Functional interaction of AT1 and AT2 receptors in fructose-induced insulin resistance and hypertension in ratsPo Shiuan Hsieh
Department of Physiology and Biophysics, National Defense Medical Center, National Defense University, Taipei, Taiwan 114
Metabolism 54:157-64. 2005
..Furthermore, AT1R- and AT2R-mediated effects on blood pressure are disassociated with their actions on glucose metabolism in this hypertensive model...
Inflammatory change of fatty liver induced by intraportal low-dose lipopolysaccharide infusion deteriorates pancreatic insulin secretion in fructose-induced insulin-resistant ratsPo Shiuan Hsieh
Department of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan
Liver Int 28:1167-75. 2008
..This study tested whether subacute inflammatory change of fatty liver induced by portal endotoxaemia is detrimental to pancreatic insulin secretion in fructose-fed rats (FFRs) with fatty liver...
- Mild portal endotoxaemia induces subacute hepatic inflammation and pancreatic beta-cell dysfunction in rats
P S Hsieh
Department of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan
Eur J Clin Invest 38:640-8. 2008
..This study tests whether portal endotoxaemia is a pathogenic link between chronic subacute hepatic inflammation and pancreatic beta-cell dysfunction...
- COX-2-mediated inflammation in fat is crucial for obesity-linked insulin resistance and fatty liver
Po Shiuan Hsieh
Department of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan
Obesity (Silver Spring) 17:1150-7. 2009
..Our findings suggest that COX-2 activation in fat inflammation is important in the development of insulin resistance and fatty liver in high fat induced obese rats...
- Diminution of hypertriglyceridemia-induced pressor effect under hyperinsulinemic condition in normal and fructose-induced insulin resistant rats
Po Shiuan Hsieh
Department of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan, ROC
Chin J Physiol 50:99-104. 2007
..The present results demonstrated that hypertriglyceridemia-induced pressor response was diminished under hyperinsulinemic condition in both normal and fructose-induced insulin resistant rats...
- Selective COX2 inhibition improves whole body and muscular insulin resistance in fructose-fed rats
P S Hsieh
Department of Physiology and Biophysics, National Defence Medical Centre, Taipei, Taiwan
Eur J Clin Invest 38:812-9. 2008
..Aims of this study were to examine the effects of COX1 and COX2 inhibitors on whole body and muscular insulin resistance in fructose-fed rats, an animal model of the metabolic syndrome...
- Suppressive effect of COX2 inhibitor on the progression of adipose inflammation in high-fat-induced obese rats
P S Hsieh
National Defense Medical Center, Taipei, Taiwan
Eur J Clin Invest 40:164-71. 2010
..The aim was to examine whether the inhibition of selective cyclooxygenase (COX) 2 activation could suppress the development of inflammatory reaction in visceral and subcutaneous abdominal fats of high-fat-induced obese rats...
- Reversal of fructose-induced hypertension and insulin resistance by chronic losartan treatment is independent of AT2 receptor activation in rats
Po Shiuan Hsieh
Department of Physiology and Biophysics, National Defense Medical Center, National Defense University, Taipei, Taiwan
J Hypertens 23:2209-17. 2005
..To examine whether angiotensin II type 2 receptors (AT2R) are involved in the reversal of fructose-induced hypertension and insulin resistance after chronic angiotensin II type 1 receptor (AT1R) blockade...
- Attenuation of insulin-mediated pressor effect and nitric oxide release in rats with fructose-induced insulin resistance
Po Shiuan Hsieh
Department of Physiology and Biophysics, National Defense Medical Center, National Defense University, Taipei, Taiwan, Republic of China
Am J Hypertens 17:707-711. 2004
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- Aqueous extract of Monascus purpureus M9011 prevents and reverses fructose-induced hypertension in rats
Po Shiuan Hsieh
Department of Physiology and Biophysics, National Defense Medical Center, National Defense University, Taipei, Taiwan, Republic of China
J Agric Food Chem 51:3945-50. 2003
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- Importance of cyclooxygenase 2-mediated low-grade inflammation in the development of fructose-induced insulin resistance in rats
Tse Tsung Liu
Department of Family and Community, Hualien Army Force Hospital, Hualien, Taiwan, Republic of China
Chin J Physiol 52:65-71. 2009
..The present study demonstrates that the COX2-mediated low-grade inflammation, especially mediated by increase in oxidative stress was important in the development of insulin resistance in fructose-fed rats...
- Augmentation of nitric oxide is crucial for the time-dependent effects of rosiglitazone on blood pressure and baroreflex function in rats
Po Shiuan Hsieh
Department of Physiology and Biophysics, National Defense Medical Center, Taipei
J Hypertens 26:83-92. 2008
..To determine the time-dependent effects of rosiglitazone (RSG) on blood pressure (MAP) and baroreflex sensitivity (BRS) and the involvement of nitric oxide (NO) in these effects...
- Discipline-specific insulin sensitivity in athletes
Yi Liang Chen
Laboratory of Exercise Biochemistry, Taipei Physical Education College, Taipei, Taiwan
Nutrition 25:1137-42. 2009
..The main goal of the study was to compare insulin sensitivity in athletes (n=757) and physically active controls (n=670) in relation to the two factors...
- Alleviation of hyperglycemia in diabetic rats by intraportal injection of insulin-producing cells generated from surgically resected human pancreatic tissue
Jia Fwu Shyu
Department of Biology and Anatomy, National Defense Medical Center, Taipei 11490, Taiwan, ROC
J Endocrinol 208:233-44. 2011
..Thus, surgically resected pancreatic tissue may represent an alternative source of functional insulin-producing cells...
Activation of estrogen receptor is crucial for resveratrol-stimulating muscular glucose uptake via both insulin-dependent and -independent pathwaysJen Ying Deng
Department of Life Science and Center for Healthy and Aging Research, College of Medicine, Chang Gung University, Tao Yuan, Taiwan
Diabetes 57:1814-23. 2008
..However, it remains unknown whether activation of ER is involved in the metabolic effects of RSV via insulin-dependent and -independent mechanisms...
- Attenuation of hypertriglyceridemia-induced pressor effect in rats with fructose-induced insulin resistance
Hung Jung Lin
Department of Emergency Medicine, Chi Mei Medical Center, Tainan, ROC
Chin J Physiol 50:16-21. 2007
..The present results suggest that the prolonged pressor response induced by acute hypertriglyceridemia is attenuated in rats with fructose-induced insulin resistance...
- Hyperinsulinemia instead of insulin resistance induces baroreflex dysfunction in chronic insulin-infused rats
Ling Zong Hong
Department of Education and Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan
Am J Hypertens 20:451-8. 2007
..The present study was undertaken to compare the effects of chronic hyperinsulinemia with or without insulin resistance on the autonomic control of heart rate (HR) in rats...
- Effect of hepatic denervation on peripheral insulin sensitivity in conscious dogs
Mary Courtney Moore
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Am J Physiol Endocrinol Metab 282:E286-96. 2002
..05 vs. Sham-Sal), 9.8 +/- 0.9 (P < 0.05 vs. Sham-Sal), and 13.6 +/- 1.8 mg. kg(-1) x min(-1), respectively. DN caused peripheral insulin resistance, and intraportal but not peripheral acetylcholine restored insulin sensitivity...
