Mark A Hull

Summary

Publications

  1. doi Omega-3 polyunsaturated fatty acids
    Mark A Hull
    Section of Molecular Gastroenterology, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, United Kingdom
    Best Pract Res Clin Gastroenterol 25:547-54. 2011
  2. pmc Reduced type II interleukin-4 receptor signalling drives initiation, but not progression, of colorectal carcinogenesis: evidence from transgenic mouse models and human case-control epidemiological observations
    Nicola Ingram
    Section of Molecular Gastroenterology, Leeds Institute of Biomedical and Clinical Sciences, Wellcome Trust Brenner Building, St James s University Hospital, Leeds, LS9 7TF, UK
    Carcinogenesis 34:2341-9. 2013
  3. pmc Regional differences in prostaglandin E₂ metabolism in human colorectal cancer liver metastases
    Alastair L Young
    Section of Molecular Gastroenterology, Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Leeds LS9 7TF, UK
    BMC Cancer 13:92. 2013
  4. doi Eicosapentaenoic acid reduces rectal polyp number and size in familial adenomatous polyposis
    Nicholas J West
    Section of Molecular Gastroenterology, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, UK
    Gut 59:918-25. 2010
  5. doi Rectal epithelial cell mitosis and expression of macrophage migration inhibitory factor are increased 3 years after Roux-en-Y gastric bypass (RYGB) for morbid obesity: implications for long-term neoplastic risk following RYGB
    Prashant Kant
    Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, St James s University Hospital, Leeds LS9 7TF, UK
    Gut 60:893-901. 2011
  6. doi Increased risk of colorectal cancer after obesity surgery
    Maryam Derogar
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, St James s University Hospital, Leeds, United Kingdom Division of Cancer Studies, King s College London, London, United Kingdom
    Ann Surg 258:983-8. 2013
  7. doi Nutritional agents with anti-inflammatory properties in chemoprevention of colorectal neoplasia
    Mark A Hull
    Leeds Institute of Molecular Medicine, St James s University Hospital, West Yorkshire, UK
    Recent Results Cancer Res 191:143-56. 2013
  8. pmc FGFR1-induced epithelial to mesenchymal transition through MAPK/PLCγ/COX-2-mediated mechanisms
    Darren C Tomlinson
    Section of Experimental Oncology, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, United Kingdom
    PLoS ONE 7:e38972. 2012
  9. doi High-frequency ultrasound for in vivo measurement of colon wall thickness in mice
    Mostafa A Abdelrahman
    Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Leeds United Kingdom
    Ultrasound Med Biol 38:432-42. 2012
  10. pmc Effect of eicosapentaenoic acid on E-type prostaglandin synthesis and EP4 receptor signaling in human colorectal cancer cells
    Gillian Hawcroft
    Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, United Kingdom
    Neoplasia 12:618-27. 2010

Collaborators

Detail Information

Publications10

  1. doi Omega-3 polyunsaturated fatty acids
    Mark A Hull
    Section of Molecular Gastroenterology, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, United Kingdom
    Best Pract Res Clin Gastroenterol 25:547-54. 2011
    ..A randomized polyp prevention trial of EPA is underway in order to test chemopreventative efficacy against 'sporadic' colorectal neoplasia...
  2. pmc Reduced type II interleukin-4 receptor signalling drives initiation, but not progression, of colorectal carcinogenesis: evidence from transgenic mouse models and human case-control epidemiological observations
    Nicola Ingram
    Section of Molecular Gastroenterology, Leeds Institute of Biomedical and Clinical Sciences, Wellcome Trust Brenner Building, St James s University Hospital, Leeds, LS9 7TF, UK
    Carcinogenesis 34:2341-9. 2013
    ..These results should prompt evaluation of the effect of pharmacological manipulation of IL-4R signalling on future CRC risk and for CRC treatment. ..
  3. pmc Regional differences in prostaglandin E₂ metabolism in human colorectal cancer liver metastases
    Alastair L Young
    Section of Molecular Gastroenterology, Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Leeds LS9 7TF, UK
    BMC Cancer 13:92. 2013
    ..To understand possible underlying mechanisms, we investigated the relationship between hypoxia, 15-PGDH and PGE2 in human CRC cells in vitro...
  4. doi Eicosapentaenoic acid reduces rectal polyp number and size in familial adenomatous polyposis
    Nicholas J West
    Section of Molecular Gastroenterology, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, UK
    Gut 59:918-25. 2010
    ....
  5. doi Rectal epithelial cell mitosis and expression of macrophage migration inhibitory factor are increased 3 years after Roux-en-Y gastric bypass (RYGB) for morbid obesity: implications for long-term neoplastic risk following RYGB
    Prashant Kant
    Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, St James s University Hospital, Leeds LS9 7TF, UK
    Gut 60:893-901. 2011
    ....
  6. doi Increased risk of colorectal cancer after obesity surgery
    Maryam Derogar
    Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, St James s University Hospital, Leeds, United Kingdom Division of Cancer Studies, King s College London, London, United Kingdom
    Ann Surg 258:983-8. 2013
    ..The purpose was to determine whether obesity surgery is associated with a long-term increased risk of colorectal cancer...
  7. doi Nutritional agents with anti-inflammatory properties in chemoprevention of colorectal neoplasia
    Mark A Hull
    Leeds Institute of Molecular Medicine, St James s University Hospital, West Yorkshire, UK
    Recent Results Cancer Res 191:143-56. 2013
    ....
  8. pmc FGFR1-induced epithelial to mesenchymal transition through MAPK/PLCγ/COX-2-mediated mechanisms
    Darren C Tomlinson
    Section of Experimental Oncology, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, United Kingdom
    PLoS ONE 7:e38972. 2012
    ..In conclusion, we have demonstrated that FGFR1 activation in UC cells lines promotes EMT via coordinated activation of multiple signalling pathways and by promoting activation of prostaglandin synthesis...
  9. doi High-frequency ultrasound for in vivo measurement of colon wall thickness in mice
    Mostafa A Abdelrahman
    Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Leeds United Kingdom
    Ultrasound Med Biol 38:432-42. 2012
    ..09 mm and 0.25 mm in distal and proximal colon, respectively. In conclusion, HF-US provides an easy to use and noninvasive method to perform anatomical investigations of mouse colon and to monitor changes in CWT...
  10. pmc Effect of eicosapentaenoic acid on E-type prostaglandin synthesis and EP4 receptor signaling in human colorectal cancer cells
    Gillian Hawcroft
    Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, United Kingdom
    Neoplasia 12:618-27. 2010
    ..We conclude that EPA-FFA drives a COX-2-dependent "PGE(2)-to-PGE(3) switch" in human CRC cells and that PGE(3) acts as a partial agonist at the PGE(2) EP4 receptor...