Peter Csermely

Summary

Affiliation: Semmelweis University
Country: Hungary

Publications

  1. pmc Salivary Genomics, Transcriptomics and Proteomics: The Emerging Concept of the Oral Ecosystem and their Use in the Early Diagnosis of Cancer and other Diseases
    T K Fábián
    Clinic of Prosthetic Dentistry, Semmelweis University, Faculty of Dentistry, Budapest, Hungary
    Curr Genomics 9:11-21. 2008
  2. pmc Learning and innovative elements of strategy adoption rules expand cooperative network topologies
    Shijun Wang
    Department of Automation, Tsinghua University, Beijing, China
    PLoS ONE 3:e1917. 2008
  3. ncbi request reprint Proteins, RNAs and chaperones in enzyme evolution: a folding perspective
    P Csermely
    Department of Medical Chemistry, Semmelweis University, Budapest, Hungary
    Trends Biochem Sci 22:147-9. 1997
  4. pmc Recruiting the younger generation to science
    Peter Csermely
    Department of Medical Chemistry, Semmelweis University, Budapest, Hungary
    EMBO Rep 4:825-8. 2003
  5. ncbi request reprint Cellular networks and the aging process
    Peter Csermely
    Department of Medical Chemistry, Semmelweis University, Budapest, Hungary
    Arch Physiol Biochem 112:60-4. 2006
  6. ncbi request reprint Chaperones as parts of cellular networks
    Peter Csermely
    Department of Medical Chemistry, Semmelweis University, Puskin Street 9, H 1 088 Budapest, Hungary
    Adv Exp Med Biol 594:55-63. 2007
  7. doi request reprint Creative elements: network-based predictions of active centres in proteins and cellular and social networks
    Peter Csermely
    Department of Medical Chemistry, Semmelweis University, Budapest, Hungary
    Trends Biochem Sci 33:569-76. 2008
  8. ncbi request reprint The efficiency of multi-target drugs: the network approach might help drug design
    Peter Csermely
    Department of Medical Chemistry, Semmelweis University, PO Box 260, H 1444 Budapest 8, Hungary
    Trends Pharmacol Sci 26:178-82. 2005
  9. ncbi request reprint Strong links are important, but weak links stabilize them
    Peter Csermely
    Department of Medical Chemistry, Semmelweis University, H 1088 Budapest, Puskin str 9, Hungary
    Trends Biochem Sci 29:331-4. 2004
  10. ncbi request reprint Water and cellular folding processes
    P Csermely
    Department of Medical Chemistry, Semmelweis University, Budapest, Hungary
    Cell Mol Biol (Noisy-le-grand) 47:791-800. 2001

Collaborators

Detail Information

Publications76

  1. pmc Salivary Genomics, Transcriptomics and Proteomics: The Emerging Concept of the Oral Ecosystem and their Use in the Early Diagnosis of Cancer and other Diseases
    T K Fábián
    Clinic of Prosthetic Dentistry, Semmelweis University, Faculty of Dentistry, Budapest, Hungary
    Curr Genomics 9:11-21. 2008
    ..We close the review by highlighting a number of possible exploratory pathways in this emerging, hot research field...
  2. pmc Learning and innovative elements of strategy adoption rules expand cooperative network topologies
    Shijun Wang
    Department of Automation, Tsinghua University, Beijing, China
    PLoS ONE 3:e1917. 2008
    ..These results suggest that a balanced duo of learning and innovation may help to preserve cooperation during the re-organization of real-world networks, and may play a prominent role in the evolution of self-organizing, complex systems...
  3. ncbi request reprint Proteins, RNAs and chaperones in enzyme evolution: a folding perspective
    P Csermely
    Department of Medical Chemistry, Semmelweis University, Budapest, Hungary
    Trends Biochem Sci 22:147-9. 1997
    ..How did evolution select proteins, not RNA, to be the major biological catalysts? Why were chaperones necessary for the evolution of modern protein enzymes?..
  4. pmc Recruiting the younger generation to science
    Peter Csermely
    Department of Medical Chemistry, Semmelweis University, Budapest, Hungary
    EMBO Rep 4:825-8. 2003
  5. ncbi request reprint Cellular networks and the aging process
    Peter Csermely
    Department of Medical Chemistry, Semmelweis University, Budapest, Hungary
    Arch Physiol Biochem 112:60-4. 2006
    ....
  6. ncbi request reprint Chaperones as parts of cellular networks
    Peter Csermely
    Department of Medical Chemistry, Semmelweis University, Puskin Street 9, H 1 088 Budapest, Hungary
    Adv Exp Med Biol 594:55-63. 2007
    ..Cellular networks are preferentially remodeled in various diseases and aging, which may help us to design novel therapeutic and anti-aging strategies...
  7. doi request reprint Creative elements: network-based predictions of active centres in proteins and cellular and social networks
    Peter Csermely
    Department of Medical Chemistry, Semmelweis University, Budapest, Hungary
    Trends Biochem Sci 33:569-76. 2008
    ....
  8. ncbi request reprint The efficiency of multi-target drugs: the network approach might help drug design
    Peter Csermely
    Department of Medical Chemistry, Semmelweis University, PO Box 260, H 1444 Budapest 8, Hungary
    Trends Pharmacol Sci 26:178-82. 2005
    ....
  9. ncbi request reprint Strong links are important, but weak links stabilize them
    Peter Csermely
    Department of Medical Chemistry, Semmelweis University, H 1088 Budapest, Puskin str 9, Hungary
    Trends Biochem Sci 29:331-4. 2004
  10. ncbi request reprint Water and cellular folding processes
    P Csermely
    Department of Medical Chemistry, Semmelweis University, Budapest, Hungary
    Cell Mol Biol (Noisy-le-grand) 47:791-800. 2001
    ..Besides proteins, RNA and DNA structure is also heavily influenced by the presence of water. This review summarizes the important aspects of these fields, and draws attention to several open questions and hypotheses...
  11. ncbi request reprint Chaperone overload is a possible contributor to 'civilization diseases'
    P Csermely
    Dept of Medical Chemistry, Semmelweis University, PO Box 260, H 1444 Budapest, Hungary
    Trends Genet 17:701-4. 2001
    ..This 'chaperone overload' hypothesis emphasizes the need for efficient ways to enhance chaperone capacity in ageing subjects, and will hopefully lead to the identification and 'repair' of silent mutations...
  12. ncbi request reprint Chaperone-percolator model: a possible molecular mechanism of Anfinsen-cage-type chaperones
    P Csermely
    Department of Medical Chemistry, Semmelweis University, H 1444 Budapest, P O Box 260, Hungary
    Bioessays 21:959-65. 1999
    ..This study compares this chaperone-percolator model with existing explanations and suggests further experiments to test it. BioEssays 1999;21:959-965...
  13. ncbi request reprint Binding affinity of proteins to hsp90 correlates with both hydrophobicity and positive charges. A surface plasmon resonance study
    P Csermely
    Department of Medical Chemistry, Semmelweis University, School of Medicine, Budapest, Hungary
    Life Sci 61:411-8. 1997
    ..Analysis of the structure of binding proteins revealed that their binding affinity depends on both hydrophobicity and positive charges making the discriminative features of hsp90 similar to those of other molecular chaperones...
  14. ncbi request reprint Molecular chaperones, stress proteins and redox homeostasis
    Eszter Papp
    Department of Medical Chemistry, Semmelweis University, P O Box 260, H 1444 Budapest 8, Hungary
    Biofactors 17:249-57. 2003
    ..Moreover, our recent data suggest that chaperones may act as a central switchboard for the transmission of redox changes in the life of the cell...
  15. ncbi request reprint Reduction of the endoplasmic reticulum accompanies the oxidative damage of diabetes mellitus
    Gábor Nardai
    Department of Medical Chemistry, Semmelweis University, Hungary
    Biofactors 17:259-67. 2003
    ..The possible consequences of these unexpected changes are also discussed...
  16. pmc Signalogs: orthology-based identification of novel signaling pathway components in three metazoans
    Tamás Korcsmáros
    Department of Genetics, Eotvos Lorand University, Budapest, Hungary
    PLoS ONE 6:e19240. 2011
    ..Despite the wide use of these methods, annotation of complete signaling pathways has not yet been transferred systematically between species...
  17. ncbi request reprint FAD oxidizes the ERO1-PDI electron transfer chain: the role of membrane integrity
    Eszter Papp
    Department of Medical Chemistry, Semmelweis University, H 1088 Budapest, Hungary
    Biochem Biophys Res Commun 338:938-45. 2005
    ..Our findings prompt further studies to elucidate the membrane-dependent steps of PDI oxidation and the role of FAD in redox folding...
  18. ncbi request reprint FAD transport and FAD-dependent protein thiol oxidation in rat liver microsomes
    Marianne Varsányi
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, 1444 Budapest, Hungary
    J Biol Chem 279:3370-4. 2004
    ..These findings support the notion that, similar to yeast, free FAD may have a decisive role in the mechanism of oxidative protein folding in the endoplasmic reticulum lumen of mammalian cells...
  19. ncbi request reprint Protein homeostasis and molecular chaperones in aging
    Mehmet Alper Arslan
    Department of Medical Chemistry, Semmelweis University, P O Box 260, H 1444, Budapest 8, Hungary
    Biogerontology 7:383-9. 2006
    ..Possible involvement of chaperones and proteolysis in immunosenescence is highlighted. Defects in zinc metabolism are also addressed in relation to aging and changes in chaperone levels...
  20. ncbi request reprint Hsp90 inhibition accelerates cell lysis. Anti-Hsp90 ribozyme reveals a complex mechanism of Hsp90 inhibitors involving both superoxide- and Hsp90-dependent events
    Amere Subbarao Sreedhar
    Department of Medical Chemistry, Semmelweis University, H 1088 Budapest, Hungary
    J Biol Chem 278:35231-40. 2003
    ....
  21. ncbi request reprint Molecular chaperones as regulatory elements of cellular networks
    Csaba Soti
    Department of Medical Chemistry, Semmelweis University, Puskin str 9, H 1088 Budapest, Hungary
    Curr Opin Cell Biol 17:210-5. 2005
    ..The same networks are preferentially remodeled in various diseases and aging, which may help us to design novel therapeutic and anti-aging strategies...
  22. pmc RNA interference links oxidative stress to the inhibition of heat stress adaptation
    Zoltan Spiro
    Department of Medical Chemistry, Semmelweis University, Budapest, Hungary
    Antioxid Redox Signal 17:890-901. 2012
    ..However, the impact of oxidative stress on heat resistance remains largely unclear...
  23. ncbi request reprint Chaperone function and chaperone overload in the aged. A preliminary analysis
    Gábor Nardai
    Department of Medical Chemistry, Semmelweis University, P O Box 260, H 1444 Budapest 8, Hungary
    Exp Gerontol 37:1257-62. 2002
    ..e. a 'chaperone overload' due to the increased amount of damaged hepatic proteins in aged rats. Experiments are in progress to elucidate the mechanism of the observed age-induced changes in chaperone function...
  24. pmc A role for SKN-1/Nrf in pathogen resistance and immunosenescence in Caenorhabditis elegans
    Diana Papp
    Department of Medical Chemistry, Semmelweis University, Budapest, Hungary
    PLoS Pathog 8:e1002673. 2012
    ..Our findings identify SKN-1 as a novel regulator of innate immunity, suggests its involvement in immunosenescence and provide an important crosstalk between pathogenic stress signaling and the xenobiotic/oxidative stress response...
  25. ncbi request reprint Network analysis of protein dynamics
    Csaba Bode
    Department of Biophysics and Radiation Biology, Semmelweis University, Puskin Street 9, H 1088 Budapest, Hungary
    FEBS Lett 581:2776-82. 2007
    ..Finally, we suggest that modular analysis, novel centrality measures, hierarchical representation of networks and the analysis of network dynamics will soon lead to an expansion of this field...
  26. doi request reprint Chaperones as integrators of cellular networks: changes of cellular integrity in stress and diseases
    Robin Palotai
    Department of Medical Chemistry, Semmelweis University, Budapest, Hungary
    IUBMB Life 60:10-8. 2008
    ..Chaperone-mediated evolvability of cellular networks may play a key role in cellular adaptation during stress and various polygenic and chronic diseases, such as cancer, diabetes or neurodegeneration...
  27. pmc Chaperones come of age
    Csaba Soti
    Department of Medical Chemistry, Semmelweis University, Budapest, Hungary
    Cell Stress Chaperones 7:186-90. 2002
    ..Here, we summarize our current knowledge about changes in chaperone expression and function in the aging process, as well as their involvement in longevity and cellular senescence...
  28. ncbi request reprint Changes of endoplasmic reticulum chaperone complexes, redox state, and impaired protein disulfide reductase activity in misfolding alpha1-antitrypsin transgenic mice
    Eszter Papp
    Semmelweis University, Department of Medical Chemistry, P O Box 260 H 1444 Budapest 8, Hungary
    FASEB J 20:1018-20. 2006
    ..Our data suggest that lower availability of PDI and a decreased protein disulfide reductase activity of the ER along with a cytoplasmic stress may contribute to the toxic effects of PiZ aggregation...
  29. ncbi request reprint Enhancement of complement-induced cell lysis: a novel mechanism for the anticancer effects of Hsp90 inhibitors
    Amere Subbarao Sreedhar
    Department of Medical Chemistry, Semmelweis University, P O Box 260, H 1444 Budapest 8, Hungary
    Immunol Lett 92:157-61. 2004
    ..This novel mechanism may significantly contribute to the anticancer effects of Hsp90 inhibitors in vivo...
  30. ncbi request reprint Photo-acoustic stimulation increases the amount of 70 kDa heat shock protein (Hsp70) in human whole saliva. A pilot study
    Tibor Károly Fábián
    Faculty of Dentistry, Semmelweis University, Clinic of Prosthetic Dentistry H 1088 Budapest, Mikszáth Kálmán square 5, Budapest, Hungary
    Int J Psychophysiol 52:211-6. 2004
    ..Increased salivary chaperones may contribute to the effectivity of photo-acoustic stimulation, because of their cytoprotective extracellular actions...
  31. pmc SignaLink 2 - a signaling pathway resource with multi-layered regulatory networks
    Dávid Fazekas
    Department of Genetics, Eotvos Lorand University, Pázmány P, S, 1C, H 1117, Budapest, Hungary
    BMC Syst Biol 7:7. 2013
    ..Here, we present SignaLink 2, which significantly extends the coverage and applications of its predecessor...
  32. pmc NRF2-ome: an integrated web resource to discover protein interaction and regulatory networks of NRF2
    Dénes Türei
    Department of Genetics, Eotvos Lorand University, Pázmány P s 1c, H 1117, Budapest, Hungary
    Oxid Med Cell Longev 2013:737591. 2013
    ..NRF2-ome can also be used as an evaluation tool to help researchers and drug developers to understand the hidden regulatory mechanisms in the complex network of NRF2...
  33. doi request reprint ModuLand plug-in for Cytoscape: determination of hierarchical layers of overlapping network modules and community centrality
    Máté Szalay-Beko
    Department of Medical Chemistry, Semmelweis University, Budapest 1444, Hungary
    Bioinformatics 28:2202-4. 2012
    ..The plug-in has a detailed JAVA-based graphical interface with various colouring options. The ModuLand tool can run on Windows, Linux or Mac OS. We demonstrate its use on protein structure and metabolic networks...
  34. doi request reprint The NRF2-related interactome and regulome contain multifunctional proteins and fine-tuned autoregulatory loops
    Diana Papp
    Department of Genetics, Eotvos Lorand University, Budapest, Hungary
    FEBS Lett 586:1795-802. 2012
    ..The presented network and the uncovered regulatory loops may facilitate the development of efficient, NRF2-based therapeutic agents...
  35. ncbi request reprint Comparative analysis of the ATP-binding sites of Hsp90 by nucleotide affinity cleavage: a distinct nucleotide specificity of the C-terminal ATP-binding site
    Csaba Soti
    Department of Medical Chemistry, Semmelweis University School of Medicine, Budapest, Hungary
    Eur J Biochem 270:2421-8. 2003
    ....
  36. ncbi request reprint Apoptosis, necrosis and cellular senescence: chaperone occupancy as a potential switch
    Csaba Soti
    Department of Medical Chemistry, Semmelweis University, PO Box 260, H 1444 Budapest, Hungary
    Aging Cell 2:39-45. 2003
    ..In the case of severe stress, this may lead to apoptosis or, following lethal stress, to cell necrosis...
  37. ncbi request reprint Stress-induced rearrangements of cellular networks: Consequences for protection and drug design
    Máté S Szalay
    Department of Medical Chemistry, Semmelweis University, Puskin str 9, H 1088 Budapest, Hungary
    FEBS Lett 581:3675-80. 2007
    ..Finally, we discuss the implications of stress-induced network rearrangements in diseases and ageing, and propose therapeutic approaches both to increase the robustness and help the repair of cellular networks...
  38. ncbi request reprint Disordered proteins and network disorder in network descriptions of protein structure, dynamics and function: hypotheses and a comprehensive review
    Peter Csermely
    Department of Medical Chemistry, Semmelweis University, H 1444 Budapest, P O Box 260, Hungary
    Curr Protein Pept Sci 13:19-33. 2012
    ....
  39. doi request reprint Misfolded proteins inhibit proliferation and promote stress-induced death in SV40-transformed mammalian cells
    Mehmet Alper Arslan
    Department of Medical Chemistry, Semmelweis University, Budapest, Hungary
    FASEB J 26:766-77. 2012
    ..Our study establishes a novel model and extends our knowledge on the mechanism of the function-independent proteotoxicity of misfolded proteins in dividing cells...
  40. doi request reprint Uniformly curated signaling pathways reveal tissue-specific cross-talks and support drug target discovery
    Tamás Korcsmáros
    Department of Genetics, Eotvos University, Budapest, Hungary
    Bioinformatics 26:2042-50. 2010
    ..However, currently, even within the same database signaling pathways are often curated at different levels of detail. This makes comparative and cross-talk analyses difficult...
  41. ncbi request reprint Molecular chaperones: the modular evolution of cellular networks
    Tamás Korcsmáros
    Department of Medical Chemistry, Semmelweis University, Budapest, Hungary
    J Biosci 32:441-6. 2007
    ..This opens the way to the chaperone-regulated modular evolution of cellular networks,and helps us to design novel therapeutic and anti-aging strategies...
  42. ncbi request reprint Perturbation waves in proteins and protein networks: applications of percolation and game theories in signaling and drug design
    Miklós A Antal
    Department of Medical Chemistry, Semmelweis University, H 1444 Budapest, P O Box 260, Hungary
    Curr Protein Pept Sci 10:161-72. 2009
    ..Furthermore, we give an overview of the dissection of signals and noise in the cellular context of various perturbations. Finally, we propose possible applications of the reviewed methodologies in drug design...
  43. pmc Nodes having a major influence to break cooperation define a novel centrality measure: game centrality
    Gábor I Simkó
    Department of Medical Chemistry, Semmelweis University, Budapest, Hungary
    PLoS ONE 8:e67159. 2013
    ..Game centrality may help to design more efficient interventions to cellular networks (in forms of drugs), to ecosystems and social networks. ..
  44. ncbi request reprint Chaperones and aging: role in neurodegeneration and in other civilizational diseases
    Csaba Soti
    Department of Medical Chemistry, Semmelweis University, P O Box 260, H 1444 8 Budapest, Hungary
    Neurochem Int 41:383-9. 2002
    ....
  45. ncbi request reprint Inhibition of Hsp90: a new strategy for inhibiting protein kinases
    Amere Subbarao Sreedhar
    Department of Medical Chemistry, Semmelweis University Medical School, P O Box 260, H 1444 Budapest 8, Hungary
    Biochim Biophys Acta 1697:233-42. 2004
    ..Our last major aspect deals with protein oxidation, since several Hsp90 inhibitors exert pro-oxidant effects...
  46. ncbi request reprint Allo-network drugs: extension of the allosteric drug concept to protein- protein interaction and signaling networks
    Andras Szilagyi
    Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary
    Curr Top Med Chem 13:64-77. 2013
    ..Finally, we summarize possible methods to identify allo-network drug targets and sites, which may develop to a promising new area of systems-based drug design...
  47. ncbi request reprint Water and molecular chaperones act as weak links of protein folding networks: energy landscape and punctuated equilibrium changes point towards a game theory of proteins
    Istvan A Kovacs
    Department of Medical Chemistry, Semmelweis University, Budapest, Hungary
    FEBS Lett 579:2254-60. 2005
    ..Both water and chaperones provide a diffuse set of rapidly fluctuating weak links (low affinity and low probability interactions), which allow the generalization of all these statements to a multitude of networks...
  48. pmc Induced fit, conformational selection and independent dynamic segments: an extended view of binding events
    Peter Csermely
    Department of Medical Chemistry, Semmelweis University, PO Box 260, H 1444 Budapest 8, Hungary
    Trends Biochem Sci 35:539-46. 2010
    ..Additionally, we highlight the dynamic complexity of binding scenarios as they relate to events such as aggregation and signalling, and the crowded cellular environment...
  49. ncbi request reprint The heat shock connection of metabolic stress and dietary restriction
    Balázs Dancsó
    Department of Medical Chemistry, Semmelweis University, Budapest, Hungary
    Curr Pharm Biotechnol 11:139-45. 2010
    ....
  50. ncbi request reprint Resveratrol induces the heat-shock response and protects human cells from severe heat stress
    Akos Putics
    Department of Medical Chemistry, Semmelweis University, Budapest, Hungary
    Antioxid Redox Signal 10:65-75. 2008
    ..Our results reveal resveratrol as a chaperone inducer that may contribute to its pleiotropic effects in ameliorating stress and promoting longevity...
  51. ncbi request reprint Systems biology of molecular chaperone networks
    Peter Csermely
    Department of Medical Chemistry, Semmelweis University, Puskin Street 9, H 1088 Budapest, Hungary
    Novartis Found Symp 291:45-54; discussion 54-8, 137-40. 2008
    ..This opens the way to the chaperone-regulated modular evolution of cellular networks, and helps us to design novel therapeutic and anti-ageing strategies...
  52. ncbi request reprint Hsp90 isoforms: functions, expression and clinical importance
    Amere Subbarao Sreedhar
    Department of Medical Chemistry, Semmelweis University School of Medicine, Budapest, Hungary
    FEBS Lett 562:11-5. 2004
    ....
  53. doi request reprint Adaptation and learning of molecular networks as a description of cancer development at the systems-level: potential use in anti-cancer therapies
    Dávid M Gyurkó
    Semmelweis University, Department of Medical Chemistry, Tuzolto u 37 47, H 1094 Budapest, Hungary
    Semin Cancer Biol 23:262-9. 2013
    ..Our hypotheses presented here underlie the need for patient-specific multi-target therapies applying the correct ratio of central hits and network influences - in an optimized sequence. ..
  54. doi request reprint How to design multi-target drugs
    Tamás Korcsmáros
    Semmelweis University, Department of Medical Chemistry, PO Box 260, H 1444 Budapest 8, Hungary and Predinet Ltd, Dongo Street 8, H 1149 Budapest, Hungary 36 1 266 2755 36 1 266 6550
    Expert Opin Drug Discov 2:799-808. 2007
    ..Here, the authors review the recent progress in this field, compare possible network attack strategies and propose several methods to find target-sets for multi-target drugs...
  55. ncbi request reprint Uncoupled redox systems in the lumen of the endoplasmic reticulum. Pyridine nucleotides stay reduced in an oxidative environment
    Simona Piccirella
    Department of Medical Chemistry, Molecular Biology, and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    J Biol Chem 281:4671-7. 2006
    ..The results demonstrated the separate existence of two redox systems in the endoplasmic reticulum lumen, which explains the contemporary functioning of oxidative folding and of powerful reductive reactions...
  56. pmc Heat shock proteins as emerging therapeutic targets
    Csaba Soti
    Department of Medical Chemistry, Semmelweis University, Budapest, Hungary
    Br J Pharmacol 146:769-80. 2005
    ..In this review, we give an overview of the therapeutic approaches and list some of the key questions of drug development in this novel and promising therapeutic approach...
  57. doi request reprint Ageing as a price of cooperation and complexity: self-organization of complex systems causes the gradual deterioration of constituent networks
    Huba J M Kiss
    Department of Medical Chemistry, Semmelweis University, Budapest, Hungary
    Bioessays 31:651-64. 2009
    ..Finally, we show how various forms of cooperation and consequent ageing emerge as key elements in all major steps of evolution from the formation of protocells to the establishment of the globalized, modern human society...
  58. ncbi request reprint The biology of extracellular molecular chaperones. Chair's introduction
    Peter Csermely
    Department of Medical Chemistry, Semmelweis University, Puskin Street 9, H 1088 Budapest, Hungary
    Novartis Found Symp 291:1-2. 2008
  59. ncbi request reprint Chaperone-related immune dysfunction: an emergent property of distorted chaperone networks
    Gábor Nardai
    Department of Medical Chemistry, Semmelweis University, H 1088 Budapest, Hungary
    Trends Immunol 27:74-9. 2006
    ..Mutations and polymorphism of chaperones and the regulators of their synthesis, heat shock factor-1, chaperone diseases, sick chaperones and chaperone overload might all affect (mostly impairing) immune responses...
  60. pmc Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review
    Peter Csermely
    Department of Medical Chemistry, Semmelweis University, P O Box 260, H 1444 Budapest 8, Hungary
    Pharmacol Ther 138:333-408. 2013
    ..Finally, we highlight network-related drug development trends helping to achieve these hallmarks by a cohesive, global approach...
  61. pmc Drug-therapy networks and the prediction of novel drug targets
    Zoltan Spiro
    Department of Medical Chemistry, Semmelweis University, H 1444 Budapest 8, Hungary
    J Biol 7:20. 2008
    ..Network approaches open new ways of predicting novel drug targets and overcoming the cellular robustness that can prevent drugs from working...
  62. ncbi request reprint Protein stress and stress proteins: implications in aging and disease
    C Soti
    Department of Medical Chemistry, Semmelweis University PO Box 260, H 1444, Budapest 8, Hungary
    J Biosci 32:511-5. 2007
    ..This review summarizes the present knowledge of protein damage, turnover, and the stress response in aging and degenerative diseases...
  63. pmc DUK114, the Drosophila orthologue of bovine brain calpain activator protein, is a molecular chaperone
    Attila Farkas
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Biochem J 383:165-70. 2004
    ..Our work is the first experimental evidence that DUK114, and possibly other members of this family, are molecular chaperones...
  64. doi request reprint Zinc supplementation boosts the stress response in the elderly: Hsp70 status is linked to zinc availability in peripheral lymphocytes
    Akos Putics
    Department of Medical Chemistry, Semmelweis University, P O Box 260, Budapest H 1444, Hungary
    Exp Gerontol 43:452-61. 2008
    ..The stress response may be a candidate pathway connecting zinc deficiency with aging and immunosenescence. Thus, proper dietary zinc intake may emerge as a chaperone inducer and an anti-aging mechanism in the immune system...
  65. ncbi request reprint Aging and molecular chaperones
    Csaba Soti
    Department of Medical Chemistry, Semmelweis University, P O Box 260, H 1444 Budapest 8, Hungary
    Exp Gerontol 38:1037-40. 2003
    ..The consequences of chaperone overload are also outlined together with several new research strategies to assess the functional status of chaperones in the aging process...
  66. ncbi request reprint Attitude toward death: does it influence dental fear?
    Gabor Fabian
    Clinic of Pediatric Dentistry and Orthodontics, Faculty of Dentistry, Semmelweis University, Szentkirályi utca 47, 1088, Budapest, Hungary
    Ann N Y Acad Sci 1113:339-49. 2007
    ..01). Our data indicate a detectable influence of fear of death on dental fear, especially in subjects with higher dental fear scores...
  67. ncbi request reprint Potential immunological functions of salivary Hsp70 in mucosal and periodontal defense mechanisms
    Tibor Károly Fábián
    Clinic of Prosthetic Dentistry, Faculty of Dentistry, Semmelweis University Budapest, Budapest, Hungary
    Arch Immunol Ther Exp (Warsz) 55:91-8. 2007
    ..e. several lesions of the mucosa and the periodontal tissues)...
  68. ncbi request reprint A Nucleotide-dependent molecular switch controls ATP binding at the C-terminal domain of Hsp90. N-terminal nucleotide binding unmasks a C-terminal binding pocket
    Csaba Soti
    Department of Medical Chemistry, Semmelweis University, P O Box 260, Budapest H 1444, Hungary
    J Biol Chem 277:7066-75. 2002
    ..Cisplatin may provide a pharmacological tool to dissect C- and N-terminal nucleotide binding of Hsp90. A model is proposed on the interactions of the two nucleotide-binding domains and the charged region of Hsp90...
  69. ncbi request reprint Diabetic changes in the redox status of the microsomal protein folding machinery
    Gábor Nardai
    Department of Medical Chemistry, Semmelweis University, P O Box 260, H 1444 Budapest 8, Hungary
    Biochem Biophys Res Commun 334:787-95. 2005
    ..Our results reveal major changes in the redox status of the endoplasmic reticulum and its redox chaperones in diabetic rats, which may contribute to the defective protein secretion of the diabetic liver...
  70. pmc Heat shock partially dissociates the overlapping modules of the yeast protein-protein interaction network: a systems level model of adaptation
    Agoston Mihalik
    Department of Medical Chemistry, Semmelweis University, Budapest, Hungary
    PLoS Comput Biol 7:e1002187. 2011
    ..Thus, our work may provide a model of a general, system-level adaptation mechanism to environmental changes...
  71. ncbi request reprint Hsp70 is present in human saliva
    Tibor Károly Fábián
    Prosthetic Dentistry Clinic, Faculty of Dentistry, Semmelweis University, Budapest, Hungary
    Med Sci Monit 9:BR62-5. 2003
    ..Chaperonins Cpn10 and Cpn60 are present in pancreatic juice, but Hsp70 is not. These observations raise the possibility that molecular chaperones may be present in other secretory fluids, such as human saliva...
  72. doi request reprint Cancer-related networks: A help to understand, predict and change malignant transformation
    Peter Csermely
    Department of Medical Chemistry, Semmelweis University, P O Box 260, H 1444 Budapest 8, Hungary Electronic address
    Semin Cancer Biol 23:209-12. 2013
    ..In conclusion, the above applications of the network approach open up new, and highly promising avenues in anti-cancer drug design. ..
  73. ncbi request reprint Potential application of network descriptions for understanding conformational changes and protonation states of ABC transporters
    Tamas Hegedus
    Membrane Research Group, Hungarian Academy of Sciences, Budapest, Hungary
    Curr Pharm Des 19:4155-72. 2013
    ..Finally, we highlight possible future aspects of pharmacological utilization of network methods and outline the future trends of this exciting field...
  74. doi request reprint Rigidity and flexibility of biological networks
    Merse E Gáspár
    Department of Medical Chemistry, Semmelweis University, Tűzoltó str 37 47, H 1094 Budapest, Hungary
    Brief Funct Genomics 11:443-56. 2012
    ..Our summary raises the possibility that the concepts of flexibility and rigidity can be generalized to all networks...
  75. pmc Network strategies to understand the aging process and help age-related drug design
    Gábor I Simkó
    Semmelweis University, Department of Medical Chemistry, PO Box 260, H 1444 Budapest, Hungary
    Genome Med 1:90. 2009
    ....
  76. ncbi request reprint Heat shock proteins in the regulation of apoptosis: new strategies in tumor therapy: a comprehensive review
    Amere Subbarao Sreedhar
    Department of Medical Chemistry, Semmelweis University, P O Box 260, H 1444 Budapest, Hungary
    Pharmacol Ther 101:227-57. 2004
    ..Finally, we show the emerging variety of pharmacological interventions inhibiting or, just conversely, inducing Hsp and review the emergence of Hsp as novel therapeutic targets in anticancer protocols...