Chad D Huff

Summary

Publications

  1. pmc Genetic analysis of ancestry, admixture and selection in Bolivian and Totonac populations of the New World
    W Scott Watkins
    Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah, 15 N 2030 E RM 2100, Salt Lake City, UT 84112, USA
    BMC Genet 13:39. 2012
  2. pmc Crohn's disease and genetic hitchhiking at IBD5
    Chad D Huff
    Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah, UT, USA
    Mol Biol Evol 29:101-11. 2012
  3. pmc Detecting positive selection from genome scans of linkage disequilibrium
    Chad D Huff
    Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT, USA
    BMC Genomics 11:8. 2010
  4. pmc Genomic analysis of natural selection and phenotypic variation in high-altitude mongolians
    Jinchuan Xing
    Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, USA
    PLoS Genet 9:e1003634. 2013
  5. pmc Genetic diversity in India and the inference of Eurasian population expansion
    Jinchuan Xing
    Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah, 15 North 2030 East, Salt Lake City, UT 84112, USA
    Genome Biol 11:R113. 2010
  6. doi request reprint Genetic evidence for high-altitude adaptation in Tibet
    Tatum S Simonson
    Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Science 329:72-5. 2010
  7. pmc Mobile elements reveal small population size in the ancient ancestors of Homo sapiens
    Chad D Huff
    Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 107:2147-52. 2010
  8. pmc Maximum-likelihood estimation of recent shared ancestry (ERSA)
    Chad D Huff
    Department of Human Genetics, University of Utah Health Sciences Center, Salt Lake City, Utah 84112, USA
    Genome Res 21:768-74. 2011
  9. pmc Toward a more uniform sampling of human genetic diversity: a survey of worldwide populations by high-density genotyping
    Jinchuan Xing
    Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Genomics 96:199-210. 2010
  10. pmc Ancestry of the Iban is predominantly Southeast Asian: genetic evidence from autosomal, mitochondrial, and Y chromosomes
    Tatum S Simonson
    Department of Human Genetics, University of Utah, Salt Lake City, Utah, United States of America
    PLoS ONE 6:e16338. 2011

Collaborators

Detail Information

Publications16

  1. pmc Genetic analysis of ancestry, admixture and selection in Bolivian and Totonac populations of the New World
    W Scott Watkins
    Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah, 15 N 2030 E RM 2100, Salt Lake City, UT 84112, USA
    BMC Genet 13:39. 2012
    ....
  2. pmc Crohn's disease and genetic hitchhiking at IBD5
    Chad D Huff
    Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah, UT, USA
    Mol Biol Evol 29:101-11. 2012
    ..Finally, our association results and expression data support IRF1 as a strong candidate for Crohn's disease causation...
  3. pmc Detecting positive selection from genome scans of linkage disequilibrium
    Chad D Huff
    Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT, USA
    BMC Genomics 11:8. 2010
    ..While most applications of these tests have suggested that positive selection has played an important role in recent human history, the results of these tests have varied dramatically...
  4. pmc Genomic analysis of natural selection and phenotypic variation in high-altitude mongolians
    Jinchuan Xing
    Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, USA
    PLoS Genet 9:e1003634. 2013
    ..Our analyses of DU Mongolians and the first Mongolian genome provide valuable insight into genetic adaptation to extreme environments. ..
  5. pmc Genetic diversity in India and the inference of Eurasian population expansion
    Jinchuan Xing
    Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah, 15 North 2030 East, Salt Lake City, UT 84112, USA
    Genome Biol 11:R113. 2010
    ..Despite recent large-scale efforts in discovering human genetic variation, India's vast reservoir of genetic diversity remains largely unexplored...
  6. doi request reprint Genetic evidence for high-altitude adaptation in Tibet
    Tatum S Simonson
    Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Science 329:72-5. 2010
    ..Identification of these genes provides support for previously hypothesized mechanisms of high-altitude adaptation and illuminates the complexity of hypoxia-response pathways in humans...
  7. pmc Mobile elements reveal small population size in the ancient ancestors of Homo sapiens
    Chad D Huff
    Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 107:2147-52. 2010
    ....
  8. pmc Maximum-likelihood estimation of recent shared ancestry (ERSA)
    Chad D Huff
    Department of Human Genetics, University of Utah Health Sciences Center, Salt Lake City, Utah 84112, USA
    Genome Res 21:768-74. 2011
    ..ERSA greatly expands the range of relationships that can be estimated from genetic data and is implemented in a freely available software package...
  9. pmc Toward a more uniform sampling of human genetic diversity: a survey of worldwide populations by high-density genotyping
    Jinchuan Xing
    Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Genomics 96:199-210. 2010
    ..We also found a substantial affinity between populations from central Asia (Kyrgyzstani and Mongolian Buryat) and America, suggesting a central Asian contribution to New World founder populations...
  10. pmc Ancestry of the Iban is predominantly Southeast Asian: genetic evidence from autosomal, mitochondrial, and Y chromosomes
    Tatum S Simonson
    Department of Human Genetics, University of Utah, Salt Lake City, Utah, United States of America
    PLoS ONE 6:e16338. 2011
    ..We conclude that migrations from Southeast Asia made a large contribution to Iban ancestry, although evidence of potential gene flow from Taiwan is also seen in uniparentally inherited marker data...
  11. pmc Limited distribution of a cardiomyopathy-associated variant in India
    Tatum S Simonson
    Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA
    Ann Hum Genet 74:184-8. 2010
    ..Our results indicate that the MYBPC3 deletion is primarily found among Indian populations and that its distribution is consistent with genome-wide patterns of variation in India...
  12. ncbi request reprint Ancestral alleles and population origins: inferences depend on mutation rate
    Alan R Rogers
    Department of Anthropology, University of Utah, USA
    Mol Biol Evol 24:990-7. 2007
    ..This is true of one data set, but not of 2 others. This also suggests the action of some factor, such as selection or ascertainment bias, that varies among data sets...
  13. pmc Mobile elements create structural variation: analysis of a complete human genome
    Jinchuan Xing
    Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah 84109, USA
    Genome Res 19:1516-26. 2009
    ....
  14. pmc Using VAAST to identify an X-linked disorder resulting in lethality in male infants due to N-terminal acetyltransferase deficiency
    Alan F Rope
    Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, 84112, USA
    Am J Hum Genet 89:28-43. 2011
    ..Here we provide evidence of a human genetic disorder resulting from direct impairment of N-terminal acetylation, one of the most common protein modifications in humans...
  15. pmc Phevor combines multiple biomedical ontologies for accurate identification of disease-causing alleles in single individuals and small nuclear families
    Marc V Singleton
    Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Am J Hum Genet 94:599-610. 2014
    ..As we demonstrate, Phevor can also use latent information in ontologies to discover genes and disease-causing alleles not previously associated with disease. ..
  16. pmc Genomic diversity and evolution of the head crest in the rock pigeon
    Michael D Shapiro
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    Science 339:1063-7. 2013
    ..We also found evidence that this trait evolved just once and spread throughout the species, and that the crest originates early in development by the localized molecular reversal of feather bud polarity...