Crohn's disease and genetic hitchhiking at IBD5Chad D Huff
Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah, UT, USA
Mol Biol Evol 29:101-11. 2012
..Finally, our association results and expression data support IRF1 as a strong candidate for Crohn's disease causation...
- Detecting positive selection from genome scans of linkage disequilibrium
Chad D Huff
Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT, USA
BMC Genomics 11:8. 2010
..While most applications of these tests have suggested that positive selection has played an important role in recent human history, the results of these tests have varied dramatically...
- Genetic diversity in India and the inference of Eurasian population expansion
Jinchuan Xing
Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah, 15 North 2030 East, Salt Lake City, UT 84112, USA
Genome Biol 11:R113. 2010
..Despite recent large-scale efforts in discovering human genetic variation, India's vast reservoir of genetic diversity remains largely unexplored...
- Mobile elements reveal small population size in the ancient ancestors of Homo sapiens
Chad D Huff
Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
Proc Natl Acad Sci U S A 107:2147-52. 2010
....
Genetic evidence for high-altitude adaptation in TibetTatum S Simonson
Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
Science 329:72-5. 2010
..Identification of these genes provides support for previously hypothesized mechanisms of high-altitude adaptation and illuminates the complexity of hypoxia-response pathways in humans...
- Maximum-likelihood estimation of recent shared ancestry (ERSA)
Chad D Huff
Department of Human Genetics, University of Utah Health Sciences Center, Salt Lake City, Utah 84112, USA
Genome Res 21:768-74. 2011
..ERSA greatly expands the range of relationships that can be estimated from genetic data and is implemented in a freely available software package...
- Toward a more uniform sampling of human genetic diversity: a survey of worldwide populations by high-density genotyping
Jinchuan Xing
Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
Genomics 96:199-210. 2010
..We also found a substantial affinity between populations from central Asia (Kyrgyzstani and Mongolian Buryat) and America, suggesting a central Asian contribution to New World founder populations...
- Ancestry of the Iban is predominantly Southeast Asian: genetic evidence from autosomal, mitochondrial, and Y chromosomes
Tatum S Simonson
Department of Human Genetics, University of Utah, Salt Lake City, Utah, United States of America
PLoS ONE 6:e16338. 2011
..We conclude that migrations from Southeast Asia made a large contribution to Iban ancestry, although evidence of potential gene flow from Taiwan is also seen in uniparentally inherited marker data...
- Limited distribution of a cardiomyopathy-associated variant in India
Tatum S Simonson
Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA
Ann Hum Genet 74:184-8. 2010
..Our results indicate that the MYBPC3 deletion is primarily found among Indian populations and that its distribution is consistent with genome-wide patterns of variation in India...
Ancestral alleles and population origins: inferences depend on mutation rateAlan R Rogers
Department of Anthropology, University of Utah, USA
Mol Biol Evol 24:990-7. 2007
..This is true of one data set, but not of 2 others. This also suggests the action of some factor, such as selection or ascertainment bias, that varies among data sets...
- Mobile elements create structural variation: analysis of a complete human genome
Jinchuan Xing
Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah 84109, USA
Genome Res 19:1516-26. 2009
....
- Using VAAST to identify an X-linked disorder resulting in lethality in male infants due to N-terminal acetyltransferase deficiency
Alan F Rope
Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, 84112, USA
Am J Hum Genet 89:28-43. 2011
..Here we provide evidence of a human genetic disorder resulting from direct impairment of N-terminal acetylation, one of the most common protein modifications in humans...
- Genomic diversity and evolution of the head crest in the rock pigeon
Michael D Shapiro
Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
Science 339:1063-7. 2013
..We also found evidence that this trait evolved just once and spread throughout the species, and that the crest originates early in development by the localized molecular reversal of feather bud polarity...
