H Farkas

Summary

Affiliation: Semmelweis University
Country: Hungary

Publications

  1. ncbi request reprint The Hungarian HAE experience
    Henriette Farkas
    Allergy and Angiooedema Outpatients Clinic, Kutvolgyi Clinical Center, Semmelweis University, Kutvolgyi ut 4, H 1125 Budapest, Hungary
    Transfus Apher Sci 29:229-33. 2003
  2. ncbi request reprint Clinical management of hereditary angio-oedema in children
    Henriette Farkas
    Semmelweis University, Kútvölgyi Directory, ENT Allergology and Angioedema Outpatient Clinic, Budapest, Hungary
    Pediatr Allergy Immunol 13:153-61. 2002
  3. ncbi request reprint Hereditary angioedema: a decade of human C1-inhibitor concentrate therapy
    Henriette Farkas
    Semmelweis University, Faculty of Medicine, 3rd Department of Internal Medicine, Budapest, Hungary
    J Allergy Clin Immunol 120:941-7. 2007
  4. doi request reprint Current pharmacotherapy of bradykinin-mediated angioedema
    Henriette Farkas
    Semmelweis University, 3rd Department of Internal Medicine, Faculty of Medicine, H 1125 Budapest, Kútvölgyiút 4, Hungary
    Expert Opin Pharmacother 14:571-86. 2013
  5. pmc HAE international home therapy consensus document
    Hilary J Longhurst
    Department of Immunology, Barts and The London NHS Trust, London, UK
    Allergy Asthma Clin Immunol 6:22. 2010
  6. pmc 2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema
    Tom Bowen
    Departments of Medicine and Paediatrics, University of Calgary, Calgary, Alberta, Canada
    Allergy Asthma Clin Immunol 6:24. 2010
  7. doi request reprint Lack of increased prevalence of immunoregulatory disorders in hereditary angioedema due to C1-inhibitor deficiency
    Henriette Farkas
    Semmelweis University, 3rd Department of Internal Medicine, Budapest, Hungary
    Clin Immunol 141:58-66. 2011
  8. pmc Management of upper airway edema caused by hereditary angioedema
    Henriette Farkas
    3rd Department of Internal Medicine, Faculty of Medicine, Semmelweis University, H 1125 Budapest, Kutvolgyi ut 4, Hungary
    Allergy Asthma Clin Immunol 6:19. 2010
  9. pmc Pediatric hereditary angioedema due to C1-inhibitor deficiency
    Henriette Farkas
    3rd Department of Internal Medicine, Faculty of Medicine, Semmelweis University, H 1125 Budapest, Kutvolgyi ut 4, Hungary
    Allergy Asthma Clin Immunol 6:18. 2010
  10. doi request reprint The effect of long-term danazol prophylaxis on liver function in hereditary angioedema-a longitudinal study
    Henriette Farkas
    Department of Internal Medicine, Semmelweis University, Budapest, Hungary
    Eur J Clin Pharmacol 66:419-26. 2010

Collaborators

  • Tom Bowen
  • K Bork
  • L Varga
  • George Fust
  • A Haris
  • P Gal
  • Peter Gergely
  • M Bely
  • Zoltan Prohaszka
  • P Garred
  • M R Daha
  • A Bygum
  • Hilary Longhurst
  • E W Nielsen
  • I Nagy
  • M M Levi
  • M Cicardi
  • Alvin Davis
  • Gábor Széplaki
  • Beata Visy
  • Istvan Karadi
  • Lajos Kalmar
  • Bernadett Blasko
  • B Visy
  • Attila Tordai
  • T Meszaros
  • Z Kelemen
  • Ibolya Czaller
  • L Czirjak
  • Róbert Szegedi
  • C Varjú
  • Goda Choi
  • C Erik Hack
  • Christoph Bucher
  • Laurence Bouillet
  • Angelo Agostoni
  • G Nagy
  • K Polner
  • Ferenc Toth
  • Z Griger
  • L Jakab
  • I Czaller
  • G Temesszentandrási
  • E Kiss
  • D Csuka
  • R Hobor
  • Dorottya Csuka
  • M Zeher
  • Kornel Simon
  • Anikó Szépvölgyi
  • E Karpati
  • Z Nagy
  • G Kumanovics
  • Z Balint
  • B Berta
  • A I Solyom
  • Zoltán Széplaki
  • Eszter Nagy
  • Zsolt Ronai
  • Greg Porebski
  • Jan Nuijens
  • Maarten R Soeters
  • Maria Sasvari-Szekely
  • Krystyna Obtulowicz
  • Barbara Bilo
  • Rene Verdonk
  • Lilla Osváth
  • Laszlo Romics
  • Melinda Nagy
  • Monika Kleiber
  • Tamas Hegedus
  • Szilvia Valentin
  • Olga Roche
  • Kálmán Fáy
  • Eva Nemeth
  • Jan H Nuijens
  • John Jakenfelds
  • E Takacs
  • Christiane Duponchel
  • George Harmat
  • Anthony J Castaldo
  • Luigi Fontana
  • Roberto Perricone
  • Christian Drouet
  • I Karadi
  • Pál N Kaposi
  • Wolfhart Kreuz
  • G Harmat
  • Emanuela Pappalardo
  • Andrea Zanichelli

Detail Information

Publications37

  1. ncbi request reprint The Hungarian HAE experience
    Henriette Farkas
    Allergy and Angiooedema Outpatients Clinic, Kutvolgyi Clinical Center, Semmelweis University, Kutvolgyi ut 4, H 1125 Budapest, Hungary
    Transfus Apher Sci 29:229-33. 2003
    ..Hungarian HAE Working Group is the main organizer of the European C1-INH Deficiency Workshops to be held at two-year intervals from 1999...
  2. ncbi request reprint Clinical management of hereditary angio-oedema in children
    Henriette Farkas
    Semmelweis University, Kútvölgyi Directory, ENT Allergology and Angioedema Outpatient Clinic, Budapest, Hungary
    Pediatr Allergy Immunol 13:153-61. 2002
    ..Undesirable adverse effects can be avoided and the patient's quality of life enhanced considerably by administering the lowest effective drug dose...
  3. ncbi request reprint Hereditary angioedema: a decade of human C1-inhibitor concentrate therapy
    Henriette Farkas
    Semmelweis University, Faculty of Medicine, 3rd Department of Internal Medicine, Budapest, Hungary
    J Allergy Clin Immunol 120:941-7. 2007
    ..The optional therapy for the acute management of HAE is administration of human C1-INH (hC1-INH) concentrate. However, hC1-INH is not available in many countries, in which case fresh frozen plasma is an alternative...
  4. doi request reprint Current pharmacotherapy of bradykinin-mediated angioedema
    Henriette Farkas
    Semmelweis University, 3rd Department of Internal Medicine, Faculty of Medicine, H 1125 Budapest, Kútvölgyiút 4, Hungary
    Expert Opin Pharmacother 14:571-86. 2013
    ..It is linked to bradykinin-enhanced vascular permeability and, therefore, it does not respond to conventional measures, but requires specific therapy...
  5. pmc HAE international home therapy consensus document
    Hilary J Longhurst
    Department of Immunology, Barts and The London NHS Trust, London, UK
    Allergy Asthma Clin Immunol 6:22. 2010
    ..It represents the opinion of the authors who have a wide range of expert experience in the management of HAE...
  6. pmc 2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema
    Tom Bowen
    Departments of Medicine and Paediatrics, University of Calgary, Calgary, Alberta, Canada
    Allergy Asthma Clin Immunol 6:24. 2010
    ....
  7. doi request reprint Lack of increased prevalence of immunoregulatory disorders in hereditary angioedema due to C1-inhibitor deficiency
    Henriette Farkas
    Semmelweis University, 3rd Department of Internal Medicine, Budapest, Hungary
    Clin Immunol 141:58-66. 2011
    ..Appropriate management of the immunoregulatory disease thus identified improves the symptoms of HAE-C1-INH...
  8. pmc Management of upper airway edema caused by hereditary angioedema
    Henriette Farkas
    3rd Department of Internal Medicine, Faculty of Medicine, Semmelweis University, H 1125 Budapest, Kutvolgyi ut 4, Hungary
    Allergy Asthma Clin Immunol 6:19. 2010
    ..Notwithstanding the foregoing, any form of upper airway edema should be regarded as a potentially life-threatening condition. None of the currently available prophylactic modalities is capable of preventing UAE with absolute certainty...
  9. pmc Pediatric hereditary angioedema due to C1-inhibitor deficiency
    Henriette Farkas
    3rd Department of Internal Medicine, Faculty of Medicine, Semmelweis University, H 1125 Budapest, Kutvolgyi ut 4, Hungary
    Allergy Asthma Clin Immunol 6:18. 2010
    ..Attenuated androgens administered in the lowest effective dose are another option. C1-INH replacement therapy is also an effective and safe agent for children. Regular monitoring and follow-up of patients are necessary...
  10. doi request reprint The effect of long-term danazol prophylaxis on liver function in hereditary angioedema-a longitudinal study
    Henriette Farkas
    Department of Internal Medicine, Semmelweis University, Budapest, Hungary
    Eur J Clin Pharmacol 66:419-26. 2010
    ..Potential hepatotoxic or liver tumor-inducing side effects of long-term danazol prophylaxis have been investigated during the follow-up of hereditary angioedema patients...
  11. ncbi request reprint Management of hereditary angioedema in pediatric patients
    Henriette Farkas
    3rd Department of Internal Medicine, Semmelweis University, Kutvolgyi ut 4, H 1125, Budapest, Hungary
    Pediatrics 120:e713-22. 2007
    ..Thus, we review our experience and published data to provide an approach to hereditary angioneurotic edema in childhood...
  12. ncbi request reprint Ultrasonography in the diagnosis and monitoring of ascites in acute abdominal attacks of hereditary angioneurotic oedema
    H Farkas
    Kutvolgyi Clinical Centre, Allergology and Angio oedema Outpatient Clinic, Semmelweis University, Budapest, Hungary
    Eur J Gastroenterol Hepatol 13:1225-30. 2001
    ..As acute abdominal attacks of the disease can mimic surgical emergencies, prompt and accurate diagnosis is essential. This study was undertaken to evaluate the usefulness of serial abdominal ultrasound (US) examinations...
  13. ncbi request reprint Angiooedema due to acquired deficiency of C1-esterase inhibitor associated with leucocytoclastic vasculitis
    H Farkas
    Allergology and Angioedema Outpatient Clinic, Semmelweis University, Kútvölgyi Centre, Budapest, Hungary
    Acta Derm Venereol 81:298-300. 2001
    ..Treatment with antimalarial agents resulted in complete resolution of symptoms and signs. Furthermore, C1-esterase inhibitor concentration and activity, as well as C1 levels, all returned to normal...
  14. ncbi request reprint Acute abdominal attack of hereditary angioneurotic oedema associated with ultrasound abnormalities suggestive of acute hepatitis
    H Farkas
    Allergology and Angio oedema Outpatient Clinic, Kutvolgyi Clinical Centre, Semmelweis University, Budapest, Hungary
    Acta Paediatr 91:971-4. 2002
    ..Conclusion: Diagnostic clues include ascites and abnormalities of hepatic structure visible with ultrasound during the oedematous attack. The importance of appropriate treatment is emphasized...
  15. doi request reprint Short-term prophylaxis in hereditary angioedema due to deficiency of the C1-inhibitor--a long-term survey
    H Farkas
    3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
    Allergy 67:1586-93. 2012
    ..Medical procedures can also provoke edematous attacks, and therefore, short-term prophylaxis (STP) is recommended before such interventions. Our aim was to evaluate the efficacy and safety of STP administered before medical procedures...
  16. ncbi request reprint Sex hormones in hereditary angioneurotic oedema
    B Visy
    Kutvolgyi Clinical Centre, Semmelweis University, Budapest, Hungary
    Clin Endocrinol (Oxf) 60:508-15. 2004
    ..Attacks usually disappear after the onset of menopause. This study was undertaken to establish any relationship between the serum levels of sex hormones and the incidence of HANO attacks...
  17. ncbi request reprint Treatment of type I and II hereditary angioedema with Rhucin((R)), a recombinant human C1 inhibitor
    Lilian Varga
    3rd Department of Internal Medicine, Semmelweis University Budapest, , Budapest, Hungary
    Expert Rev Clin Immunol 4:653-61. 2008
    ..This should facilitate successful regulatory approval in the near future, which is indispensable in order to make Rhucin available for patients with hereditary angioedema or other disorders amenable to C1 inhibitor replacement...
  18. doi request reprint C1-inhibitor autoantibodies in SLE
    T Meszaros
    3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
    Lupus 19:634-8. 2010
    ..These findings indicate that the anti-C1-INH level is higher in SLE patients than in healthy controls and furthermore, the anti-C1-INH level correlates with the duration and activity of the disease...
  19. doi request reprint Abdominal symptoms of hereditary angioedema and early weaning
    Z Kelemen
    Faculty of Medicine, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
    Eur J Clin Nutr 64:1025-7. 2010
    ..We did not find any relationship between these factors. Although breastfeeding is known to confer protection against numerous diseases, it showed no efficacy against the manifestations of HAE in our patient population...
  20. ncbi request reprint Cross-cultural adaptation of the disabilities of the arm, shoulder, and hand (DASH) questionnaire into Hungarian and investigation of its validity in patients with systemic sclerosis
    C Varjú
    Department of Immunology and Rheumatology, Faculty of Medicine, University of Pecs, Pecs, Hungary
    Clin Exp Rheumatol 26:776-83. 2008
    ..To adapt and validate the Hungarian version of the DASH and the shorter QuickDASH Outcome Measures and to establish their validity in patients with systemic sclerosis (SSc)...
  21. pmc Depressed activation of the lectin pathway of complement in hereditary angioedema
    L Varga
    3rd Department of Internal Medicine, Semmelweis University, Hungarian Academy of Sciences, Budapest, Hungary
    Clin Exp Immunol 153:68-74. 2008
    ..0001) in healthy controls, but there was no significant correlation in the HAE patients. We conclude that the activation of LP might also occur in subjects with C1INH deficiency, which is reflected by the low MASP-2 and C4 levels...
  22. ncbi request reprint Anti-cholesterol antibody levels in hereditary angioedema
    Lilian Varga
    Third Department of Internal Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    J Cell Mol Med 11:1377-83. 2007
    ..The latter would be a potential explanation for the lack of an increased incidence of infectious diseases in HAE patients, but might lead to increased autoimmunity...
  23. ncbi request reprint Adverse effects of danazol prophylaxis on the lipid profiles of patients with hereditary angioedema
    Gábor Széplaki
    Third Department of Internal Medicine, Faculty of Medicine, Semmelweis University, Budapest, Kutvolgyi ut 4, H 1125 Budapest, Hungary
    J Allergy Clin Immunol 115:864-9. 2005
    ..Patients experience recurrent bouts of edema, which can occur in almost any region of the body. As regards the treatment of the disease, danazol (an attenuated androgen) is used, among other agents, for long-term prophylaxis...
  24. ncbi request reprint Mutation screening of the C1 inhibitor gene among Hungarian patients with hereditary angioedema
    Lajos Kalmar
    Laboratory of Molecular Genetics, National Medical Center, Institute of Hematology and Immunology, Budapest, Hungary
    Hum Mutat 22:498. 2003
    ..14107delA, g.16749_;16775dup, g.16810T>A, g.16885C>G) were detected in 16 families affecting primarily exon 3 (6/13) of the C1INH gene. In the 3 remaining families, known mutations were identified affecting primarily exon 8 (2/3)...
  25. ncbi request reprint HAEdb: a novel interactive, locus-specific mutation database for the C1 inhibitor gene
    Lajos Kalmar
    Laboratory of Molecular Genetics, National Medical Center, Institute of Hematology and Immunology, Budapest, Hungary
    Hum Mutat 25:1-5. 2005
    ..This database may facilitate future comprehensive analyses of C1-INH mutations and also provide regular help for molecular diagnostic testing of HAE patients in different centers...
  26. ncbi request reprint Deep venous thrombosis associated with acquired angioedema type II in a patient heterozygous for the mutation of factor V Leiden: effective treatment and follow-up for four years
    Gábor Széplaki
    Third Department of Internal Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    Thromb Haemost 95:898-9. 2006
  27. ncbi request reprint C1-inhibitor (C1-INH) autoantibodies in hereditary angioedema. Strong correlation with the severity of disease in C1-INH concentrate naïve patients
    Lilian Varga
    3rd Department of Internal Medicine, Semmelweis University, Kútvölgyi 4, H 1125 Budapest, Hungary
    Mol Immunol 44:1454-60. 2007
    ..Most probable production of these autoantibodies is the consequence of the activation of complement and other plasma enzyme systems during HAE attacks. Determination of IgM C1-INH-Abs can be used as an activity marker in HAE...
  28. ncbi request reprint Relationship between copy number of genes (C4A, C4B) encoding the fourth component of complement and the clinical course of hereditary angioedema (HAE)
    Bernadett Blasko
    3rd Department of Internal Medicine, Semmelweis University, Kutvolgyi ut 4, H 1125 Budapest, Hungary
    Mol Immunol 44:2667-74. 2007
    ..These observations indicate that high copy number of the C4B gene can be a protective factor against disease severity in HAE and therefore its determination is warranted...
  29. ncbi request reprint Helicobacter pylori infection as a triggering factor of attacks in patients with hereditary angioedema
    Beata Visy
    Madarász Street Hospital of the Heim Pál Pediatric Hospital, Budapest, Hungary
    Helicobacter 12:251-7. 2007
    ..The present study aimed to reinvestigate the relationship between H. pylori infection and the attack rate in the framework of an international collaborative study...
  30. doi request reprint The natural history of hereditary angioedema and the impact of treatment with human C1-inhibitor concentrate during pregnancy: a long-term survey
    Ibolya Czaller
    Semmelweis University, 3rd Department of Internal Medicine, Budapest, Hungary
    Eur J Obstet Gynecol Reprod Biol 152:44-9. 2010
    ..The course of hereditary angioedema (HAE) and the efficacy and safety of human C1-INH concentrate were appraised during pregnancy and the postpartum period, in patients with HAE...
  31. ncbi request reprint Long-term danazol prophylaxis does not lead to increased carotid intima-media thickness in hereditary angioedema patients
    Róbert Szegedi
    Department of Neurology, Kutvolgyi Clinical Centre, Semmelweis University, Budapest, Hungary
    Atherosclerosis 198:184-91. 2008
    ..Our aim in the present study was to investigate the impact of danazol treatment on the risk of atherosclerosis in HAE patients...
  32. doi request reprint Acquired angioedema associated with primary antiphospholipid syndrome in a patient with antithrombin III deficiency
    Gábor Széplaki
    Third Department of Internal Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    Int Arch Allergy Immunol 146:164-8. 2008
    ..Thrombophilia should be considered a provoking factor of AAE and should be carefully sought for in these patients, as the key to successful management of AAE is the effective treatment of the underlying disease...
  33. ncbi request reprint Recombinant human C1-inhibitor in the treatment of acute angioedema attacks
    Goda Choi
    Department of Internal Medicine, Academic Medical Center, Free University Medical Center, Amsterdam, The Netherlands
    Transfusion 47:1028-32. 2007
    ..This study was undertaken to investigate the effects of rHuC1INH in the treatment of acute angioedema attacks in patients with a hereditary C1-inhibitor deficiency...
  34. ncbi request reprint [Effectiveness of mometasone furoate nasal spray in seasonal allergic rhinitis. First experiences in practice after the introduction of the drug in Hungary]
    Henriette Farkas
    Semmelweis Egyetem, Budapest, Általános Orvostudományi Kar, Kútvölgyi Klinikai Tömb, Fül orr gégészeti, Allergológiai és Angiooedema Szakrendeles
    Orv Hetil 143:1929-33. 2002
    ..The authors appraised the clinical efficacy of mometasone furoate in patients with seasonal allergic rhinitis and rhinoconjunctivitis...
  35. ncbi request reprint Hereditary and acquired angioedema: problems and progress: proceedings of the third C1 esterase inhibitor deficiency workshop and beyond
    Angelo Agostoni
    University of Milan, Italy
    J Allergy Clin Immunol 114:S51-131. 2004
    ..This supplement seeks to raise awareness and aid diagnosis of HAE, optimize treatment for all patients, and provide a platform for further research in this rare, partially understood disorder...
  36. ncbi request reprint Hereditary angiodema: a current state-of-the-art review, VII: Canadian Hungarian 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema
    Tom Bowen
    Department of Medicine and Paediatrics, University of Calgary, Alberta, Canada
    Ann Allergy Asthma Immunol 100:S30-40. 2008
    ..We published the Canadian 2003 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema (HAE; C1 inhibitor [C1-INH] deficiency) in 2004...
  37. ncbi request reprint Canadian 2003 International Consensus Algorithm For the Diagnosis, Therapy, and Management of Hereditary Angioedema
    Tom Bowen
    Department of Medicine and Paeditrics, University of Calgary, Calgary, Alberta T2N 2T8, Canada
    J Allergy Clin Immunol 114:629-37. 2004
    ..Hopefully evidence to support approaches to the management of HAE will approach the level of meta-analysis of randomized controlled trials in the near future...