Sergio Huerta

Summary

Publications

  1. doi request reprint Smac mimetics as new cancer therapeutics
    Derrick J Chen
    Department of Surgery, University of Texas Southwestern at Dallas Dallas VA Medical Center, Dallas, Texas, USA
    Anticancer Drugs 20:646-58. 2009
  2. doi request reprint In vitro and in vivo radiosensitization of colorectal cancer HT-29 cells by the smac mimetic JP-1201
    Sergio Huerta
    Department of Surgery, University of Texas Southwestern Medical Center Dallas VA Medical Center, Dallas, TX 75216, USA
    Surgery 148:346-53. 2010
  3. doi request reprint Murine orthotopic model for the assessment of chemoradiotherapeutic interventions in rectal cancer
    Sergio Huerta
    Departments of Surgery and Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75126, USA
    Anticancer Drugs 22:371-6. 2011
  4. doi request reprint Feasibility of a supervised inpatient low-calorie diet program for massive weight loss prior to RYGB in superobese patients
    Sergio Huerta
    Department of Surgery, Dallas VA Medical Center, 4500 Lancaster Road, Dallas, TX 75216, USA
    Obes Surg 20:173-80. 2010
  5. doi request reprint Radiosensitization of HT-29 cells and xenografts by the nitric oxide donor DETANONOate
    Xiaohuan Gao
    Department of Surgery, Dallas VA Medical Center, University of Texas Southwestern, Dallas, Texas, USA
    J Surg Oncol 100:149-58. 2009
  6. doi request reprint In vitro and in vivo sensitization of SW620 metastatic colon cancer cells to CDDP-induced apoptosis by the nitric oxide donor DETANONOate: Involvement of AIF
    Sergio Huerta
    Department of Surgery, University of Texas Southwestern at Dallas, 4500 Lancaster Road, Dallas, TX 75216, USA
    Nitric Oxide 20:182-94. 2009
  7. doi request reprint Tissue microarray constructs to predict a response to chemoradiation in rectal cancer
    Sergio Huerta
    Department of Surgery, University of Texas Southwestern Medical Center, United States
    Dig Liver Dis 42:679-84. 2010
  8. doi request reprint Role of p53, Bax, p21, and DNA-PKcs in radiation sensitivity of HCT-116 cells and xenografts
    Sergio Huerta
    Department of Surgery, University of Texas Southwestern Medical Center and North Texas VA Health Care System, Dallas, Texas 75216, USA
    Surgery 154:143-51. 2013
  9. doi request reprint Evaluating an evidence-based bundle for preventing surgical site infection: a randomized trial
    Thomas Anthony
    Department of Surgical Services, Veterans Affairs North Texas Health Care System, 4500 S Lancaster Road, Dallas, TX 75216, USA
    Arch Surg 146:263-9. 2011
  10. ncbi request reprint Modification of gene products involved in resistance to apoptosis in metastatic colon cancer cells: roles of Fas, Apaf-1, NFkappaB, IAPs, Smac/DIABLO, and AIF
    Sergio Huerta
    Department of Gastrointestinal and Endocrine Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75216, USA
    J Surg Res 142:184-94. 2007

Collaborators

Detail Information

Publications30

  1. doi request reprint Smac mimetics as new cancer therapeutics
    Derrick J Chen
    Department of Surgery, University of Texas Southwestern at Dallas Dallas VA Medical Center, Dallas, Texas, USA
    Anticancer Drugs 20:646-58. 2009
    ..A variety of Smac mimetic types comprising peptides, polynucleotides, and compounds have been studied both in vitro and in vivo. This discussion addresses the current status of Smac mimetics in cancer research...
  2. doi request reprint In vitro and in vivo radiosensitization of colorectal cancer HT-29 cells by the smac mimetic JP-1201
    Sergio Huerta
    Department of Surgery, University of Texas Southwestern Medical Center Dallas VA Medical Center, Dallas, TX 75216, USA
    Surgery 148:346-53. 2010
    ..This study was undertaken to assess the radiosensitizing properties of the smac mimetic JP-1201 in radioresistant HT-29 colorectal cancer cells in vitro and established xenografts in SCID mice...
  3. doi request reprint Murine orthotopic model for the assessment of chemoradiotherapeutic interventions in rectal cancer
    Sergio Huerta
    Departments of Surgery and Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75126, USA
    Anticancer Drugs 22:371-6. 2011
    ..This model represents a modified technique that allows the assessment of chemoradiotherapeutic interventions in rectal cancer...
  4. doi request reprint Feasibility of a supervised inpatient low-calorie diet program for massive weight loss prior to RYGB in superobese patients
    Sergio Huerta
    Department of Surgery, Dallas VA Medical Center, 4500 Lancaster Road, Dallas, TX 75216, USA
    Obes Surg 20:173-80. 2010
    ..This study was undertaken to determine the feasibility of an inpatient low-calorie program for a substantial decrease of preoperative weight (>10 points in BMI) in superobese patients...
  5. doi request reprint Radiosensitization of HT-29 cells and xenografts by the nitric oxide donor DETANONOate
    Xiaohuan Gao
    Department of Surgery, Dallas VA Medical Center, University of Texas Southwestern, Dallas, Texas, USA
    J Surg Oncol 100:149-58. 2009
    ..Mechanisms of radioresistance in rectal cancer remain unclear...
  6. doi request reprint In vitro and in vivo sensitization of SW620 metastatic colon cancer cells to CDDP-induced apoptosis by the nitric oxide donor DETANONOate: Involvement of AIF
    Sergio Huerta
    Department of Surgery, University of Texas Southwestern at Dallas, 4500 Lancaster Road, Dallas, TX 75216, USA
    Nitric Oxide 20:182-94. 2009
    ..Altogether, these findings underscore the potential therapeutic application of NO donors and subtoxic chemotherapeutic drugs in the treatment of advanced colon cancer resistant to conventional chemotherapeutic agents...
  7. doi request reprint Tissue microarray constructs to predict a response to chemoradiation in rectal cancer
    Sergio Huerta
    Department of Surgery, University of Texas Southwestern Medical Center, United States
    Dig Liver Dis 42:679-84. 2010
    ..To identify, using tissue microarray (TMA), an immunohistochemical panel predictive of response to ionizing radiation (IR) in rectal cancer...
  8. doi request reprint Role of p53, Bax, p21, and DNA-PKcs in radiation sensitivity of HCT-116 cells and xenografts
    Sergio Huerta
    Department of Surgery, University of Texas Southwestern Medical Center and North Texas VA Health Care System, Dallas, Texas 75216, USA
    Surgery 154:143-51. 2013
    ..Molecular factors that dictate tumor response to ionizing radiation in rectal cancer are not well described...
  9. doi request reprint Evaluating an evidence-based bundle for preventing surgical site infection: a randomized trial
    Thomas Anthony
    Department of Surgical Services, Veterans Affairs North Texas Health Care System, 4500 S Lancaster Road, Dallas, TX 75216, USA
    Arch Surg 146:263-9. 2011
    ..To determine if an evidence-based practice bundle would result in a significantly lower rate of surgical site infections (SSIs) when compared with standard practice...
  10. ncbi request reprint Modification of gene products involved in resistance to apoptosis in metastatic colon cancer cells: roles of Fas, Apaf-1, NFkappaB, IAPs, Smac/DIABLO, and AIF
    Sergio Huerta
    Department of Gastrointestinal and Endocrine Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75216, USA
    J Surg Res 142:184-94. 2007
    ..In the present report, we investigated the apoptotic gene products that might account for colon cancer evasion of immune attack and chemoradioresistance-induced apoptosis...
  11. ncbi request reprint Rectal cancer and importance of chemoradiation in the treatment
    Sergio Huerta
    University of Texas Southwestern Medical Center, 4500 Lancaster Road, Dallas, Texas 75216, USA
    Adv Exp Med Biol 685:124-33. 2010
    ..This chapter describes colon cancer with emphasis on the molecular mechanisms that may lead to chemoradio-resistance of cells with cytotoxically induced DNA injury in rectal cancer...
  12. doi request reprint Preoperative weight loss decreases the operative time of gastric bypass at a Veterans Administration hospital
    Sergio Huerta
    Department of Surgery, Dallas VA Medical Center, 4500 Lancaster Road, Dallas, TX 75216, USA
    Obes Surg 18:508-12. 2008
    ..This study assessed whether preoperative weight loss resulted in favorable outcomes after open Roux-en Y gastric bypass (RYGB)...
  13. ncbi request reprint A strategy for reducing surgical backlogs: lessons from a veterans administration hospital
    Bryce W Murray
    Dallas VA Medical Center, Surgical Services 112, 4500 South Lancaster Road, Dallas, TX 75216, USA
    Am Surg 77:597-601. 2011
    ..6% vs. 20.9% for weekday IHs, P = 0.75). Elective cases can be accomplished more rapidly during nontraditional operating times if there are multiple support teams and rooms available...
  14. doi request reprint Mechanisms of resistance to ionizing radiation in rectal cancer
    Sergio Huerta
    Department of Surgery, University of Texas Southwestern Medical Center Dallas VA Medical Center, 4500 Lancaster Road, Dallas, TX 75216, USA
    Expert Rev Mol Diagn 9:469-80. 2009
    ..This article reviews the current evidence available to identify a molecular profile predictive of the best response to ionizing radiation...
  15. doi request reprint Reassessing the need for prophylactic surgery in patients with porcelain gallbladder: case series and systematic review of the literature
    Zarrish S Khan
    Department of Surgery, The University of Texas Southwestern Medical Center, Dallas, TX, USA
    Arch Surg 146:1143-7. 2011
    ..To evaluate the risk of gallbladder cancer (GBC) in patients with a porcelain gallbladder (PGB)...
  16. doi request reprint Outcomes of laparoscopic and open colectomy at academic centers
    J Esteban Varela
    Minimally Invasive Surgery, Surgical Service, Veterans Affairs North Texas Health Care System, Dallas, TX, USA
    Am J Surg 196:403-6. 2008
    ..Laparoscopic techniques have emerged as a suitable approach for colon resection. This study determined and compared the outcomes of patients undergoing laparoscopic or open colectomy at United States academic centers...
  17. ncbi request reprint Nitric oxide donors: novel cancer therapeutics (review)
    Sergio Huerta
    Department of Gastrointestinal and Endocrine Surgery, UT Southwestern Medical Center VA North Texas Health Care System, Dallas, TX 75216, USA
    Int J Oncol 33:909-27. 2008
    ..In the present report, we discuss classic nitric oxide donors and their potential therapeutic roles as cytotoxic agents or chemo-radio or -immune-sensitizing compounds in the treatment of drug-resistant cancers...
  18. ncbi request reprint New directions in the preoperative management of adenocarcinoma of the rectum
    Sergio Huerta
    Division of Surgery, University of Texas Southwestern Medical Center, Dallas VA Medical Center, 4500 S Lancaster Road, Dallas, TX 75225, USA
    Crit Rev Oncog 17:393-6. 2012
    ..The following discussion addresses possible strategies of investigation to increase patients achieving a complete obliteration of rectal tumors following neoadjuvant chemoradio therapies...
  19. ncbi request reprint Predictors of early mortality in veteran patients with pancreatic cancer
    Ali Siddiqui
    University of Texas Southwestern Medical Center Veterans Affairs North Texas Health Care System, 4500 Lancaster Rd, Dallas, TX 75216, USA
    Am J Surg 194:362-6. 2007
    ....
  20. doi request reprint Elevated HbA1c is an independent predictor of aggressive clinical behavior in patients with colorectal cancer: a case-control study
    Ali A Siddiqui
    Department of Internal Medicine, Dallas Veterans Affairs Medical Center, 4500 S Lancaster Road 111B1, Dallas, TX 75216, USA
    Dig Dis Sci 53:2486-94. 2008
    ..The aim of this study was to seek an association between the control of type 2 diabetes mellitus (T2DM), as determined by hemoglobin A1c (HbA1c) levels, and the outcome of colorectal cancer (CRC)...
  21. doi request reprint Oxaliplatin as a radiosensitizing agent in rectal cancer
    Sergio Huerta
    University of Texas Southwestern Medical Center, Dallas, Texas 75216, USA
    Anticancer Drugs 22:317-23. 2011
    ..This study reviews the results of these trials and the current status of oxaliplatin as a radiosensitizing agent in the neoadjuvant management of rectal cancer...
  22. ncbi request reprint Critical concepts in the oncogenesis of adenocarcionoma of the rectum
    Sergio Huerta
    Division of Surgery, University of Texas Southwestern Medical Center, Dallas VA Medical Center, 4500 S Lancaster Road, Dallas, TX 75225, USA
    Crit Rev Oncog 17:323-9. 2012
    ..The critical concepts in the oncogenesis of rectal cancer are areas of dynamic progression and require constant assessment...
  23. ncbi request reprint Assessment of comorbid conditions in veteran patients after Roux-en-Y gastric bypass
    Sergio Huerta
    University of Texas Southwestern Medical Center Veterans Administration North Texas Health Care System, 4500 Lancaster Rd, Dallas, TX 75216, United States
    Am J Surg 194:48-52. 2007
    ..The present study assessed the degree to which comorbid conditions improved after bariatric surgery in veteran patients...
  24. doi request reprint Recent advances in the molecular diagnosis and prognosis of colorectal cancer
    Sergio Huerta
    University of Texas Southwestern Medical Center, Dallas VA Medical Center, Surgical Services 112, Dallas, Texas 75216, USA
    Expert Rev Mol Diagn 8:277-88. 2008
    ..This report presents a summary of the current status of the molecular markers of colorectal cancer to establish a diagnosis, determine prognosis and chemoradiotherapeutic interventions, and assess relapse following curative surgery...
  25. ncbi request reprint Predictors of distant metastasis and mortality in patients with stage II colorectal cancer
    John H Heinzerling
    University of Texas Southwestern Medical Center Veteran s Affairs North Texas Health Care System, Dallas, Texas, USA
    Am Surg 73:230-8. 2007
    ..007; OR = 4.5) independently predicted distant metastasis, whereas preoperative carcinoembryonic antigen (P = 0.038; OR = 2.8) and patients undergoing an APR (P = 0.019; OR = 25) independently predicted mortality...
  26. pmc Coughing-induced bowel transection in a patient with an incarcerated inguinal hernia: a case report
    Hekmat Hakiman
    University of Texas Southwestern Medical Center Department of surgery, 5323 Harry Hines Blvd, Dallas, TX, 75390 9159, USA
    J Med Case Rep 7:47. 2013
    ..abstract:..
  27. pmc Current evidence-based opinions in the management of adenocarcionoma of the rectum
    Sergio Huerta
    Division of Surgery, University of Texas Southwestern Medical Center Dallas VA Medical Center, Dallas, USA
    Indian J Surg 71:356-62. 2009
    ..In the present report, we review the current evidence in the new strategies pertaining to the multimodality approach in the management of rectal cancer...
  28. pmc Indications and recommended approach for surgical intervention of metastatic disease to the gallbladder
    Zarrish S Khan
    Department of Surgery, UT Southwestern Medical Center, Harry Hines Blvd, Dallas, 75219, USA
    World J Surg Oncol 8:80. 2010
    ....
  29. doi request reprint Gastric bypass and On-Q pump: effectiveness of Soaker Catheter system on recovery of bariatric surgery patients
    Chandramouli P Iyer
    Anesthesiology and Pain Management Service, Dallas Veterans Affairs Medical Center, Dallas, TX 75216, USA
    Surg Obes Relat Dis 6:181-4. 2010
    ..We hypothesized that patients receiving ropivacaine would report lower levels of morphine requirement and pain, would have shorter hospital stays, and would return to ambulating faster than patients in the control group...
  30. ncbi request reprint Surgical site infections after colorectal surgery: do risk factors vary depending on the type of infection considered?
    Jennifer Blumetti
    Department of Surgery, University of Texas, Southwestern Medical Center, Dallas, TX, USA
    Surgery 142:704-11. 2007
    ..The purpose of this study was to compare risk factors for the development of incisional versus organ/space infections in patients undergoing colorectal surgery...