K J Kovacs

Summary

Affiliation: Institute of Experimental Medicine
Country: Hungary

Publications

  1. ncbi Interleukin-1α expression precedes IL-1β after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues
    Nadia M Luheshi
    University of Manchester, UK
    J Neuroinflammation 8:186. 2011
  2. ncbi Systemic inflammatory challenges compromise survival after experimental stroke via augmenting brain inflammation, blood- brain barrier damage and brain oedema independently of infarct size
    Adam Denes
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary
    J Neuroinflammation 8:164. 2011
  3. ncbi Measurement of immediate-early gene activation- c-fos and beyond
    K J Kovacs
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary
    J Neuroendocrinol 20:665-72. 2008
  4. ncbi GABAergic mechanisms constraining the activity of the hypothalamo-pituitary-adrenocortical axis
    K J Kovacs
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Szigony u 43, Budapest, H 1083 Hungary
    Ann N Y Acad Sci 1018:466-76. 2004
  5. ncbi Neurohypophyseal hormones in the integration of physiological responses to immune challenges
    Krisztina J Kovacs
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Szigony u 43 H 1083, Budapest, Hungary
    Prog Brain Res 139:127-46. 2002
  6. ncbi c-Fos as a transcription factor: a stressful (re)view from a functional map
    K J Kovacs
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary
    Neurochem Int 33:287-97. 1998
  7. ncbi C-kit ligand (Stem Cell Factor) affects neuronal activity, stimulates pituitary-adrenal axis and prolactin secretion in rats
    K J Kovacs
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary
    J Neuroimmunol 65:133-41. 1996
  8. ncbi Glucocorticoid negative feedback selectively targets vasopressin transcription in parvocellular neurosecretory neurons
    K J Kovacs
    Laboratory of Neuronal Structure and Function, The Salk Institute for Biological Studies and Foundation for Medical Research, La Jolla, California 92037, USA
    J Neurosci 20:3843-52. 2000
  9. ncbi Functional heterogeneity of the responses of histaminergic neuron subpopulations to various stress challenges
    I H Miklós
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Szigony u 43 H 1083, Budapest, Hungary
    Eur J Neurosci 18:3069-79. 2003
  10. ncbi GABAergic innervation of corticotropin-releasing hormone (CRH)-secreting parvocellular neurons and its plasticity as demonstrated by quantitative immunoelectron microscopy
    I H Miklós
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Szigony u 43 H 1083, Budapest, Hungary
    Neuroscience 113:581-92. 2002

Collaborators

Detail Information

Publications19

  1. ncbi Interleukin-1α expression precedes IL-1β after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues
    Nadia M Luheshi
    University of Manchester, UK
    J Neuroinflammation 8:186. 2011
    ..In order to determine this we investigated the temporal and spatial profiles of IL-1α and IL-1β expression after cerebral ischemia...
  2. ncbi Systemic inflammatory challenges compromise survival after experimental stroke via augmenting brain inflammation, blood- brain barrier damage and brain oedema independently of infarct size
    Adam Denes
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary
    J Neuroinflammation 8:164. 2011
    ..It is not understood whether systemic inflammatory challenges impair outcome after stroke by increasing brain injury only or whether they have direct effects on brain oedema, cerebrovascular inflammation and blood-brain barrier damage...
  3. ncbi Measurement of immediate-early gene activation- c-fos and beyond
    K J Kovacs
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary
    J Neuroendocrinol 20:665-72. 2008
    ..Furthermore, combinations between novel imaging techniques, such as magnetic resonance and IEG-based mapping strategies, will open new means with which to study functional activity in the neurosecretory systems...
  4. ncbi GABAergic mechanisms constraining the activity of the hypothalamo-pituitary-adrenocortical axis
    K J Kovacs
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Szigony u 43, Budapest, H 1083 Hungary
    Ann N Y Acad Sci 1018:466-76. 2004
    ..During stress, GABAergic cells that are known to project to the PVH become activated and are involved in restraining the cellular, transcriptional, and hormonal responses to stress...
  5. ncbi Neurohypophyseal hormones in the integration of physiological responses to immune challenges
    Krisztina J Kovacs
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Szigony u 43 H 1083, Budapest, Hungary
    Prog Brain Res 139:127-46. 2002
  6. ncbi c-Fos as a transcription factor: a stressful (re)view from a functional map
    K J Kovacs
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary
    Neurochem Int 33:287-97. 1998
    ..The first part of the review focuses on recent functional data on c-fos as transcription factor, while the second part discusses c-fos as a cellular marker of transcriptional activity in the stress-related circuitry...
  7. ncbi C-kit ligand (Stem Cell Factor) affects neuronal activity, stimulates pituitary-adrenal axis and prolactin secretion in rats
    K J Kovacs
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary
    J Neuroimmunol 65:133-41. 1996
    ....
  8. ncbi Glucocorticoid negative feedback selectively targets vasopressin transcription in parvocellular neurosecretory neurons
    K J Kovacs
    Laboratory of Neuronal Structure and Function, The Salk Institute for Biological Studies and Foundation for Medical Research, La Jolla, California 92037, USA
    J Neurosci 20:3843-52. 2000
    ....
  9. ncbi Functional heterogeneity of the responses of histaminergic neuron subpopulations to various stress challenges
    I H Miklós
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Szigony u 43 H 1083, Budapest, Hungary
    Eur J Neurosci 18:3069-79. 2003
    ..These results suggest, for the first time, the functional heterogeneity of histaminergic neuron population, the components of which are recruited in a stressor- and subgroup-specific manner...
  10. ncbi GABAergic innervation of corticotropin-releasing hormone (CRH)-secreting parvocellular neurons and its plasticity as demonstrated by quantitative immunoelectron microscopy
    I H Miklós
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Szigony u 43 H 1083, Budapest, Hungary
    Neuroscience 113:581-92. 2002
    ....
  11. ncbi Effect of intrahippocampal dexamethasone on the levels of amino acid transmitters and neuronal excitability
    I Abraham
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary
    Brain Res 733:56-63. 1996
    ....
  12. ncbi Anaphylactoid reactions activate hypothalamo-pituitary-adrenocortical axis: comparison with endotoxic reactions
    A Foldes
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary
    Brain Res Bull 52:573-9. 2000
    ..Changes in these parameters are compared to those seen in rats challenged with bacterial endotoxin, LPS...
  13. ncbi Role of hypothalamic inputs in maintaining pituitary-adrenal responsiveness in repeated restraint
    D Zelena
    Laboratory of Stress Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, 1450 Budapest, Hungary
    Am J Physiol Endocrinol Metab 285:E1110-7. 2003
    ..PVH seems to be important for the repeated restraint-induced ACTH and POMC mRNA stimulation, but it appears to partially mediate other restraint-induced hormonal changes...
  14. ncbi Histamine differentially affects hypothalamic neuronal circuits during systemic allergic reaction
    A N Gerencsér
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, P O BOX 67, H 1450 Budapest, Hungary
    Inflamm Res 56:S15-6. 2007
  15. ncbi Central autonomic control of the bone marrow: multisynaptic tract tracing by recombinant pseudorabies virus
    A Denes
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Szigony u 43, Budapest, H 1083 Hungary
    Neuroscience 134:947-63. 2005
    ....
  16. ncbi Direct inhibitory effect of glucocorticoids on corticotrophin-releasing hormone gene expression in neurones of the paraventricular nucleus in rat hypothalamic organotypic cultures
    B Bali
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary
    J Neuroendocrinol 20:1045-51. 2008
    ..Type II corticosteroid receptor agonists act directly on paraventricular neurones to inhibit basal and forskolin-induced CRH mRNA expression in explant cultures of the rat hypothalamus...
  17. ncbi Postnatal handling alters the activation of stress-related neuronal circuitries
    I M Abrahám
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Szigony u 43, 1083, Hungary
    Eur J Neurosci 12:3003-14. 2000
    ..Together, these data provide functional anatomical evidence that environmental enrichment in the early postnatal period attenuates the reactivity of stress-related neuronal circuitries in the adult rat brain...
  18. ncbi Corticosterone peak is responsible for stress-induced elevation of glutamate in the hippocampus
    I Abraham
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary
    Stress 2:171-81. 1998
    ..These changes may also contribute to negative feedback effect of CORT on hypothalamo-pituitary-adrenocortical (HPA) axis via the hippocampus during stress...
  19. ncbi Double activity imaging reveals distinct cellular targets of haloperidol, clozapine and dopamine D(3) receptor selective RGH-1756
    K J Kovacs
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary
    Neuropharmacology 40:383-93. 2001
    ..RGH-1756 targets haloperidol-sensitive cells in the caudate putamen, but cells that are activated by clozapine and RGH-1756 in the major island of Calleja are different...