Wang C, Xu W, Zhang Y, Zhang F, Huang K. PARP1 promote autophagy in cardiomyocytes via modulating FoxO3a transcription. Cell Death Dis. 2018;9:1047 pubmed publisher
..Together, these data indicate that PARP1-mediated poly(ADP-ribosyl)ation of FoxO3a plays a key role in cardiomyocyte autophagy. The utilization of PARP1 as a therapeutic target for related cardiovascular diseases would be desirable. ..
Wang C, Xu W, Zhang Y, Huang D, Huang K. Poly(ADP-ribosyl)ated PXR is a critical regulator of acetaminophen-induced hepatotoxicity. Cell Death Dis. 2018;9:819 pubmed publisher
..We propose that inhibition of PARP1-dependent poly(ADP-ribosyl)ation might represent a novel approach for the treatment of drug-induced hepatotoxicity. ..
Xu W, Wang C, Liang M, Chen L, Fu Q, Zhang F, et al
. A20 prevents obesity-induced development of cardiac dysfunction. J Mol Med (Berl). 2018;96:159-172 pubmed publisher
..A20 represses TAK1 activation and the downstream inhibition of P38, JNK1/2, and the NF-?B pathway. TAK1 overexpression retards the beneficial effects of A20. ..