Erin L Hsu
Hsu E, Sonn K, Kannan A, Bellary S, Yun C, Hashmi S, et al
. Dioxin Exposure Impairs BMP-2-Mediated Spinal Fusion in a Rat Arthrodesis Model. J Bone Joint Surg Am. 2015;97:1003-10 pubmed publisher
..Since dioxin and other similar cigarette smoke toxins exert their effects through Ahr pathway activation, the receptor represents a potential therapeutic target to improve spinal fusion rates in patients who smoke. ..
Yun C, Katchko K, Schallmo M, Jeong S, Yun J, Chen C, et al
. Aryl Hydrocarbon Receptor Antagonists Mitigate the Effects of Dioxin on Critical Cellular Functions in Differentiating Human Osteoblast-Like Cells. Int J Mol Sci. 2018;19: pubmed publisher
..In addition, the AhR may represent a potential therapeutic target for orthopedic patients who smoke cigarettes, or those who are exposed to secondhand smoke or other environmental sources of aryl hydrocarbons. ..