Thomas J Hudson

Summary

Publications

  1. pmc Correction of population stratification in large multi-ethnic association studies
    David Serre
    Genome Quebec Innovation Centre, McGill University, Montreal, Quebec, Canada
    PLoS ONE 3:e1382. 2008
  2. pmc Asthma and genes encoding components of the vitamin D pathway
    Yohan Bosse
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Canada
    Respir Res 10:98. 2009
  3. pmc The living microarray: a high-throughput platform for measuring transcription dynamics in single cells
    Saravanan Rajan
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    BMC Genomics 12:115. 2011
  4. doi request reprint Cancer genome variation in children, adolescents, and young adults
    Thomas J Hudson
    Ontario Institute for Cancer Research, Toronto, Ontario, Canada
    Cancer 117:2262-7. 2011
  5. doi request reprint Genome-wide analysis of transcript isoform variation in humans
    Tony Kwan
    Department of Human Genetics, McGill University, 740 Dr Penfield, Room 7210, Montreal, Quebec H3A 1A4, Canada
    Nat Genet 40:225-31. 2008
  6. doi request reprint Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scans
    Yohan Bosse
    Laval Hospital Research Center, Laval University, Pavillon Margeritte d Youville, Chemin Sainte Foy, Quebec, QC, Canada
    Hum Genet 125:305-18. 2009
  7. pmc Survey of allelic expression using EST mining
    Bing Ge
    McGill University and Genome Quebec Innovation Centre, Montreal, Quebec H3A 1A, Canada
    Genome Res 15:1584-91. 2005
  8. ncbi request reprint Identification of a chromosome 8p locus for early-onset coronary heart disease in a French Canadian population
    James C Engert
    McGill University Health Centre, Montreal, Quebec, Canada
    Eur J Hum Genet 16:105-14. 2008
  9. pmc Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol
    Guillaume Pare
    McGill University and Genome Quebec Innovation Centre, Montreal, Canada
    Am J Hum Genet 80:673-82. 2007
  10. ncbi request reprint Global analysis of chromosome X gene expression in primary cultures of normal ovarian surface epithelial cells and epithelial ovarian cancer cell lines
    Marie Hélène Benoît
    Department of Human Genetics, McGill University, Montreal, Quebec H3A 1A1, Canada
    Int J Oncol 30:5-17. 2007

Collaborators

Detail Information

Publications66

  1. pmc Correction of population stratification in large multi-ethnic association studies
    David Serre
    Genome Quebec Innovation Centre, McGill University, Montreal, Quebec, Canada
    PLoS ONE 3:e1382. 2008
    ..Unfortunately such a recruitment strategy is likely to complicate the study design and to generate concerns regarding population stratification...
  2. pmc Asthma and genes encoding components of the vitamin D pathway
    Yohan Bosse
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Canada
    Respir Res 10:98. 2009
    ..Genetic variants at the vitamin D receptor (VDR) locus are associated with asthma and atopy. We hypothesized that polymorphisms in other genes of the vitamin D pathway are associated with asthma or atopy...
  3. pmc The living microarray: a high-throughput platform for measuring transcription dynamics in single cells
    Saravanan Rajan
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    BMC Genomics 12:115. 2011
    ..However, endpoint measurements obtained from methods that pool populations of cells are not amenable to studying time-dependent processes that show cell heterogeneity...
  4. doi request reprint Cancer genome variation in children, adolescents, and young adults
    Thomas J Hudson
    Ontario Institute for Cancer Research, Toronto, Ontario, Canada
    Cancer 117:2262-7. 2011
    ..Issues that are more relevant to children, adolescents, and young adult patients with cancer are highlighted...
  5. doi request reprint Genome-wide analysis of transcript isoform variation in humans
    Tony Kwan
    Department of Human Genetics, McGill University, 740 Dr Penfield, Room 7210, Montreal, Quebec H3A 1A4, Canada
    Nat Genet 40:225-31. 2008
    ..This extra layer of molecular diversity may account for natural phenotypic variation and disease susceptibility...
  6. doi request reprint Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scans
    Yohan Bosse
    Laval Hospital Research Center, Laval University, Pavillon Margeritte d Youville, Chemin Sainte Foy, Quebec, QC, Canada
    Hum Genet 125:305-18. 2009
    ..The low cost associated with a pooling-based GWAS clearly justifies its use in screening for genetic determinants of complex diseases...
  7. pmc Survey of allelic expression using EST mining
    Bing Ge
    McGill University and Genome Quebec Innovation Centre, Montreal, Quebec H3A 1A, Canada
    Genome Res 15:1584-91. 2005
    ..We provide in silico as well as experimental evidence that this strategy does allow significant enrichment of genes harboring common heritable cis-acting polymorphisms in linkage disequilibrium with expressed alleles...
  8. ncbi request reprint Identification of a chromosome 8p locus for early-onset coronary heart disease in a French Canadian population
    James C Engert
    McGill University Health Centre, Montreal, Quebec, Canada
    Eur J Hum Genet 16:105-14. 2008
    ..In conclusion, a genome-wide scan and additional fine mapping provide evidence for a locus on chromosome 8 that contributes to CHD in a French Canadian population...
  9. pmc Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol
    Guillaume Pare
    McGill University and Genome Quebec Innovation Centre, Montreal, Canada
    Am J Hum Genet 80:673-82. 2007
    ..Using an independent validation sample of 806 individuals, we confirm the EDN1 association (P<.005), whereas the LCAT association was nonsignificant (P=.12)...
  10. ncbi request reprint Global analysis of chromosome X gene expression in primary cultures of normal ovarian surface epithelial cells and epithelial ovarian cancer cell lines
    Marie Hélène Benoît
    Department of Human Genetics, McGill University, Montreal, Quebec H3A 1A1, Canada
    Int J Oncol 30:5-17. 2007
    ..Despite an alteration in XIST expression and differences in allelic content in the EOC cell lines, the chromosome X transcriptome was modified modestly when compared with that of NOSE samples...
  11. pmc Differential allelic expression in the human genome: a robust approach to identify genetic and epigenetic cis-acting mechanisms regulating gene expression
    David Serre
    McGill University, Montreal, Quebec, Canada
    PLoS Genet 4:e1000006. 2008
    ....
  12. doi request reprint Fine mapping of the insulin-induced gene 2 identifies a variant associated with LDL cholesterol and total apolipoprotein B levels
    Ron Do
    Department of Human Genetics, McGill University, Montreal, Canada
    Circ Cardiovasc Genet 3:454-61. 2010
    ..Because INSIG2 plays an important role in cholesterol biosynthesis, we hypothesized that human INSIG2 variants might play a role in the regulation of plasma lipid and lipoprotein levels...
  13. pmc Genetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitis
    Alexandra Chloe Villani
    Department of Gastroenterology, McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada
    PLoS ONE 4:e7154. 2009
    ..The NLRP3 region was recently reported to be associated with Crohn's disease (CD) susceptibility. We therefore sought to evaluate MEFV as an inflammatory bowel disease (IBD) susceptibility gene...
  14. ncbi request reprint Mapping cis-acting regulatory variation in recombinant congenic strains
    Peter D Lee
    McGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada
    Physiol Genomics 25:294-302. 2006
    ..We propose the use of this integrated experimental approach in multiple tissues from this and other RCS panels as a means for genome-wide cataloging of genetic regulatory mechanisms in laboratory strains of mice...
  15. doi request reprint K45R variant of squalene synthase increases total cholesterol levels in two study samples from a French Canadian population
    Ron Do
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    Hum Mutat 29:689-94. 2008
    ..These results suggest that this coding variant in the squalene synthase gene influences plasma cholesterol levels, possibly by affecting the intracellular production of cholesterol...
  16. ncbi request reprint Mapping common regulatory variants to human haplotypes
    Tomi Pastinen
    McGill University and Genome Quebec Innovation Center, Montreal, Quebec, Canada
    Hum Mol Genet 14:3963-71. 2005
    ..Our survey suggests that detailed mapping of allele-specific in vivo expression will provide a rich source of regulatory SNPs or haplotypes that should be given high priority in association studies of human phenotypes...
  17. ncbi request reprint Association of urokinase-type plasminogen activator with asthma and atopy
    Philippe Bégin
    University of Montreal Community Genomic Medicine Centre, Chicoutimi University Hospital, Saguenay, Quebec, Canada
    Am J Respir Crit Care Med 175:1109-16. 2007
    ..This region has demonstrated evidence for linkage in a genome scan for asthma in a sample from northeastern Quebec. Here, we hypothesized that uPA may function as a regulator of asthma susceptibility...
  18. doi request reprint Genetic variants associated with myocardial infarction risk factors in over 8000 individuals from five ethnic groups: The INTERHEART Genetics Study
    Sonia S Anand
    Population Health Research Institute, Hamilton Health Sciences, Ontario, Canada
    Circ Cardiovasc Genet 2:16-25. 2009
    ..Myocardial infarction (MI) is a leading cause of death globally, but specific genetic variants that influence MI and MI risk factors have not been assessed on a global basis...
  19. ncbi request reprint From gene profiling to diagnostic markers: IL-18 and FGF-2 complement CA125 as serum-based markers in epithelial ovarian cancer
    Cécile Le Page
    Centre de Recherche du Center Hospitalier de l Université de Montréal CR CHUM, Institut du Cancer de Montreal, Montreal, Quebec, Canada
    Int J Cancer 118:1750-8. 2006
    ..Prospective studies with a large cohort of susceptible ovarian cancer patients will be required to expand these findings...
  20. doi request reprint Polymorphisms in the interleukin-22 receptor alpha-1 gene are associated with severe chronic rhinosinusitis
    Leandra Mfuna Endam
    Department of Otolaryngology, Hotel Dieu Hospital, Montreal University, Montreal, PQ, Canada
    Otolaryngol Head Neck Surg 140:741-7. 2009
    ..Stimulation of interleukin-22 receptor alpha-1 (IL22RA1) was reported to increase the innate immune responses in inflammatory diseases. Moreover, a reduced level of IL22RA1 was found in patients with recalcitrant CRS with nasal polyps...
  21. pmc Influence of leukotriene gene polymorphisms on chronic rhinosinusitis
    Hasan Al-Shemari
    Department of Otolaryngology Head and Neck Surgery, McGill University, Montreal, QC, Canada
    BMC Med Genet 9:21. 2008
    ..Advances in genomics offer powerful tools to explore this disorder. The goal of this study was to evaluate the effect of single nucleotide polymorphisms (SNP) on CRS in a panel of genes related to cysteinyl leukotriene metabolism...
  22. pmc Genes to diseases (G2D) computational method to identify asthma candidate genes
    Karine Tremblay
    Department of Medicine, Laval University, Quebec, Quebec, Canada
    PLoS ONE 3:e2907. 2008
    ..These results demonstrate that the G2D tool can be useful in the selection of candidate genes located in chromosomal regions linked to a complex trait...
  23. doi request reprint A cis-acting regulatory variant in the IL2RA locus
    Hui Qi Qu
    Endocrine Genetics Lab, The McGill University Health Center and Montreal Children s Hospital, Montreal, Quebec, Canada
    J Immunol 183:5158-62. 2009
    ....
  24. pmc An evaluation of the performance of tag SNPs derived from HapMap in a Caucasian population
    Alexandre Montpetit
    McGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada
    PLoS Genet 2:e27. 2006
    ..Overall, our study supports the use of HapMap data in other Caucasian populations, but the SNP density and the bias towards high-frequency SNPs have to be taken into account when designing association studies...
  25. ncbi request reprint Assessment of Toll-like receptor 2 gene polymorphisms in severe chronic rhinosinusitis
    Marc A Tewfik
    Department of Otolaryngology, Montreal General Hospital, McGill University, Montreal, Quebec
    J Otolaryngol Head Neck Surg 37:552-8. 2008
    ..aureus in this condition, we suspected that polymorphisms in TLR2 genes are implicated in this condition...
  26. doi request reprint Genetic variation in immune signaling genes differentially expressed in asthmatic lung tissues
    Karine Tremblay
    Hopital Laval, Universite Laval, Quebec, Canada
    J Allergy Clin Immunol 122:529-36.e17. 2008
    ..Eight genes in the immune signaling pathway shown to be differentially expressed in asthmatic lung biopsy specimens in a previous microarray experiment were selected as candidate genes for asthma susceptibility...
  27. ncbi request reprint Influence of human genome polymorphism on gene expression
    Tomi Pastinen
    Genome Quebec Innovation Centre, McGill University, Room 7105, 740 Dr Penfield Avenue, Montreal, Que, Canada H3A 1A4
    Hum Mol Genet 15:R9-16. 2006
    ..We also conclude that there is insufficient knowledge as to the feasibility of comprehensive studies of trans-acting variation in the human genome...
  28. ncbi request reprint Common polymorphisms in the promoter of the visfatin gene (PBEF1) influence plasma insulin levels in a French-Canadian population
    Swneke D Bailey
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada H3A 1A1
    Diabetes 55:2896-902. 2006
    ..002). These SNPs were also associated with fasting glucose (P <or= 0.02). In addition, a more distal SNP (rs7789066) was significantly associated with the apolipoprotein B component of VLDL (P = 0.012)...
  29. ncbi request reprint Germ-line DNA copy number variation frequencies in a large North American population
    George Zogopoulos
    Sam Minuk Cancer Genetics and Biomarker Laboratories, Fred Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Toronto, Canada
    Hum Genet 122:345-53. 2007
    ..This North American population-based map will be a useful resource for future genetic studies...
  30. pmc Patterns of variation in DNA segments upstream of transcription start sites
    Damian Labuda
    Centre de Recherche, Hopital Sainte Justine, Montreal, Quebec, Canada
    Hum Mutat 28:441-50. 2007
    ....
  31. doi request reprint Cancer genomics: technology, discovery, and translation
    Ben Tran
    FRCPC, Princess Margaret Hospital, Drug Development Program, 610 University Ave, Ste 5 718, Toronto, Ontario, M5G 2M9, Canada
    J Clin Oncol 30:647-60. 2012
    ....
  32. ncbi request reprint Toward further mapping of the association between the IL2RA locus and type 1 diabetes
    Hui Qi Qu
    Endocrine Genetics Laboratory, McGill University Health Center Montreal Children s Hospital, Montreal, Quebec, Canada
    Diabetes 56:1174-6. 2007
    ....
  33. pmc MLH1 region polymorphisms show a significant association with CpG island shore methylation in a large cohort of healthy individuals
    Andrea J Savio
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 7:e51531. 2012
    ..These results indicate that CpG island shore methylation in PBCs may be influenced by genotype as well as the normal aging process...
  34. doi request reprint Clinical genomics information management software linking cancer genome sequence and clinical decisions
    Stuart Watt
    Ontario Institute for Cancer Research, Toronto, Ontario, Canada
    Genomics 102:140-7. 2013
    ....
  35. pmc Germline EPHB2 receptor variants in familial colorectal cancer
    George Zogopoulos
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    PLoS ONE 3:e2885. 2008
    ..Rare germline EPHB2 variants may contribute to a small fraction of hereditary colorectal cancer...
  36. ncbi request reprint Functional organization of a Schwann cell enhancer
    Eric Denarier
    Laboratory of Developmental Biology, Molecular Oncology Group H 5, McGill University Health Centre, Montreal, Quebec, H3A 1A1, Canada
    J Neurosci 25:11210-7. 2005
    ..Finally, this investigation demonstrates that in vivo functional analysis, supported by controlled transgenesis, can be a robust complement to molecular and bioinformatics approaches to regulatory mechanisms...
  37. doi request reprint Modulation of the allergic asthma transcriptome following resiquimod treatment
    Pierre Camateros
    Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec
    Physiol Genomics 38:303-18. 2009
    ..The recruitment of NK cells to the lungs may also have application in the treatment of virally induced asthma exacerbations...
  38. pmc Heritability of alternative splicing in the human genome
    Tony Kwan
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    Genome Res 17:1210-8. 2007
    ..This report illustrates that our approach can detect both annotated and novel alternatively spliced variants, and that such variation among individuals is heritable and genetically controlled...
  39. ncbi request reprint Polymorphisms in the tumour necrosis factor alpha-induced protein 3 (TNFAIP3) gene are associated with chronic rhinosinusitis
    Chantale Cormier
    Department of Otolaryngology, Hotel Dieu de Montreal, Montreal, QC, Canada
    J Otolaryngol Head Neck Surg 38:133-41. 2009
    ..Our objective was to determine whether polymorphisms in genes in the TNF superfamily (TNF, TNF-alpha-induced protein 3, TNF-alpha-induced protein 6) were associated with chronic rhinosinusitis...
  40. ncbi request reprint Increased plasticity of genomic imprinting of Dlk1 in brain is due to genetic and epigenetic factors
    Sylvie Croteau
    Department of Obstetrics and Gynecology, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada
    Mamm Genome 16:127-35. 2005
    ..Thus, the imprinting status of Dlk1 in the brain depends upon trans-acting genetic influences and correlates with the methylation status of a specific subregion of the IG DMR...
  41. ncbi request reprint Cis-acting regulatory variation in the human genome
    Tomi Pastinen
    McGill University and Genome Quebec Innovation Centre, 740 Drive Penfield Avenue, Montreal, Quebec H3A 1A4, Canada
    Science 306:647-50. 2004
    ..We discuss the current state of knowledge and technologies used for mapping and characterizing genetic variation controlling human gene expression...
  42. pmc Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects
    Zari Dastani
    Cardiovascular Genetics Laboratory, McGill University Health Centre, Royal Victoria Hospital, Montreal, Quebec, Canada
    Eur J Hum Genet 18:342-7. 2010
    ..Our data constitute additional evidence for a locus on chromosome 16q23-24 that affects HDL-C levels in two independent French-Canadian studies...
  43. doi request reprint Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation
    Saravanan Rajan
    Department of Human Genetics, McGill University, Canada
    Physiol Genomics 44:183-97. 2012
    ....
  44. ncbi request reprint Elucidating cis- and trans-regulatory variation using genetical genomics
    Robert Sladek
    McGill University and Genome Quebec Innovation Centre, 740 Ave Dr Penfield, Montreal, Quebec, Canada, H3A 1A4
    Trends Genet 22:245-50. 2006
    ..Two recent studies using approaches capitalizing on intercrossed mouse strains and novel computational methods have yielded examples of trans-regulatory networks...
  45. pmc Transmission-ratio distortion and allele sharing in affected sib pairs: a new linkage statistic with reduced bias, with application to chromosome 6q25.3
    Mathieu Lemire
    McGill University and Genome Quebec Innovation Centre, and Departments of Human Genetics and Medicine, McGill University, Montreal, Quebec, Canada
    Am J Hum Genet 75:571-86. 2004
    ..The method is applied to a sample of pedigrees ascertained for asthma in a chromosomal region in which TRD has been reported. Results are consistent with the presence of transmission distortion in that region...
  46. ncbi request reprint Microarray analysis of brain RNA in mice with methylenetetrahydrofolate reductase deficiency and hyperhomocysteinemia
    Zhoutao Chen
    Department of Biology, McGill University, Montreal, Canada
    Brain Res Gene Expr Patterns 1:89-93. 2002
    ..We propose that neuronal damage by hyperhomocysteinemia may involve disruption of intracellular calcium...
  47. pmc Specific variants in the MLH1 gene region may drive DNA methylation, loss of protein expression, and MSI-H colorectal cancer
    Miralem Mrkonjic
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 5:e13314. 2010
    ..We hypothesized that specific polymorphisms in the MLH1 gene region predispose it to DNA methylation, resulting in the loss of MLH1 gene expression, mismatch-repair function, and consequently to genome-wide microsatellite instability...
  48. pmc Reduced proportions of natural killer T cells are present in the relatives of lupus patients and are associated with autoimmunity
    Joan Wither
    Arthritis Centre of Excellence, Division of Genetics and Development, Toronto Western Hospital Research Institute, University Health Network, Toronto, Ontario, Canada
    Arthritis Res Ther 10:R108. 2008
    ..Here, we used flow cytometry to investigate whether some of the immune abnormalities that are seen in the peripheral blood lymphocyte population of lupus patients are seen in their first-degree relatives...
  49. ncbi request reprint Gene expression microarray analysis and genome databases facilitate the characterization of a chromosome 22 derived homogeneously staining region
    Suzanna L Arcand
    Department of Human Genetics, McGill University, Montreal, Canada
    Mol Carcinog 41:17-38. 2004
    ....
  50. pmc Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray
    Yi an Chen
    Genetics and Genome Biology Program, Hospital for Sick Children, Toronto, ON, Canada
    Epigenetics 8:203-9. 2013
    ..Therefore, investigators should exercise caution when significant biological associations are found using these array platforms. A list of all cross-reactive probes and polymorphic CpGs identified by us are annotated in this paper...
  51. ncbi request reprint Discrimination between serous low malignant potential and invasive epithelial ovarian tumors using molecular profiling
    Veronique Ouellet
    Centre de Recherche du Centre Hospitalier de l Université de Montréal Institut du cancer de Montréal, Montreal, Canada
    Oncogene 24:4672-87. 2005
    ..These results define signature patterns for gene expression of LMPs and TOVs and identify gene candidates that warrant further study to deepen our understanding of the biology of EOC...
  52. doi request reprint Integrated genomic, transcriptomic, and RNA-interference analysis of genes in somatic copy number gains in pancreatic ductal adenocarcinoma
    Nardin Samuel
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Pancreas 42:1016-26. 2013
    ..This study used an integrated analysis of copy number, gene expression, and RNA interference screens for identification of putative driver genes harbored in somatic copy number gains in pancreatic ductal adenocarcinoma (PDAC)...
  53. ncbi request reprint Anatomy of a founder effect: myotonic dystrophy in Northeastern Quebec
    Vania Yotova
    Centre de Recherche, Hopital Sainte Justine, 3175 Cote Sainte Catherine, Montreal, PQ, Canada, H3T 1C5
    Hum Genet 117:177-87. 2005
    ....
  54. ncbi request reprint Toward a comprehensive set of asthma susceptibility genes
    Yohan Bosse
    McGill University, Génome Québec Innovation Center, Montreal, Quebec, Canada
    Annu Rev Med 58:171-84. 2007
    ..Notwithstanding the difficulties in making sense of the vast amount of new genetic data, we already see the emergence of new biological pathways of atopy, airway remodeling, and asthma that may lead to novel therapeutic approaches...
  55. ncbi request reprint Association of vitamin D receptor genetic variants with susceptibility to asthma and atopy
    Audrey H Poon
    McGill Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    Am J Respir Crit Care Med 170:967-73. 2004
    ..These results identify VDR variants as genetic risk factors for asthma/atopy and implicate a non-human leukocyte antigen immunoregulatory molecule in the pathogenesis of asthma and atopy...
  56. ncbi request reprint Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24
    Brent W Zanke
    Cancer Care Ontario, 620 University Avenue, Toronto, Ontario M5G 1L7, Canada
    Nat Genet 39:989-94. 2007
    ..i.): 1.07-1.26; P = 5.05 x 10(-4)). A summary across all seven studies at the 8q24 locus was highly significant (OR = 1.17, c.i.: 1.12-1.23; P = 3.16 x 10(-11)). This locus has also been implicated in prostate cancer...
  57. ncbi request reprint G-protein-coupled receptors and asthma endophenotypes: the cysteinyl leukotriene system in perspective
    Miles D Thompson
    Department of Laboratory Medicine and Pathobiology, University of Toronto, and Department of Medical Genetics and Microbiology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Mol Diagn Ther 10:353-66. 2006
    ..The genetic variant(s) of receptors that are associated with endophenotypes are discussed in the context of the extent to which they contribute to a disease phenotype or altered drug efficacy...
  58. ncbi request reprint 1alpha,25-dihydroxy-vitamin D3 stimulation of bronchial smooth muscle cells induces autocrine, contractility, and remodeling processes
    Yohan Bosse
    McGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada
    Physiol Genomics 29:161-8. 2007
    ..The most significant network of upregulated genes included genes involved in morphogenesis, cell growth, and survival as well as genes encoding structural proteins, which are potentially involved in airway remodeling...
  59. pmc Common variants in the NLRP3 region contribute to Crohn's disease susceptibility
    Alexandra Chloe Villani
    Division of Gastroenterology, McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada
    Nat Genet 41:71-6. 2009
    ..Mutations in NLRP3 are known to be responsible for three rare autoinflammatory disorders. These results suggest that the NLRP3 region is also implicated in the susceptibility of more common inflammatory diseases such as Crohn's disease...
  60. ncbi request reprint Susceptibility to leprosy is associated with PARK2 and PACRG
    Marcelo T Mira
    McGill Centre for the Study of Host Resistance and Department of Human Genetics, McGill University, 1650 Cedar Avenue, Montreal, PQ H3G1A4, Canada
    Nature 427:636-40. 2004
    ..Variants in the regulatory region shared by PARK2 and PACRG therefore act as common risk factors for leprosy...
  61. pmc Gene expression in HL60 granulocytoids and human polymorphonuclear leukocytes exposed to Candida albicans
    Alaka Mullick
    Biotechnology Research Institute, Montreal, Quebec H4P 2R2, Canada
    Infect Immun 72:414-29. 2004
    ..albicans. Similar changes were seen in these primary human cells, lending support to the validity of this model...
  62. pmc Large-scale recombination rate patterns are conserved among human populations
    David Serre
    McGill University and Genome Quebec Innovation Center, Montreal, Quebec H3A 1A4, Canada
    Genome Res 15:1547-52. 2005
    ..Local deviations from the overall pattern of conservation of the recombination rates can be used to select candidate regions with large polymorphic inversions or under local selection...
  63. pmc Disruption of AP1S1, causing a novel neurocutaneous syndrome, perturbs development of the skin and spinal cord
    Alexandre Montpetit
    McGill University, Montreal, Quebec, Canada
    PLoS Genet 4:e1000296. 2008
    ..Together, these results confirm AP1S1 as the gene responsible for MEDNIK syndrome and demonstrate a critical role of AP1S1 in development of the skin and spinal cord...
  64. doi request reprint Feasibility of real time next generation sequencing of cancer genes linked to drug response: results from a clinical trial
    Ben Tran
    Department of Medical Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Int J Cancer 132:1547-55. 2013
    ..Additionally, actionable mutations identified in this study were relatively stable between archival and biopsy samples, implying that cancer mutations that are good predictors of drug response may remain constant across clinical stages...
  65. doi request reprint Translating genomics to the clinic: implications of cancer heterogeneity
    Nardin Samuel
    Ontario Institute for Cancer Research, Toronto, Ontario, Canada
    Clin Chem 59:127-37. 2013
    ..Interpreting these data in the context of tumor complexity poses a challenge for cancer genomics...