Function of the cytoskeleton in gravisensing during spaceflightM Hughes-Fulford
Laboratory of Cell Growth, Northern California Institute for Research and Education, University of California San Francisco, San Francisco, California 94121, USA
Adv Space Res 32:1585-93. 2003
..We therefore hypothesize that microgravity would inhibit growth in either G1, or G2/M...
Key gravity-sensitive signaling pathways drive T cell activationJ B Boonyaratanakornkit
Lab of Cell Growth, Veteran's Affairs Medical Center, San Francisco, California 94121, USA
FASEB J 19:2020-2. 2005
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- Human prostate cancer cells lack feedback regulation of low-density lipoprotein receptor and its regulator, SREBP2
Y Chen
Laboratory of Cell Growth, University of California San Francisco and Veterans Affairs Medical Center, USA
Int J Cancer 91:41-5. 2001
..The data also suggest that the sterol regulatory element and SREBP2 play a role in the loss of sterol feedback regulation in cancer cells...
- Early immune response and regulation of IL-2 receptor subunits
Millie Hughes-Fulford
Northern California Institute for Research and Education, San Francisco, CA, United States
Cell Signal 17:1111-24. 2005
..Taken together, these results suggest that the PKA in addition to PKC and MAPK pathways plays a role in early T-cell activation and induction of IL-2, IL-2R(alpha) and IFN(gamma) gene expression...
- Effects of microgravity on osteoblast growth
M Hughes-Fulford
Laboratory of Cell Growth and Differentiation, Veteran's Administration Medical Center, San Francisco, CA, USA
Gravit Space Biol Bull 11:51-60. 1998
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- Lessons learned about spaceflight and cell biology experiments
Millie Hughes-Fulford
Northern California Institute for Research and Education, San Francisco, CA, USA
J Gravit Physiol 11:105-9. 2004
..Finally, spaceflight experiments are rewarding and worth your effort and patience...
- Microgravity modifies protein kinase C isoform translocation in the human monocytic cell line U937 and human peripheral blood T-cells
Jason P Hatton
Laboratory of Cell Growth, Veterans Affairs Medical Center, Mail Code 151F, San Francisco, California 94121, USA
J Cell Biochem 87:39-50. 2002
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- Arachidonic acid, an omega-6 fatty acid, induces cytoplasmic phospholipase A2 in prostate carcinoma cells
Millie Hughes-Fulford
Laboratory of Cell Growth, Mail Code 151F, Department of Medicine, Northern California Institute for Research and Education and Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
Carcinogenesis 26:1520-6. 2005
..Since cPLA2 is upstream in the eicosanoid pathway, it may be a good alternative for a pharmaceutical target for the treatment of cancer...
- Fatty acid regulates gene expression and growth of human prostate cancer PC-3 cells
M Hughes-Fulford
Laboratory of Cell Growth, Veterans Affairs Medical Center San Francisco, CA 94121, USA
Carcinogenesis 22:701-7. 2001
..These data suggest that unregulated over-expression of LDLr in tumor cells would permit increased availability of AA, which induces immediate early genes c-fos and cox-2 within minutes of uptake...
- Signal transduction and mechanical stress
Millie Hughes-Fulford
Laboratory of Cell Growth, Department of Medicine, Veterans Affairs Medical Center, University of California, and Northern California Institute for Research and Education, San Francisco, CA 94121, USA
Sci STKE 2004:RE12. 2004
..Here, we examine the various types of stress and the sequential response of transduction pathways that result in changes in gene expression and the ensuing proliferation of osteoblasts...
- Osteoblast fibronectin mRNA, protein synthesis, and matrix are unchanged after exposure to microgravity
M Hughes-Fulford
Laboratory of Cell Growth and Differentiation, Veteran s Affairs Medical Center and University of California Medical Center, San Francisco, 94121, USA
FASEB J 13:S121-7. 1999
..These data also suggest that after a total period of 43 h of spaceflight FN transcription, translation, or altered matrix assembly is not responsible for the altered cell shape or altered matrix formation of osteoblasts...
