E Szathmary

Summary

Affiliation: Collegium Budapest
Country: Hungary

Publications

  1. pmc Computational identification of obligatorily autocatalytic replicators embedded in metabolic networks
    Adám Kun
    Collegium Budapest, Institute for Advanced Study, Szentháromság utca 2, Budapest H 1014, Hungary
    Genome Biol 9:R51. 2008
  2. pmc On origin of genetic code and tRNA before translation
    Andrei S Rodin
    Human Genetics Center, School of Public Health, University of Texas, Houston, TX 77225, USA
    Biol Direct 6:14. 2011
  3. pmc One ancestor for two codes viewed from the perspective of two complementary modes of tRNA aminoacylation
    Andrei S Rodin
    Collegium Budapest, Institute for Advanced Study, Budapest, Hungary
    Biol Direct 4:4. 2009
  4. pmc Genetic hitchhiking can promote the initial spread of strong altruism
    Mauro Santos
    Departament de Genetica i de Microbiologia, Grup de Biologia Evolutiva, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    BMC Evol Biol 8:281. 2008
  5. pmc Prebiotic replicase evolution in a surface-bound metabolic system: parasites as a source of adaptive evolution
    Balázs Könnyu
    Institute of Biology, Eotvos University, Budapest, Hungary
    BMC Evol Biol 8:267. 2008
  6. pmc A new replicator: a theoretical framework for analysing replication
    István Zachar
    MTA ELTE Theoretical Biology and Ecology Research Group, Pázmány P sétány 1 C, H 1117 Budapest, Hungary
    BMC Biol 8:21. 2010
  7. pmc The origin of replicators and reproducers
    Eors Szathmary
    Collegium Budapest, Institute for Advanced Study, Hungary
    Philos Trans R Soc Lond B Biol Sci 361:1761-76. 2006
  8. ncbi request reprint Obituary: John Maynard Smith (1920-2004)
    Eors Szathmary
    Collegium Budapest, Szentháromság utca 2, Budapest, Hungary
    Nature 429:258-9. 2004
  9. ncbi request reprint From biological analysis to synthetic biology
    Eors Szathmary
    Research Group of Theoretical Biology and Ecology, Eötvös University and Collegium Budapest, Hungary
    Curr Biol 14:R145-6. 2004
  10. ncbi request reprint Why are there four letters in the genetic alphabet?
    Eors Szathmary
    Institute for Advanced Study, Berlin
    Nat Rev Genet 4:995-1001. 2003

Collaborators

Detail Information

Publications25

  1. pmc Computational identification of obligatorily autocatalytic replicators embedded in metabolic networks
    Adám Kun
    Collegium Budapest, Institute for Advanced Study, Szentháromság utca 2, Budapest H 1014, Hungary
    Genome Biol 9:R51. 2008
    ..We provide the first systems-level analysis searching for small-molecular autocatalytic components in the metabolisms of diverse organisms, including an inferred minimal metabolism...
  2. pmc On origin of genetic code and tRNA before translation
    Andrei S Rodin
    Human Genetics Center, School of Public Health, University of Texas, Houston, TX 77225, USA
    Biol Direct 6:14. 2011
    ....
  3. pmc One ancestor for two codes viewed from the perspective of two complementary modes of tRNA aminoacylation
    Andrei S Rodin
    Collegium Budapest, Institute for Advanced Study, Budapest, Hungary
    Biol Direct 4:4. 2009
    ..Accordingly, in this communication we focus on the acceptor stem...
  4. pmc Genetic hitchhiking can promote the initial spread of strong altruism
    Mauro Santos
    Departament de Genetica i de Microbiologia, Grup de Biologia Evolutiva, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    BMC Evol Biol 8:281. 2008
    ....
  5. pmc Prebiotic replicase evolution in a surface-bound metabolic system: parasites as a source of adaptive evolution
    Balázs Könnyu
    Institute of Biology, Eotvos University, Budapest, Hungary
    BMC Evol Biol 8:267. 2008
    ..In seeking for a scientific explanation one has to search for step-by-step evolutionary changes from prebiotic chemistry to the emergence of the first proto-cell...
  6. pmc A new replicator: a theoretical framework for analysing replication
    István Zachar
    MTA ELTE Theoretical Biology and Ecology Research Group, Pázmány P sétány 1 C, H 1117 Budapest, Hungary
    BMC Biol 8:21. 2010
    ..Therefore, it is importance to decide the nature and characteristics of any multiplying entity, in a detailed and formal way...
  7. pmc The origin of replicators and reproducers
    Eors Szathmary
    Collegium Budapest, Institute for Advanced Study, Hungary
    Philos Trans R Soc Lond B Biol Sci 361:1761-76. 2006
    ..The stochastic corrector model shows how such a bag of genes can survive, and what the role of chromosome formation and intragenic recombination could be. Prebiotic and early evolution cannot be understood without the models of dynamics...
  8. ncbi request reprint Obituary: John Maynard Smith (1920-2004)
    Eors Szathmary
    Collegium Budapest, Szentháromság utca 2, Budapest, Hungary
    Nature 429:258-9. 2004
  9. ncbi request reprint From biological analysis to synthetic biology
    Eors Szathmary
    Research Group of Theoretical Biology and Ecology, Eötvös University and Collegium Budapest, Hungary
    Curr Biol 14:R145-6. 2004
  10. ncbi request reprint Why are there four letters in the genetic alphabet?
    Eors Szathmary
    Institute for Advanced Study, Berlin
    Nat Rev Genet 4:995-1001. 2003
    ..Here, I argue that there are theoretical, experimental and computational reasons to believe that having four base types is a frozen relic from the RNA world, when RNA was genetic as well as enzymatic material...
  11. pmc Coevolution of metabolic networks and membranes: the scenario of progressive sequestration
    Eors Szathmary
    Collegium Budapest Institute for Advanced Study, 2 Szentháromság utca, 1014 Budapest, Hungary
    Philos Trans R Soc Lond B Biol Sci 362:1781-7. 2007
    ....
  12. ncbi request reprint The origin of the genetic code: amino acids as cofactors in an RNA world
    E Szathmary
    Department of Plant Taxonomy and Ecology, Eotvos University, Budapest and Collegium Budapest, Szentháromság u 2, H 1014 Budapest, Hungary
    Trends Genet 15:223-9. 1999
    ..Recent experimental findings, including selection for ribozymes catalyzing peptide-bond formation and those utilizing an amino acid cofactor, hold promise that scenarios of this major transition can be tested...
  13. ncbi request reprint Evolution. Darwin for all seasons
    Eors Szathmary
    Institute of Biology, Eötvös University Budapest, and Collegium Budapest Institute for Advanced Study, 2 Szentháromság utca, H 1014 Budapest, Hungary
    Science 313:306-7. 2006
  14. ncbi request reprint From replicators to reproducers: the first major transitions leading to life
    E Szathmary
    Department of Plant Taxonomy and Ecology, Eotvos University, Budapest, Hungary
    J Theor Biol 187:555-71. 1997
    ..We outline Griesemer's concept of a reproducer, which brings out the essential role of development in evolution...
  15. ncbi request reprint Survival of replicators with parabolic growth tendency and exponential decay
    I Scheuring
    Department of Plant Taxonomy and Ecology, Research Group for Ecology and Theoretical Biology, Eotvos University, Ludovika ter 2, H 1083 Budapest, Hungary
    J Theor Biol 212:99-105. 2001
    ..Exponential decay acting on single- and double-strands, combined with parabolic growth, may or may not result in a dynamical coexistence of self-replicators...
  16. pmc The evolution of replicators
    E Szathmary
    Collegium Budapest Institute for Advanced Study, Hungary
    Philos Trans R Soc Lond B Biol Sci 355:1669-76. 2000
    ..Memes in human culture are unlimited hereditary, phenotypic replicators, based on language. The typical path of evolution goes from limited to unlimited heredity, and from attractor-based to modular (digital) replicators...
  17. pmc Lack of evolvability in self-sustaining autocatalytic networks constraints metabolism-first scenarios for the origin of life
    Vera Vasas
    Collegium Budapest, Institute for Advanced Study, H 1014 Budapest, Hungary
    Proc Natl Acad Sci U S A 107:1470-5. 2010
    ....
  18. ncbi request reprint Real ribozymes suggest a relaxed error threshold
    Adám Kun
    Collegium Budapest, Institute for Advanced Study, Szentháromság u 2 Budapest H 1014, Hungary
    Nat Genet 37:1008-11. 2005
    ..Incidentally, this genome size coincides with that estimated for a minimal cell achieved by top-down analysis, omitting the genes dealing with translation...
  19. ncbi request reprint Dark Dune Spots: possible biomarkers on Mars?
    Tibor Gánti
    Collegium Budapest, Institute for Advanced Study, Budapest, Hungary
    Orig Life Evol Biosph 33:515-57. 2003
    ..When the frost cover disappears MSOs go to a dormant, desiccated state. We propose further studies to be carried out by orbiters and landers travelling to Mars and by analysis of partial analogues on earth...
  20. ncbi request reprint In silico simulations reveal that replicators with limited dispersal evolve towards higher efficiency and fidelity
    Peter Szabo
    Department of Plant Taxonomy and Ecology, Research Group of Ecology and Theoretical Biology, Eotvos University, 1 C Pázmány P sétány, H 1117 Budapest, Hungary
    Nature 420:340-3. 2002
    ....
  21. ncbi request reprint "Living" under the challenge of information decay: the stochastic corrector model vs. hypercycles
    Elias Zintzaras
    Collegium Budapest, Institute for Advanced Study, Szentháromság u 2, H 1014, Budapest, Hungary
    J Theor Biol 217:167-81. 2002
    ..However, a population of SCM protocells can tolerate higher deleterious mutation rates and reaches an equilibrium mutational load lower than that in a population of HPC protocells...
  22. ncbi request reprint Selective scenarios for the emergence of natural language
    Szabolcs Számadó
    Collegium Budapest Institute for Advanced Study, Szentháromság u 2, H 1014, Budapest, Hungary
    Trends Ecol Evol 21:555-61. 2006
    ..Although individually none of these criteria are highly constraining, taken together they could provide a useful evolutionary framework for thinking about the evolution of human language...
  23. doi request reprint Analysis of dark albedo features on a southern polar dune field of Mars
    Andras Horvath
    Collegium Budapest Institute for Advanced Study, Budapest, Hungary
    Astrobiology 9:90-103. 2009
    ....
  24. ncbi request reprint Origin of sex revisited
    Mauro Santos
    Collegium Budapest, Institute for Advanced Study, Szentháromság u 2, Budapest, Hungary
    Orig Life Evol Biosph 33:405-32. 2003
    ..The scenario we have explored numerically is fully consistent with the idea that the universal ancestor was not a discrete entity but an ensemble of proto-organisms that exchanged much genetic information...
  25. pmc In silico detection of tRNA sequence features characteristic to aminoacyl-tRNA synthetase class membership
    Eena Jakó
    Theoretical Biology and Ecology Research Group of the Hungarian Academy of Sciences, Department of Plant Taxonomy and Ecology, Budapest, Hungary
    Nucleic Acids Res 35:5593-609. 2007
    ..The ECP analysis might contribute to the understanding of tRNA evolution and could enrich the sequence analysis tool repertoire...