Research Topics
| A E CzeizelSummaryAffiliation: Foundation for the Community Control of Hereditary Diseases Country: Hungary Publications
| Collaborators
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Detail Information
Publications
Primary prevention of neural-tube defects and some other major congenital abnormalities: recommendations for the appropriate use of folic acid during pregnancyA E Czeizel
Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
Paediatr Drugs 2:437-49. 2000..This provides a practical means to ensure all women, especially those from lower socioeconomic backgrounds and/or with a low level of education who are more likely to have unplanned pregnancies, have an adequate folic acid intake...
A population-based case-control teratologic study of nalidixic acidA E Czeizel
Foundation for the Community Control of Hereditary Diseases Department of Human Genetics and Teratology, National Center for Epidemiology, Budapest, Hungary
Int J Gynaecol Obstet 73:221-8. 2001....
A population-based case-control teratologic study of oral chloramphenicol treatment during pregnancyA E Czeizel
WHO Collaborating Centre for the Community Control of Hereditary Diseases Department of Human Genetics and Teratology, National Center for Epidemiology, Budapest, Hungary
Eur J Epidemiol 16:323-7. 2000..Thus, chloramphenicol treatment during early pregnancy presents little, if any, teratogenic risk to the fetus in humans...
The teratogenic risk of trimethoprim-sulfonamides: a population based case-control studyA E Czeizel
Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
Reprod Toxicol 15:637-46. 2001..These agents have antifolate effects and other antifolate agents can induce multiple congenital abnormalities, neural-tube defects, cardiovascular, and other malformations in animal experiments and in humans...
The ethical issues of the postmarketing surveillance of drug teratogenicity in HungaryA E Czeizel
Foundation for Community Control of Hereditary Diseases, H 1026 Budapest, Törökvész lejt_32, Hungary
Pharmacoepidemiol Drug Saf 10:635-9. 2001..To discuss some ethical issues of the postmarketing surveillance of drug teratogenicity...
A population-based case-control teratologic study of oral erythromycin treatment during pregnancyA E Czeizel
Foundation for the Community Control of Hereditary Diseases, Department of Human Genetics and Teratology, National Center for Epidemiology, Budapest, Hungary
Reprod Toxicol 13:531-6. 1999..Thus, treatment with oral erythromycin during pregnancy did not present detectable teratogenic risk to the fetus...
Augmentin treatment during pregnancy and the prevalence of congenital abnormalities: a population-based case-control teratologic studyA E Czeizel
Foundation for the Community Control of Hereditary Diseases, Department of Human, Genetics and Teratology, National Center for Epidemiology, 1026 Budapest, Torokvesz Lejto 32, Budapest, Hungary
Eur J Obstet Gynecol Reprod Biol 97:188-92. 2001..To study the human teratogenic potential of augmentin (amoxicillin+clavulanic acid) treatment during pregnancy...
Maternal kidney stones during pregnancy and adverse birth outcomes, particularly congenital abnormalities in the offspringF Banhidy
Second Department of Obstetrics and Gynecology, Semmelweis University, School of Medicine, Budapest, Hungary
Arch Gynecol Obstet 275:481-7. 2007..The possible adverse birth outcomes, particularly congenital abnormalities (CAs) in pregnant women with kidney stones (KS) previously have not been evaluated; therefore, we decided to study this possible association...
A study of teratogenic and fetotoxic effects of large doses of meprobamate used for a suicide attempt by 42 pregnant womenG Timmermann
Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
Toxicol Ind Health 24:97-107. 2008..Very large doses of meprobamate that were used for self-poisoning during pregnancy did not result in teratogenic or fetotoxic, including neurotoxic, effects on fetal development...
A study of the effects of large doses of glutethimide that were used for self-poisoning during pregnancy on human fetusesD Petik
Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
Toxicol Ind Health 24:69-78. 2008..Very large doses of glutethimide used for a suicide attempt by 16 pregnant women did not produce teratogenic or fetotoxic (including neurotoxic) effects in their children...
A study of the effects of large doses of medazepam used for self-poisoning in 10 pregnant women on fetal developmentJ Gidai
Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
Toxicol Ind Health 24:61-8. 2008..Our experiences show the feasibility and benefits of use of the self-poisoning model in estimating human teratogenic and fetotoxic risks of drugs...
A population-based case-control study of oral chlordiazepoxide use during pregnancy and risk of congenital abnormalitiesA E Czeizel
Genetics Department, Foundation for the Community Control of Hereditary Diseases, Torokvesz Lejto 32, Budapest 1026, Hungary
Neurotoxicol Teratol 26:593-8. 2004..In conclusion, therapeutic doses of chlordiazepoxide during pregnancy are unlikely to pose a substantial teratogenic risk to the human fetus, although a somewhat higher rate of congenital cardiovascular malformations cannot be excluded...
A study of the teratogenic and fetotoxic effects of large doses of barbital, hexobarbital and butobarbital used for suicide attempts by pregnant womenG Timmermann
Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
Toxicol Ind Health 24:109-19. 2008..The very large doses of barbital, hexobarbital and/or butobarbital used for self-poisoning during pregnancy were not teratogenic to the children, although it must be recognized that the number of exposed children was limited...
Recall bias in a case-control surveillance system on the use of medicine during pregnancyM Rockenbauer
Department of Human Genetics and Teratology, Center for Epidemiology, Foundation for Community Control and Hereditary Diseases, Budapest, Hungary
Epidemiology 12:461-6. 2001..A case-control surveillance system of this type may frequently cause spurious associations, with biased odds ratios up to a factor of 1.9...
A study of the teratogenic and fetotoxic effects of large doses of chlordiazepoxide used for self-poisoning by 35 pregnant womenJ Gidai
Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
Toxicol Ind Health 24:41-51. 2008..Very large doses of chlordiazepoxide used for suicide attempts during pregnancy did not induce a higher rate of congenital abnormalities but were associated with dose-dependent intrauterine growth retardation...
A study of the potential teratogenic effects of large doses of drugs rarely used for a suicide attempt during pregnancyG Timmermann
Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
Toxicol Ind Health 24:121-31. 2008..Experience of the authors shows the feasibility and benefits of using the self-poisoning model in estimating human teratogenic/fetotoxic risks of exposure to drugs...
A population-based case-control teratologic study of ampicillin treatment during pregnancyA E Czeizel
Foundation for the Community Control of Hereditary Diseases, Department of Human Genetics and Teratology, National Center for Epidemiology, 1026 Budapest, Hungary
Am J Obstet Gynecol 185:140-7. 2001....
No association found between use of very large doses of diazepam by 112 pregnant women for a suicide attempt and congenital abnormalities in their offspringJ Gidai
Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
Toxicol Ind Health 24:29-39. 2008..The very large doses of diazepam used for self-poisoning during pregnancy did not increase the rate of congenital abnormalities in the offspring...
An evaluation of data for 10 children born to mothers who attempted suicide by taking large doses of alprazolam during pregnancyJ Gidai
Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
Toxicol Ind Health 24:53-60. 2008..Our study shows that the self-poisoning model is feasible and provides beneficial information for use in estimating human teratogenic and fetotoxic risks of drugs...
A population-based case-control study of the safety of oral anti-tuberculosis drug treatment during pregnancyA E Czeizel
Foundation for the Community Control of Hereditary Diseases, Department of Human Genetics and Teratology, National Center for Epidemiology, Budapest, Hungary
Int J Tuberc Lung Dis 5:564-8. 2001..To study the human teratogenic potential of isoniazid and other anti-tuberculosis drug treatment during pregnancy...
A study of the teratogenic and fetotoxic effects of large doses of amobarbital used for a suicide attempt by 14 pregnant womenD Petik
Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
Toxicol Ind Health 24:79-85. 2008..Exposure to very large doses of amobarbital that were used for self-poisoning during pregnancy did not produce teratogenic effects in this study...
Human germinal mutagenic effects in relation to intentional and accidental exposure to toxic agentsA E Czeizel
Department of Human Genetics and Teratology, National Institute of Hygiene WHO Collaborating Centre from the Community Control of Hereditary Diseases, Budapest, Hungary
Environ Health Perspect 104:615-7. 1996..Environmental investigations have pointed to the excessive use of trichlorfon at local fish farms as the cause...
Use of cephalosporins during pregnancy and in the presence of congenital abnormalities: a population-based, case-control studyA E Czeizel
Department of Human Genetics and Teratology, National Center for Epidemiology, World Health Organization Collaborating Center for the Community Control of Hereditary Diseases, Budapest, Hungary
Am J Obstet Gynecol 184:1289-96. 2001..However, further studies are needed to clarify the teratogenic and fetal toxic effects of different cephalosporins separately...
A study of the potential teratogenic effect of large doses of promethazine used for a suicide attempt by 32 pregnant womenD Petik
Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
Toxicol Ind Health 24:87-96. 2008..Our experience shows the feasibility and benefits of using the self-poisoning model in estimating human teratogenic/fetotoxic risks of exposure to drugs...
Gestational age and prevalence of preterm birth after vaginal metronidazole treatment during pregnancyZ Kazy
Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
Int J Gynaecol Obstet 87:161-2. 2004
Use of antibiotics during pregnancyA E Czeizel
WHO Collaborating Centre for the Community Control of Hereditary Diseases, Department of Human Genetics and Teratology National Institute of Public Health, Budapest, Hungary
Eur J Obstet Gynecol Reprod Biol 81:1-8. 1998....
Nitrofurantoin and congenital abnormalitiesA E Czeizel
Department of Human Genetics and Teratology, Foundation for the Community Control of Hereditary Diseases, National Centre for Epidemiology, Torokvesz Lejto 32, 1026, Budapest, Hungary
Eur J Obstet Gynecol Reprod Biol 95:119-26. 2001..To study human teratogenic potential of oral nitrofurantoin treatment during pregnancy. MATERIALS and..
The higher rate of multiple births after periconceptional multivitamin supplementation: an analysis of causesA E Czeizel
Department of Human Genetics and Teratology, National Institute of Hygiene, Budapest, Hungary
Acta Genet Med Gemellol (Roma) 43:175-84. 1994..anovulation. Nonetheless, our study showed that periconceptional multivitamin supplementation, with or without ovarian stimulation, increases the rate of multiple births...
Self-poisoning during pregnancy as a model for teratogenic risk estimation of drugsA E Czeizel
Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
Toxicol Ind Health 24:11-28. 2008..g., dose-response estimation) in comparison with other methods. It is suggested that an international monitoring system of self-poisoned pregnant women should be established to provide a larger database...
Vaginal treatment with povidone--iodine suppositories during pregnancyA E Czeizel
Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
Int J Gynaecol Obstet 84:83-5. 2004
Oral tinidazole treatment during pregnancy and teratogenesisA E Czeizel
Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
Int J Gynaecol Obstet 83:305-6. 2003
Description and mission evaluation of the Hungarian case-control surveillance of congenital abnormalities, 1980-1996A E Czeizel
Foundation for Community Control of Hereditary Diseases, Budapest, Hungary
Teratology 63:176-85. 2001....
A population-based case-control teratologic study of furazidine, a nitrofuran-derivative treatment during pregnancyA E Czeizel
Department of Human Genetics and Teratology, National Center for Epidemiology, Budapest, Hungary
Clin Nephrol 53:257-63. 2000..To study human teratogenic potential of furazidine treatment during pregnancy...
Possible association of folic acid supplementation during pregnancy with reduction of preterm birth: a population-based studyA E Czeizel
Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
Eur J Obstet Gynecol Reprod Biol 148:135-40. 2010..Thus the possible fetal growth promoting and/or preterm birth reducing effect of vitamin supplements in the second and mainly in the third trimester was studied...
Maternal urinary tract infection and related drug treatments during pregnancy and risk of congenital abnormalities in the offspringF Banhidy
Second Department of Obstetrics and Gynecology, Semmelweis University, School of Medicine, Budapest, Hungary
BJOG 113:1465-71. 2006..Only one study showed an association with atrial septal defect, thus we decided to check this possible association...
Timing of suicide attempts by self-poisoning during pregnancy and pregnancy outcomesA E Czeizel
Department of Human Genetics and Teratology, National Institute of Public Health WHO Collaborating Centre for the Community Control of Hereditary Diseases, Budapest, Hungary
Int J Gynaecol Obstet 65:39-45. 1999..The purpose of this study was to examine the timing and consequences of suicide attempts by self-poisoning during pregnancy...
Teratologic evaluation of 178 infants born to mothers who attempted suicide by drugs during pregnancyA E Czeizel
Department of Human Genetics and Teratology, National Institute of Public Health WHO Collaborating Centre for the Community Control of Hereditary Diseases, Budapest, Hungary
Obstet Gynecol 90:195-201. 1997..To identify the teratogenic risk of large doses of various drugs taken by women in attempting suicide...
Maternal employment status and isolated orofacial clefts in HungaryE Puho
National Centre for Epidemiology, Department of Human Genetics and Teratology, Budapest, Hungary
Cent Eur J Public Health 13:144-8. 2005..To study the role of maternal employment status as indicator of socioeconomic status in the origin of isolated orofacial clefts (OFC) and in the use of periconceptional folic acid/multivitamin supplementation...
Smoking and alcohol drinking during pregnancy. The reliability of retrospective maternal self-reported informationA E Czeizel
Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
Cent Eur J Public Health 12:179-83. 2004..The reliability of retrospective maternal self-reported information regarding smoking and alcohol drinking during pregnancy seemed necessary to be checked...
Ovarian cysts, clomiphene therapy, and the risk of neural tube defectsF Banhidy
Second Department of Obstetrics and Gynecology, Semmelweis University, School of Medicine, Budapest, Hungary
Int J Gynaecol Obstet 100:86-8. 2008
Congenital abnormalities and indicators of germinal mutations in the vicinity of an acrylonitrile producing factoryA E Czeizel
WHO Collaborating Centre for the Community Control of Hereditary Diseases, Department of Human Genetics and Teratology, National Centre of Epidemiology, Budapest, Hungary
Mutat Res 427:105-23. 1999..The detailed analysis of congenital abnormalities in all settlements of a given territory may help to detect clusters of congenital abnormalities and their possible relation to the environmental hazards...
Orofacial clefts in Hungary. Epidemiological and genetic data, primary preventionA E Czeizel
Department of Human Genetics and Teratology, National Institute of Public Health, Budapest, Hungary
Folia Phoniatr Logop 49:111-6. 1997..Finally the recent controversial data concerning the primary prevention of isolated orofacial clefts by periconceptional folic acid-containing multivitamins are summarized...
Experience of the Hungarian Preconception Service between 1984 and 2010A E Czeizel
Foundation for Community Control of Hereditary Disease, 1026 Budapest, Torokvesz Lejto 32, Hungary
Eur J Obstet Gynecol Reprod Biol 161:18-25. 2012..In conclusion, the Hungarian experience demonstrates the feasibility and usefulness of preconception care in the prevention of adverse birth outcomes including congenital abnormalities and preterm births...
Drug exposure in pregnant womenA E Czeizel
Foundation for the Communication Control of Hereditary Diseases, Budapest, Hungary
Lupus 13:740-5. 2004..Medical doctors and other experts therefore need more education to know the principles and findings of modern human teratology because it may help us to have a better balance between the risk and benefit of drug use during pregnancy...
A changing pattern in the association of oral contraceptives and the different groups of congenital limb deficienciesA E Czeizel
Department of Human Genetics and Teratology, National Institute of Hygiene, Budapest, Hungary
Contraception 51:19-24. 1995..05 mg) used in the periconceptional period was found in the mothers of cases with terminal transverse defect (adjusted relative odds 1.9 with 95% confidence interval of 1.1-3.4). This risk is minimised by the use of recent low-dose pills...
A case-control study of congenital abnormality and dimenhydrinate usage during pregnancyA E Czeizel
Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
Arch Gynecol Obstet 271:113-8. 2005..The objective was to determine the teratogenicity of dimenhydrinate, an anti-emetic drug...
The possible preterm birth preventive effect of ampicillin during pregnancyZ Kazy
Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
Arch Gynecol Obstet 274:215-21. 2006..CONCLUSIONS: Ampicillin treatment, particularly in the first trimester of gestation, can reduce the proportion of preterm birth in pregnant women with acute infectious diseases of the genitourinary and respiratory system...
Teratogenic effects of vaginal boric acid treatment during pregnancyN Acs
Second Department of Obstetrics and Gynecology, Semmelweis University, School of Medicine, and Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
Int J Gynaecol Obstet 93:55-6. 2006
Tetanus toxoid and congenital abnormalitiesA E Czeizel
Department of Human Genetics and Teratology, National Institute of Public Health WHO Collaborating Centre for the Community Control of Hereditary Diseases, Budapest, Hungary
Int J Gynaecol Obstet 64:253-8. 1999..To study the human teratogenic potential of tetanus vaccination during pregnancy...
Phenolphthalein treatment in pregnant women and congenital abnormalities in their offspring: A population-based case-control studyF Banhidy
Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
Drug Discov Ther 2:357-67. 2008..In conclusion phenolphthalein treatment in pregnant women associates with a higher risk for Hirschsprung's disease in their children, but this finding is only a signal which needs confirmation or rejection in other studies...
Case-control study of teratogenic potential of thiethylperazine, an anti-emetic drugA E Czeizel
Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
BJOG 110:497-9. 2003..Thus, the aim of the study was to investigate the possible human teratogenic effect of thiethylperazine...
Validation studies of drug exposures in pregnant womenA E Czeizel
Foundation for Community Control of Hereditary Diseases, and Department of Obstetrics, Gynecology and Gynecological Oncology, St Stephen Hospital, Budapest, Hungary
Pharmacoepidemiol Drug Saf 12:409-16. 2003..Thus the evaluation of drug use on the basis of medically recorded prescribed drugs and/or usual recommendations produces a bias thus it is necessary to complete it with information from the patients...
The check-up of reproductive health and genetic counselingA E Czeizel
Department of Human Genetics and Teratology, WHO Collaborating Centre for the Community Control of Hereditary Diseases, National Institute of Hygiene, Budapest, Hungary
Genet Couns 3:61-6. 1992....
Association of epilepsy with different groups of microcephalyG M Abdel-Salam
Department of Human Genetics and Teratology, National Center for Epidemiology, Budapest, Hungary
Dev Med Child Neurol 42:760-7. 2000..The pathogenetic classification proposed is of value in delineating the prevalence of epilepsy and LD in the different varieties of MC as compared with the etiological classification...
Frequency of the R3500Q mutation of the apolipoprotein B-100 gene in a sample screened clinically for familial hypercholesterolemia in HungaryA Kalina
Cardiology Department, MAV Hospital, Táncsics M 20, 1014, Budapest, Hungary
Atherosclerosis 154:247-51. 2001..Because FDB is one of the independent causes of early onset CHD, the R3500Q mutation should be considered in families with a high frequency of cardiovascular diseases...
The risk of limb deficiencies and other congenital abnormalities in children exposed in utero to calcium channel blockersH T Sørensen
Danish Epidemiology Science Centre at the Department of Epidemiology and Social Medicine, University of Aarhus, Aarhus, Denmark
Acta Obstet Gynecol Scand 80:397-401. 2001..We examined the risk of malformations following exposure in utero to calcium channel blockers...
Effect of doxycycline treatment during pregnancy for birth outcomesZ Kazy
Reprod Toxicol 24:279-80. 2007
Levamisole (Decaris) treatment during pregnancyZ Kazy
Reprod Toxicol 19:3. 2004
A possible dose-dependent teratogenic effect of ergotamineN Acs
Reprod Toxicol 22:551-2. 2006
Antiepileptic drug use, folic acid supplementation, and congenital abnormalities: a population-based case-control studyD Kjaer
The Danish Epidemiology Science Centre, Department of Epidemiology, Institute of Public Health, University of Aarhus, Aarhus, Denmark
BJOG 115:98-103. 2008....
Parenteral polymyxin B treatment during pregnancyZ Kazy
Reprod Toxicol 20:181-2. 2005
Risk of specific congenital abnormalities in offspring of women with diabetesG L Nielsen
Department of Clinical Epidemiology, Aarhus University Hospitals and Aalborg Hospital, DK 9000 Aalborg, Denmark
Diabet Med 22:693-6. 2005..To assess the extent to which the increased risk of congenital abnormalities seen in women with pre-gestational insulin-treated diabetes mellitus is unspecific or related to the embryology of specific organs...
