Research Topics
Species | Z NusserSummaryAffiliation: Institute of Experimental Medicine Country: Hungary Publications
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Detail Information
Publications
Differential subcellular distribution of ion channels and the diversity of neuronal functionZoltan Nusser
Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony Street 43, 1083 Budapest, Hungary
Curr Opin Neurobiol 22:366-71. 2012..Here I suggest that within a given neuron type every ion channel has a unique cell surface distribution pattern, with the functional consequence that this dramatically increases the computational power of nerve cells...
Virus-mediated swapping of zolpidem-insensitive with zolpidem-sensitive GABA(A) receptors in cortical pyramidal cellsMáté Sümegi
Division of Cerebral Structure, National Institute for Physiological Sciences, Okazaki 444 8787, Japan
J Physiol 590:1517-34. 2012..In addition, this virus-based approach opens up the possibility of modifying multiple cell types in distinct brain regions and performing alternative recombination-based intersectional genetic manipulations...
AMPA and NMDA receptors: similarities and differences in their synaptic distributionZ Nusser
Institute of Experimental Medicine, Hungarian Academy of Sciences, Hungary
Curr Opin Neurobiol 10:337-41. 2000....- Disruption of GABA(A) receptors on GABAergic interneurons leads to increased oscillatory power in the olfactory bulb networkZ Nusser
Department of Neurology, UCLA School of Medicine, Los Angeles 90095 1769, California, USA
J Neurophysiol 86:2823-33. 2001.... - Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cellsZoltan Nusser
Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
J Neurophysiol 87:2624-8. 2002..Furthermore, we have identified distinct pharmacological tools to selectively modify tonic and phasic inhibitions, allowing future studies to investigate their specific roles in neuronal function... - Variability in the subcellular distribution of ion channels increases neuronal diversityZoltan Nusser
Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, 1083 Budapest, Hungary
Trends Neurosci 32:267-74. 2009..Here, I suggest that variations in the subcellular distribution of ion channels are previously unrecognized means of increasing neuronal diversity and, thus, the computational power of the brain... - Release-independent short-term facilitation at GABAergic synapses in the olfactory bulbZ Nusser
Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony Street 43, 1083 Budapest, Hungary
Neuropharmacology 43:573-83. 2002..These results reveal a heterogeneity in the short-term plasticity of evoked IPSCs in juxtaglomerular cells and demonstrate that the short-term facilitation at some GABAergic synapses is independent of release... - Differential regulation of synaptic GABAA receptors by cAMP-dependent protein kinase in mouse cerebellar and olfactory bulb neuronesZ Nusser
Department of Neurology, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
J Physiol 521:421-35. 1999..Furthermore, our results show that the effect of PKA-mediated phosphorylation on synaptic inhibition depends upon the subunit composition of postsynaptic GABAA receptors... - Synapse-specific contribution of the variation of transmitter concentration to the decay of inhibitory postsynaptic currentsZ Nusser
Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095-1769, USA
Biophys J 80:1251-61. 2001..Thus, our results suggest a synapse-specific contribution of the variation of the spatiotemporal profile of GABA to the decay of IPSCs... - Quantal size is independent of the release probability at hippocampal excitatory synapsesAgota A Biró
Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, 1083 Budapest, Hungary
J Neurosci 25:223-32. 2005..8 +/- 0.8-fold) fully accounted for the marked short-term facilitation of EPSCs (5.0 +/- 0.7-fold), and q was independent of P(r). Our results are consistent with the "one-release site, one-vesicle" hypothesis... - Distinct deep short-axon cell subtypes of the main olfactory bulb provide novel intrabulbar and extrabulbar GABAergic connectionsMark D Eyre
Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, 1083 Budapest, Hungary
J Neurosci 28:8217-29. 2008..Our results reveal multiple dSAC subtypes, each specialized to influence MOB activity by selectively innervating GABAergic interneurons, and provide direct evidence for novel intrabulbar and extrabulbar GABAergic projections... - Cell type dependence and variability in the short-term plasticity of EPSCs in identified mouse hippocampal interneuronesAttila Losonczy
Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Budapest, Hungary
J Physiol 542:193-210. 2002..Our results demonstrate that the short-term plasticity of EPSCs is cell type dependent, but with significant heterogeneity within all three interneurone populations... - Release probability-dependent scaling of the postsynaptic responses at single hippocampal GABAergic synapsesAgota A Biró
Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, 1083 Budapest, Hungary
J Neurosci 26:12487-96. 2006.... - External tufted cells in the main olfactory bulb form two distinct subpopulationsMiklos Antal
Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony Street 43, 1083 Budapest, Hungary
Eur J Neurosci 24:1124-36. 2006..However, cells within each subpopulation exhibit pronounced variability, suggesting a large degree of specialization evolved to fulfil specific functional requirements in olfactory information processing... - Synapse independence breaks down during highly synchronous network activity in the rat hippocampusAgota A Biró
Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony Street 43, 1083 Budapest, Hungary
Eur J Neurosci 22:1257-62. 2005..Our data demonstrate that synapse independence breaks down during synchronous presynaptic activity, but the point-to-point communication is preserved when PCs fire asynchronously... - Changes in synaptic structure underlie the developmental speeding of AMPA receptor-mediated EPSCsLaurence Cathala
1] Department of Pharmacology, University College London, UK
Nat Neurosci 8:1310-8. 2005..Our findings raise the possibility that structural alterations could be a general mechanism underlying the change in the time course of AMPAR-mediated synaptic transmission... - Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptorsMark Farrant
Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
Nat Rev Neurosci 6:215-29. 2005..In this review, we consider the distinct roles of synaptic and extrasynaptic GABA receptor subtypes in the control of neuronal excitability... - Spillover of glutamate onto synaptic AMPA receptors enhances fast transmission at a cerebellar synapseDavid A DiGregorio
Department of Physiology, University College London, Gower Street, London WC1E 6BT, United Kingdom
Neuron 35:521-33. 2002..We propose that spillover of glutamate improves transmission efficacy by both increasing the amplitude and duration of the EPSP and reducing fluctuations arising from the probabilistic nature of transmitter release... - Persistently active cannabinoid receptors mute a subpopulation of hippocampal interneuronsAttila Losonczy
Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, 43 Szigony Street, 1083, Budapest, Hungary
Proc Natl Acad Sci U S A 101:1362-7. 2004..The selective muting of specific GABAergic INs, achieved by persistent presynaptic cannabinoid receptor activation, provides a state-dependent switch in cortical networks... - Cell type-dependent expression of HCN1 in the main olfactory bulbNoemi B Holderith
Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony Street 43, 1083 Budapest, Hungary
Eur J Neurosci 18:344-54. 2003..Our results demonstrate a cell type-dependent expression of HCN1 in the olfactory bulb and predict a differential contribution of distinct juxtaglomerular cell types to network oscillations... - Reduction of excitatory postsynaptic responses by persistently active metabotropic glutamate receptors in the hippocampusAttila Losonczy
Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, 1083 Budapest, Hungary; and Medical Research Council, Anatomical Neuropharmacology Unit, University Department of Pharmacology, Oxford OX1 3TH, United Kingdom
J Neurophysiol 89:1910-9. 2003..2 microM LY341495: mGluR2/3/8) suggests that persistently active mGluR2/3/8 control the excitability of hippocampal network... - Specificity of immunoreactions: the importance of testing specificity in each methodAndrea Lorincz
Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, 1083 Budapest, Hungary
J Neurosci 28:9083-6. 2008 - Unique clustering of A-type potassium channels on different cell types of the main olfactory bulbMihaly Kollo
Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Budapest, Hungary
Eur J Neurosci 27:1686-99. 2008..Our study provides evidence for highly non-uniform subcellular distributions of A-type K+ channels and predicts their involvements in novel forms of intercellular communication in the olfactory pathway... - Novel subcellular distribution pattern of A-type K+ channels on neuronal surfaceMihaly Kollo
Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, 1083 Budapest, Hungary
J Neurosci 26:2684-91. 2006..Based on our results and on the known properties of A-type K+ channels, we propose that strategically clustered K+ channels at unique membrane specializations could mediate a novel type of communication between nerve cells... - Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendritesAndrea Lorincz
Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences Szigony Street 43, 1083 Budapest, Hungary
Nat Neurosci 5:1185-93. 2002..Our results reveal the complex cell surface distribution of voltage-gated ion-channels, and predict its role in increasing the computational power of single neurons via subcellular domain and input-specific mechanisms...