Genomes and Genes

Species

Kai Huang

Summary

Publications

  1. Wang C, Xu W, Zhang Y, Zhang F, Huang K. PARP1 promote autophagy in cardiomyocytes via modulating FoxO3a transcription. Cell Death Dis. 2018;9:1047 pubmed publisher
    ..Together, these data indicate that PARP1-mediated poly(ADP-ribosyl)ation of FoxO3a plays a key role in cardiomyocyte autophagy. The utilization of PARP1 as a therapeutic target for related cardiovascular diseases would be desirable. ..
  2. Wang C, Xu W, Zhang Y, Huang D, Huang K. Poly(ADP-ribosyl)ated PXR is a critical regulator of acetaminophen-induced hepatotoxicity. Cell Death Dis. 2018;9:819 pubmed publisher
    ..We propose that inhibition of PARP1-dependent poly(ADP-ribosyl)ation might represent a novel approach for the treatment of drug-induced hepatotoxicity. ..
  3. Xu W, Wang C, Liang M, Chen L, Fu Q, Zhang F, et al. A20 prevents obesity-induced development of cardiac dysfunction. J Mol Med (Berl). 2018;96:159-172 pubmed publisher
    ..A20 represses TAK1 activation and the downstream inhibition of P38, JNK1/2, and the NF-?B pathway. TAK1 overexpression retards the beneficial effects of A20. ..