Topical therapy in anosmia: relevance of steroid-responsivenessM Stenner
Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, University Hospital of Cologne, Cologne, Germany
Laryngoscope 118:1681-6. 2008
....
Olfactory function in acute rhinitisT Hummel
Department of Otorhinolaryngology, University of Dresden, Germany
Ann N Y Acad Sci 855:616-24. 1998
..This indicates that the common cold has a small effect on olfactory function which may be independent of nasal congestion...
- Chemosensory event-related potentials change with age
T Hummel
Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Erlangen, Germany
Electroencephalogr Clin Neurophysiol 108:208-17. 1998
..The age-related decrease of CSERP amplitudes appeared to follow a different time course for responses to trigeminal and olfactory stimulants...
- Effects of the nasal decongestant oxymetazoline on human olfactory and intranasal trigeminal function in acute rhinitis
T Hummel
Department of Otorhinolaryngology, University of Dresden, Germany
Eur J Clin Pharmacol 54:521-8. 1998
..The placebo-controlled, randomized, double-blind study was performed to investigate dose-related effects of oxymetazoline on olfactory function during the course of the spontaneously occurring cold...
- Trigeminal chemosensitivity: Differences in relation to the time of the day
J Lotsch
Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Germany
Chem Senses 23:755-9. 1998
..Day-night differences were found with N 1 P2 amplitudes, P2 latencies and pain ratings. It is concluded that the time of the day must not be ignored when human chemosensitivity is investigated at suprathreshold levels...
- The negative mucosal potential: separating central and peripheral effects of NSAIDs in man
J Lotsch
Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Germany
Eur J Clin Pharmacol 52:359-64. 1997
..For this purpose, experimental conditions were created in which NSAIDs had previously been observed to produce effects on phasic and tonic pain by either central or peripheral mechanisms...
Effects of azapropazone on pain-related brain activity in human subjectsJ Lotsch
Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Germany
Br J Clin Pharmacol 40:545-52. 1995
..4. Analgesic properties of azapropazone were demonstrated in man. The topographical pattern of the changes in the CSSERPs and the effects on EEG background activity suggest a central component of the analgesic action of azapropazone...
- Prevalence of smell loss in Parkinson's disease--a multicenter study
A Haehner
Department of Otorhinolaryngology, University of Dresden Medical School, Dresden, Germany
Parkinsonism Relat Disord 15:490-4. 2009
..This figure falls to 74.5%, however, when adjusted to age-related norms. Thus, olfactory dysfunction should be considered as a reliable marker of the disease...
- Comparison of the antinociception produced by two oral formulations of ibuprofen: ibuprofen effervescent vs ibuprofen tablets
T Hummel
Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Germany
Eur J Clin Pharmacol 52:107-14. 1997
..The aim of this study was to compare the dose-related effects of both ibuprofen tablets and ibuprofen effervescent [placebo, 400 and 800 mg ibuprofen (Aktren)] on phasic pain...
- Correlation between olfactory bulb volume and olfactory function in children and adolescents
T Hummel
Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, 01307 Dresden, Germany
Exp Brain Res 214:285-91. 2011
..In conclusion, for the first time, the present study showed a correlation between OB volume and olfactory functions in children...
- A threshold-like measure for the assessment of olfactory sensitivity: the "random" procedure
G Kobal
Department of Pharmacology, , Erlangen, Germany
Eur Arch Otorhinolaryngol 258:168-72. 2001
..6, P < 0.001). Based on these data, and the fact that the new test requires little time and is easy to use, this approach can be expected to suit clinical needs...
- Differences in anosmic and normosmic group in bimodal odorant perception: a functional- MRI study
E Iannilli
Department of Otorhinolaryngology, University of Dresden Medical School, Dresden, Germany
Rhinology 49:458-63. 2011
..These results suggest that the olfactory system modifies trigeminally mediated information causing an evident effect in the differentiation between stimulus intensities...
- Increasing olfactory bulb volume due to treatment of chronic rhinosinusitis--a longitudinal study
V Gudziol
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
Brain 132:3096-101. 2009
..To our knowledge, this is the first longitudinal study that describes an enlargement of the human olfactory bulb due to improvement of peripheral olfactory function...
- Normative data for the "Sniffin' Sticks" including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects
T Hummel
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, 01307, Dresden, Germany
Eur Arch Otorhinolaryngol 264:237-43. 2007
..Further, the present data suggest specific changes of individual olfactory functions in relation to age, with odor thresholds declining most dramatically compared to odor discrimination and odor identification...
- Immunohistochemical, volumetric, and functional neuroimaging studies in patients with idiopathic Parkinson's disease
T Hummel
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Dresden, Germany
J Neurol Sci 289:119-22. 2010
..Thus, it seems that cerebral changes, and not changes at the level of the olfactory epithelium, are the basis of the olfactory loss observed in PD patients...
- Screening of olfactory function with a four-minute odor identification test: reliability, normative data, and investigations in patients with olfactory loss
T Hummel
Department of Otorhinolaryngology, University of Dresden Medical School, Germany
Ann Otol Rhinol Laryngol 110:976-81. 2001
..When only 6 odors were used for calculating scores, for anosmics the 95th percentile was at a score of 4. These data provide a basis for the screening of patients by means of "Sniffin' Sticks."..
- Chemosensory event-related potentials in relation to side of stimulation, age, sex, and stimulus concentration
B A Stuck
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Mannheim, Germany
Clin Neurophysiol 117:1367-75. 2006
..SIGNIFICANCE: The present results obtained in a representative group of healthy subjects establishes a comprehensive set of data, which will serve as reference for future work in this area of research...
- Olfactory bulb volumes in patients with idiopathic Parkinson's disease a pilot study
A Mueller
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Dresden, Germany
J Neural Transm 112:1363-70. 2005
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- Peripheral electrophysiological responses decrease in response to repetitive painful stimulation of the human nasal mucosa
T Hummel
Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Germany
Neurosci Lett 212:37-40. 1996
..In contrast, the decrease of NMP amplitudes was stronger the shorter the ISI (P < 0.01). These findings are in line with the view that the NMP reflects activation of epithelial nociceptors (C-fibers and/or A delta-fibers)...
- Responses to nasal irritation obtained from the human nasal mucosa
T Hummel
Department of Otorhinolaryngology, University of Dresden, Germany
Rhinology 36:168-72. 1998
..46); it appeared at the same time when the subjects' tracking of the painful sensations reached its maximum amplitude. These findings suggest that the NMP is suited for the investigation of peripheral nociceptive events in man...
- Investigation of the topographical differences in somatosensory sensitivity of the human nasal mucosa
M Scheibe
Department of Otorhinolaryngology, University of Dresden Medical School, Dresden, Germany
Rhinology 50:290-3. 2012
..The present study aimed to investigate whether different sites in the human nasal mucosa react differently to unspecific electrical stimuli...
- OLAF: standardization of international olfactory tests
C Hummel
Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, 01307, Dresden, Germany
Eur Arch Otorhinolaryngol 269:871-80. 2012
..In conclusion, the currently described software is expected to further facilitate and standardize olfactory testing with the "Sniffin' Sticks" test battery...
- Are there sex-related differences in responses to repetitive olfactory/trigeminal stimuli?
M Scheibe
Department of Otorhinolaryngology, Smell and Taste Clinic, University of Dresden Medical School, Germany
Eur Arch Otorhinolaryngol 266:1323-6. 2009
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- Reduced olfactory bulb volume and olfactory sensitivity in patients with acute major depression
S Negoias
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Dresden, Germany
Neuroscience 169:415-21. 2010
..These results might be related to reduced neurogenesis in major depression that could be reflected also at the level of the olfactory bulb...
- Responses to olfactory and intranasal trigeminal stimuli: relation to the respiratory cycle
A Haehner
Department of Otorhinolaryngology, University of Dresden Medical School, 01307 Dresden, Fetscherstr 74, Germany
Neuroscience 175:178-83. 2011
..These data indicate on an electrophysiological level that there is priming of both olfactory and trigeminally mediated sensations in relation to the respiratory cycle...
- Peripherally obtained electrophysiological responses to olfactory stimulation in man: electro-olfactograms exhibit a smaller degree of desensitization compared with subjective intensity estimates
T Hummel
Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Germany
Brain Res 717:160-4. 1996
..Based on the present data peripheral encoding in the olfactory system appears to be less subject to desensitization compared to the decrease of intensity estimates...
- Intranasal localizability of odorants: influence of stimulus volume
J Frasnelli
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, Dresden, Germany
Chem Senses 36:405-10. 2011
..This study suggests that differences in stimulus volume may explain some discrepant findings within the trigeminal chemosensory literature and supports the concept that vanillin may be a "relatively pure" olfactory stimulus...
- Sense of smell in workers exposed to agricultural odours
V Gudziol
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstr 74, 01307 Dresden, Germany
Occup Med (Lond) 57:149-51. 2007
..To investigate the effect of occupational exposure to agricultural odours on sense of smell...
- Correlation between olfactory bulb volume and olfactory function
D Buschhüter
Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, 01307 Dresden, Germany
Neuroimage 42:498-502. 2008
..In conclusion, the present data obtained from a relatively large group of subjects forms the basis for age-related normative values of OB volumes...
- Electrical responses to chemosensory stimulation recorded from the vomeronasal duct and the respiratory epithelium in humans
T Hummel
Smell and Taste Clinic, Department of Otorhinolaryngology, Technical University of Dresden Medical School, Dresden, Germany
Int J Psychophysiol 81:116-20. 2011
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- A study on the prognostic significance of qualitative olfactory dysfunction
J Reden
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany
Eur Arch Otorhinolaryngol 264:139-44. 2007
..Phantosmia disappears at a faster rate than parosmia. These insights into qualitative olfactory dysfunction are regarded to be significant in the counseling of patients with olfactory loss...
- Cerebral processing of gustatory stimuli in patients with taste loss
C Hummel
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstr 74, 01307 Dresden, Germany
Behav Brain Res 185:59-64. 2007
..It may ultimately prove useful in terms of the prognostic evaluation of individual patients...
- Normative values for the assessment of gustatory function using liquid tastants
H Gudziol
Department of Otorhinolaryngology, University of Jena, Jena, Germany
Acta Otolaryngol 127:658-61. 2007
..The present study introduces normative data for the 'three-drop test' of gustatory function...
- Intranasal trigeminal function in subjects with and without an intact sense of smell
E Iannilli
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, 01307 Dresden, Germany
Brain Res 1139:235-44. 2007
..These data suggest that the processing of the trigeminally mediated information is different in the presence or absence of an intact sense of smell, pointing towards the intimate connection between the two chemosensory systems...
- Central processing of trigeminal activation in humans
T Hummel
Department of Otorhinolaryngology, University of Dresden Medical School, Smell and Taste Clinic, Dresden, Germany
Ann N Y Acad Sci 1170:190-5. 2009
..Both the orbitofrontal cortex and the rostral insula appear to be of significance in the amplification of trigeminal input, which is missing in patients with olfactory loss...
- Qualitative and quantitative olfactometric evaluation of different concentrations of ethanol peppermint oil solutions
D Krone
Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstr. 74, 01307 Dresden, Germany
Phytother Res 15:135-8. 2001
..1%, 0.5%, or 1% peppermint oil when tested on separate days...
- The effect of a herbal combination of primrose, gentian root, vervain, elder flowers, and sorrel on olfactory function in patients with a sinonasal olfactory dysfunction
J Reden
Department of Otorhinolaryngology, University of Dresden Medical School, Dresden, Germany
Rhinology 49:342-6. 2011
..g., when applied without preceding administration of prednisolone, or when used in patients with certain degrees of rhinosinusitis...
- Handedness is a determining factor in lateralized olfactory discrimination
T Hummel
Department of Otorhinolaryngology, University of Dresden, Germany
Chem Senses 23:541-4. 1998
..The data indicate that, similar to other sensory systems, higher olfactory functions exhibit a certain degree of lateralization...
- Frequency and localization of the putative vomeronasal organ in humans in relation to age and gender
M Knecht
Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstr. 74, 01307 Dresden, Germany
Laryngoscope 111:448-52. 2001
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- Decreased trigeminal sensitivity in anosmia
H Gudziol
Department of Otorhinolaryngology, Friedrich Schiller University of Jena Medical School, Jena, Germany
ORL J Otorhinolaryngol Relat Spec 63:72-5. 2001
..This may have implications for the medicolegal investigation of anosmic patients where trigeminal stimuli are frequently used to assess the patient's response bias...
- Interactions between the chemical senses: trigeminal function in patients with olfactory loss
J Frasnelli
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Dresden, Germany
Int J Psychophysiol 65:177-81. 2007
..On peripheral levels, however, adaptive mechanisms seem to produce an increase in the trigeminal responsiveness of patients with hyposmia or anosmia...
- Subjects with congenital anosmia have larger peripheral but similar central trigeminal responses
J Frasnelli
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Dresden, Germany
Cereb Cortex 17:370-7. 2007
..The results of the study are discussed by proposing a model of mixed sensory adaptation/compensation in the interactions between olfactory and the trigeminal system...
- Treatment of smell loss with systemic methylprednisolone
V A Schriever
Department of Otorhinolaryngology, University of Dresden Medical School, Dresden, Germany
Rhinology 50:284-9. 2012
..Although a prospective randomized control trail is preferred for such an investigation, using the current approach, we were able to test a very large patient population...
- Euosmia: a rare form of parosmia
B N Landis
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Dresden, Germany
Acta Otolaryngol 126:101-3. 2006
..In contrast, parosmias always seem to be unpleasant. We report the case of a female with post-infectious hyposmia who reported a pleasant parosmia to selected odorants. We have called this rare clinical presentation euosmia...
- Peripheral and central nervous changes in patients with rheumatoid arthritis in response to repetitive painful stimulation
T Hummel
Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, 01307, Dresden, Germany
Int J Psychophysiol 37:177-83. 2000
..While the NMP did not differ between groups, patients had larger cortical responses to the first stimuli of a series of painful stimuli. This may indicate that in RA central nervous changes of nociceptive processing are present...
- Trigeminal activation using chemical, electrical, and mechanical stimuli
E Iannilli
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, Dresden, Germany
Pain 139:376-88. 2008
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- Smell and taste disorders in polyneuropathy: a prospective study of chemosensory disorders
J G Heckmann
Department of Neurology, University of Erlangen Nuremberg, Erlangen, Germany
Acta Neurol Scand 120:258-63. 2009
..The aim of the study was to assess the occurrence and the frequency of chemosensory dysfunction in patients with polyneuropathy (PNP)...
- Gray matter alterations in parosmia
T Bitter
Department of Otorhinolaryngology, Friedrich Schiller University, Jena, Germany
Neuroscience 177:177-82. 2011
..The present results indicate that reduced gray matter volume in brain regions supporting odor discrimination and memory is related to disturbed olfactory sensation in parosmia...
- Factors affecting pain intensity in a pain model based upon tonic intranasal stimulation in humans
J Lotsch
Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Erlangen, Germany
Inflamm Res 47:446-50. 1998
..The aim of the present study was to investigate the influence of flow, humidity and temperature of the air-stream on the intensity of the evoked pain sensations...
- Post-infectious olfactory dysfunction exhibits a seasonal pattern
I Konstantinidis
Smell and Taste Clinic, Department of Otorhinolaryngology, , Dresden, Germany
Rhinology 44:135-9. 2006
..g. parainfluenza type III. CONCLUSION: Post-URTI olfactory dysfunction exhibits spring seasonality with peaks in March and May and possible causative factors being influenza and parainfluenza viruses (type III), respectively...
- Assessment of intranasal trigeminal function
T Hummel
Department of Otorhinolaryngology, University of Dresden, Fetscherstr 74, 01307, Dresden, Germany
Int J Psychophysiol 36:147-55. 2000
..g. by environmental influences or analgesic drugs...
- Clinical presentation of qualitative olfactory dysfunction
J Frasnelli
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, 01307 Dresden, Germany
Eur Arch Otorhinolaryngol 261:411-5. 2004
..Further, emphasis is placed on the fact that only a detailed and directed history of the patient can provide cues to the correct diagnosis...
- Mometasone furoate nasal spray improves olfactory performance in seasonal allergic rhinitis
B A Stuck
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, D-68135 Mannheim, Germany
Allergy 58:1195. 2003
- Ratings of overall olfactory function
B N Landis
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Dresden, Germany
Chem Senses 28:691-4. 2003
..The ratings seem to reflect changes of nasal airway patency to a larger degree than measurable olfactory function. The results further indicate that this is mainly due to the limited attention the sense of smell receives in daily life...
- Assessment of olfactory function after septoplasty: a longitudinal study
O Pfaar
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, 01307 Dresden, Germany
Rhinology 42:195-9. 2004
..In contrast, postoperative changes were only seen for odor discrimination. Apart from psychological explanations of this finding, it may be hypothesized that these observations result from changes in intranasal airflow following surgery...
- Olfactory function following nasal surgery: a 1-year follow-up
V A Schriever
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstr 74, 01307, Dresden, Germany
Eur Arch Otorhinolaryngol 270:107-11. 2013
..5 months, and 32% after 12 months. Nasal sinus surgery produced an increase in measured olfactory function, but not nasal septum surgery. This increase appeared to be stable over the examined period of 12 months...
- Gustatory function in chronic inflammatory middle ear diseases
B N Landis
Department of Otorhinolaryngology, Smell and Taste Clinic, University of Dresden Medical School, Dresden, Germany
Laryngoscope 115:1124-7. 2005
..Changes of gustatory function after ear surgery have been studied extensively. However, little is known on the influence of repeated/chronic inflammation within the middle ear on taste...
- Intranasal trigeminal function in children
T Hummel
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Dresden, Germany
Dev Med Child Neurol 49:849-53. 2007
..No sex-related difference was found for odour localization. These results provide data for normal intranasal trigeminal function in children. They also indicate that trigeminal sensitivity is already well-developed in children...
- Sildenafil affects olfactory function
V Gudziol
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Dresden, Germany
J Urol 177:258-61; discussion 261. 2007
..Sildenafil is the first member of a new class of oral drugs effective for erectile dysfunction. However, approximately 20% of patients complain about nasal congestion after sildenafil administration...
- Recording of the human electro-olfactogram
M Knecht
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, 01307 Dresden, Germany
Physiol Behav 83:13-9. 2004
..In conclusion, in combination with nasal endoscopy and air-dilution olfactometry, the EOG is a unique part of a large array of techniques used to provide a complete picture of the processing of olfactory information in humans...
- Comparison of lateralized and binasal olfactory thresholds
J Frasnelli
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, 01307 Dresden, Germany
Rhinology 40:129-34. 2002
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- A study on the frequency of olfactory dysfunction
B N Landis
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, 01307 Dresden, Germany
Laryngoscope 114:1764-9. 2004
..CONCLUSION: The data in the study revealed that olfactory dysfunction among subjects under 65 years of age is more frequent than previously reported...
- Olfactory modulation of nausea during early pregnancy?
T Hummel
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Germany
BJOG 109:1394-7. 2002
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- Olfactory sensitivity of subjects working in odorous environments
T Hummel
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, 01307 Dresden, Germany
Chem Senses 29:533-6. 2004
..Taken together, results from the present study do not support the idea that odorous environments are deleterious to general olfactory function...
- Olfactory function in patients with idiopathic Parkinson's disease: effects of deep brain stimulation in the subthalamic nucleus
T Hummel
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden, Medical School, Dresden, Germany
J Neural Transm 112:669-76. 2005
..This may indicate that deep brain stimulation has a positive effect on the cognitive processing of olfactory information in PD patients...
