William J M Hrushesky

Summary

Publications

  1. pmc Imaging multidimensional therapeutically relevant circadian relationships
    Jamil Singletary
    Medical Chronobiology Laboratory, WJB Dorn VA Medical Center, University of South Carolina, SC 29209, USA
    Int J Biomed Imaging 2009:231539. 2009
  2. pmc Validation of actigraphy to assess circadian organization and sleep quality in patients with advanced lung cancer
    James F Grutsch
    Cancer Treatment Centers of America at Midwestern Regional Medical Center, Zion, IL, USA
    J Circadian Rhythms 9:4. 2011
  3. pmc The association of quality of life with potentially remediable disruptions of circadian sleep/activity rhythms in patients with advanced lung cancer
    James F Grutsch
    Cancer Treatment Centers of America at Midwestern Regional Medical Center, Zion, IL 60099, USA
    BMC Cancer 11:193. 2011
  4. pmc Recurrence and mortality according to estrogen receptor status for breast cancer patients undergoing conservative surgery. Ipsilateral breast tumour recurrence dynamics provides clues for tumour biology within the residual breast
    Romano Demicheli
    Scientific Direction, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy
    BMC Cancer 10:656. 2010
  5. pmc Sunspot dynamics are reflected in human physiology and pathophysiology
    William J M Hrushesky
    Medical Chronobiology Laboratory, University of South Carolina, Columbia, South Carolina, USA
    Astrobiology 11:93-103. 2011
  6. doi request reprint Circadian clock manipulation for cancer prevention and control and the relief of cancer symptoms
    William J M Hrushesky
    Medical Chronobiology Laboratory, WJB Dorn VA Medical Center, Columbia, SC 29209, USA
    Integr Cancer Ther 8:387-97. 2009
  7. doi request reprint The circadian clock gene Per1 suppresses cancer cell proliferation and tumor growth at specific times of day
    Xiaoming Yang
    Dorn Research Institute, WJB Dorn Veterans Affairs Medical Center, Columbia, South Carolina 29209, USA
    Chronobiol Int 26:1323-39. 2009
  8. doi request reprint Beta-catenin induces beta-TrCP-mediated PER2 degradation altering circadian clock gene expression in intestinal mucosa of ApcMin/+ mice
    Xiaoming Yang
    Medical Chronobiology Laboratory, Dorn Research Institute, WJB Dorn Veterans Affairs Medical Center, University of South Carolina, Columbia, SC, USA
    J Biochem 145:289-97. 2009
  9. doi request reprint Period 2 mutation accelerates ApcMin/+ tumorigenesis
    Patricia A Wood
    Medical Chronobiology Laboratory, Dorn Research Institute, Columbia, South Carolina, USA
    Mol Cancer Res 6:1786-93. 2008
  10. doi request reprint Circadian time-dependent tumor suppressor function of period genes
    Xiaoming Yang
    Medical Chronobiology Laboratory, WJB Dorn VA Medical Center, Columbia, SC, USA
    Integr Cancer Ther 8:309-16. 2009

Collaborators

Detail Information

Publications30

  1. pmc Imaging multidimensional therapeutically relevant circadian relationships
    Jamil Singletary
    Medical Chronobiology Laboratory, WJB Dorn VA Medical Center, University of South Carolina, SC 29209, USA
    Int J Biomed Imaging 2009:231539. 2009
    ..The systems and methods used to create these depictions are provided, as well as three example supplementary movies...
  2. pmc Validation of actigraphy to assess circadian organization and sleep quality in patients with advanced lung cancer
    James F Grutsch
    Cancer Treatment Centers of America at Midwestern Regional Medical Center, Zion, IL, USA
    J Circadian Rhythms 9:4. 2011
    ..abstract:..
  3. pmc The association of quality of life with potentially remediable disruptions of circadian sleep/activity rhythms in patients with advanced lung cancer
    James F Grutsch
    Cancer Treatment Centers of America at Midwestern Regional Medical Center, Zion, IL 60099, USA
    BMC Cancer 11:193. 2011
    ..This study was initiated to determine the relationship between the severity of potentially remediable cancer-associated circadian disruption and quality of life among patients with advanced lung cancer...
  4. pmc Recurrence and mortality according to estrogen receptor status for breast cancer patients undergoing conservative surgery. Ipsilateral breast tumour recurrence dynamics provides clues for tumour biology within the residual breast
    Romano Demicheli
    Scientific Direction, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy
    BMC Cancer 10:656. 2010
    ..The study was designed to determine how tumour hormone receptor status affects the subsequent pattern over time (dynamics) of breast cancer recurrence and death following conservative primary breast cancer resection...
  5. pmc Sunspot dynamics are reflected in human physiology and pathophysiology
    William J M Hrushesky
    Medical Chronobiology Laboratory, University of South Carolina, Columbia, South Carolina, USA
    Astrobiology 11:93-103. 2011
    ..These findings add to the growing evidence that solar magnetic storm periodicities are mirrored by cyclic phase-locked rhythms of similar period length or lengths in human physiology and pathophysiology...
  6. doi request reprint Circadian clock manipulation for cancer prevention and control and the relief of cancer symptoms
    William J M Hrushesky
    Medical Chronobiology Laboratory, WJB Dorn VA Medical Center, Columbia, SC 29209, USA
    Integr Cancer Ther 8:387-97. 2009
    ..These drugs and strategies can, in turn, be used to make cancer patients with advanced disease feel and function more normally...
  7. doi request reprint The circadian clock gene Per1 suppresses cancer cell proliferation and tumor growth at specific times of day
    Xiaoming Yang
    Dorn Research Institute, WJB Dorn Veterans Affairs Medical Center, Columbia, South Carolina 29209, USA
    Chronobiol Int 26:1323-39. 2009
    ..The data of the study suggest Per1 has tumor-suppressor function that diminishes cancer proliferation and tumor growth, but only at specific times of day...
  8. doi request reprint Beta-catenin induces beta-TrCP-mediated PER2 degradation altering circadian clock gene expression in intestinal mucosa of ApcMin/+ mice
    Xiaoming Yang
    Medical Chronobiology Laboratory, Dorn Research Institute, WJB Dorn Veterans Affairs Medical Center, University of South Carolina, Columbia, SC, USA
    J Biochem 145:289-97. 2009
    ..These findings suggest that disruption of the peripheral intestinal circadian clock may be intimately involved in beta-catenin induced intestinal epithelial neoplastic transformation in both mouse and man...
  9. doi request reprint Period 2 mutation accelerates ApcMin/+ tumorigenesis
    Patricia A Wood
    Medical Chronobiology Laboratory, Dorn Research Institute, Columbia, South Carolina, USA
    Mol Cancer Res 6:1786-93. 2008
    ....
  10. doi request reprint Circadian time-dependent tumor suppressor function of period genes
    Xiaoming Yang
    Medical Chronobiology Laboratory, WJB Dorn VA Medical Center, Columbia, SC, USA
    Integr Cancer Ther 8:309-16. 2009
    ..These data suggest that the therapeutic efficacy of antiproliferation agents depends on the time of day of drug delivery. The optimal times of day may be shifted in tumors that have mutant Period genes...
  11. doi request reprint Down regulation of circadian clock gene Period 2 accelerates breast cancer growth by altering its daily growth rhythm
    Xiaoming Yang
    Medical Chronobiology Laboratory, WJB Dorn VA Medical Center, 6439 Garners Ferry Road, Columbia, SC 29209, USA
    Breast Cancer Res Treat 117:423-31. 2009
    ..Therefore, Per2 and perhaps other clock genes represent a new class of potential therapeutic targets whose manipulation will modulate cancer growth and cancer cell proliferation...
  12. doi request reprint Cleavage of the retinal pigment epithelium-specific protein RPE65 under oxidative stress
    Hyunju Lee
    Department of Ophthalmology, University of South Carolina, Columbia, SC 29208, USA
    Int J Biol Macromol 47:104-8. 2010
    ..RPE45 is generated in vitro by recombinant caspases via an ubiquitination-dependent mechanism. Collectively, our results indicate that oxidative stress during the visual cycle results in cleavage of RPE65...
  13. ncbi request reprint Circadian transcription profile of mouse breast cancer under light-dark and dark-dark conditions
    Eun Young Oh
    Medical Chronobiology Laboratory, Dorn Research Institute, WJB Dorn VA Medical Center, 6439 Garners Ferry Road, Columbia, SC 29209, U S A
    Cancer Genomics Proteomics 7:311-22. 2010
    ..These results suggest that in addition to the circadian clock control of gene transcription, altering light, feeding, physical activity and other factors characteristically affect the expression of many genes...
  14. doi request reprint Melatonin reprogrammes proteomic profile in light-exposed retina in vivo
    Ruonan Zhang
    Department of Ophthalmology, University of South Carolina, Columbia, SC 29208, USA
    Int J Biol Macromol 47:255-60. 2010
    ..Identification of melatonin target proteins in our study provides a basis for future studies on melatonin's potential in preventing or treating light-induced retinal degeneration...
  15. doi request reprint Clock genes and cancer
    Patricia A Wood
    Medical Chronobiology Laboratory, WJB Dorn VA Medical Center, School of Medicine, University of South Carolina, Columbia, SC 29209, USA
    Integr Cancer Ther 8:303-8. 2009
    ..PERIOD proteins may offer new targets for cancer prevention and control...
  16. ncbi request reprint Sun exposure, sexual behavior and uterine cervical human papilloma virus
    William J M Hrushesky
    Epidemiology and Biostatistics, Norman J Arnold School of Public Health, University of South Carolina School of Medicine, Columbia, SC, USA
    Int J Biometeorol 50:167-73. 2006
    ..Confirming this relationship elsewhere may be important, because whatever the risk conferred by sunlight is, in principle, behaviorally avoidable...
  17. ncbi request reprint Circadian clock coordinates cancer cell cycle progression, thymidylate synthase, and 5-fluorouracil therapeutic index
    Patricia A Wood
    William Jennings Bryan Dorn Veterans Affairs Medical Center, University of South Carolina School of Medicine, 6439 Garners Ferry Road, Columbia, 29209, USA
    Mol Cancer Ther 5:2023-33. 2006
    ....
  18. ncbi request reprint Seasonal modulation of post-resection breast cancer metastasis
    Eun Young Oh
    Dorn Research Institute, WJB Dorn VA Medical Center, Columbia, SC 29209, USA
    Breast Cancer Res Treat 111:219-28. 2008
    ..In order to better understand this seasonal cancer biology, we investigated the circannual pattern of post-resection breast cancer metastasis, under genetically and environmentally controlled conditions...
  19. doi request reprint Discovery of candidate genes and pathways that may help explain fertility cycle stage dependent post-resection breast cancer outcome
    Eun Young Oh
    Medical Chronobiological Laboratory, WJB Dorn VA Medical Center, 6439 Garners Ferry Road, Columbia, SC 29209, USA
    Breast Cancer Res Treat 118:345-59. 2009
    ....
  20. doi request reprint Global breast cancer seasonality
    Eun Young Oh
    Medical Chronobiological Laboratory, Dorn Research Institute, WJB Dorn VA Medical Center, School of Medicine and School of Public Health, University of South Carolina, 6439 Garners Ferry Road, Columbia, SC 29209, USA
    Breast Cancer Res Treat 123:233-43. 2010
    ..Its mechanism may depend upon seasonal sunlight mediation of vitamin D and seasonal mediation of nocturnal melatonin peak level and duration...
  21. ncbi request reprint Season, sun, sex, and cervical cancer
    William J M Hrushesky
    Department of Epidemiology and Biostatistics, Norman J Arnold of Public Health, University of South Carolina, Columbia, SC 29209, USA
    Cancer Epidemiol Biomarkers Prev 14:1940-7. 2005
    ..We now investigate whether premalignant and malignant cervical epithelial changes are also seasonal and related to seasonal sunlight fluency...
  22. doi request reprint Actigraphic assessment of daily sleep-activity pattern abnormalities reflects self-assessed depression and anxiety in outpatients with advanced non-small cell lung cancer
    Jovelyn Du-Quiton
    Medical Chronobiological Laboratory, WJB Dorn Veterans Affairs Medical Center, Columbia, SC 29209, USA
    Psychooncology 19:180-9. 2010
    ....
  23. ncbi request reprint Circadian timing in cancer treatment: the biological foundation for an integrative approach
    Christopher G Lis
    Cancer Treatment Centers of America, Midwestern Regional Medical Center, Zion, IL 60099, USA
    Integr Cancer Ther 2:105-11. 2003
    ..There is now increasing evidence to suggest that the administration of cytotoxic agents, at the appropriate circadian phase, can significantly increase the therapeutic index of current cancer therapies...
  24. pmc Mammalian TIMELESS is required for ATM-dependent CHK2 activation and G2/M checkpoint control
    Xiaoming Yang
    Medical Chronobiology Laboratory, Wm Jennings Bryan Dorn Veterans Affairs Medical Center, Columbia, SC 29209, USA
    J Biol Chem 285:3030-4. 2010
    ..TIM is, thereby, a potential novel anticancer drug target whose inhibition may enhance the therapeutic cytotoxicity of agents that activate DNA damage pathways as part of their mechanism...
  25. ncbi request reprint Cancer growth and spread are saltatory and phase-locked to the reproductive cycle through mediators of angiogenesis
    Patricia A Wood
    Reseach Service, W J B Dorn V A Medical Center, Columbia, SC 29209 1639, USA
    Mol Cancer Ther 4:1065-75. 2005
    ..These fertility cycle-induced effects on tumor biology also seem to extend to non-breast cancer biology...
  26. ncbi request reprint Daily coordination of cancer growth and circadian clock gene expression
    Shaojin You
    Medical Chronobiology Laboratory, Dorn Research Institute, WJB Dorn VA Medical Center and the School of Medicine, University of South Carolina, Columbia, SC 29209, USA
    Breast Cancer Res Treat 91:47-60. 2005
    ..These same genes are also rhythmically expressed each day within each peripheral tissue...
  27. doi request reprint Prohibitin as an oxidative stress biomarker in the eye
    Hyunju Lee
    Department of Ophthalmology, University of South Carolina, Columbia, SC 29208, USA
    Int J Biol Macromol 47:685-90. 2010
    ..Our proteomic approach implies that prohibitin in the RPE and the retina could be a new biomarker protein of oxidative stress in aging and diabetes...
  28. pmc Circadian disruption, Per3, and human cytokine secretion
    Jaclyn Guess
    Department of Epidemiology and Biostatistics, Cancer Prevention and Control Program, University of South Carolina, 915 Greene Street, Columbia, SC 29208, USA
    Integr Cancer Ther 8:329-36. 2009
    ..Biological processes linking circadian disruption with cancer remain to be elucidated. Increased inflammatory cytokine secretion may play a role...
  29. ncbi request reprint Sex cycle modulates cancer growth
    Patricia A Wood
    WJB Dorn VA Medical Center, and the University of South Carolina School of Medicine, 6439 Garners Ferry Road, Columbia, SC 20209, USA
    Breast Cancer Res Treat 91:95-102. 2005
    ..There is strong support for the former in large retrospective studies of surgical resection timing within the menstrual cycle and the following experiments were conducted to critically evaluate the latter...
  30. pmc Developmental abnormalities in multiple proliferative tissues of Apc(Min/+) mice
    Shaojin You
    Center for Colon Cancer Research, Dorn Research Institute, WJB Dorn Veterans Affairs Medical Center 151, Columbia, SC 29209, USA
    Int J Exp Pathol 87:227-36. 2006
    ....