Janina Kulka

Summary

Affiliation: Semmelweis University
Country: Hungary

Publications

  1. ncbi request reprint Extracellular matrix components in breast carcinomas
    Anna Kadar
    2nd Department of Pathology, Semmelweis University of Medicine, Ulloi ut 93, 1091 Budapest, Hungary
    Semin Cancer Biol 12:243-57. 2002
  2. doi request reprint Lymphoepithelioma-like carcinoma of the breast: not Epstein-Barr virus-, but human papilloma virus-positive
    Janina Kulka
    2nd Department of Pathology, Semmelweis University, Budapest 1091, Hungary
    Hum Pathol 39:298-301. 2008
  3. doi request reprint [Pathological aspects of in situ carcinoma/intraepithelial neoplasia of the breast]
    Janina Kulka
    Semmelweis Egyetem, Általános Orvostudományi Kar II Patológiai Intézet Budapest Üllői út 93 1091
    Orv Hetil 151:45-53. 2010
  4. doi request reprint [MicroRNA-profiling in breast- and salivary gland-derived adenoid cystic carcinomas]
    Orsolya Kiss
    Semmelweis Egyetem, Általános Orvostudományi Kar, II Patológiai Intézet, Budapest
    Orv Hetil 154:963-8. 2013
  5. doi request reprint [Immunohistochemical phenotype of breast carcinomas predicts the effectiveness of primary systemic therapy]
    Janina Kulka
    Semmelweis Egyetem II sz Patológiai Intézet 1091 Budapest Üllői út 93
    Magy Onkol 53:335-43. 2009
  6. doi request reprint Expression of tight junction protein claudin-4 in basal-like breast carcinomas
    Janina Kulka
    2nd Department of Pathology, Semmelweis University, 93 Ulloi ut, 1091, Budapest, Hungary
    Pathol Oncol Res 15:59-64. 2009
  7. ncbi request reprint [Her2/neu receptor: one of the basic factors rendering tailored therapy feasible in breast cancer patients]
    Janina Kulka
    Orvostudományi Kar, II Pathologiai Intézet, Budapest
    Orv Hetil 146:785-90. 2005
  8. doi request reprint [Pathology background of targeted therapy; quality control in pathology]
    Janina Kulka
    Semmelweis Egyetem II sz Patológiai Intézet 1091 Budapest Üllői út 93
    Magy Onkol 54:343-50. 2010
  9. doi request reprint Expression of tight junction molecules in breast carcinomas analysed by array PCR and immunohistochemistry
    Anna Maria Tokes
    2nd Department of Pathology, Semmelweis University, Ulloi ut 93, 1091 Budapest, Hungary
    Pathol Oncol Res 18:593-606. 2012
  10. doi request reprint MicroRNA expression profiling in benign (sporadic and hereditary) and recurring adrenal pheochromocytomas
    Zsófia Tömböl
    Faculty of Medicine, 2nd Department of Medicine, Semmelweis University, Budapest, Hungary
    Mod Pathol 23:1583-95. 2010

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Extracellular matrix components in breast carcinomas
    Anna Kadar
    2nd Department of Pathology, Semmelweis University of Medicine, Ulloi ut 93, 1091 Budapest, Hungary
    Semin Cancer Biol 12:243-57. 2002
    ....
  2. doi request reprint Lymphoepithelioma-like carcinoma of the breast: not Epstein-Barr virus-, but human papilloma virus-positive
    Janina Kulka
    2nd Department of Pathology, Semmelweis University, Budapest 1091, Hungary
    Hum Pathol 39:298-301. 2008
    ....
  3. doi request reprint [Pathological aspects of in situ carcinoma/intraepithelial neoplasia of the breast]
    Janina Kulka
    Semmelweis Egyetem, Általános Orvostudományi Kar II Patológiai Intézet Budapest Üllői út 93 1091
    Orv Hetil 151:45-53. 2010
    ..In this review, I would like to share the new and recently adapted views regarding intraepithelial neoplastic lesions of the breast...
  4. doi request reprint [MicroRNA-profiling in breast- and salivary gland-derived adenoid cystic carcinomas]
    Orsolya Kiss
    Semmelweis Egyetem, Általános Orvostudományi Kar, II Patológiai Intézet, Budapest
    Orv Hetil 154:963-8. 2013
    ..Aim: The aim of the authors was to compare the miRNA-expression profile of breast- and salivary gland-derived cases...
  5. doi request reprint [Immunohistochemical phenotype of breast carcinomas predicts the effectiveness of primary systemic therapy]
    Janina Kulka
    Semmelweis Egyetem II sz Patológiai Intézet 1091 Budapest Üllői út 93
    Magy Onkol 53:335-43. 2009
    ..Patients with triple negative and HER2-positive cancers are likely to achieve pCR after neoadjuvant chemotherapy...
  6. doi request reprint Expression of tight junction protein claudin-4 in basal-like breast carcinomas
    Janina Kulka
    2nd Department of Pathology, Semmelweis University, 93 Ulloi ut, 1091, Budapest, Hungary
    Pathol Oncol Res 15:59-64. 2009
    ..This observation may be seen as a further proof that basal-like carcinomas represent a separable group amongst grade 3 breast carcinomas...
  7. ncbi request reprint [Her2/neu receptor: one of the basic factors rendering tailored therapy feasible in breast cancer patients]
    Janina Kulka
    Orvostudományi Kar, II Pathologiai Intézet, Budapest
    Orv Hetil 146:785-90. 2005
    ..This drug, called trastuzumab (Herceptin), has been used in advanced breast carcinoma as adjuvant or primary treatment. In clinical trials its advantage in early stage breast carcinomas has been investigated so far...
  8. doi request reprint [Pathology background of targeted therapy; quality control in pathology]
    Janina Kulka
    Semmelweis Egyetem II sz Patológiai Intézet 1091 Budapest Üllői út 93
    Magy Onkol 54:343-50. 2010
    ..Kulka J, Szirtes I, Szász AM, Kupcsulik P, Kenessey I, Lotz G, Tímár J. Pathology background of targeted therapy; quality control in pathology...
  9. doi request reprint Expression of tight junction molecules in breast carcinomas analysed by array PCR and immunohistochemistry
    Anna Maria Tokes
    2nd Department of Pathology, Semmelweis University, Ulloi ut 93, 1091 Budapest, Hungary
    Pathol Oncol Res 18:593-606. 2012
    ..Further studies are necessary to examine whether the downregulation of the above mentioned TJ associated genes and proteins may contribute to the malignant progression of invasive ductal breast carcinomas...
  10. doi request reprint MicroRNA expression profiling in benign (sporadic and hereditary) and recurring adrenal pheochromocytomas
    Zsófia Tömböl
    Faculty of Medicine, 2nd Department of Medicine, Semmelweis University, Budapest, Hungary
    Mod Pathol 23:1583-95. 2010
    ..MicroRNA expression patterns differ between various sporadic, hereditary and recurring tumors and miR-1225-3p may be useful for identifying recurring pheochromocytomas...
  11. ncbi request reprint The expression of five different claudins in invasive breast carcinomas: comparison of pT1pN1 and pT1pN0 tumors
    Anna Maria Tokes
    2nd Department of Pathology, Semmelweis University, Budapest, Ulloi út, Hungary
    Pathol Res Pract 201:537-44. 2005
    ..On the basis of our findings, it seems that CLDN 1, CLDN 4, and CLDN 7 may rather have an important role in tumorigenesis or in cell-to-cell adhesion...
  12. pmc The CIN4 chromosomal instability qPCR classifier defines tumor aneuploidy and stratifies outcome in grade 2 breast cancer
    Attila Marcell Szasz
    2nd Department of Pathology, Semmelweis University, Budapest, Hungary
    PLoS ONE 8:e56707. 2013
    ....
  13. doi request reprint [Morphological and immunophenotypical heterogeneity in breast cancers of young and elderly women]
    Lilla Madaras
    II sz Patológiai Intézet, Semmelweis Egyetem, Budapest, Hungary
    Magy Onkol 56:75-8. 2012
    ..With the development of molecular techniques and accurate prognostic and treatment information rendered to samples the question may be soon answered...
  14. doi request reprint [Treatment of pregnancy associated breast cancer]
    Borbála Székely
    Semmelweis Egyetem, Általános Orvostudományi Kar, Radiológiai és Onkoterápiás Klinika, Budapest
    Orv Hetil 151:1299-303. 2010
    ..The newborn is on close neurohabilitation follow-up due to the evidence of generalized muscle dystonia. Had the patient accepted chemotherapy, the damage of the newborn baby would have been avoidable...
  15. doi request reprint Stromal matrix protein expression following preoperative systemic therapy in breast cancer
    Anna Maria Tokes
    Second Department of Pathology, Semmelweis University, 93 Ulloi ut, 1091 Budapest, Hungary
    Clin Cancer Res 15:731-9. 2009
    ..The aim of the present study was to analyze the qualitative and quantitative changes of representative tumor stroma proteins in the context of neoadjuvant therapy and the response of patients undergoing preoperative systemic therapy...
  16. doi request reprint Retrospective analysis of clinicopathological characteristics and family history data of early-onset breast cancer: a single-institutional study of hungarian patients
    Lilla Madaras
    2nd Department of Pathology, Semmelweis University, Budapest, Hungary
    Pathol Oncol Res 19:723-9. 2013
    ..The fact that a high rate of death occurred and no significant difference in OS were notable regarding the scheme of systemic therapies (neoadjuvant vs. adjuvant) highlight the necessity of the development of new treatment strategies...
  17. pmc The potential prognostic value of connexin 26 and 46 expression in neoadjuvant-treated breast cancer
    Ivett Teleki
    1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
    BMC Cancer 13:50. 2013
    ..In this study we correlated Cx expression and cell proliferation with disease survival and pathological response to neoadjuvant chemotherapy in breast cancers using existing classification systems...
  18. ncbi request reprint Detection of HER-2/neu gene amplification in breast carcinomas using quantitative real-time PCR - a comparison with immunohistochemical and FISH results
    Janina Kulka
    2nd Department of Pathology, Semmelweis University, Budapest, H 1091, Hungary
    Pathol Oncol Res 12:197-204. 2006
    ..Amongst the immunohistochemistry score 2+ cases, 10 of 18 showed gene amplification by qPCR while 10 of 26 by FISH. In conclusion, a well calibrated HER-2/neu qPCR assay may serve as useful alternative to FISH in breast cancer patients...
  19. pmc Claudin-1, -3 and -4 proteins and mRNA expression in benign and malignant breast lesions: a research study
    Anna Maria Tokes
    2nd Department of Pathology, Semmelweis University, Budapest, Hungary
    Breast Cancer Res 7:R296-305. 2005
    ..We compared levels of protein and mRNA expression of three members of the claudin (CLDN) family in malignant breast tumours and benign lesions...
  20. doi request reprint Radial scar-significant diagnostic challenge
    Zsofia Egyed
    Mamma Breast Health Corporation, Kapás u 29, Budapest, H 1023, Hungary
    Pathol Oncol Res 14:123-9. 2008
    ..Due to the complex diagnostic approach the nature of the "black stars" is known in the majority of cases prior to the surgical biopsy...
  21. doi request reprint A 3-gene proliferation score (TOP-FOX-67) can re-classify histological grade-2, ER-positive breast cancers into low- and high-risk prognostic categories
    Borbála Székely
    2nd Department of Pathology, Semmelweis University, Budapest, Hungary
    Breast Cancer Res Treat 138:691-8. 2013
    ..A 3-gene proliferation score shows similar prognostic value as the GGI in ER-positive, grade-2 cancers and may serve as basis for a PCR-based assay that could aid prognostic prediction for clinically intermediate-risk cancers...
  22. doi request reprint Identification of a claudin-4 and E-cadherin score to predict prognosis in breast cancer
    Attila M Szász
    Second Department of Pathology, Semmelweis University, Budapest, Hungary
    Cancer Sci 102:2248-54. 2011
    ..In breast cancer, the CURIO provides additional prognostic information besides the routinely utilized diagnostic approaches and factors...
  23. ncbi request reprint [Tenascin-C expression in human breast tumors]
    Anna Maria Tokes
    Semmelweis Egyetem, Általános Orvostudományi Kar, II Patológia Intézet, Budapest
    Orv Hetil 144:1901-7. 2003
    ..Within the tenascin family the most examined and most controversial member is tenascin-C. It has been suggested that tenascin-C decreases cell adhesion, promotes invasion and metastases, and may play role in pathological angiogenesis...
  24. doi request reprint [Comparison of breast cancer in young and old women based on clinicopathological features]
    Borbála Székely
    Semmelweis Egyetem, AOK, Radiológiai és Onkoterápiás Klinika, 1082 Budapest, Üllői út 78 a
    Magy Onkol 54:19-26. 2010
    ..The media and primary school education as well should be involved in educating women concerning this aspect. The individual follow-up of young patients with positive family history should also be established...
  25. ncbi request reprint [Role of osteopontin in the formation of microcalcifications in breast cancer]
    Anna Maria Tokes
    Semmelweis Egyetem, Általános Orvostudományi Kar, II Pathologiai Intézet, Budapest
    Orv Hetil 143:1841-6. 2002
    ..Osteopontin, a non-collagen, Ca-binding phosphoprotein, plays roles in both physiological and pathological mineralisation processes. Its expression may be severely altered in malignant tumours...
  26. doi request reprint Pigmented papillary carcinoma: a rare tumor of the male breast
    Andrea Farkas
    Department of Pathology, St Imre Hospital, Budapest, Hungary
    Pathol Oncol Res 14:341-3. 2008
    ..7 cm in diameter with an ill defined border on ultrasonography behind the mamilla. To the best of our knowledge this is the third case report of this type of tumor in male breast...
  27. doi request reprint Syndecan-4 promotes cytokinesis in a phosphorylation-dependent manner
    Anikó Keller-Pintér
    2nd Department of Pathology, Semmelweis University, Budapest, Hungary
    Cell Mol Life Sci 67:1881-94. 2010
    ..Expression of phosphomimicking Ser179Glu SDC4 resulted in incomplete abscission, whereas expression of the phospho-resistant SDC4 led to giant, multinucleated cells...
  28. doi request reprint Differences in the expression of histamine-related genes and proteins in normal human adrenal cortex and adrenocortical tumors
    Peter M Szabó
    2nd Department of Medicine, Faculty of Medicine, Semmelweis University, 1088 Budapest, Szentkiralyi str 46, Hungary
    Virchows Arch 455:133-42. 2009
    ..Adrenocortical tumorigenesis might, thus, be characterized by reduced histamine biosynthesis; furthermore, different adrenocortical tumor subtypes may show unique histamine receptor expression profiles...
  29. doi request reprint The role of radiotherapy in the conservative treatment of ductal carcinoma in situ of the breast
    Csaba Polgar
    Department of Radiotherapy, National Institute of Oncology, Rath Gy u 7 9, Budapest, 1122, Hungary
    Pathol Oncol Res 14:179-92. 2008
    ....
  30. pmc Prognostic potential of ERG (ETS-related gene) expression in prostatic adenocarcinoma
    A Marcell Szász
    2nd Department of Pathology, Semmelweis University, 93 Ulloi ut, 1091, Budapest, Hungary
    Int Urol Nephrol 45:727-33. 2013
    ..We evaluate the association of both ERG and claudin-4, claudin-5, and beta-catenin expression in tumor tissues of patients with organ-confined and advanced prostatic adenocarcinomas...
  31. ncbi request reprint [Oncocytic tumor of the adrenal gland]
    Andrea Farkas
    Semmelweis Egyetem, Általános Orvostudományi Kar, II Pathologiai Intézet, Budapest
    Orv Hetil 146:1453-8. 2005
    ..Histopathological examination revealed an oncocytic adenoma of the adrenal cortex. The authors describe the morphology and the differential diagnosis of this rare tumor of the adrenal gland...
  32. doi request reprint Claudin-7-positive synchronous spontaneous intrahepatic cholangiocarcinoma, adenocarcinoma and adenomas of the gallbladder in a Bearded dragon (Pogona vitticeps)
    Csaba Jakab
    Department of Pathology and Forensic Veterinary Medicine, Szent Istvan University, István u 2 H 1078, Budapest, Hungary
    Acta Vet Hung 59:99-112. 2011
    ..The antibovine anti-vimentin and humanised anti-Ki-67 antibodies did not show crossreactivity in the different samples from the Bearded dragon...
  33. ncbi request reprint Claudin expression in breast tumors
    Janina Kulka
    Hum Pathol 36:859; author reply 860. 2005
  34. ncbi request reprint [The results of cetuximab treatment of a patient with multiple pretreated, irinotecan resistant metastatic colorectal cancer]
    István Sipocz
    Petz Aladár Megyei Oktató Kórház, Gyor
    Magy Onkol 49:337-42. 2005
    ..The therapeutic answer could be excellent in this case, as it occurred in our case...
  35. ncbi request reprint [Quality control of HER2 immunohistochemistry--results from a Hungarian study]
    Gabor Cserni
    Bács Kiskun Megyei Onkormányzat Kórháza, 6000 Kecskemét
    Magy Onkol 51:23-9. 2007
    ..The evaluation of the HER2 status of breast cancers gives reliable results only if adequate quality control measures are implemented, and this study was an important step in this respect...
  36. ncbi request reprint Sentinel lymph node biopsy in staging small (up to 15 mm) breast carcinomas. Results from a European multi-institutional study
    Gabor Cserni
    Department of Pathology, Bacs Kiskun County Teaching Hospital, Kecskemet, H 6000, Hungary
    Pathol Oncol Res 13:5-14. 2007
    ..With macrometastases the risk of non-SLN involvement increases, and further axillary treatment should be generally indicated...
  37. ncbi request reprint Divergences in diagnosing nodular breast lesions of noncarcinomatous nature
    Gabor Cserni
    Department of Pathology, Bacs Kiskun County Teaching Hospital, Kecskemet, H 6000, Hungary
    Pathol Oncol Res 12:216-21. 2006
    ....
  38. ncbi request reprint Sentinel lymph node biopsy and non-sentinel node involvement in special type breast carcinomas with a good prognosis
    Gabor Cserni
    Department of Pathology, Bacs Kiskun County Teaching Hospital, Nyiri ut 38, H 6000 Kecskemet, Hungary
    Eur J Cancer 43:1407-14. 2007
    ..The opposite presentation of these factors would mandate SLN biopsy and axillary dissection, respectively...
  39. ncbi request reprint Validation of clinical prediction rules for a low probability of nonsentinel and extensive lymph node involvement in breast cancer patients
    Gabor Cserni
    Department of Surgical Pathology, Bacs Kiskun County Teaching Hospital, Nyiri ut 38, H 6000 Kecskemet, Hungary
    Am J Surg 194:288-93. 2007
    ..Two recently developed clinical prediction rules aim to anticipate the lack of nonsentinel lymph node metastases and the involvement of less than 4 lymph nodes in breast cancer patients with positive sentinel lymph nodes (SLNs)...
  40. ncbi request reprint [Coding of core biopsies of the breast: B1-B5]
    Janina Kulka
    Orv Hetil 144:1357. 2003
  41. doi request reprint Expression and localisation of claudin-1, -2, -3, -4, -5, -7 and -10 proteins in the normal canine mammary gland
    Csaba Jakab
    Department of Pathology and Forensic Veterinary Medicine, Faculty of Veterinary Medicine, Szent Istvan University, H 1078 Budapest, Istvan u 2, Hungary
    Acta Vet Hung 56:341-52. 2008
    ..The results of our study support the concept that they are indeed preserved, since the same type of claudins, in identical distribution, could be detected in our canine mammary tissue samples as could be found in human mammary tissue...
  42. ncbi request reprint [New TNM classification of breast tumors]
    Gabor Cserni
    Bács Kiskun Megyei Onkormányzat Kórháza, Kecskemet
    Orv Hetil 144:1563-8. 2003
    ..Both the newly implemented Hungarian breast cancer screening programme and the national cancer registry require the adequate reporting of the disease with particular emphasis on its extent...