Arpad Mike

Summary

Affiliation: Institute of Experimental Medicine
Location: Budapest, Hungary

Publications

  1. ncbi request reprint Ca(2+)-sensitive inhibition by Pb(2+) of alpha7-containing nicotinic acetylcholine receptors in hippocampal neurons
    A Mike
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore 21201, USA
    Brain Res 873:112-23. 2000
  2. pmc Rapid desensitization of the rat α7 nAChR is facilitated by the presence of a proline residue in the outer β-sheet
    Thomas J McCormack
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    J Physiol 588:4415-29. 2010
  3. doi request reprint Binding of sodium channel inhibitors to hyperpolarized and depolarized conformations of the channel
    N Lenkey
    Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, P O B 67, H 1450 Budapest, Hungary
    Neuropharmacology 60:191-200. 2011
  4. pmc Fast- or slow-inactivated state preference of Na+ channel inhibitors: a simulation and experimental study
    Robert Karoly
    Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    PLoS Comput Biol 6:e1000818. 2010
  5. ncbi request reprint The enigmatic drug binding site for sodium channel inhibitors
    Arpad Mike
    Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, P O BOX 67, H 1450 Budapest, Hungary
    Curr Mol Pharmacol 3:129-44. 2010
  6. pmc Non-synaptic receptors and transporters involved in brain functions and targets of drug treatment
    E S Vizi
    Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    Br J Pharmacol 160:785-809. 2010
  7. ncbi request reprint Converging effects of Ginkgo biloba extract at the level of transmitter release, NMDA and sodium currents and dendritic spikes
    Bernadett K Szasz
    Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    Planta Med 74:1235-9. 2008
  8. ncbi request reprint The unusual state-dependent affinity of P2X3 receptors can be explained by an allosteric two-open-state model
    R Karoly
    Institute of Experimental Medicine, Hungarian Academy of Sciences, P O BOX 67, H 1450 Budapest, Hungary
    Mol Pharmacol 73:224-34. 2008
  9. ncbi request reprint Direct inhibitory effect of fluoxetine on N-methyl-D-aspartate receptors in the central nervous system
    Bernadett K Szasz
    Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43, Budapest, Hungary
    Biol Psychiatry 62:1303-9. 2007
  10. ncbi request reprint The mechanism of activity-dependent sodium channel inhibition by the antidepressants fluoxetine and desipramine
    N Lenkey
    Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    Mol Pharmacol 70:2052-63. 2006

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Ca(2+)-sensitive inhibition by Pb(2+) of alpha7-containing nicotinic acetylcholine receptors in hippocampal neurons
    A Mike
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore 21201, USA
    Brain Res 873:112-23. 2000
    ..Pb(2+)-induced inhibition of alpha7 nAChRs, which was hindered by the enhancement of extracellular Ca(2+) concentrations, may contribute to the neurotoxicity of the heavy metal...
  2. pmc Rapid desensitization of the rat α7 nAChR is facilitated by the presence of a proline residue in the outer β-sheet
    Thomas J McCormack
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    J Physiol 588:4415-29. 2010
    ..Our results indicate that rapid desensitization of the wild-type rat α7 nAChR is facilitated by the presence of the proline residue within the β9 strand...
  3. doi request reprint Binding of sodium channel inhibitors to hyperpolarized and depolarized conformations of the channel
    N Lenkey
    Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, P O B 67, H 1450 Budapest, Hungary
    Neuropharmacology 60:191-200. 2011
    ....
  4. pmc Fast- or slow-inactivated state preference of Na+ channel inhibitors: a simulation and experimental study
    Robert Karoly
    Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    PLoS Comput Biol 6:e1000818. 2010
    ..We suggest that conclusions based on voltage protocols that are used to detect slow-inactivated state preference are unreliable and should be re-evaluated...
  5. ncbi request reprint The enigmatic drug binding site for sodium channel inhibitors
    Arpad Mike
    Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, P O BOX 67, H 1450 Budapest, Hungary
    Curr Mol Pharmacol 3:129-44. 2010
    ..We conclude that sodium channel inhibitors must be heterogenous in terms of binding sites and inhibition mechanisms, and propose that this heterogeneity should be taken into consideration during drug development...
  6. pmc Non-synaptic receptors and transporters involved in brain functions and targets of drug treatment
    E S Vizi
    Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    Br J Pharmacol 160:785-809. 2010
    ....
  7. ncbi request reprint Converging effects of Ginkgo biloba extract at the level of transmitter release, NMDA and sodium currents and dendritic spikes
    Bernadett K Szasz
    Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    Planta Med 74:1235-9. 2008
    ..The lack of effect by GBE on dendritic spike initiation in neocortical layer 5 pyramidal neurons indicates that the integrative functions may remain intact during the inhibitory actions of GBE...
  8. ncbi request reprint The unusual state-dependent affinity of P2X3 receptors can be explained by an allosteric two-open-state model
    R Karoly
    Institute of Experimental Medicine, Hungarian Academy of Sciences, P O BOX 67, H 1450 Budapest, Hungary
    Mol Pharmacol 73:224-34. 2008
    ..By using simulations and experiments, we analyzed the process of high-affinity binding site formation upon agonist exposure and propose an explanation, which helps to resolve the apparent conflict regarding the mechanism of HAD...
  9. ncbi request reprint Direct inhibitory effect of fluoxetine on N-methyl-D-aspartate receptors in the central nervous system
    Bernadett K Szasz
    Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43, Budapest, Hungary
    Biol Psychiatry 62:1303-9. 2007
    ....
  10. ncbi request reprint The mechanism of activity-dependent sodium channel inhibition by the antidepressants fluoxetine and desipramine
    N Lenkey
    Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    Mol Pharmacol 70:2052-63. 2006
    ..Our results suggest that different drugs can produce use-dependent sodium channel inhibition by different mechanisms...
  11. ncbi request reprint Nonsynaptic receptors for GABA and glutamate
    E Sylvester Vizi
    Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    Curr Top Med Chem 6:941-8. 2006
    ....
  12. ncbi request reprint Pb2+ via protein kinase C inhibits nicotinic cholinergic modulation of synaptic transmission in the hippocampus
    Maria F M Braga
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, 655 West Baltimore St, Baltimore, MD 21201, USA
    J Pharmacol Exp Ther 311:700-10. 2004
    ..Long-lasting inhibition of alpha7* nAChR modulation of synaptic transmission may contribute to the persistent cognitive impairment that results from childhood Pb(2+) intoxication...
  13. ncbi request reprint A novel modulatory mechanism of sodium currents: frequency-dependence without state-dependent binding
    A Mike
    Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, P O B 67, H 1450 Budapest, Hungary
    Neuroscience 125:1019-28. 2004
    ..This mechanism of inhibition could provide a selective inhibition of neurons not only with high frequency bursting activity but also with moderately depolarized membrane potential...
  14. ncbi request reprint Inhibitory effect of the DA uptake blocker GBR 12909 on sodium channels of hippocampal neurons
    Arpad Mike
    Department of Pharmacology, Hungarian Academy of Sciences, Budapest, Hungary
    Neuroreport 14:1945-9. 2003
    ..Our results suggest that caution is needed for the interpretation of data when GBR 12909 is used for the inhibition of dopamine uptake at concentrations above the submicromolar range...
  15. ncbi request reprint Differential effect of nicotinic agonists on the [3H]norepinephrine release from rat hippocampal slices
    J P Kiss
    Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest
    Neurochem Res 26:943-50. 2001
    ..Our results suggest that special caution is required for the interpretation of data, when DMPP or lobeline are used as nicotinic agonists...
  16. ncbi request reprint Choline and acetylcholine have similar kinetic properties of activation and desensitization on the alpha7 nicotinic receptors in rat hippocampal neurons
    A Mike
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, 655 W Baltimore St, Baltimore, MD 21201, USA
    Brain Res 882:155-68. 2000
    ..Our results established that the main difference between choline and ACh is of affinity, and support the concept that the switching of endogenous agonist may change the desensitization-resensitization dynamics of alpha7 nAChRs...
  17. ncbi request reprint Neuronal nicotinic receptors in synaptic functions in humans and rats: physiological and clinical relevance
    E X Albuquerque
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore 21201, USA
    Behav Brain Res 113:131-41. 2000
    ..These mechanisms, which appear to be retained across species, might explain the involvement of nAChRs in cognitive functions and in such neurological disorders as Alzheimer's disease and schizophrenia...
  18. pmc Classification of drugs based on properties of sodium channel inhibition: a comparative automated patch-clamp study
    Nora Lenkey
    Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    PLoS ONE 5:e15568. 2010
    ..We also aimed to investigate if different properties of inhibition correlate with specific chemical properties of the compounds...