Dániel Silhavy

Summary

Affiliation: Agricultural Biotechnology Center
Country: Hungary

Publications

  1. pmc Plant nonsense-mediated mRNA decay is controlled by different autoregulatory circuits and can be induced by an EJC-like complex
    Tünde Nyikó
    Agricultural Biotechnology Center, Institute for Genetics, Szent Györgyi 4, H 2100, Godollo, Hungary
    Nucleic Acids Res 41:6715-28. 2013
  2. pmc Both introns and long 3'-UTRs operate as cis-acting elements to trigger nonsense-mediated decay in plants
    Sándor Kertész
    Agricultural Biotechnology Center, Godollo, Hungary
    Nucleic Acids Res 34:6147-57. 2006
  3. pmc A viral protein suppresses RNA silencing and binds silencing-generated, 21- to 25-nucleotide double-stranded RNAs
    Dániel Silhavy
    Agricultural Biotechnology Center, Plant Biology Institute, PO Box 411, H 2101, Godollo, Hungary
    EMBO J 21:3070-80. 2002
  4. pmc Aureusvirus P14 is an efficient RNA silencing suppressor that binds double-stranded RNAs without size specificity
    Zsuzsanna Mérai
    Agricultural Biotechnology Center, Plant Science Institute, P O Box 411, H 2101 Gödöllõ, Hungary
    J Virol 79:7217-26. 2005
  5. pmc Short defective interfering RNAs of tombusviruses are not targeted but trigger post-transcriptional gene silencing against their helper virus
    Gyorgy Szittya
    Agricultural Biotechnology Center, Plant Biology Institute, P O Box 411, H 2101 Gödöllõ, Hungary
    Plant Cell 14:359-72. 2002
  6. pmc Low temperature inhibits RNA silencing-mediated defence by the control of siRNA generation
    Gyorgy Szittya
    Agricultural Biotechnology Center, Plant Biology, PO Box 411, H 2101, Godollo, Hungary
    EMBO J 22:633-40. 2003
  7. ncbi request reprint Effects and side-effects of viral RNA silencing suppressors on short RNAs
    Dániel Silhavy
    Agricultural Biotechnology Center, Plant Biology, PO Box 411, H 2101, Godollo, Hungary
    Trends Plant Sci 9:76-83. 2004
  8. pmc Inter-kingdom conservation of mechanism of nonsense-mediated mRNA decay
    Zoltán Kerényi
    Agricultural Biotechnology Center, Godollo, Hungary
    EMBO J 27:1585-95. 2008
  9. pmc Double-stranded RNA binding may be a general plant RNA viral strategy to suppress RNA silencing
    Zsuzsanna Mérai
    Agricultural Biotechnology Center, H 2101 Gödöllõ, P O Box 411, Hungary
    J Virol 80:5747-56. 2006
  10. ncbi request reprint Phosphorylation of the N- and C-terminal UPF1 domains plays a critical role in plant nonsense-mediated mRNA decay
    Farkas Kerényi
    Agricultural Biotechnology Center, Szent Györgyi 4, H 2100, Godollo, Hungary
    Plant J 76:836-48. 2013

Collaborators

Detail Information

Publications15

  1. pmc Plant nonsense-mediated mRNA decay is controlled by different autoregulatory circuits and can be induced by an EJC-like complex
    Tünde Nyikó
    Agricultural Biotechnology Center, Institute for Genetics, Szent Györgyi 4, H 2100, Godollo, Hungary
    Nucleic Acids Res 41:6715-28. 2013
    ....
  2. pmc Both introns and long 3'-UTRs operate as cis-acting elements to trigger nonsense-mediated decay in plants
    Sándor Kertész
    Agricultural Biotechnology Center, Godollo, Hungary
    Nucleic Acids Res 34:6147-57. 2006
    ..We have also identified plant UPF1 and showed that tethering of UPF1 to either the 5'- or 3'-UTR of an mRNA results in reduced transcript accumulation. Thus, plant UPF1 might bind to mRNA in a late, irreversible phase of NMD...
  3. pmc A viral protein suppresses RNA silencing and binds silencing-generated, 21- to 25-nucleotide double-stranded RNAs
    Dániel Silhavy
    Agricultural Biotechnology Center, Plant Biology Institute, PO Box 411, H 2101, Godollo, Hungary
    EMBO J 21:3070-80. 2002
    ..Moreover, the observation that p19-expressing transgenic plants show altered leaf morphology might indicate that the p19-targeted PTGS pathway is also important in the regulation of plant development...
  4. pmc Aureusvirus P14 is an efficient RNA silencing suppressor that binds double-stranded RNAs without size specificity
    Zsuzsanna Mérai
    Agricultural Biotechnology Center, Plant Science Institute, P O Box 411, H 2101 Gödöllõ, Hungary
    J Virol 79:7217-26. 2005
    ..Finally, sequence analyses suggest that P14 and P19 suppressors diverged from an ancient dsRNA binding suppressor that evolved as a nested protein within the common ancestor of aureusvirus-tombusvirus movement proteins...
  5. pmc Short defective interfering RNAs of tombusviruses are not targeted but trigger post-transcriptional gene silencing against their helper virus
    Gyorgy Szittya
    Agricultural Biotechnology Center, Plant Biology Institute, P O Box 411, H 2101 Gödöllõ, Hungary
    Plant Cell 14:359-72. 2002
    ..Because PTGS operates in a wide variety of different organisms, this model is applicable to DI RNA generation and accumulation in both plant and animal cells...
  6. pmc Low temperature inhibits RNA silencing-mediated defence by the control of siRNA generation
    Gyorgy Szittya
    Agricultural Biotechnology Center, Plant Biology, PO Box 411, H 2101, Godollo, Hungary
    EMBO J 22:633-40. 2003
    ..However, temperature does not influence the accumulation of micro (mi) RNAs, which play a role in developmental regulation, suggesting that the two classes of small (si and mi) RNAs are generated by different nuclease complexes...
  7. ncbi request reprint Effects and side-effects of viral RNA silencing suppressors on short RNAs
    Dániel Silhavy
    Agricultural Biotechnology Center, Plant Biology, PO Box 411, H 2101, Godollo, Hungary
    Trends Plant Sci 9:76-83. 2004
    ..Thus, suppressors contribute to viral symptoms. These findings fuel further research to test whether certain symptoms caused by animal viruses are also manifestations of altered RNA regulatory pathways...
  8. pmc Inter-kingdom conservation of mechanism of nonsense-mediated mRNA decay
    Zoltán Kerényi
    Agricultural Biotechnology Center, Godollo, Hungary
    EMBO J 27:1585-95. 2008
    ..We propose that a complex, autoregulated NMD mechanism operated in stem eukaryotes, and that despite aspect of the mechanism being simplified in different lineages, feedback regulation was retained in all kingdoms...
  9. pmc Double-stranded RNA binding may be a general plant RNA viral strategy to suppress RNA silencing
    Zsuzsanna Mérai
    Agricultural Biotechnology Center, H 2101 Gödöllõ, P O Box 411, Hungary
    J Virol 80:5747-56. 2006
    ..The findings that many unrelated silencing suppressors bind dsRNA suggest that dsRNA binding is a general silencing suppression strategy which has evolved independently many times...
  10. ncbi request reprint Phosphorylation of the N- and C-terminal UPF1 domains plays a critical role in plant nonsense-mediated mRNA decay
    Farkas Kerényi
    Agricultural Biotechnology Center, Szent Györgyi 4, H 2100, Godollo, Hungary
    Plant J 76:836-48. 2013
    ..SMG7 binds the phosphorylated S/TQ sites of the UPF1 component of the NMD complex, and then it induces the degradation of the NMD target. ..
  11. doi request reprint Functional analysis of the grapevine paralogs of the SMG7 NMD factor using a heterolog VIGS-based gene depletion-complementation system
    Anna Hangyáné Benkovics
    Agricultural Biotechnology Center, Szent Györgyi 4, 2100 Gödöllő, Hungary
    Plant Mol Biol 75:277-90. 2011
    ..Using heterolog depletion/complementation assays we demonstrate that both grapevine SMG7 copies retained the complete NMD activity and both of them are under NMD control, whilst SMG7L has lost NMD activity and NMD control...
  12. ncbi request reprint Double-stranded RNA-binding proteins could suppress RNA interference-mediated antiviral defences
    Zsuzsanna Lichner
    Agricultural Biotechnology Center, Plant Biology Institute, P O Box 411, H 2101, Godollo, Hungary
    J Gen Virol 84:975-80. 2003
    ..Here, it is shown that heterologous dsRBPs suppressed RNAi in plants, indicating that in natural host-virus interactions, pathogen-encoded dsRBPs could inactivate RNAi-mediated host defences...
  13. ncbi request reprint Plant upstream ORFs can trigger nonsense-mediated mRNA decay in a size-dependent manner
    Tünde Nyikó
    Agricultural Biotechnology Center, Szent Györgyi 4, 2100 Gödöllő, Hungary
    Plant Mol Biol 71:367-78. 2009
    ....
  14. ncbi request reprint Size-dependent cell-to-cell movement of defective interfering RNAs of Cymbidium ringspot virus
    Gyorgy Szittya
    Agricultural Biotechnology Center, Plant Science Institute, PO Box 411, 2101 Gödöllö, Hungary
    J Gen Virol 83:1505-10. 2002
    ..Our results also demonstrated that the size of DI RNAs is important in the colonization of inoculated leaves, suggesting that DI RNA dimers are quickly selected for cell-to-cell movement if short DI RNA monomers are used for infection...
  15. pmc Molecular mechanism of RNA silencing suppression mediated by p19 protein of tombusviruses
    Lóránt Lakatos
    Agricultural Biotechnology Center, Plant Biology Institute, Gödöll, Hungary
    EMBO J 23:876-84. 2004
    ..Furthermore, the obtained results also suggest that the p19-mediated sequestration of siRNAs in virus-infected cells blocks the spread of the mobile, systemic signal of RNA silencing...