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Species | H FarkasSummaryAffiliation: Semmelweis University Country: Hungary Publications
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Publications
The Hungarian HAE experienceHenriette Farkas
Allergy and Angiooedema Outpatients Clinic, Kutvolgyi Clinical Center, Semmelweis University, Kutvolgyi ut 4, H 1125 Budapest, Hungary
Transfus Apher Sci 29:229-33. 2003..Hungarian HAE Working Group is the main organizer of the European C1-INH Deficiency Workshops to be held at two-year intervals from 1999...- Clinical management of hereditary angio-oedema in childrenHenriette Farkas
Semmelweis University, Kútvölgyi Directory, ENT Allergology and Angioedema Outpatient Clinic, Budapest, Hungary
Pediatr Allergy Immunol 13:153-61. 2002..Undesirable adverse effects can be avoided and the patient's quality of life enhanced considerably by administering the lowest effective drug dose... - Hereditary angioedema: a decade of human C1-inhibitor concentrate therapyHenriette Farkas
Semmelweis University, Faculty of Medicine, 3rd Department of Internal Medicine, Budapest, Hungary
J Allergy Clin Immunol 120:941-7. 2007..The optional therapy for the acute management of HAE is administration of human C1-INH (hC1-INH) concentrate. However, hC1-INH is not available in many countries, in which case fresh frozen plasma is an alternative... 
Current pharmacotherapy of bradykinin-mediated angioedemaHenriette Farkas
Semmelweis University, 3rd Department of Internal Medicine, Faculty of Medicine, H 1125 Budapest, Kútvölgyiút 4, Hungary
Expert Opin Pharmacother 14:571-86. 2013..The range of targeted therapeutic options has increased in recent years and includes measures to handle emergencies, prevent edematous episodes and manage additional types of bradykinin-mediated angioedema...
HAE international home therapy consensus documentHilary J Longhurst
Department of Immunology, Barts and The London NHS Trust, London, UK
Allergy Asthma Clin Immunol 6:22. 2010..It represents the opinion of the authors who have a wide range of expert experience in the management of HAE...- 2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedemaTom Bowen
Departments of Medicine and Paediatrics, University of Calgary, Calgary, Alberta, Canada
Allergy Asthma Clin Immunol 6:24. 2010.... - Lack of increased prevalence of immunoregulatory disorders in hereditary angioedema due to C1-inhibitor deficiencyHenriette Farkas
Semmelweis University, 3rd Department of Internal Medicine, Budapest, Hungary
Clin Immunol 141:58-66. 2011..Appropriate management of the immunoregulatory disease thus identified improves the symptoms of HAE-C1-INH... - Management of upper airway edema caused by hereditary angioedemaHenriette Farkas
3rd Department of Internal Medicine, Faculty of Medicine, Semmelweis University, H 1125 Budapest, Kutvolgyi ut 4, Hungary
Allergy Asthma Clin Immunol 6:19. 2010..Notwithstanding the foregoing, any form of upper airway edema should be regarded as a potentially life-threatening condition. None of the currently available prophylactic modalities is capable of preventing UAE with absolute certainty... - Pediatric hereditary angioedema due to C1-inhibitor deficiencyHenriette Farkas
3rd Department of Internal Medicine, Faculty of Medicine, Semmelweis University, H 1125 Budapest, Kutvolgyi ut 4, Hungary
Allergy Asthma Clin Immunol 6:18. 2010..Attenuated androgens administered in the lowest effective dose are another option. C1-INH replacement therapy is also an effective and safe agent for children. Regular monitoring and follow-up of patients are necessary... - The effect of long-term danazol prophylaxis on liver function in hereditary angioedema-a longitudinal studyHenriette Farkas
Department of Internal Medicine, Semmelweis University, Budapest, Hungary
Eur J Clin Pharmacol 66:419-26. 2010..Potential hepatotoxic or liver tumor-inducing side effects of long-term danazol prophylaxis have been investigated during the follow-up of hereditary angioedema patients... - Management of hereditary angioedema in pediatric patientsHenriette Farkas
3rd Department of Internal Medicine, Semmelweis University, Kutvolgyi ut 4, H 1125, Budapest, Hungary
Pediatrics 120:e713-22. 2007..Thus, we review our experience and published data to provide an approach to hereditary angioneurotic edema in childhood... - Ultrasonography in the diagnosis and monitoring of ascites in acute abdominal attacks of hereditary angioneurotic oedemaH Farkas
Kutvolgyi Clinical Centre, Allergology and Angio oedema Outpatient Clinic, Semmelweis University, Budapest, Hungary
Eur J Gastroenterol Hepatol 13:1225-30. 2001..As acute abdominal attacks of the disease can mimic surgical emergencies, prompt and accurate diagnosis is essential. This study was undertaken to evaluate the usefulness of serial abdominal ultrasound (US) examinations... - Angiooedema due to acquired deficiency of C1-esterase inhibitor associated with leucocytoclastic vasculitisH Farkas
Allergology and Angioedema Outpatient Clinic, Semmelweis University, Kútvölgyi Centre, Budapest, Hungary
Acta Derm Venereol 81:298-300. 2001..Treatment with antimalarial agents resulted in complete resolution of symptoms and signs. Furthermore, C1-esterase inhibitor concentration and activity, as well as C1 levels, all returned to normal... - Acute abdominal attack of hereditary angioneurotic oedema associated with ultrasound abnormalities suggestive of acute hepatitisH Farkas
Allergology and Angio oedema Outpatient Clinic, Kutvolgyi Clinical Centre, Semmelweis University, Budapest, Hungary
Acta Paediatr 91:971-4. 2002..Conclusion: Diagnostic clues include ascites and abnormalities of hepatic structure visible with ultrasound during the oedematous attack. The importance of appropriate treatment is emphasized... - Short-term prophylaxis in hereditary angioedema due to deficiency of the C1-inhibitor--a long-term surveyH Farkas
3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
Allergy 67:1586-93. 2012..Medical procedures can also provoke edematous attacks, and therefore, short-term prophylaxis (STP) is recommended before such interventions. Our aim was to evaluate the efficacy and safety of STP administered before medical procedures... - Sex hormones in hereditary angioneurotic oedemaB Visy
, Semmelweis University, Budapest, Hungary
Clin Endocrinol (Oxf) 60:508-15. 2004..034). This difference existed independently of age and danazol dose. CONCLUSION: In view of these results, the monitoring of progesterone and SHBG levels can prove useful in the prediction of attacks in hereditary angioneurotic oedema... - Treatment of type I and II hereditary angioedema with Rhucin((R)), a recombinant human C1 inhibitorLilian Varga
3rd Department of Internal Medicine, Semmelweis University Budapest, , Budapest, Hungary
Expert Rev Clin Immunol 4:653-61. 2008..This should facilitate successful regulatory approval in the near future, which is indispensable in order to make Rhucin available for patients with hereditary angioedema or other disorders amenable to C1 inhibitor replacement... - C1-inhibitor autoantibodies in SLET Meszaros
3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
Lupus 19:634-8. 2010..These findings indicate that the anti-C1-INH level is higher in SLE patients than in healthy controls and furthermore, the anti-C1-INH level correlates with the duration and activity of the disease... - Abdominal symptoms of hereditary angioedema and early weaningZ Kelemen
Faculty of Medicine, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
Eur J Clin Nutr 64:1025-7. 2010..We did not find any relationship between these factors. Although breastfeeding is known to confer protection against numerous diseases, it showed no efficacy against the manifestations of HAE in our patient population... - Cross-cultural adaptation of the disabilities of the arm, shoulder, and hand (DASH) questionnaire into Hungarian and investigation of its validity in patients with systemic sclerosisC Varjú
Department of Immunology and Rheumatology, Faculty of Medicine, University of Pecs, Pecs, Hungary
Clin Exp Rheumatol 26:776-83. 2008..To adapt and validate the Hungarian version of the DASH and the shorter QuickDASH Outcome Measures and to establish their validity in patients with systemic sclerosis (SSc)... - Depressed activation of the lectin pathway of complement in hereditary angioedemaL Varga
3rd Department of Internal Medicine, Semmelweis University, Hungarian Academy of Sciences, Budapest, Hungary
Clin Exp Immunol 153:68-74. 2008..0001) in healthy controls, but there was no significant correlation in the HAE patients. We conclude that the activation of LP might also occur in subjects with C1INH deficiency, which is reflected by the low MASP-2 and C4 levels... - Anti-cholesterol antibody levels in hereditary angioedemaLilian Varga
Third Department of Internal Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary
J Cell Mol Med 11:1377-83. 2007..The latter would be a potential explanation for the lack of an increased incidence of infectious diseases in HAE patients, but might lead to increased autoimmunity... - Adverse effects of danazol prophylaxis on the lipid profiles of patients with hereditary angioedemaGábor Széplaki
Third Department of Internal Medicine, Faculty of Medicine, Semmelweis University, Budapest, Kutvolgyi ut 4, H 1125 Budapest, Hungary
J Allergy Clin Immunol 115:864-9. 2005..Patients experience recurrent bouts of edema, which can occur in almost any region of the body. As regards the treatment of the disease, danazol (an attenuated androgen) is used, among other agents, for long-term prophylaxis... - Mutation screening of the C1 inhibitor gene among Hungarian patients with hereditary angioedemaLajos Kalmar
Laboratory of Molecular Genetics, National Medical Center, Institute of Hematology and Immunology, Budapest, Hungary
Hum Mutat 22:498. 2003..14107delA, g.16749_;16775dup, g.16810T>A, g.16885C>G) were detected in 16 families affecting primarily exon 3 (6/13) of the C1INH gene. In the 3 remaining families, known mutations were identified affecting primarily exon 8 (2/3)... - HAEdb: a novel interactive, locus-specific mutation database for the C1 inhibitor geneLajos Kalmar
Laboratory of Molecular Genetics, National Medical Center, Institute of Hematology and Immunology, Budapest, Hungary
Hum Mutat 25:1-5. 2005..This database may facilitate future comprehensive analyses of C1-INH mutations and also provide regular help for molecular diagnostic testing of HAE patients in different centers... - Deep venous thrombosis associated with acquired angioedema type II in a patient heterozygous for the mutation of factor V Leiden: effective treatment and follow-up for four yearsGábor Széplaki
Third Department of Internal Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary
Thromb Haemost 95:898-9. 2006 - C1-inhibitor (C1-INH) autoantibodies in hereditary angioedema. Strong correlation with the severity of disease in C1-INH concentrate naïve patientsLilian Varga
3rd Department of Internal Medicine, Semmelweis University, Kútvölgyi 4, H 1125 Budapest, Hungary
Mol Immunol 44:1454-60. 2007..Most probable production of these autoantibodies is the consequence of the activation of complement and other plasma enzyme systems during HAE attacks. Determination of IgM C1-INH-Abs can be used as an activity marker in HAE... - Relationship between copy number of genes (C4A, C4B) encoding the fourth component of complement and the clinical course of hereditary angioedema (HAE)Bernadett Blasko
3rd Department of Internal Medicine, Semmelweis University, Kutvolgyi ut 4, H 1125 Budapest, Hungary
Mol Immunol 44:2667-74. 2007..These observations indicate that high copy number of the C4B gene can be a protective factor against disease severity in HAE and therefore its determination is warranted... - Helicobacter pylori infection as a triggering factor of attacks in patients with hereditary angioedemaBeata Visy
Madarász Street Hospital of the Heim Pál Pediatric Hospital, Budapest, Hungary
Helicobacter 12:251-7. 2007..The present study aimed to reinvestigate the relationship between H. pylori infection and the attack rate in the framework of an international collaborative study... - The natural history of hereditary angioedema and the impact of treatment with human C1-inhibitor concentrate during pregnancy: a long-term surveyIbolya Czaller
Semmelweis University, 3rd Department of Internal Medicine, Budapest, Hungary
Eur J Obstet Gynecol Reprod Biol 152:44-9. 2010..The course of hereditary angioedema (HAE) and the efficacy and safety of human C1-INH concentrate were appraised during pregnancy and the postpartum period, in patients with HAE... - Long-term danazol prophylaxis does not lead to increased carotid intima-media thickness in hereditary angioedema patientsRóbert Szegedi
Department of Neurology, Kutvolgyi Clinical Centre, Semmelweis University, Budapest, Hungary
Atherosclerosis 198:184-91. 2008..Our aim in the present study was to investigate the impact of danazol treatment on the risk of atherosclerosis in HAE patients... - Acquired angioedema associated with primary antiphospholipid syndrome in a patient with antithrombin III deficiencyGábor Széplaki
Third Department of Internal Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary
Int Arch Allergy Immunol 146:164-8. 2008..Thrombophilia should be considered a provoking factor of AAE and should be carefully sought for in these patients, as the key to successful management of AAE is the effective treatment of the underlying disease... - Recombinant human C1-inhibitor in the treatment of acute angioedema attacksGoda Choi
Department of Internal Medicine, Academic Medical Center, Free University Medical Center, Amsterdam, The Netherlands
Transfusion 47:1028-32. 2007..This study was undertaken to investigate the effects of rHuC1INH in the treatment of acute angioedema attacks in patients with a hereditary C1-inhibitor deficiency... - [Effectiveness of mometasone furoate nasal spray in seasonal allergic rhinitis. First experiences in practice after the introduction of the drug in Hungary]Henriette Farkas
Semmelweis Egyetem, Budapest, , , ,
Orv Hetil 143:1929-33. 2002..CONCLUSION: These results demonstrate that mometasone furoate nasal spray is a safe and effective intranasal corticosteroid for the therapy of SAR/SARC seasonal allergic rhinitis and rhinoconjunctivitis... - Hereditary and acquired angioedema: problems and progress: proceedings of the third C1 esterase inhibitor deficiency workshop and beyondAngelo Agostoni
University of Milan, Italy
J Allergy Clin Immunol 114:S51-131. 2004..This supplement seeks to raise awareness and aid diagnosis of HAE, optimize treatment for all patients, and provide a platform for further research in this rare, partially understood disorder... - Hereditary angiodema: a current state-of-the-art review, VII: Canadian Hungarian 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary AngioedemaTom Bowen
Department of Medicine and Paediatrics, University of Calgary, Alberta, Canada
Ann Allergy Asthma Immunol 100:S30-40. 2008..We published the Canadian 2003 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema (HAE; C1 inhibitor [C1-INH] deficiency) in 2004... - Canadian 2003 International Consensus Algorithm For the Diagnosis, Therapy, and Management of Hereditary AngioedemaTom Bowen
Department of Medicine and Paeditrics, University of Calgary, Calgary, Alberta T2N 2T8, Canada
J Allergy Clin Immunol 114:629-37. 2004..Hopefully evidence to support approaches to the management of HAE will approach the level of meta-analysis of randomized controlled trials in the near future...