K J Kovacs

Summary

Affiliation: Institute of Experimental Medicine
Country: Hungary

Publications

  1. ncbi request reprint CRH: the link between hormonal-, metabolic- and behavioral responses to stress
    Krisztina J Kovacs
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary Electronic address
    J Chem Neuroanat 54:25-33. 2013
  2. pmc Interleukin-1α expression precedes IL-1β after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues
    Nadia M Luheshi
    University of Manchester, UK
    J Neuroinflammation 8:186. 2011
  3. pmc Systemic inflammatory challenges compromise survival after experimental stroke via augmenting brain inflammation, blood- brain barrier damage and brain oedema independently of infarct size
    Adam Denes
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary
    J Neuroinflammation 8:164. 2011
  4. ncbi request reprint c-Fos as a transcription factor: a stressful (re)view from a functional map
    K J Kovacs
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary
    Neurochem Int 33:287-97. 1998
  5. ncbi request reprint Glucocorticoid negative feedback selectively targets vasopressin transcription in parvocellular neurosecretory neurons
    K J Kovacs
    Laboratory of Neuronal Structure and Function, The Salk Institute for Biological Studies and Foundation for Medical Research, La Jolla, California 92037, USA
    J Neurosci 20:3843-52. 2000
  6. ncbi request reprint C-kit ligand (Stem Cell Factor) affects neuronal activity, stimulates pituitary-adrenal axis and prolactin secretion in rats
    K J Kovacs
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary
    J Neuroimmunol 65:133-41. 1996
  7. doi request reprint Measurement of immediate-early gene activation- c-fos and beyond
    K J Kovacs
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary
    J Neuroendocrinol 20:665-72. 2008
  8. ncbi request reprint GABAergic mechanisms constraining the activity of the hypothalamo-pituitary-adrenocortical axis
    K J Kovacs
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Szigony u 43, Budapest, H 1083 Hungary
    Ann N Y Acad Sci 1018:466-76. 2004
  9. ncbi request reprint Neurohypophyseal hormones in the integration of physiological responses to immune challenges
    Krisztina J Kovacs
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Szigony u 43 H 1083, Budapest, Hungary
    Prog Brain Res 139:127-46. 2002
  10. ncbi request reprint Functional heterogeneity of the responses of histaminergic neuron subpopulations to various stress challenges
    I H Miklós
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Szigony u 43 H 1083, Budapest, Hungary
    Eur J Neurosci 18:3069-79. 2003

Collaborators

Detail Information

Publications23

  1. ncbi request reprint CRH: the link between hormonal-, metabolic- and behavioral responses to stress
    Krisztina J Kovacs
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary Electronic address
    J Chem Neuroanat 54:25-33. 2013
    ..This review summarizes past and recent findings related to CRH gene regulation and its involvement in the neuroendocrine, autonomic and behavioral stress reaction. ..
  2. pmc Interleukin-1α expression precedes IL-1β after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues
    Nadia M Luheshi
    University of Manchester, UK
    J Neuroinflammation 8:186. 2011
    ..In order to determine this we investigated the temporal and spatial profiles of IL-1α and IL-1β expression after cerebral ischemia...
  3. pmc Systemic inflammatory challenges compromise survival after experimental stroke via augmenting brain inflammation, blood- brain barrier damage and brain oedema independently of infarct size
    Adam Denes
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary
    J Neuroinflammation 8:164. 2011
    ..It is not understood whether systemic inflammatory challenges impair outcome after stroke by increasing brain injury only or whether they have direct effects on brain oedema, cerebrovascular inflammation and blood-brain barrier damage...
  4. ncbi request reprint c-Fos as a transcription factor: a stressful (re)view from a functional map
    K J Kovacs
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary
    Neurochem Int 33:287-97. 1998
    ..The first part of the review focuses on recent functional data on c-fos as transcription factor, while the second part discusses c-fos as a cellular marker of transcriptional activity in the stress-related circuitry...
  5. ncbi request reprint Glucocorticoid negative feedback selectively targets vasopressin transcription in parvocellular neurosecretory neurons
    K J Kovacs
    Laboratory of Neuronal Structure and Function, The Salk Institute for Biological Studies and Foundation for Medical Research, La Jolla, California 92037, USA
    J Neurosci 20:3843-52. 2000
    ....
  6. ncbi request reprint C-kit ligand (Stem Cell Factor) affects neuronal activity, stimulates pituitary-adrenal axis and prolactin secretion in rats
    K J Kovacs
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary
    J Neuroimmunol 65:133-41. 1996
    ....
  7. doi request reprint Measurement of immediate-early gene activation- c-fos and beyond
    K J Kovacs
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary
    J Neuroendocrinol 20:665-72. 2008
    ..Furthermore, combinations between novel imaging techniques, such as magnetic resonance and IEG-based mapping strategies, will open new means with which to study functional activity in the neurosecretory systems...
  8. ncbi request reprint GABAergic mechanisms constraining the activity of the hypothalamo-pituitary-adrenocortical axis
    K J Kovacs
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Szigony u 43, Budapest, H 1083 Hungary
    Ann N Y Acad Sci 1018:466-76. 2004
    ..During stress, GABAergic cells that are known to project to the PVH become activated and are involved in restraining the cellular, transcriptional, and hormonal responses to stress...
  9. ncbi request reprint Neurohypophyseal hormones in the integration of physiological responses to immune challenges
    Krisztina J Kovacs
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Szigony u 43 H 1083, Budapest, Hungary
    Prog Brain Res 139:127-46. 2002
  10. ncbi request reprint Functional heterogeneity of the responses of histaminergic neuron subpopulations to various stress challenges
    I H Miklós
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Szigony u 43 H 1083, Budapest, Hungary
    Eur J Neurosci 18:3069-79. 2003
    ..These results suggest, for the first time, the functional heterogeneity of histaminergic neuron population, the components of which are recruited in a stressor- and subgroup-specific manner...
  11. ncbi request reprint Role of hypothalamic inputs in maintaining pituitary-adrenal responsiveness in repeated restraint
    D Zelena
    Laboratory of Stress Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, 1450 Budapest, Hungary
    Am J Physiol Endocrinol Metab 285:E1110-7. 2003
    ..PVH seems to be important for the repeated restraint-induced ACTH and POMC mRNA stimulation, but it appears to partially mediate other restraint-induced hormonal changes...
  12. ncbi request reprint Effect of intrahippocampal dexamethasone on the levels of amino acid transmitters and neuronal excitability
    I Abraham
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary
    Brain Res 733:56-63. 1996
    ....
  13. ncbi request reprint GABAergic innervation of corticotropin-releasing hormone (CRH)-secreting parvocellular neurons and its plasticity as demonstrated by quantitative immunoelectron microscopy
    I H Miklós
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Szigony u 43 H 1083, Budapest, Hungary
    Neuroscience 113:581-92. 2002
    ....
  14. ncbi request reprint Anaphylactoid reactions activate hypothalamo-pituitary-adrenocortical axis: comparison with endotoxic reactions
    A Foldes
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary
    Brain Res Bull 52:573-9. 2000
    ..Changes in these parameters are compared to those seen in rats challenged with bacterial endotoxin, LPS...
  15. ncbi request reprint Histamine differentially affects hypothalamic neuronal circuits during systemic allergic reaction
    A N Gerencsér
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, P O BOX 67, H 1450 Budapest, Hungary
    Inflamm Res 56:S15-6. 2007
  16. doi request reprint Direct inhibitory effect of glucocorticoids on corticotrophin-releasing hormone gene expression in neurones of the paraventricular nucleus in rat hypothalamic organotypic cultures
    B Bali
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary
    J Neuroendocrinol 20:1045-51. 2008
    ..Type II corticosteroid receptor agonists act directly on paraventricular neurones to inhibit basal and forskolin-induced CRH mRNA expression in explant cultures of the rat hypothalamus...
  17. ncbi request reprint Postnatal handling alters the activation of stress-related neuronal circuitries
    I M Abrahám
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Szigony u 43, 1083, Hungary
    Eur J Neurosci 12:3003-14. 2000
    ..Together, these data provide functional anatomical evidence that environmental enrichment in the early postnatal period attenuates the reactivity of stress-related neuronal circuitries in the adult rat brain...
  18. ncbi request reprint Central autonomic control of the bone marrow: multisynaptic tract tracing by recombinant pseudorabies virus
    A Denes
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Szigony u 43, Budapest, H 1083 Hungary
    Neuroscience 134:947-63. 2005
    ....
  19. ncbi request reprint Corticosterone peak is responsible for stress-induced elevation of glutamate in the hippocampus
    I Abraham
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary
    Stress 2:171-81. 1998
    ..These changes may also contribute to negative feedback effect of CORT on hypothalamo-pituitary-adrenocortical (HPA) axis via the hippocampus during stress...
  20. ncbi request reprint Double activity imaging reveals distinct cellular targets of haloperidol, clozapine and dopamine D(3) receptor selective RGH-1756
    K J Kovacs
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary
    Neuropharmacology 40:383-93. 2001
    ..RGH-1756 targets haloperidol-sensitive cells in the caudate putamen, but cells that are activated by clozapine and RGH-1756 in the major island of Calleja are different...
  21. ncbi request reprint Histamine is a multicoloured player in many physiological functions; it has a significant role in regulation of white adipose tissue and food intake
    A Falus
    Department of Genetics, Cell and Immunobiology, Semmelweis University, Budapest, Hungary
    Eur J Clin Invest 32:221-2. 2002
  22. pmc Cell sorting in a Petri dish controlled by computer vision
    Z Kornyei
    Institute of Experimental Medicine of the Hungarian Academy of Sciences, Budapest, Hungary
    Sci Rep 3:1088. 2013
    ..Hydrodynamic simulations confirmed the experimental sorting efficiency and a cell damage risk similar to that of normal FACS...