Chen Huang

Summary

Publications

  1. pmc FOXM1 and its oncogenic signaling in pancreatic cancer pathogenesis
    Chen Huang
    Department of General Surgery, Shanghai Jiaotong University Affiliated First People s Hospital, Shanghai, People s Republic of China Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA Electronic address
    Biochim Biophys Acta 1845:104-16. 2014
  2. ncbi request reprint Current research status of endoscopic submucosal dissection for colorectal neoplasms
    Chen Huang
    Department of General Surgery, Affiliated First People s Hospital, Shanghai Jiao Tong University, Shanghai, PR China
    Clin Invest Med 35:E158-64. 2012
  3. pmc Laparoscopic and open resection for colorectal cancer: an evaluation of cellular immunity
    Chen Huang
    Department of General Surgery, Affiliated First People s Hospital, Shanghai Jiao Tong University, Shanghai, PR China
    BMC Gastroenterol 10:127. 2010
  4. ncbi request reprint [Inhibitory effect of AG490 on invasion and metastasis of human pancreatic cancer cells in vitro]
    Chen Huang
    Department of General Surgery, Affiliated First People s Hospital, Shanghai Jiao Tong University, Shanghai 200080, China
    Zhonghua Zhong Liu Za Zhi 28:890-3. 2006
  5. pmc Dysregulated expression of FOXM1 isoforms drives progression of pancreatic cancer
    Xiangyu Kong
    Department of Gastroenterology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, PR China
    Cancer Res 73:3987-96. 2013
  6. doi request reprint STAT3-targeting RNA interference inhibits pancreatic cancer angiogenesis in vitro and in vivo
    Chen Huang
    Department of General Surgery, Affiliated First People s Hospital, Shanghai Jiao Tong University, 200080 Shanghai, PR China
    Int J Oncol 38:1637-44. 2011
  7. ncbi request reprint [Effect of RNAi-mediated STAT3 gene inhibition on metastasis of human pancreatic cancer cells]
    Zhen Gao
    Department of General Surgery, Affiliated First People s Hospital, Shanghai Jiaotong University, Shanghai 200080, China
    Zhonghua Wai Ke Za Zhi 46:1010-3. 2008
  8. pmc STAT3 knockdown reduces pancreatic cancer cell invasiveness and matrix metalloproteinase-7 expression in nude mice
    Hai Dong Li
    Department of General Surgery, Affiliated First People s Hospital, Shanghai Jiao Tong University, Shanghai, China
    PLoS ONE 6:e25941. 2011
  9. pmc Effects of IL-6 and AG490 on regulation of Stat3 signaling pathway and invasion of human pancreatic cancer cells in vitro
    Chen Huang
    Department of General Surgery, Affiliated First People s Hospital, Shanghai Jiao Tong University, Shanghai, PR China
    J Exp Clin Cancer Res 29:51. 2010
  10. pmc The critical role of dysregulated FOXM1-PLAUR signaling in human colon cancer progression and metastasis
    Dawei Li
    Department of General Surgery, Shanghai Jiaotong University Affiliated First People s Hospital, Shanghai, People s Republic of China
    Clin Cancer Res 19:62-72. 2013

Collaborators

Detail Information

Publications28

  1. pmc FOXM1 and its oncogenic signaling in pancreatic cancer pathogenesis
    Chen Huang
    Department of General Surgery, Shanghai Jiaotong University Affiliated First People s Hospital, Shanghai, People s Republic of China Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA Electronic address
    Biochim Biophys Acta 1845:104-16. 2014
    ....
  2. ncbi request reprint Current research status of endoscopic submucosal dissection for colorectal neoplasms
    Chen Huang
    Department of General Surgery, Affiliated First People s Hospital, Shanghai Jiao Tong University, Shanghai, PR China
    Clin Invest Med 35:E158-64. 2012
    ..This review article discusses the current research on endoscopic submucosal dissection for colorectal neoplasms. Please see supplementary files for the accompanying video ESD with snare...
  3. pmc Laparoscopic and open resection for colorectal cancer: an evaluation of cellular immunity
    Chen Huang
    Department of General Surgery, Affiliated First People s Hospital, Shanghai Jiao Tong University, Shanghai, PR China
    BMC Gastroenterol 10:127. 2010
    ..This study aimed to compare the cellular immune responses of patients who underwent laparoscopic (LCR) and open resections (OCR) for colorectal cancer...
  4. ncbi request reprint [Inhibitory effect of AG490 on invasion and metastasis of human pancreatic cancer cells in vitro]
    Chen Huang
    Department of General Surgery, Affiliated First People s Hospital, Shanghai Jiao Tong University, Shanghai 200080, China
    Zhonghua Zhong Liu Za Zhi 28:890-3. 2006
    ..To investigate the effect and mechanism of blockade of STAT3 signaling pathway by JAK specific inhibitor-AG490 on invasion and metastasis of human highly metastatic pancreatic cancer line SW1990 in vitro...
  5. pmc Dysregulated expression of FOXM1 isoforms drives progression of pancreatic cancer
    Xiangyu Kong
    Department of Gastroenterology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, PR China
    Cancer Res 73:3987-96. 2013
    ..Our findings strongly suggest that targeting specific FOXM1 isoforms effectively attenuates pancreatic cancer development and progression...
  6. doi request reprint STAT3-targeting RNA interference inhibits pancreatic cancer angiogenesis in vitro and in vivo
    Chen Huang
    Department of General Surgery, Affiliated First People s Hospital, Shanghai Jiao Tong University, 200080 Shanghai, PR China
    Int J Oncol 38:1637-44. 2011
    ....
  7. ncbi request reprint [Effect of RNAi-mediated STAT3 gene inhibition on metastasis of human pancreatic cancer cells]
    Zhen Gao
    Department of General Surgery, Affiliated First People s Hospital, Shanghai Jiaotong University, Shanghai 200080, China
    Zhonghua Wai Ke Za Zhi 46:1010-3. 2008
    ..To investigate the effect of RNAi-mediated STAT3 gene inhibition on metastasis of human pancreatic cancer cells and its underlying mechanism...
  8. pmc STAT3 knockdown reduces pancreatic cancer cell invasiveness and matrix metalloproteinase-7 expression in nude mice
    Hai Dong Li
    Department of General Surgery, Affiliated First People s Hospital, Shanghai Jiao Tong University, Shanghai, China
    PLoS ONE 6:e25941. 2011
    ..The aim of the present study was to investigate the effects of STAT3 knockdown in nude mouse xenografts of pancreatic cancer cells and underlying gene expression...
  9. pmc Effects of IL-6 and AG490 on regulation of Stat3 signaling pathway and invasion of human pancreatic cancer cells in vitro
    Chen Huang
    Department of General Surgery, Affiliated First People s Hospital, Shanghai Jiao Tong University, Shanghai, PR China
    J Exp Clin Cancer Res 29:51. 2010
    ..This study aimed to investigate the mechanisms of activation and blocking of the Stat3 signaling pathway and its effects on invasion and metastasis of human pancreatic cancer cells...
  10. pmc The critical role of dysregulated FOXM1-PLAUR signaling in human colon cancer progression and metastasis
    Dawei Li
    Department of General Surgery, Shanghai Jiaotong University Affiliated First People s Hospital, Shanghai, People s Republic of China
    Clin Cancer Res 19:62-72. 2013
    ..The mammalian Forkhead Box (Fox) transcription factor FOXM1 is implicated in tumorigenesis including mouse intestinal cancer. However, the clinical significance of FOXM1 signaling in human colorectal cancer pathogenesis remains unknown...
  11. pmc Lentivirus-mediated shRNA interference targeting STAT3 inhibits human pancreatic cancer cell invasion
    Guang Yang
    Department of General Surgery, Affiliated First People s Hospital, Shanghai Jiao Tong University, Shanghai 200080, China
    World J Gastroenterol 15:3757-66. 2009
    ..To investigate RNA interference targeting signal transducer and activator of transcription-3 (STAT3) on invasion of human pancreatic cancer cells...
  12. ncbi request reprint Regulation of miR-155 affects pancreatic cancer cell invasiveness and migration by modulating the STAT3 signaling pathway through SOCS1
    Chen Huang
    Department of General Surgery, Affiliated First People s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, P R China
    Oncol Rep 30:1223-30. 2013
    ..In conclusion, miR-155 plays an important role in the regulation of pancreatic cancer cell invasion and migration by modulating the STAT3 signaling pathway and reducing SOCS1 expression in pancreatic cancer cells...
  13. ncbi request reprint RNA interference-mediated signal transducers and activators of transcription 3 gene silencing inhibits invasion and metastasis of human pancreatic cancer cells
    Zhengjun Qiu
    Department of General Surgery, Affiliated First People s Hospital, Shanghai Jiao Tong University, Shanghai, China
    Cancer Sci 98:1099-106. 2007
    ....
  14. pmc A novel FoxM1-caveolin signaling pathway promotes pancreatic cancer invasion and metastasis
    Chen Huang
    Shanghai Key Laboratory of Pancreatic Diseases Research, Department of General Surgery, Shanghai Jiaotong University Affiliated First People s Hospital, Shanghai, PR China
    Cancer Res 72:655-65. 2012
    ..Collectively, our findings defined Cav-1 as an important downstream oncogenic target of FoxM1, suggesting that dysregulated signaling of this novel FoxM1-Cav-1 pathway promotes pancreatic cancer development and progression...
  15. pmc Down-regulation of STAT3 expression by vector-based small interfering RNA inhibits pancreatic cancer growth
    Chen Huang
    Department of General Surgery, Affiliated First People s Hospital, Shanghai Jiao Tong University, Shanghai 200080, China
    World J Gastroenterol 17:2992-3001. 2011
    ..To evaluate the effect of RNA interference (RNAi) mediated silence of signal transduction and activation of transcription (STAT)3 on the growth of human pancreatic cancer cells both in vitro and in vivo...
  16. doi request reprint Hypoxia-induced snail expression through transcriptional regulation by HIF-1α in pancreatic cancer cells
    Guang hui Zhu
    Department of General Surgery, Fengxian Central Hospital, Shanghai, 201400, China
    Dig Dis Sci 58:3503-15. 2013
    ..Intratumoral hypoxia and epithelial-mesenchymal transition are involved in tumor invasion and metastasis...
  17. doi request reprint Analysis of the potential for pancreatic cancer metastasis in vitro and in vivo
    Chen Huang
    Department of General Surgery, Shanghai Jiaotong University Affiliated First People s Hospital, Shanghai, PRChina
    Methods Mol Biol 980:301-19. 2013
    ..Specifically, we report the details of these approaches, including in vitro assays of migration, invasion, adhesion, and angiogenesis and in vivo models of liver and lung metastasis and angiogenesis...
  18. pmc Crosstalk of Sp1 and Stat3 signaling in pancreatic cancer pathogenesis
    Chen Huang
    Shanghai Key Laboratory of Pancreatic Diseases Research, Shanghai Jiaotong University Affiliated First People s Hospital, Shanghai, People s Republic of China
    Cytokine Growth Factor Rev 23:25-35. 2012
    ..Therefore, targeting both Sp1 and Stat3 is a potential preventive and therapeutic strategy for pancreatic cancer...
  19. ncbi request reprint Expression of hypoxia-inducible factor-1 alpha and associated proteins in pancreatic ductal adenocarcinoma and their impact on prognosis
    Hong Cheng Sun
    Department of General Surgery, Affiliated First People s Hospital, Shanghai Jiao Tong University, Shanghai 200080, PR China
    Int J Oncol 30:1359-67. 2007
    ..These results suggest that over-expression of HIF-1alpha may play an important role in cancer progression through up-regulation of VEGF and Glut-1 in PDA patients. HIF-1alpha and VEGF are potential candidates for predicting survival...
  20. pmc Is laparoscopic colorectal cancer surgery associated with an increased risk in obese patients? A retrospective study from China
    Xiang Xia
    Department of General Surgery, Shanghai Jiaotong University Affiliated First People s Hospital, 100 Hai Ning Road Shanghai 200080 People s Republic of China
    World J Surg Oncol 12:184. 2014
    ..The impact of obesity on surgical outcomes after laparoscopic colorectal cancer resection in Chinese patients is still unclear...
  21. ncbi request reprint Phosph-Akt1 expression is associated with a favourable prognosis in pancreatic cancer
    Jun Liu
    Department of General Surgery, Shanghai Jiaotong University Affiliated First People s Hospital, People s Republic of China
    Ann Acad Med Singapore 39:548-7. 2010
    ..This study aims to investigate the expressions and relevance of Akt and p-Akt1 in pancreatic cancer tissues and their clinical significance...
  22. doi request reprint Expression and prognostic significance of CD151, c-Met, and integrin alpha3/alpha6 in pancreatic ductal adenocarcinoma
    Guang hui Zhu
    Department of General Surgery, Affiliated First People s Hospital, Shanghai Jiao Tong University, 200080, Shanghai, China
    Dig Dis Sci 56:1090-8. 2011
    ..CD151, c-Met, and integrin alpha3/alpha6 are all involved in the hepatocyte growth factor (HGF)/c-Met signal pathway, which plays an important role in the malignant progression of tumors...
  23. ncbi request reprint Inhibition of STAT3 activity with AG490 decreases the invasion of human pancreatic cancer cells in vitro
    Chen Huang
    Department of General Surgery, Affiliated First People s Hospital, Shanghai Jiao Tong University, Shanghai 200080, China
    Cancer Sci 97:1417-23. 2006
    ....
  24. pmc FOXM1c promotes pancreatic cancer epithelial-to-mesenchymal transition and metastasis via upregulation of expression of the urokinase plasminogen activator system
    Chen Huang
    Authors Affiliations Shanghai Key Laboratory of Pancreatic Diseases Research Departments of General Surgery and Oncology, Shanghai Jiaotong University Affiliated First People s Hospital Department of Oncology and Tumor Institute, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, People s Republic of China and Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, Texas
    Clin Cancer Res 20:1477-88. 2014
    ..However, the molecular mechanisms by which FOXM1 promotes pancreatic tumor epithelial-to-mesenchymal transition (EMT) and metastasis are unknown...
  25. pmc Natural orifice transluminal endoscopic surgery: new minimally invasive surgery come of age
    Chen Huang
    Department of General Surgery, Affiliated First People s Hospital, Shanghai Jiao Tong University, Shanghai, China
    World J Gastroenterol 17:4382-8. 2011
    ..So what is the current situation of NOTES and how many challenges do we still face? This review discusses the current research progress in NOTES...
  26. doi request reprint Fractional exhaled nitric oxide in Chinese children with asthma and allergies--a two-city study
    Zhuohui Zhao
    Department of Environmental Health, School of Public Health, Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai, PR China
    Respir Med 107:161-71. 2013
    ..The lower level of FeNO in Taiyuan is in agreement with previous studies showing lower prevalence of asthma and allergy in Taiyuan as compared to Shanghai...
  27. doi request reprint IDO-competent-DCs induced by IFN-γ attenuate acute rejection in rat liver transplantation
    Xing Sun
    Department of Surgery, Shanghai First People s Hospital, School of Medicine, Shanghai Jiao Tong University, 100 Haining Road, Shanghai, 200080, China
    J Clin Immunol 32:837-47. 2012
    ..We established a stable rat model of liver transplantation using Sprague-Dawley rats and Wistar rats in order to investigate the role of the IDO gene in acute rejection after rat liver transplantation...
  28. pmc Role of SUMO-specific protease 2 in reprogramming cellular glucose metabolism
    Shuang Tang
    Department of Nuclear Medicine, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China
    PLoS ONE 8:e63965. 2013
    ..In conclusion, SENP2 represses glycolysis and shifts glucose metabolic strategy, in part through inhibition of AKT phosphorylation. Our study reveals a novel function of SENP2 in regulating glucose metabolism...