He Feng Huang

Summary

Publications

  1. ncbi request reprint Matrix metalloproteinase 2 is associated with changes in steroid hormones in the sera and peritoneal fluid of patients with endometriosis
    He Feng Huang
    Department of Reproductive Endocrinology, Women s Hospital, Zhejiang University School of Medicine, Zhejiang, China
    Fertil Steril 81:1235-9. 2004
  2. doi request reprint Functional expression of large-conductance calcium-activated potassium channels in human endometrium: a novel mechanism involved in endometrial receptivity and embryo implantation
    Run Ju Zhang
    Department of Reproductive Endocrinology, Key Laboratory of Reproductive Genetics, Ministry of Education, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, China
    J Clin Endocrinol Metab 97:543-53. 2012
  3. pmc Transgenerational glucose intolerance with Igf2/H19 epigenetic alterations in mouse islet induced by intrauterine hyperglycemia
    Guo Lian Ding
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    Diabetes 61:1133-42. 2012
  4. ncbi request reprint Endometrial carcinoma tumorigenesis and pharmacotherapy research
    J Shu
    School of Medicine, Zhejiang University, Hangzhou, China
    Minerva Endocrinol 37:117-32. 2012
  5. pmc Down-regulation of S100A11, a calcium-binding protein, in human endometrium may cause reproductive failure
    Xin Mei Liu
    Department of Reproductive Endocrinology, Zhejiang Women s Hospital, and Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou 310006, China
    J Clin Endocrinol Metab 97:3672-83. 2012
  6. pmc Methylation levels at IGF2 and GNAS DMRs in infants born to preeclamptic pregnancies
    Jing He
    Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310006, China
    BMC Genomics 14:472. 2013
  7. pmc Ignored adult primary hypothyroidism presenting chiefly with persistent ovarian cysts: a need for increased awareness
    Jing Shu
    Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China
    Reprod Biol Endocrinol 9:119. 2011
  8. ncbi request reprint [Research progress of the diseases associated infertility and assisted reproductive technology]
    He Feng Huang
    The Affiliated Obstetrics and Gynecology Hospital, College of Medicine, Zhejiang University, Hangzhou, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 36:417-23. 2007
  9. ncbi request reprint Function of aquaporins in female and male reproductive systems
    He Feng Huang
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
    Hum Reprod Update 12:785-95. 2006
  10. ncbi request reprint Nitric oxide mediates inhibitory effect of leptin on insulin-like growth factor I augmentation of 17beta-estradiol production in human granulosa cells
    He Feng Huang
    Department of Reproductive Endocrinology, Women s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China
    Biol Reprod 72:102-6. 2005

Collaborators

Detail Information

Publications90

  1. ncbi request reprint Matrix metalloproteinase 2 is associated with changes in steroid hormones in the sera and peritoneal fluid of patients with endometriosis
    He Feng Huang
    Department of Reproductive Endocrinology, Women s Hospital, Zhejiang University School of Medicine, Zhejiang, China
    Fertil Steril 81:1235-9. 2004
    ....
  2. doi request reprint Functional expression of large-conductance calcium-activated potassium channels in human endometrium: a novel mechanism involved in endometrial receptivity and embryo implantation
    Run Ju Zhang
    Department of Reproductive Endocrinology, Key Laboratory of Reproductive Genetics, Ministry of Education, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, China
    J Clin Endocrinol Metab 97:543-53. 2012
    ..Large-conductance calcium-activated potassium channels (BK(Ca) channels) mediate physiological processes in nonexcitable cells...
  3. pmc Transgenerational glucose intolerance with Igf2/H19 epigenetic alterations in mouse islet induced by intrauterine hyperglycemia
    Guo Lian Ding
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    Diabetes 61:1133-42. 2012
    ..Furthermore, altered Igf2 and H19 gene expression was found in sperm of adult F1-GDM, regardless of the presence of IGT, indicating that changes of epigenetics in germ cells contributed to transgenerational transmission...
  4. ncbi request reprint Endometrial carcinoma tumorigenesis and pharmacotherapy research
    J Shu
    School of Medicine, Zhejiang University, Hangzhou, China
    Minerva Endocrinol 37:117-32. 2012
    ..This article reviews the current understanding of its risk factors, recent conceptions on its tumorigenesis and advances on its drug therapies...
  5. pmc Down-regulation of S100A11, a calcium-binding protein, in human endometrium may cause reproductive failure
    Xin Mei Liu
    Department of Reproductive Endocrinology, Zhejiang Women s Hospital, and Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou 310006, China
    J Clin Endocrinol Metab 97:3672-83. 2012
    ....
  6. pmc Methylation levels at IGF2 and GNAS DMRs in infants born to preeclamptic pregnancies
    Jing He
    Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310006, China
    BMC Genomics 14:472. 2013
    ....
  7. pmc Ignored adult primary hypothyroidism presenting chiefly with persistent ovarian cysts: a need for increased awareness
    Jing Shu
    Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China
    Reprod Biol Endocrinol 9:119. 2011
    ..In addition, the exons of the gene encoding the human follicle-stimulating hormone receptor were sequenced...
  8. ncbi request reprint [Research progress of the diseases associated infertility and assisted reproductive technology]
    He Feng Huang
    The Affiliated Obstetrics and Gynecology Hospital, College of Medicine, Zhejiang University, Hangzhou, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 36:417-23. 2007
  9. ncbi request reprint Function of aquaporins in female and male reproductive systems
    He Feng Huang
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
    Hum Reprod Update 12:785-95. 2006
    ..This article extensively reviews the distribution of AQPs in mammalian reproductive tissues and discusses their possible physiological and pathophysiological roles...
  10. ncbi request reprint Nitric oxide mediates inhibitory effect of leptin on insulin-like growth factor I augmentation of 17beta-estradiol production in human granulosa cells
    He Feng Huang
    Department of Reproductive Endocrinology, Women s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China
    Biol Reprod 72:102-6. 2005
    ..The inhibitory effect of leptin on IGF-I augmentation of E2 production in human GCs was attenuated by L-NAME, strongly suggesting that NO may mediate the action of leptin in human GCs...
  11. doi request reprint In vitro fertilization alters growth and expression of Igf2/H19 and their epigenetic mechanisms in the liver and skeletal muscle of newborn and elder mice
    Fang Le
    Center of Reproductive Medicine, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    Biol Reprod 88:75. 2013
    ....
  12. pmc Involvement of cyclin B1 in progesterone-mediated cell growth inhibition, G2/M cell cycle arrest, and apoptosis in human endometrial cell
    Li Tang
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    Reprod Biol Endocrinol 7:144. 2009
    ..Large-dose treatment with progesterone has been used for treatment of endometrial proliferative disorders. However, the mechanisms behind remain unknown...
  13. ncbi request reprint Poor ovarian response to gonadotropin stimulation is associated with low expression of follicle-stimulating hormone receptor in granulosa cells
    Jie Cai
    Department of Reproductive Endocrinology, Women s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
    Fertil Steril 87:1350-6. 2007
    ..To explore the importance of follicle-stimulating hormone receptor (FSHR) in granulosa cells in the ovarian response to gonadotropin stimulation...
  14. ncbi request reprint [Research on the protocol of limited ovarian stimulation to prevent ovarian hyperstimulation syndrome]
    Yi Min Zhu
    The Reproductive Medical Center, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
    Zhonghua Fu Chan Ke Za Zhi 41:740-4. 2006
    ..To investigate whether the limited ovarian stimulation (LOS) could avoid the severe ovarian hyperstimulation syndrome (OHSS) in patients with high risk of OHSS...
  15. ncbi request reprint High bone morphogenetic protein-15 level in follicular fluid is associated with high quality oocyte and subsequent embryonic development
    Yan Ting Wu
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People s Republic of China
    Hum Reprod 22:1526-31. 2007
    ..The aim of this study is to investigate BMP-15 level in human follicular fluid (FF) and its possible role in determining oocyte quality and developmental potential...
  16. ncbi request reprint Aquaporin-2 expression in human endometrium correlates with serum ovarian steroid hormones
    Rong Huan He
    Department of Reproductive Endocrinology, Women s Hospital, Zhejiang University School of Medicine, Zhejiang 310006, China
    Life Sci 79:423-9. 2006
    ..The high level of endometrial AQP2 expression was observed at the mid-secretory phase, the time of embryo implantation, suggesting that AQP2 might play physiological roles in the uterine receptivity...
  17. pmc Bone morphogenetic protein-15 in follicle fluid combined with age may differentiate between successful and unsuccessful poor ovarian responders
    Yan Ting Wu
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    Reprod Biol Endocrinol 10:116. 2012
    ....
  18. ncbi request reprint [Ovarian response to gonadotropin stimulation depends on the level of follicle stimulating hormone receptor on granulosa cells]
    Jie Cai
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
    Zhonghua Fu Chan Ke Za Zhi 41:372-4. 2006
    ..To investigate the role of follicle stimulating hormone receptor (FSHR) expression on granulosa cells in ovarian response of women undergoing gonadotropin stimulation...
  19. doi request reprint Aquaporin-1 plays a crucial role in estrogen-induced tubulogenesis of vascular endothelial cells
    Li Bo Zou
    The Key Laboratory of Reproductive Genetics, Zhejiang University, Hangzhou 310058, China
    J Clin Endocrinol Metab 98:E672-82. 2013
    ..Elucidation of the molecular mechanisms governing AQP1-mediated, estrogen-induced angiogenesis may contribute to an improved understanding of tumor development...
  20. doi request reprint Identification of a mutation in GDF9 as a novel cause of diminished ovarian reserve in young women
    Ting Ting Wang
    Key Laboratory of Reproductive Genetics, Zhejiang University, Ministry of Education, Hangzhou, China
    Hum Reprod 28:2473-81. 2013
    ..Do any mutations in growth differentiation factor 9 (GDF9) have a role in diminished ovarian reserve (DOR) in young women?..
  21. ncbi request reprint Ovarian stimulation with GnRH agonist, but not GnRH antagonist, partially restores the expression of endometrial integrin beta3 and leukaemia-inhibitory factor and improves uterine receptivity in mice
    Heng Chao Ruan
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
    Hum Reprod 21:2521-9. 2006
    ..In this study, the effects of different OS on the expression of endometrial integrin beta3 subunit and leukaemia-inhibitory factor (LIF) during the implantation window and the implantation rate in mice were investigated...
  22. doi request reprint Expression of aquaporins in human embryos and potential role of AQP3 and AQP7 in preimplantation mouse embryo development
    Yun Xiong
    Key Laboratory of Reproductive Genetics, Zhejiang University, Ministry of Education, Hangzhou, China
    Cell Physiol Biochem 31:649-58. 2013
    ..Water channels, also named aquaporins (AQPs), play crucial roles in cellular water homeostasis...
  23. ncbi request reprint [In vitro maturation--n vitro fertilization--embryo transfer--frozen-thawed of human oocytes]
    Yi Min Zhu
    The Affiliated Obstetrics and Gynecology Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 36:443-8. 2007
    ....
  24. pmc Insufficient maintenance DNA methylation is associated with abnormal embryonic development
    Li jun Yin
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, Zhejiang 310006, China
    BMC Med 10:26. 2012
    ..Abnormal function of these DNMTs may have serious consequences for embryonic development...
  25. doi request reprint Endoplasmic reticulum stress induced by oxidative stress in decidual cells: a possible mechanism of early pregnancy loss
    Hui Juan Gao
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou 310006, Zhejiang, China
    Mol Biol Rep 39:9179-86. 2012
    ....
  26. doi request reprint G546A polymorphism of growth differentiation factor-9 contributes to the poor outcome of ovarian stimulation in women with diminished ovarian reserve
    Ting Ting Wang
    Department of Reproductive Endocrinology, Zhejiang Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, People s Republic of China
    Fertil Steril 94:2490-2. 2010
    ..G169A, c.C447T and c.G546A, were detected. We found GDF-9 c.G546A, but not c.G169A or c.C447T, to be correlated with the poor ovarian stimulation and in vitro fertilization outcomes in women with DOR...
  27. ncbi request reprint 50-Hertz electromagnetic fields induce gammaH2AX foci formation in mouse preimplantation embryos in vitro
    Qiong Luo
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, China
    Biol Reprod 75:673-80. 2006
    ..The DNA damage induced by EMFs could be at least partly repaired by the natural activation of DNA damage-repair mechanism or prevented by the simultaneous treatment of noise magnetic fields...
  28. pmc Persistence and intergenerational transmission of differentially expressed genes in the testes of intracytoplasmic sperm injection conceived mice
    Li ya Wang
    Key Laboratory of Reproductive Genetics Zhejiang, Ministry of Education, and Centre of Reproductive Medicine, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
    J Zhejiang Univ Sci B 14:372-81. 2013
    ..The data demonstrated that superovulation, in vitro culture, and mechanical stimulation involved in ICSI had a cumulative effect on the differential expression of these male reproductive genes...
  29. doi request reprint Small-conductance calcium-activated K(+) channels 3 (SK3) regulate blastocyst hatching by control of intracellular calcium concentration
    Yong Chao Lu
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, China
    Hum Reprod 27:1421-30. 2012
    ..The present study was designed to investigate the expression of small-conductance calcium-activated K(+) channels 3 (SK3) in preimplantation embryos and to explore their role in the underlying mechanism of blastocyst hatching...
  30. pmc Resistin levels of serum and follicular fluid in non-obese patients with polycystic ovary syndrome during IVF cycles
    Xiu E Lu
    Women s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
    J Zhejiang Univ Sci B 6:897-902. 2005
    ....
  31. doi request reprint Attenuated oocyte fertilization and embryo development associated with altered growth factor/signal transduction induced by endometriotic peritoneal fluid
    Guo Lian Ding
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People s Republic of China
    Fertil Steril 93:2538-44. 2010
    ....
  32. doi request reprint Downregulative effects of nitric oxide on oocyte fertilization and embryo development: possible roles of nitric oxide in the pathogenesis of endometriosis-associated infertility
    Qiong Luo
    Department of Reproductive Endocrinology, Women s Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China
    Cell Physiol Biochem 26:1023-8. 2010
    ..To investigate the effects of elevated nitric oxide (NO) levels in peritoneal fluids (PF) on oocyte fertilization and pre-implantation embryo development, and the relation of those effects to endometriosis-associated infertility...
  33. ncbi request reprint Association of serum and follicular fluid leptin concentrations with granulosa cell phosphorylated signal transducer and activator of transcription 3 expression in fertile patients with polycystic ovarian syndrome
    Mei Gen Li
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, 2 Xue Shi Road, Hangzhou, Zhejiang, 31006, China
    J Clin Endocrinol Metab 92:4771-6. 2007
    ....
  34. doi request reprint High expression of L-selectin ligand in secretory endometrium is associated with better endometrial receptivity and facilitates embryo implantation in human being
    Bo Wang
    Department of Reproductive Endocrinology, Women s Hospital, Zhejiang University School of Medicine, 2 Xue Shi Road, Hangzhou, Zhejiang, China
    Am J Reprod Immunol 60:127-34. 2008
    ..Therefore, we investigated the impact of L-selectin ligand on establishing pregnancy in women undergoing in vitro fertilization and embryo transfer (IVF-ET)...
  35. doi request reprint Decreased expression of endometrial vessel AQP1 and endometrial epithelium AQP2 related to anovulatory uterine bleeding in premenopausal women
    Chun Feng
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
    Menopause 15:648-54. 2008
    ..The aim of the present study was to investigate the characteristics of endometrial AQPs in women with anovulatory uterine bleeding and explore the relationship between endometrial AQPs and ovarian steroids...
  36. doi request reprint Altered aquaporin expression in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin-9 in granulosa cells through the phosphatidylinositol 3-kinase pathway
    Fan Qu
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, 2 Xueshi Road, Hangzhou, Zhejiang Province 310006, China
    Hum Reprod 25:1441-50. 2010
    ....
  37. ncbi request reprint [Expression of aquaporin 9 in granulosa cells of patients with polycystic ovary syndrome in IVF-cycles]
    Xiu E Lu
    The Affiliated Obstetrics and Gynecology Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 36:449-53. 2007
    ..To investigate aquaporin 9 (AQP9) mRNA and protein expression in antrum follicle and luteinizing granulosa cells of polycystic ovarian syndrome (PCOS) ovary, and its relation to follicular fluid steroids hormone levels during IVF cycles...
  38. ncbi request reprint [Women with poor response to ovarian stimulation have increased follicular bone morphogenetic protein-15 levels]
    Yan Ting Wu
    The Affiliated Obstetrics and Gynecology Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 36:439-42. 2007
    ..To evaluate the levels of bone morphogenetic protein-15 (BMP-15) in human follicular fluid (FF) and its association with response to ovarian stimulation...
  39. ncbi request reprint [Expression of cyclin B1 and cyclin-dependent kanasel in ectopic and eutopic endometrium tissues of patients with endometriosis]
    Li Tang
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, Zhejiang 310006, China
    Zhonghua Yi Xue Za Zhi 87:179-83. 2007
    ..To investigate the possible roles of cyclin B1 and cyclin-dependent kanase1 cyclin-dependent kanase1 play in the pathogenesis and development of endometriosis and their association with the ovarian hormones...
  40. ncbi request reprint [Dynamic assay of serum inhibin B and estradiol concentrations obtained after gonadotrophin therapy as predictors of ovarian response in vitro fertilization cycle]
    Min fang Miao
    Department of Gynecology Women s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
    Zhonghua Fu Chan Ke Za Zhi 41:114-7. 2006
    ..To study prospectively the values of basal and dynamic measurement of inhibin B (INHB), estrodiol (E(2)) following gonadotrophin therapy in vitro fertilization (IVF) cycles in predicting ovarian response to stimulation in young women...
  41. doi request reprint Functions of water channels in male and female reproductive systems
    Dan Zhang
    Department of Reproductive Endocrinology, Zhejiang Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
    Mol Aspects Med 33:676-90. 2012
    ..Researches have also focused on aquaporins as therapeutic targets. This review discusses recent advances in uncovering the physiological and pathophysiological roles of aquaporins in the reproductive systems...
  42. doi request reprint A molecular mechanism underlying ovarian dysfunction of polycystic ovary syndrome: hyperandrogenism induces epigenetic alterations in the granulosa cells
    Fan Qu
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, Zhejiang 310006, China
    J Mol Med (Berl) 90:911-23. 2012
    ..Hyperandrogenism induces the epigenetic alterations of PPARG1, NCOR1, and HDAC3 in GCs, which are involved in the ovarian dysfunction of HA PCOS...
  43. doi request reprint Homeobox A7 stimulates breast cancer cell proliferation by up-regulating estrogen receptor-alpha
    Yu Zhang
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada
    Biochem Biophys Res Commun 440:652-7. 2013
    ..This finding contributes to our understanding of the role HOXA7 plays in regulating the proliferation of ER-positive cancer cells. ..
  44. ncbi request reprint [Preimplantation genetic diagnosis of chromosome abnormality by fluorescence in-situ hybridization]
    Chen ming Xu
    Reproductive Medical Center, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
    Zhonghua Fu Chan Ke Za Zhi 39:453-6. 2004
    ..To perform preimplantation genetic diagnosis (PGD) of chromosome abnormality using fluorescence in-situ hybridization (FISH)...
  45. doi request reprint Reduced expression and function of aquaporin-3 in mouse metaphase-II oocytes induced by controlled ovarian hyperstimulation were associated with subsequent low fertilization rate
    Qing Xia Meng
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, Zhejiang, China
    Cell Physiol Biochem 21:123-8. 2008
    ..The present study aimed to investigate whether functional AQP3 was expressed in oocytes induced by controlled ovarian hyperstimulation (COH), and whether altered oocyte AQP3 expression was associated with changes in fertilization rate...
  46. ncbi request reprint [The expression of integrin beta3 in mice's endometrium during the implantation window based on different ovarian stimulation protocols]
    Heng Chao Ruan
    Women s Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China
    Zhonghua Yi Xue Za Zhi 84:857-60. 2004
    ..To compare the uterine receptivity with different ovarian stimulation protocols, the endometrial expression of Integrin beta3 in mice's during the implantation window underwent different ovarian stimulation were studied...
  47. pmc Alteration of fatty acid metabolism in the liver, adipose tissue, and testis of male mice conceived through assisted reproductive technologies: fatty acid metabolism in ART mice
    Li ya Wang
    Centre of Reproductive Medicine, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, China
    Lipids Health Dis 12:5. 2013
    ..Therefore, we hypothesized that ART micromanipulation may affect lipid metabolism in offspring, and focused on the fatty acid metabolism in ART male offspring in this study...
  48. ncbi request reprint Autologous mature follicular fluid: its role in in vitro maturation of human cumulus-removed oocytes
    Xiao Ming Zhu
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
    Fertil Steril 90:1094-102. 2008
    ....
  49. doi request reprint Identification of estrogen response element in the aquaporin-2 gene that mediates estrogen-induced cell migration and invasion in human endometrial carcinoma
    Li Bo Zou
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, Zhejiang 310006, China
    J Clin Endocrinol Metab 96:E1399-408. 2011
    ..Accumulating evidence suggests that aquaporins (AQP) can facilitate cell migration, invasion, and proliferation in tumor development in addition to water transport...
  50. pmc Different sperm sources and parameters can influence intracytoplasmic sperm injection outcomes before embryo implantation
    Yue Hong Lu
    Department of Reproductive Endocrinology, Key Laboratory of Reproductive Genetics, Ministry of Education, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
    J Zhejiang Univ Sci B 13:1-10. 2012
    ..25% (9/719). In conclusion, different sperm sources and parameters can affect ICSI outcomes before embryo implantation. A full assessment of offspring malformation will require further study using a larger sample size...
  51. ncbi request reprint [Preimplantation genetic diagnosis of translocation]
    Yu li Qian
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
    Zhonghua Fu Chan Ke Za Zhi 43:581-3. 2008
    ....
  52. pmc Proteomic analysis on the alteration of protein expression in the early-stage placental villous tissue of electromagnetic fields associated with cell phone exposure
    Qiong Luo
    Department of Reproductive Endocrinology, Women s Hospital, Zhejiang University School of Medicine, Ministry of Education Key Laboratory of Reproductive Genetic, Women s Reproductive Health Laboratory, Hangzhou, China
    Reprod Sci 20:1055-61. 2013
    ....
  53. ncbi request reprint Proteomic analysis on the alteration of protein expression in the placental villous tissue of early pregnancy loss
    Ai xia Liu
    Department of Reproductive Endocrinology, Zhejiang University School of Medicine, Hangzhou, China
    Biol Reprod 75:414-20. 2006
    ....
  54. ncbi request reprint [Outcome of in vitro fertilization-embryo transfer in treatment of polycystic ovarian syndrome]
    Xiu E Lu
    Department of Reproduction Endocrinology, The Affiliated Obstetrics and Gynecological Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 35:319-22. 2006
    ..To evaluate the outcome of in vitro fertilization embryo transfer (IVF-ET) in treatment of polycystic ovarian syndrome (PCOS) with infertility...
  55. ncbi request reprint Specific peptide patterns of follicular fluids at different growth stages analyzed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
    Ai xia Liu
    Department of Reproductive Endocrinology, Women s Hospital, Zhejiang University School of Medicine, 2 Xue Shi Rd, Hangzhou, Zhejiang 310006, China
    Biochim Biophys Acta 1770:29-38. 2007
    ..Identification of such proteins in our experiment further proved that the direct analysis of tryptic digests could be of practical value...
  56. doi request reprint General imprinting status is stable in assisted reproduction-conceived offspring
    Chun Feng
    Department of Reproductive Endocrinology, Women s Hospital, Zhejiang University, Hangzhou, Zhejiang, People s Republic of China
    Fertil Steril 96:1417-1423.e9. 2011
    ..To evaluate whether the genomic imprinting status of assistant reproductive technology (ART)-conceived offspring is stable...
  57. pmc Dynamic measurements of serum inhibin B and estradiol: a predictive evaluation of ovarian response to gonadotrophin stimulation in the early stage of IVF treatment
    Ming fang Miao
    Department of Reproductive Endocrinology, Women s Hospital, Zhejiang University, Hangzhou, China
    J Zhejiang Univ Sci B 10:35-45. 2009
    ..We dynamically measured serum inhibin B and estradiol in the early stage of hormonal stimulation to predict the ovarian response in in vitro fertilization (IVF) treatment...
  58. ncbi request reprint [Polymorphism in insulin receptor gene exon 17 in women with polycystic ovary syndrome]
    Li Jin
    Department of Gynaecology, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
    Zhonghua Fu Chan Ke Za Zhi 40:323-6. 2005
    ..To investigate insulin receptor (INSR) genotype exon 17 frequencies in women with polycystic ovary syndrome (PCOS) and to elucidate its role in the pathogenesis of PCOS...
  59. ncbi request reprint Epigenetic Inheritance of Paternally Expressed Imprinted Genes in the Testes of ICSI Mice
    Xiang Rong Xu
    Centre of Reproductive Medicine, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
    Curr Pharm Des 20:1764-71. 2014
    ..In vitro culture and mechanical stimulation were the main factors inducing the down regulation of paternally expressed imprinted genes in testes. ..
  60. doi request reprint Alterations in the frequency of trinucleotide repeat dynamic mutations in offspring conceived through assisted reproductive technology
    Ying Ming Zheng
    Department of Reproductive Endocrinology, Zhejiang University School of Medicine, Zhejiang, China
    Hum Reprod 28:2570-80. 2013
    ..does the frequency of trinucleotide repeat dynamic mutations in offspring conceived through assisted reproductive technology (ART) compare with the frequency of these mutations in control offspring conceived from spontaneous pregnancies?..
  61. ncbi request reprint [Increased nitric oxide levels in peritoneal fluids of minor-endometriosis patients and its relation to IVF-ET outcomes]
    Qiong Luo
    Department of Reproduction Endocrinology, The Affiliated Obstetrics and Gynecology Hospital, College of Medicine, Zhejiang University, Hangzhou, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 36:424-8. 2007
    ..To investigate the role of nitric oxide (NO) in the pathogenesis of early endometriosis-associated infertility...
  62. ncbi request reprint [Expressions of peripheral lymph node addressin and GlcNAc-6-sulfotransferase in endometrium and their impacts on implantation]
    Bo Wang
    Department of Reproductive Endocrinology, Women s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China
    Beijing Da Xue Xue Bao 36:575-80. 2004
    ..To investigate the expressions of peripheral lymph node addressin(PNAd) and GlcNAc-6-sulfotransferase (GlcNAc6ST) in endometrium and their impacts on implantation...
  63. doi request reprint Sustained endoplasmic reticulum stress as a cofactor of oxidative stress in decidual cells from patients with early pregnancy loss
    Ai xia Liu
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, Zhejiang 310006, China
    J Clin Endocrinol Metab 96:E493-7. 2011
    ..It has been suggested that elevated reactive oxygen species trigger endoplasmic reticulum (ER) stress by influencing ER function. However, it is unclear whether ER stress is associated with EPL...
  64. ncbi request reprint Vascular endothelial growth factor and matrix metalloproteinase-2 expedite formation of endometriosis in the early stage ICR mouse model
    Xiu E Lu
    Department of Reproductive Endocrinology, Women s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
    Fertil Steril 86:1175-81. 2006
    ..To establish a mouse model for endometriosis and to evaluate roles of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 (MMP-2) in the formation of disease...
  65. ncbi request reprint Increased expression of c-fos protein associated with increased matrix metalloproteinase-9 protein expression in the endometrium of endometriotic patients
    Hong Pan
    Department of Reproductive Endocrinology, Women s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People s Republic of China
    Fertil Steril 90:1000-7. 2008
    ....
  66. ncbi request reprint [Cathepsin D expression in ovaries from polycystic ovarian syndrome patients]
    Min Jin
    The Affiliated Obstetrics and Gynecology Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 36:429-32. 2007
    ..To investigate the expression of cathepsin D in ovary of patients with polycystic ovarian syndrome (PCOS)...
  67. doi request reprint Assisted reproductive technology may increase clinical mutation detection in male offspring
    Chun Feng
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, Zhejiang, China
    Fertil Steril 90:92-6. 2008
    ..To investigate the risks of chromosome mutation after ART for couples with comparable genetic backgrounds...
  68. ncbi request reprint A novel SNP at exon 17 of INSR is associated with decreased insulin sensitivity in Chinese women with PCOS
    Li Jin
    Department of Reproductive Endocrinology, Women s Hospital, Zhejiang University School of Medicine, Hangzhou, China
    Mol Hum Reprod 12:151-5. 2006
    ....
  69. pmc Homeobox A7 increases cell proliferation by up-regulation of epidermal growth factor receptor expression in human granulosa cells
    Yu Zhang
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, China
    Reprod Biol Endocrinol 8:61. 2010
    ..The deregulation of HOX genes is frequently associated with human reproductive system disorders. However, knowledge regarding the role of HOX genes in human granulosa cells is limited...
  70. ncbi request reprint [Clinical analysis of ovarian tumor in infertility women]
    Hui Juan Gao
    The Reproductive Medical Center, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    Zhonghua Fu Chan Ke Za Zhi 42:688-91. 2007
    ..To determine the clinical characteristics and management of ovarian tumor in infertility women...
  71. pmc Preimplantation genetic diagnosis for Down syndrome pregnancy
    Yu Zhang
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
    J Zhejiang Univ Sci B 8:515-21. 2007
    ..To evaluate the effect of preimplantation genetic diagnosis (PGD) conducted for women who had Down syndrome pregnancy previously...
  72. ncbi request reprint [Expression profile of aquaporin 1 in patients with menorrhagia]
    Chao Chao Sun
    The Affiliated Obstetrics and Gynecology Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 36:433-8. 2007
    ..To investigate the expression of aquaporin 1 (AQP1) in endometrium of patients with menorrhagia...
  73. ncbi request reprint High frequency of Y chromosome microdeletions in idiopathic azoospermic men with high follicle-stimulating hormone levels
    Li Quan Wang
    Department of Reproductive Endocrinology, Women s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310 006, China
    Fertil Steril 83:1050-2. 2005
    ..The results suggest that it may be necessary to detect microdeletions in patients with azoospermia, especially for those with high serum FSH levels, before assisted reproductive technology (ART) is provided to them...
  74. pmc Normal epigenetic inheritance in mice conceived by in vitro fertilization and embryo transfer
    Lei Li
    Centre of Reproductive Medicine, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    J Zhejiang Univ Sci B 12:796-804. 2011
    ....
  75. ncbi request reprint [Research on minimal to mild endometriosis associated infertility]
    Xi Jing Chen
    The Affiliated Obstetrics and Gynecology HospitalìCollege of Medicine, Zhejiang University, Hangzhou, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 36:515-20. 2007
    ..They may disturb steps necessary to achieve successful pregnancy, such as ovulation,gamete transport, fertilization, embryo transport and implantation. Any disturbance to one of the steps mentioned above may lead to pregnant loss...
  76. doi request reprint Cryoprotectants up-regulate expression of mouse oocyte AQP7, which facilitates water diffusion during cryopreservation
    Ya Jing Tan
    Key Laboratory of Reproductive Genetics Zhejiang University, Ministry of Education, Hangzhou, PR China
    Fertil Steril 99:1428-35. 2013
    ..To investigate the effects of cryoprotectants on the expression of AQP7 in oocytes...
  77. doi request reprint High expression levels of cyclin B1 and Polo-like kinase 1 in ectopic endometrial cells associated with abnormal cell cycle regulation of endometriosis
    Li Tang
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People s Republic of China
    Fertil Steril 91:979-87. 2009
    ..To investigate the possible roles of cyclin B1/cyclin-dependent kinase (cdc2) and Polo-like kinase 1 (Plk1) in the pathogenesis of endometriosis...
  78. pmc Effects of In Vitro Maturation on Histone Acetylation in Metaphase II Oocytes and Early Cleavage Embryos
    Ning Wang
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, 310006 Hangzhou, China
    Obstet Gynecol Int 2010:989278. 2010
    ..By function of selection, parts of the changes could be recovered in late embryo development...
  79. doi request reprint Expression of aquaporin-1 in normal, hyperplasic, and carcinomatous endometria
    Hong Pan
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, China
    Int J Gynaecol Obstet 101:239-44. 2008
    ..To explore the relationship between aquaporin-1 (AQP1) and endometrial adenocarcinoma...
  80. doi request reprint Adriamycin induces H2AX phosphorylation in human spermatozoa
    Zhong Xiang Li
    Department of Reproductive Endocrinology, Women s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China
    Asian J Androl 10:749-57. 2008
    ..To investigate whether adriamycin induces DNA damage and the formation of gammaH2AX (the phosphorylated form of histone H2AX) foci in mature spermatozoa...
  81. doi request reprint Comparative proteomic analysis of human placenta derived from assisted reproductive technology
    Yu Zhang
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    Proteomics 8:4344-56. 2008
    ..The present results reveal that abnormal protein profiles are involved in ART placenta and these differentially expressed proteins may be valuable for the evaluation of potential association between ART treatment and offspring outcome...
  82. ncbi request reprint [Progress in research on oocytes parthenogenetic activation]
    Mei lian Peng
    The Affiliated Obstetrics and Gynecological Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 36:307-12. 2007
    ..The main activation method of human oocyte is chemical methods. The rates of activation and cleavage depend on the age, origin,and culture conditions of the oocyte...
  83. pmc Accuracy of a combined score of zygote and embryo morphology for selecting the best embryos for IVF
    Yu li Qian
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
    J Zhejiang Univ Sci B 9:649-55. 2008
    ..To evaluate the accuracy of a scoring system combining zygote and embryo morphology in predicting the outcome of in vitro fertilization (IVF) treatment...
  84. ncbi request reprint [Progress in the derivation, culture of human embryonic stem cells]
    Chen ming Xu
    Department of Reproductive Endocrinology, The Obstetrics and Gynecology Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 37:103-7. 2008
    ..The main emphasis over the last several years has been in finding defined serum-and feeder layer-free system for derivation and culture of hES cells to enable the clinical use of hES cell for cell transplantation...
  85. ncbi request reprint Gonadotropins and ovarian cancer
    Jung Hye Choi
    Department of Obstetrics and Gynecology, Zhejiang University School of Medicine, China
    Endocr Rev 28:440-61. 2007
    ..Finally, we will discuss the clinical applications of gonadotropins in ovarian cancer and the recent progress in drug development...
  86. ncbi request reprint [Retrospective analysis of 6 cases of miliary tuberculosis in pregnant women after in vitro fertilization and embryo transfer]
    Hui Juan Gao
    The Reproductive Medical Center, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
    Zhonghua Jie He He Hu Xi Za Zhi 30:848-50. 2007
    ..To analyze the clinical characteristics of haematogenous disseminated tuberculosis in pregnant women after in vitro fertilization and embryo transfer (IVF-ET)...
  87. ncbi request reprint Effects of preimplantation embryos on expressions of DNA methyltransferase 1 in mouse oviduct epithelial cells
    Qiong xiao Huang
    Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310006 PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 22:364-7. 2005
    ..To investigate the effects of mouse preimplantation embryos on the expressions of DNA methyltransferase 1(Dnmt1) of mouse oviduct epithelial cells...
  88. ncbi request reprint [Genetic imprinting and embryonic development]
    Li jun Yin
    The Affiliated Obstetrics and Gynecology HospitalìCollege of Medicine, Zhejiang University, Hangzhou, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 36:509-14. 2007
    ..Genetic imprinting is important for the nucleus totipotential of primordial germ cell, maturation of gamete,growth and development of embryo, structure and function of placenta as well as postnatal growth and development of individuals...
  89. ncbi request reprint [Expression patterns of GCN5 and HDAC1 in preimplantational mouse embryos and effects of in-vitro cultures on their expressions]
    Dong Mei Zhao
    Women s Hospital, Zhejiang University School of Medicine
    Shi Yan Sheng Wu Xue Bao 38:513-9. 2005
    ..Those results showed that in -vitro culture environments could inhibit GCN5 expression and decrease the expression of HDAC1 in mouse preimplantation embryos, which might affect the correct embryonic gene expression...
  90. ncbi request reprint [Expression of leptin mRNA in luteinized granulosa cells and leptin levels in serum and follicular fluid of non-obese infertile patients with polycystic ovary syndrome]
    Xi Ping Lu
    Dongyang Municipal People s Hospital, Dongyang 322100, China
    Zhonghua Yi Xue Za Zhi 85:88-91. 2005
    ..To investigate the expression of leptin mRNA in luteinized granulose cells and the leptin level in serum and follicular fluid of non-obese patients with polycystic ovary syndrome (PCOS)...