Sanyuan Hu



  1. Wang Y, Zhang X, Liu T, Zhong M, Wan H, Liu S, et al. Jejunum-ileum circuit procedure improves glucose metabolism in diabetic rats independent of weight loss. Obesity (Silver Spring). 2016;24:342-51 pubmed publisher
    ..JIC-S relieves diabetes independent of weight loss, as it promotes the secretion of anti-diabetic hormones and inhibits hepatic glucose production. The prolonging of LAT , however, diminishes the hypoglycemic effect. ..
  2. Liu L, Liu C, Fotouhi O, Fan Y, Wang K, Xia C, et al. TERT Promoter Hypermethylation in Gastrointestinal Cancer: A Potential Stool Biomarker. Oncologist. 2017;22:1178-1188 pubmed publisher
    ..This proof-of-concept study suggests the feasibility of stool TERT promoter methylation analyses for noninvasive screening of GIC. ..
  3. Shao Y, Fu Y, Wang Q, Cheng Z, Zhang G, Hu S. Khubchandani's procedure combined with stapled posterior rectal wall resection for rectocele. World J Gastroenterol. 2019;25:1421-1431 pubmed publisher
    ..5%) as moderate, and 2 (2/37, 5.4%) as poor. Khubchandani's procedure combined with stapled posterior rectal wall resection is an effective, feasible, and safe procedure with minor trauma to rectocele. ..
  4. Wei G, Yi S, Yong D, Shaozhuang L, Guangyong Z, Sanyuan H. miR-320 mediates diabetes amelioration after duodenal-jejunal bypass via targeting adipoR1. Surg Obes Relat Dis. 2018;14:960-971 pubmed publisher
    ..miR-320 regulates the adipoR1-mediated amelioration of T2D in DJB and should be explored as a potential target for T2D treatment. ..
  5. Wang W, Zhang J, Zhan X, Lin T, Yang M, Hu J, et al. SOX4 is associated with poor prognosis in cholangiocarcinoma. Biochem Biophys Res Commun. 2014;452:614-21 pubmed publisher
    ..Collectively, our results define an important role for SOX4 in CCA by orchestrating EMT and modulation on EGFR expression. SOX4 expression may serve as a prognostic marker for patients with IHCC. ..
  6. Chai J, Zhang G, Liu S, Hu C, Han H, Hu S, et al. Exclusion of the Distal Ileum Cannot Reverse the Anti-Diabetic Effects of Duodenal-Jejunal Bypass Surgery. Obes Surg. 2016;26:261-8 pubmed publisher
    ..The beneficial effects of DJB in glycemic control could not be reversed by excluding the distal ileum. ..
  7. Tang Y, Tang S, Hu S. Comparative Efficacy and Safety of Laparoscopic Greater Curvature Plication and Laparoscopic Sleeve Gastrectomy: A Meta-analysis. Obes Surg. 2015;25:2169-75 pubmed publisher
    ..54) and postoperative hospital stay (p = 0.44) were comparable between the two groups. LGCP is inferior to LSG not only in terms of providing effective weight loss but also in terms of safety. ..
  8. Zhang G, Zhang X, Zhan H, Hu S. Vacuum suction fixation versus staple fixation in TAPP laparoscopic hernia repair: introduction of a new technique for mesh fixation. Surg Endosc. 2016;30:114-20 pubmed publisher
    ..There is no significant difference in recurrence, operation time, postoperative pain or hospital stay. The vacuum suction fixation technique is more economical with lower incidence of scrotal emphysema. ..
  9. Li M, Li H, Zhou Z, Zhou Y, Wang Y, Zhang X, et al. Duodenal-Jejunal Bypass Surgery Ameliorates Glucose Homeostasis and Reduces Endoplasmic Reticulum Stress in the Liver Tissue in a Diabetic Rat Model. Obes Surg. 2016;26:1002-9 pubmed publisher
    ..DJB ameliorates glucose homeostasis. Meanwhile, our study helps to reveal that the reduced hepatic ER stress and the decreased JNK activity may contribute to the improved glucose homeostasis after DJB. ..

More Information


  1. Zhan H, Xu J, Wu D, Zhang T, Hu S. Pancreatic cancer stem cells: new insight into a stubborn disease. Cancer Lett. 2015;357:429-37 pubmed publisher
    ..We seek to further understand PCSCs and explore potential therapeutic targets for pancreatic cancer. ..
  2. Zhan H, Xu J, Wang L, Zhang G, Hu S. Lymph node ratio is an independent prognostic factor for patients after resection of pancreatic cancer. World J Surg Oncol. 2015;13:105 pubmed publisher
    ..Our study indicated that LNR >0.2 was an independent adverse prognostic factor for pancreatic cancer, which may provide important information for prognostic assessment. ..
  3. Zhang X, Liu T, Wang Y, Zhong M, Zhang G, Liu S, et al. Comparative Effects of Bile Diversion and Duodenal-Jejunal Bypass on Glucose and Lipid Metabolism in Male Diabetic Rats. Obes Surg. 2016;26:1565-75 pubmed publisher
    ..However, other mechanisms associated with DJB also appear to make complementary contributions to metabolic regulation. ..
  4. request reprint
    Du H, Wang Z, Xu H, Wu Q, Zhan H, Hu S. [The effects of sleeve gastrectomy on renal function in type 2 diabetic rats]. Zhonghua Wai Ke Za Zhi. 2015;53:617-21 pubmed
    ..43)%) (t = 0.781-5.025, all P < 0.05). The sleeve gastrectomy procedure can improve the renal function in a diabetes rat model may be through protecting the podocytes function and preventing the mesangial expansion of glomeruli. ..
  5. Wang Y, Zhang X, Zhong M, Liu T, Zhang G, Liu S, et al. Improvements of Glucose and Lipid Metabolism After Jejuno-ileal Circuit Procedure in a Non-obese Diabetic Rat Model. Obes Surg. 2016;26:1768-76 pubmed publisher
    ..JIC alleviated lipometabolic disorders in hyperglycemic rats, which may contribute to the amelioration of insulin sensitivity and glycemic control. ..
  6. Bin J, Binghai Z, Sanyuan H. Liver Exposure Using Sterile Glove Pouch During Laparoscopic Right Liver Surgery in Hepatocellular Carcinoma Patients. World J Surg. 2016;40:946-50 pubmed publisher
    ..Our data suggests that a sterile glove pouch could enhance exposure in surgical field, which results in decrease in blood loss and procedure time. More studies with large sample size, large tumor size, and longer follow-up are needed. ..
  7. Zhang X, Wang Y, Zhong M, Liu T, Han H, Zhang G, et al. Duodenal-Jejunal Bypass Preferentially Elevates Serum Taurine-Conjugated Bile Acids and Alters Gut Microbiota in a Diabetic Rat Model. Obes Surg. 2016;26:1890-9 pubmed publisher
    ..DJB preferentially increases serum taurine-conjugated BAs, probably because of more BA reabsorption in the terminal ileum. The gut microbiota is altered with more Firmicutes and Proteobacteria and less Bacteroidetes. ..
  8. Cheng Y, Zhan H, Wang L, Xu J, Zhang G, Zhang Z, et al. Analysis of 100 consecutive cases of resectable pancreatic neuroendocrine neoplasms: clinicopathological characteristics and long-term outcomes. Front Med. 2016;10:444-450 pubmed publisher
    ..Non-functional pNENs present a more aggressive behavioral model and have poorer prognosis than functional pNENs. ..
  9. Zhang X, Liu S, Zhang G, Zhong M, Liu T, Wei M, et al. Bariatric Surgery Ameliorates Diabetic Cardiac Dysfunction by Inhibiting ER Stress in a Diabetic Rat Model. Obes Surg. 2017;27:1324-1334 pubmed publisher
    ..DJB and SG ameliorated cardiac dysfunction by inhibiting PERK-mediated pathway. And no difference was observed on the effects of DJB and SG on ER stress-dependent myocardium damage in diabetic rats. ..
  10. Wang L, Xu J, Li F, Zhan H, Liu H, Chen W, et al. Partial Splenectomy is Superior to Total Splenectomy for Selected Patients with Hemangiomas or Cysts. World J Surg. 2017;41:1281-1286 pubmed publisher
    ..Laparoscopic PS shows lower morbidity and equal therapeutic efficacy compared with laparotomic PS and can be widely performed. ..
  11. Zhan H, Zhou B, Cheng Y, Xu J, Wang L, Zhang G, et al. Crosstalk between stromal cells and cancer cells in pancreatic cancer: New insights into stromal biology. Cancer Lett. 2017;392:83-93 pubmed publisher
    ..Moreover, targeting stroma components may provide new therapeutic strategies for this stubborn disease. ..
  12. Wu D, Yan Z, Cheng Y, Zhong M, Liu S, Zhang G, et al. Deactivation of the NLRP3 inflammasome in infiltrating macrophages by duodenal-jejunal bypass surgery mediates improvement of beta cell function in type 2 diabetes. Metabolism. 2018;81:1-12 pubmed publisher
    ..NLRP3 inflammasome deactivation in infiltrating macrophages is involved in marked beta cell function improvement after DJB surgery. ..
  13. Zhan H, Wang Y, Li C, Xu J, Zhou B, Zhu J, et al. LincRNA-ROR promotes invasion, metastasis and tumor growth in pancreatic cancer through activating ZEB1 pathway. Cancer Lett. 2016;374:261-71 pubmed publisher
    ..Together, these results indicate that linc-ROR acts as an important regulator of ZEB1, can promote invasion and metastasis in PC, and may represent a novel therapeutic target. ..
  14. request reprint
    Zhan H, Xu J, Wang L, Wu D, Zhang G, Hu S. FoxQ1 is a Novel Molecular Target for Pancreatic Cancer and is Associated with Poor Prognosis. Curr Mol Med. 2015;15:469-77 pubmed
    ..181-3.705, P=0.01). These data indicate that FoxQ1 expression is negatively associated with the overall survival of PC patients, and that this protein may therefore represent a novel molecular target and new prognostic biomarker for PC. ..