelweis Egyetem, Általános Orvostudományi Kar, I Belgyógyászati Klinika, Budapest
    Orv Hetil 144:2509-15. 2003
    ..The clinical manifestation of the disease can be preceded by the treatment...
  72. ncbi request reprint Natural history of ulcerative colitis: current knowledge
    Lajos Sandor Kiss
    1st Department of Medicine, Semmelweis University, Budapest, Hungary
    Curr Drug Targets 12:1390-5. 2011
    ..Those identified may eventually lead to a more personalized, tailored therapy. In this review article, the authors summarize the available evidence on the natural history and predictive markers for evaluating the course of UC...
  73. doi request reprint Thiopurines in Crohn's disease, is there something new?
    Pal Miheller
    Semmelweis University, 2nd Department of Medicine, Budapest, Koranyi, Hungary
    Expert Opin Drug Metab Toxicol 6:1505-14. 2010
    ..Major complications occur in patients with low thiopurine-S-methyltransferase (TPMT) enzyme activity; however, the clinical relevance of these tests remains conflictive...
  74. ncbi request reprint [Wilson disease]
    Margit Abonyi
    Semmelweis Egyetem, Általános Orvostudományi Kar, I Belgyógyászati Klinika, Budapest
    Orv Hetil 145:2147-51. 2004
    ..Genetic screening should only be advised if there is a predominant mutation characteristic for the geographic area. The authors discuss the modern diagnostic and therapeutic possibilities of Wilson disease...
  75. pmc Double balloon enteroscopy examinations in general anesthesia
    Laszlo Zubek
    Department of Anaesthesiology and Intensive Therapy, Semmelweis University, Kútvölgyi Str 4, H 1125 Budapest, Hungary
    World J Gastroenterol 16:3418-22. 2010
    ..To demonstrate that the double balloon enteroscopy (DBE) can be safely performed in general anesthesia with intubation...
  76. doi request reprint [Effectiveness of new, once-daily 5-aminosalicylic acid in the treatment of ulcerative colitis]
    Peter Laszlo Lakatos
    Semmelweis Egyetem, Altalános Orvostudományi Kar I Belgyógyászati Klinika Budapest Korányi S 2 A 1083
    Orv Hetil 150:397-404. 2009
    ..In this systematic review, the authors summarize the available literature on the short- and medium-term efficacy and safety of the new once-daily mesalazine formulations...
  77. ncbi request reprint Selection criteria for preoperative endoscopic retrograde cholangiopancreatography before laparoscopic cholecystectomy and endoscopic treatment of bile duct stones: results of a retrospective, single center study between 1996-2002
    Laszlo Lakatos
    1st Department of Medicine, Csolnoky F, Province Hospital, Veszprem, H 8200, Hungary
    World J Gastroenterol 10:3495-9. 2004
    ..The optimal treatment for bile duct stones (in terms of cost, complications and accuracy) is unclear. The aim of our study was to determine the predictive factors for preoperative endoscopic retrograde cholangiopancreatography (ERCP)...
  78. ncbi request reprint Relationship between the tumor necrosis factor alpha polymorphism and the serum C-reactive protein levels in inflammatory bowel disease
    Agnes Vatay
    3rd Department of Internal Medicine, Research Laboratory, Semmelweis University, Kutvolgyi ut 4, 1125 Budapest, Hungary
    Immunogenetics 55:247-52. 2003
    ....
  79. doi request reprint Different associations of health related quality of life with pain, psychological distress and coping strategies in patients with irritable bowel syndrome and inflammatory bowel disorder
    Gabriella Seres
    Institute of Behavioural Sciences, Semmelweis University of Medicine, Budapest, Hungary
    J Clin Psychol Med Settings 15:287-95. 2008
    ..These results suggest there are differences between IBS and UC patients in the role of physical and psychological factors in QOL and emphasize the importance of cognitive processes in IBS...