G Cserni

..The intensive p53 staining observed only in the sarcomatoid area supports the role of the TP53 gene in the transformation of chromophobe renal carcinoma to sarcomatoid carcinoma...

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..Because of the existing controversy, we searched for a cutoff value for the number of lymph nodes (LNs) to be examined in order to establish a reliable node-negative stage in colorectal carcinomas (CRCs)...

..It is therefore the method of choice...

..To assess the constancy of the histological grade of invasive breast carcinomas by comparing primary tumours with their axillary metastases and local or regional recurrences...

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..Adjuvant systemic treatment, indicated on the basis of the NPI is less influenced by staging strategies and definitions of metastases than that given on the basis of nodal status alone...

..Histopathological factors may help identifying a subgroup of breast cancer patients with metastases confined to the sentinel lymph nodes (SLNs)...

..The nodal stage of colorectal cancers is prognostically important. Most current staging guidelines concentrate on the minimum number of evaluated lymph nodes required for an adequate node-negative stage...

..Future trends including ancillary studies, quality control issues, prediction of non-SLN involvement, and suggestions concerning the minimum requirements for the histology of axillary SLNs are also discussed...

..Vital dye-guided sentinel node biopsy is affordable in most hospitals, but may be of limited accuracy in identifying all sentinel nodes. Leaving sentinel nodes in the axilla may result in a false nodal staging of breast carcinomas...

..To implement an audit scheme to increase the lymph node yield from axillary clearance specimens...

..THE fact that invasive lobular carcinoma (ILC) is often multicentric has led to mastectomies being regularly performed for this disease in some settings. Reproducibility of the histological typing of breast cancer was investigated...

..The use of frozen sections for purposes of diagnosis is recognized to involve a degree of uncertainty. A retrospective study of breast specimen frozen section diagnoses was undertaken in order to analyse the major pitfalls...

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..A minimum of 6 nodes, and an optimum of 16 nodes or more, are suggested from these series...

..To test the hypothesis that a correct qualitative assessment of axillary nodal status can be established by examining only a limited number of lymph nodes...

..To assess the value of the intensive histological work up of axillary sentinel lymph nodes (SLN) to demonstrate regional metastatic disease...

..Objective: To assess the value of cytokeratin IHC for the detection of metastases in sentinel lymph nodes of patients with invasive lobular carcinoma...

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..To examine the frequency of extracapsular extension (ECE) of sentinel lymph node (SLN) metastases in breast cancer according to metastasis size, and to characterise ECE in micometastases...

..Even in settings where nodal staging by SLNB is based on molecular tests at least a proportion of the lymph node should be investigated histologically...

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..These results question the practice of excluding patients with palpable axillary lymph node enlargement from less radical staging procedures such as axillary sampling or sentinel node biopsy...

..To evaluate two detailed step sectioning protocols for sentinel lymph nodes (SLNs)...

..Current evidence in favour of a change in the requisite of assessing as may lymph nodes as is possible, and concentrating the efforts on only a selected number of lymph nodes, is weak...

..e. approximately 2% of all patients initially staged by SN biopsy. The methods for the intraoperative and molecular assessment of SNs are also surveyed...

..The need for further axillary treatment in patients with breast cancer with low-volume sentinel node (SN) involvement (micrometastases or smaller) is controversial...

..In this Expert Opinion we present reviews from two authors, providing American and European perspectives on the approach to sentinel lymph node evaluation...

..To create and use a geometrical model for sentinel lymph node (SLN) histopathology in breast cancer...

..It is essential to differentiate MFH from more frequent renal cell carcinomas, because MFH represents a worse prognosis and requires different treatment...

..Secretory meningioma can simulate metastatic disease both clinically and pathologically. Secretory meningioma and tumour-to-tumour metastasis are each rare, and we believe this to be the first report of their coincidence...

..The results suggest the definitions of these distribution patterns require refinements for a more reliable and reproducible diagnosis if one wants to associate prognostic information with this variable...

..Segmental resection of the cervical part of the esophagus was performed successfully via a new type of operation on dogs...

..A new skin symptom ("mechanic's hands") predicts the disease, in particular the interstitial lung pathology, which is its most relevant internal manifestation...