Role of cancer stem cells in spine tumors: review of current literatureWesley Hsu
Department of Neurosurgery, Wake Forest Baptist Medical Center, Winston Salem, NC 27157 1029, USA
Neurosurgery 71:117-25. 2012
..This discussion is followed by a review of what is known about the role of CSCs in the most common primary tumors of the osseous spine...
- Animal model of intramedullary spinal cord glioma using human glioblastoma multiforme neurospheres
Wesley Hsu
Department of Neurosurgery, The Johns Hopkins Hospital, Baltimore, Maryland, USA
J Neurosurg Spine 16:315-9. 2012
..In this study, the authors' goal was to develop a novel spinal cord tumor model using a human neurosphere cell line...
- Strategies to avoid wrong-site surgery during spinal procedures
Wesley Hsu
Department of Neurosurgery, Wake Forest Baptist Medical Center, Winston Salem, North Carolina 27157 1029, USA
Neurosurg Focus 31:E5. 2011
..The following review discusses important issues that can help prevent WSS during spinal procedures...
- Image-guided, endoscopic, transcervical resection of cervical chordoma
Wesley Hsu
Department of Neurosurgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
J Neurosurg Spine 12:431-5. 2010
....
- Three-level en bloc spondylectomy for chordoma
Michelle J Clarke
Department of Neurosurgery, Mayo Clinic, Rochester, MN 55905, USA
Neurosurgery 68:325-33; discussion 333. 2011
..However, these procedures often are complex and require the surgeon to plan a procedure that results in negative tumor margins, protects vital neurovascular structures, and concludes with a viable biomechanical reconstruction...
- A new technique for intraoperative reduction of occipitocervical instability
Wesley Hsu
Department of Neurosurgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Neurosurgery 66:319-23; discussion 323-4. 2010
..Anterior decompression by means of a transoral or transcervical approach followed by posterior instrumentation commonly is used to treat this pathology...
Lysis of intracerebral hematoma with stereotactically implanted tissue plasminogen activator polymers in a rabbit modelQuoc-Anh Thai
Division of Cerebrovascular Neurosurgery, Department of Neurosurgery, School of Medicine, The Johns Hopkins University, Baltimore, Maryland 21287, USA
J Neurosurg 105:424-9. 2006
..Stereotactic implantation of tPA-loaded EVAc polymers significantly reduced ICH volume. Polymers loaded with tPA may be useful clinically for lysis of ICH without the side effects of systemic administration of tPA...
- Adjacent-level range of motion and intradiscal pressure after posterior cervical decompression and fixation: an in vitro human cadaveric model
Ryan M Kretzer
Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Spine (Phila Pa 1976) 37:E778-85. 2012
..This in vitro human cadaveric study measured adjacent-level kinematics after posterior cervical decompression and fixation...
- Intramedullary spinal cord tumor surgery: can we do it without intraoperative neurophysiological monitoring?
Wesley Hsu
Department of Neurosurgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Childs Nerv Syst 26:241-5. 2010
..The objective of this review is to discuss the utilization of intraoperative neurophysiological monitoring (IONM) during spinal cord tumor surgery...
- Stereotactic radiosurgery for spine tumors: review of current literature
Wesley Hsu
Department of Neurosurgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Stereotact Funct Neurosurg 88:315-21. 2010
..The purpose of this review is to summarize the pertinent literature regarding the use of SR for lesions of the spine and spinal cord. Particular emphasis will be placed on large clinical series of both primary and secondary spine tumors...
- Multidisciplinary management of primary tumors of the vertebral column
Wesley Hsu
Department of Neurosurgery, The Johns Hopkins University School of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Curr Treat Options Oncol 10:107-25. 2009
..This review will discuss the most common primary bone tumors and focus on recent surgical, medical, and radiation treatment advances...
- Generation of chordoma cell line JHC7 and the identification of Brachyury as a novel molecular target
Wesley Hsu
Department of Neurosurgery and Oncology, Brain Tumor Stem Cell Laboratory, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
J Neurosurg 115:760-9. 2011
..Thus, the objective of this study was to establish the first fully characterized primary chordoma cell line expressing gain of the T gene locus that readily recapitulates the original parental tumor phenotype in vitro and in vivo...
- Surgical considerations of spinal ependymomas in the pediatric population
Wesley Hsu
Department of Neurosurgery, The Johns Hopkins University School of Medicine, Meyer Bldg 8 161, 600 N Wolfe St, Baltimore, MD 21287, USA
Childs Nerv Syst 25:1253-9. 2009
..Spinal ependymoma is the second most common spinal cord tumor in children. The clinical evaluation of these patients, operative techniques, postoperative management considerations, and long-term outcomes are discussed...
- Transoral approaches to the cervical spine
Wesley Hsu
Department of Neurosurgery, The Johns Hopkins University School of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Neurosurgery 66:119-25. 2010
..Endoscopic endonasal and endoscopic transcervical approaches are promising alternatives that may become more mainstream as experience with these approaches increases...
- Dural prostate adenocarcinoma metastasis with subdural hematoma mimicking the appearance of an epidural hematoma
Michael J Dorsi
Department of Neurosurgery, Johns Hopkins Medical Institutions, Baltimore, MD, United States
Clin Neurol Neurosurg 112:501-4. 2010
..Here we describe the clinical presentation, evaluation and surgical intervention of a patient with a dural prostate carcinoma metastasis with chronic subdural hematoma mimicking an epidural hematoma...
- Intraoperative localization of thoracic spine level with preoperative percutaneous placement of intravertebral polymethylmethacrylate
Wesley Hsu
Department of Neurosurgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
J Spinal Disord Tech 21:72-5. 2008
..To evaluate the safety and utility of preoperative vertebroplasty for intraoperative localization of thoracic spinal levels...
- Delivery of stereotactic radiosurgery: a cross-platform comparison
Trang Nguyen
Department of Neurosurgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Neurol Res 33:787-91. 2011
..The objective of this review is to compare and contrast the various currently available stereotactic radiosurgery platforms...
- Delayed intracranial delivery of a nitric oxide donor from a controlled-release polymer prevents experimental cerebral vasospasm in rabbits
Gustavo Pradilla
Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Neurosurgery 55:1393-9; discussion 1399-1400. 2004
..This inhibition was dose-dependent. This further confirms the role of NO in the pathogenesis of vasospasm...
- Epidural abscesses of the CNS
Gustavo Pradilla
Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Lancet Neurol 8:292-300. 2009
..Increased clinical awareness can greatly improve outcomes by helping to diagnose patients earlier...
- Clear-cell chondrosarcoma of the lumbar spine: case report and review of the literature
Wesley Hsu
Department of Neurosurgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Neurosurgery 68:E1160-4; discussion 1164. 2011
..Clear-cell chondrosarcoma is a rare subtype of chondrosarcoma. These osseous tumors are most commonly found in the end of long bones. We report a rare case of clear-cell chondrosarcoma of the osseous spine...
- Pretruncal nonaneurysmal subarachnoid hemorrhage causing basilar artery vasospasm
Wesley Hsu
Department of Neurosurgery, The Johns Hopkins University School of Medicine, Johns Hopkins Medical Institutions, Meyer Bldg 8 161, 600 N Wolfe St, Baltimore, MD 21287, USA
Neurocrit Care 13:256-60. 2010
..Although vasospasm is a common occurrence after aneurysmal subarachnoid hemorrhage and can lead to significant morbidity and mortality, vasospasm in the setting of PNSAH is rare...
- Frameless stereotaxy-assisted clipping of distal anterior cerebral artery aneurysm: technical note and case series
Wesley Hsu
Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Comput Aided Surg 13:41-6. 2008
..We report a case series of five patients in which frameless stereotaxy and CT angiographic data sets were used to minimize the extent of surgery required to clip distal ACA aneurysms...
- Keyhole to the brain: Walter Dandy and neuroendoscopy
Wesley Hsu
Department of Neurosurgery, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
J Neurosurg Pediatr 3:439-42. 2009
..This paper reviews his contributions to the early evolution of this growing and important field of neurosurgery...
- Local delivery of interleukin-2 and adriamycin is synergistic in the treatment of experimental malignant glioma
Wesley Hsu
Departments of Neurosurgery and Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Neurooncol 74:135-40. 2005
..CONCLUSIONS: Both ADR and IL-2, when delivered locally, are effective monotherapeutic agents against experimental intracranial gliosarcoma. The combination ADR and IL-2 therapy is more effective than either agent alone...
- Accuracy of percutaneous placement of a ventriculoatrial shunt under ultrasonography guidance: a retrospective study at a single institution
Philippe Metellus
Departments of Neurosurgery, Johns Hopkins Hospital, Baltimore, Maryland, USA
J Neurosurg 110:867-70. 2009
..The authors therefore conclude that percutaneous placement of a VA shunt under preoperative radiographic guidance and ultrasonographic monitoring is a safe, effective, and reliable technique that is simple to learn...
- Epidemiology of brachial plexus injury in the pediatric multitrauma population in the United States
Michael J Dorsi
Department of Neurosurgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Neurosurg Pediatr 5:573-7. 2010
..The aim of this study was to estimate the prevalence of brachial plexus injury (BPI) in pediatric multitrauma patients...
