Z Nusser

Summary

Affiliation: Institute of Experimental Medicine
Country: Hungary

Publications

  1. doi request reprint Differential subcellular distribution of ion channels and the diversity of neuronal function
    Zoltan Nusser
    Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony Street 43, 1083 Budapest, Hungary
    Curr Opin Neurobiol 22:366-71. 2012
  2. pmc Virus-mediated swapping of zolpidem-insensitive with zolpidem-sensitive GABA(A) receptors in cortical pyramidal cells
    Máté Sümegi
    Division of Cerebral Structure, National Institute for Physiological Sciences, Okazaki 444 8787, Japan
    J Physiol 590:1517-34. 2012
  3. ncbi request reprint AMPA and NMDA receptors: similarities and differences in their synaptic distribution
    Z Nusser
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Hungary
    Curr Opin Neurobiol 10:337-41. 2000
  4. ncbi request reprint Disruption of GABA(A) receptors on GABAergic interneurons leads to increased oscillatory power in the olfactory bulb network
    Z Nusser
    Department of Neurology, UCLA School of Medicine, Los Angeles 90095 1769, California, USA
    J Neurophysiol 86:2823-33. 2001
  5. ncbi request reprint Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cells
    Zoltan Nusser
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
    J Neurophysiol 87:2624-8. 2002
  6. doi request reprint Variability in the subcellular distribution of ion channels increases neuronal diversity
    Zoltan Nusser
    Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, 1083 Budapest, Hungary
    Trends Neurosci 32:267-74. 2009
  7. ncbi request reprint Release-independent short-term facilitation at GABAergic synapses in the olfactory bulb
    Z Nusser
    Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony Street 43, 1083 Budapest, Hungary
    Neuropharmacology 43:573-83. 2002
  8. pmc Differential regulation of synaptic GABAA receptors by cAMP-dependent protein kinase in mouse cerebellar and olfactory bulb neurones
    Z Nusser
    Department of Neurology, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    J Physiol 521:421-35. 1999
  9. pmc Synapse-specific contribution of the variation of transmitter concentration to the decay of inhibitory postsynaptic currents
    Z Nusser
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095-1769, USA
    Biophys J 80:1251-61. 2001
  10. ncbi request reprint Quantal size is independent of the release probability at hippocampal excitatory synapses
    Agota A Biró
    Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, 1083 Budapest, Hungary
    J Neurosci 25:223-32. 2005

Collaborators

Detail Information

Publications25

  1. doi request reprint Differential subcellular distribution of ion channels and the diversity of neuronal function
    Zoltan Nusser
    Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony Street 43, 1083 Budapest, Hungary
    Curr Opin Neurobiol 22:366-71. 2012
    ..Here I suggest that within a given neuron type every ion channel has a unique cell surface distribution pattern, with the functional consequence that this dramatically increases the computational power of nerve cells...
  2. pmc Virus-mediated swapping of zolpidem-insensitive with zolpidem-sensitive GABA(A) receptors in cortical pyramidal cells
    Máté Sümegi
    Division of Cerebral Structure, National Institute for Physiological Sciences, Okazaki 444 8787, Japan
    J Physiol 590:1517-34. 2012
    ..In addition, this virus-based approach opens up the possibility of modifying multiple cell types in distinct brain regions and performing alternative recombination-based intersectional genetic manipulations...
  3. ncbi request reprint AMPA and NMDA receptors: similarities and differences in their synaptic distribution
    Z Nusser
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Hungary
    Curr Opin Neurobiol 10:337-41. 2000
    ....
  4. ncbi request reprint Disruption of GABA(A) receptors on GABAergic interneurons leads to increased oscillatory power in the olfactory bulb network
    Z Nusser
    Department of Neurology, UCLA School of Medicine, Los Angeles 90095 1769, California, USA
    J Neurophysiol 86:2823-33. 2001
    ....
  5. ncbi request reprint Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cells
    Zoltan Nusser
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
    J Neurophysiol 87:2624-8. 2002
    ..Furthermore, we have identified distinct pharmacological tools to selectively modify tonic and phasic inhibitions, allowing future studies to investigate their specific roles in neuronal function...
  6. doi request reprint Variability in the subcellular distribution of ion channels increases neuronal diversity
    Zoltan Nusser
    Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, 1083 Budapest, Hungary
    Trends Neurosci 32:267-74. 2009
    ..Here, I suggest that variations in the subcellular distribution of ion channels are previously unrecognized means of increasing neuronal diversity and, thus, the computational power of the brain...
  7. ncbi request reprint Release-independent short-term facilitation at GABAergic synapses in the olfactory bulb
    Z Nusser
    Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony Street 43, 1083 Budapest, Hungary
    Neuropharmacology 43:573-83. 2002
    ..These results reveal a heterogeneity in the short-term plasticity of evoked IPSCs in juxtaglomerular cells and demonstrate that the short-term facilitation at some GABAergic synapses is independent of release...
  8. pmc Differential regulation of synaptic GABAA receptors by cAMP-dependent protein kinase in mouse cerebellar and olfactory bulb neurones
    Z Nusser
    Department of Neurology, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    J Physiol 521:421-35. 1999
    ..Furthermore, our results show that the effect of PKA-mediated phosphorylation on synaptic inhibition depends upon the subunit composition of postsynaptic GABAA receptors...
  9. pmc Synapse-specific contribution of the variation of transmitter concentration to the decay of inhibitory postsynaptic currents
    Z Nusser
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095-1769, USA
    Biophys J 80:1251-61. 2001
    ..Thus, our results suggest a synapse-specific contribution of the variation of the spatiotemporal profile of GABA to the decay of IPSCs...
  10. ncbi request reprint Quantal size is independent of the release probability at hippocampal excitatory synapses
    Agota A Biró
    Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, 1083 Budapest, Hungary
    J Neurosci 25:223-32. 2005
    ..8 +/- 0.8-fold) fully accounted for the marked short-term facilitation of EPSCs (5.0 +/- 0.7-fold), and q was independent of P(r). Our results are consistent with the "one-release site, one-vesicle" hypothesis...
  11. pmc Distinct deep short-axon cell subtypes of the main olfactory bulb provide novel intrabulbar and extrabulbar GABAergic connections
    Mark D Eyre
    Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, 1083 Budapest, Hungary
    J Neurosci 28:8217-29. 2008
    ..Our results reveal multiple dSAC subtypes, each specialized to influence MOB activity by selectively innervating GABAergic interneurons, and provide direct evidence for novel intrabulbar and extrabulbar GABAergic projections...
  12. pmc Cell type dependence and variability in the short-term plasticity of EPSCs in identified mouse hippocampal interneurones
    Attila Losonczy
    Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Budapest, Hungary
    J Physiol 542:193-210. 2002
    ..Our results demonstrate that the short-term plasticity of EPSCs is cell type dependent, but with significant heterogeneity within all three interneurone populations...
  13. pmc Release probability-dependent scaling of the postsynaptic responses at single hippocampal GABAergic synapses
    Agota A Biró
    Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, 1083 Budapest, Hungary
    J Neurosci 26:12487-96. 2006
    ....
  14. pmc External tufted cells in the main olfactory bulb form two distinct subpopulations
    Miklos Antal
    Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony Street 43, 1083 Budapest, Hungary
    Eur J Neurosci 24:1124-36. 2006
    ..However, cells within each subpopulation exhibit pronounced variability, suggesting a large degree of specialization evolved to fulfil specific functional requirements in olfactory information processing...
  15. pmc Synapse independence breaks down during highly synchronous network activity in the rat hippocampus
    Agota A Biró
    Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony Street 43, 1083 Budapest, Hungary
    Eur J Neurosci 22:1257-62. 2005
    ..Our data demonstrate that synapse independence breaks down during synchronous presynaptic activity, but the point-to-point communication is preserved when PCs fire asynchronously...
  16. ncbi request reprint Changes in synaptic structure underlie the developmental speeding of AMPA receptor-mediated EPSCs
    Laurence Cathala
    1 Department of Pharmacology, University College London, UK
    Nat Neurosci 8:1310-8. 2005
    ..Our findings raise the possibility that structural alterations could be a general mechanism underlying the change in the time course of AMPAR-mediated synaptic transmission...
  17. ncbi request reprint Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors
    Mark Farrant
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Rev Neurosci 6:215-29. 2005
    ..In this review, we consider the distinct roles of synaptic and extrasynaptic GABA receptor subtypes in the control of neuronal excitability...
  18. ncbi request reprint Spillover of glutamate onto synaptic AMPA receptors enhances fast transmission at a cerebellar synapse
    David A DiGregorio
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Neuron 35:521-33. 2002
    ..We propose that spillover of glutamate improves transmission efficacy by both increasing the amplitude and duration of the EPSP and reducing fluctuations arising from the probabilistic nature of transmitter release...
  19. pmc Persistently active cannabinoid receptors mute a subpopulation of hippocampal interneurons
    Attila Losonczy
    Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, 43 Szigony Street, 1083, Budapest, Hungary
    Proc Natl Acad Sci U S A 101:1362-7. 2004
    ..The selective muting of specific GABAergic INs, achieved by persistent presynaptic cannabinoid receptor activation, provides a state-dependent switch in cortical networks...
  20. ncbi request reprint Cell type-dependent expression of HCN1 in the main olfactory bulb
    Noemi B Holderith
    Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony Street 43, 1083 Budapest, Hungary
    Eur J Neurosci 18:344-54. 2003
    ..Our results demonstrate a cell type-dependent expression of HCN1 in the olfactory bulb and predict a differential contribution of distinct juxtaglomerular cell types to network oscillations...
  21. ncbi request reprint Reduction of excitatory postsynaptic responses by persistently active metabotropic glutamate receptors in the hippocampus
    Attila Losonczy
    Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, 1083 Budapest, Hungary and Medical Research Council, Anatomical Neuropharmacology Unit, University Department of Pharmacology, Oxford OX1 3TH, United Kingdom
    J Neurophysiol 89:1910-9. 2003
    ..2 microM LY341495: mGluR2/3/8) suggests that persistently active mGluR2/3/8 control the excitability of hippocampal network...
  22. pmc Specificity of immunoreactions: the importance of testing specificity in each method
    Andrea Lorincz
    Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, 1083 Budapest, Hungary
    J Neurosci 28:9083-6. 2008
  23. pmc Unique clustering of A-type potassium channels on different cell types of the main olfactory bulb
    Mihaly Kollo
    Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Budapest, Hungary
    Eur J Neurosci 27:1686-99. 2008
    ..Our study provides evidence for highly non-uniform subcellular distributions of A-type K+ channels and predicts their involvements in novel forms of intercellular communication in the olfactory pathway...
  24. pmc Novel subcellular distribution pattern of A-type K+ channels on neuronal surface
    Mihaly Kollo
    Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, 1083 Budapest, Hungary
    J Neurosci 26:2684-91. 2006
    ..Based on our results and on the known properties of A-type K+ channels, we propose that strategically clustered K+ channels at unique membrane specializations could mediate a novel type of communication between nerve cells...
  25. ncbi request reprint Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites
    Andrea Lorincz
    Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences Szigony Street 43, 1083 Budapest, Hungary
    Nat Neurosci 5:1185-93. 2002
    ..Our results reveal the complex cell surface distribution of voltage-gated ion-channels, and predict its role in increasing the computational power of single neurons via subcellular domain and input-specific mechanisms...