Ottó Lehoczky

..Second-line chemotherapies result in a progression-free interval of 2,3-42 months...

..The first publications on this treatment form are promising, however, a final policy in this matter can only be assumed after finishing the evaluation of the comprehensive, randomised studies (GOG-0182-ICON5) in progress...

..However, neoadjuvant chemotherapy remain as an alternative treatment for patients with ovarian cancer of advanced stage and poor internal status, for whom there is no other choice for tumor elimination...

..The optimal result is more frequent in operations performed by gynecologist oncologists as is in surgery administered by general gynecologists or general surgeons...

..In this study the authors evaluated the results of the docetaxel-carboplatin combination treatment in two oncological centers...

..Thrombotic events are infrequently observed in erythropoietin treatments for the anemia in tumorous patients with chemotherapy. The manufacturers call attention to this possible side effect of all kind of such drugs...

..The authors administered two doses of oral methylprednisolone in combination with 3mg granisetron intravenously for the prophylaxis of cisplatin-induced emesis in gynecologic cancer patients...

..9%, 1.1%, p = 0.8572). Data of the authors underline the importance of prophylaxis and treatment of anemia in chemotherapy courses of ovarian cancer patients...

..The final diagnoses was proved by cervical conisation in the first patient and by hysterectomy in the second one. Authors call attention for the possibility of the rare site of symptom free recurrence...

..Paclitaxel-carboplatin combination chemotherapy has been administered worldwide in the first-line adjuvant treatment of epithelial ovarian cancers since the mid 1990's...

..Authors conclude the addition of an anxiolytic drug does not improve the antiemetic effectivity of the granisetron-methylprednisolone combination in the first 24 hours of cisplatin chemotherapy...

..According to this document the blood transfusions are indicated at the level of 9 g/dL of hemoglobin. Up to this year a definitive limit for applying blood transfusion in chemotherapy-induced anemia has not been determined in Hungary...

..Topotecan inhibits the topoisomerase-I enzyme resulting its stabilisation on the DNA and the suspension of replication and transcription...

..75% complete response and 11% major response rates were found. Authors conclude that fast dissolving ondansetron is a new and effective preparation that enriches the panel of available supporting drugs...

..Hypersensitive reaction is its most serious side effect including hypotension, respiratory distress, extensive urticaria or an intense cardiotoxicity. Due to these signs several physicians abandon of the otherwise hopeful chemotherapy...

..This is the rationale for several new chemotherapy trials, however the expected results are awaited yet. The pyrimidine analogue drug gemcitabine belongs also to this group of hopeful therapies to increase the outcomes...

..The authors summarize the results of paclitaxel-carboplatin therapy of the years from 2000 to 2002, and compare them to the results observed in 2002...

..Weekly docetaxel therapy is a new therapeutical form of relapsed ovarian cancer. Phase I and II trials of this administration form are rare in the literature of this tumor type. The authors report on a retrospective study of this treatment...

..The side effect observed in chronic renal failure patients calls the attention to the precise compliance with the instructions of the manufacturers...

..The aim of this study was to evaluate toxicity profile and effectiveness of this treatment in patients with recurrent ovarian cancer...

..These results, which are similar to the literature data have led to the agreement: paclitaxel can be applied in ovarian cancer patients only in first-line chemotherapy in Hungary from the year 2000...

..Fibroepithelial stromal polyp is generally an easily recognizable entity, but certain cases cause differential diagnostic problems...

..One patient complained of severe neuropathy (nervus oculomotorius paresis), and another one developed severe ECG abnormalities CONCLUSIONS: When suitable premedication is applied few side-effects of PTXL therapy are reported...