T Hovi

Summary

Publications

  1. pmc Evolution of type 2 vaccine derived poliovirus lineages. Evidence for codon-specific positive selection at three distinct locations on capsid wall
    Tapani Hovi
    Virology Unit, Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare THL, Helsinki, Finland
    PLoS ONE 8:e66836. 2013
  2. pmc Hand washing with soap and water together with behavioural recommendations prevents infections in common work environment: an open cluster-randomized trial
    Carita Savolainen-Kopra
    National Institute for Health and Welfare THL, Department of Infectious Disease Surveillance and Control, Intestinal Viruses Unit, PO Box 30, FIN 00271 Helsinki, Finland
    Trials 13:10. 2012
  3. pmc STOPFLU: is it possible to reduce the number of days off in office work by improved hand-hygiene?
    Carita Savolainen-Kopra
    National Institute for Health and Welfare THL, Department of Infectious Disease Surveillance and Control, Gastrointestinal Infections Unit, Helsinki, Finland
    Trials 11:69. 2010
  4. doi Role of environmental poliovirus surveillance in global polio eradication and beyond
    T Hovi
    National Institute for Health and Welfare, Mannerheimintie 166, Helsinki, Finland
    Epidemiol Infect 140:1-13. 2012
  5. ncbi Molecular epidemiology of coxsackievirus B4 and disclosure of the correct VP1/2A(pro) cleavage site: evidence for high genomic diversity and long-term endemicity of distinct genotypes
    M N Mulders
    Department of Virology, Enterovirus Laboratory and Department of Infectious Disease Epidemiology, HIV Laboratory, National Public Health Institute KTL, Mannerheimintie 166, 00300 Helsinki, Finland
    J Gen Virol 81:803-12. 2000
  6. ncbi Mechanisms of coxsackievirus-induced damage to human pancreatic beta-cells
    M Roivainen
    Enterovirus Laboratory, National Public Health Institute, Helsinki, Finland
    J Clin Endocrinol Metab 85:432-40. 2000
  7. ncbi Enterovirus infection in human pancreatic islet cells, islet tropism in vivo and receptor involvement in cultured islet beta cells
    P Ylipaasto
    Enterovirus Laboratory, National Public Health Institute, Helsinki, Finland
    Diabetologia 47:225-39. 2004
  8. ncbi Several different enterovirus serotypes can be associated with prediabetic autoimmune episodes and onset of overt IDDM. Childhood Diabetes in Finland (DiMe) Study Group
    M Roivainen
    Department of Virology, National Public Health Institute, Helsinki, Finland
    J Med Virol 56:74-8. 1998
  9. ncbi Coxsackievirus immunization delays onset of diabetes in non-obese diabetic mice
    B Davydova
    Enterovirus Laboratory, National Public Health Institute KTL, Helsinki, Finland
    J Med Virol 69:510-20. 2003
  10. ncbi Expression of Coxsackievirus B4 proteins VP0 and 2C in Escherichia coli and generation of virus protein recognizing antisera
    T Harkonen
    Enterovirus Laboratory, National Public Health Institute, Helsinki, Finland
    J Virol Methods 69:147-58. 1997

Detail Information

Publications39

  1. pmc Evolution of type 2 vaccine derived poliovirus lineages. Evidence for codon-specific positive selection at three distinct locations on capsid wall
    Tapani Hovi
    Virology Unit, Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare THL, Helsinki, Finland
    PLoS ONE 8:e66836. 2013
    ..Further studies on sufficiently large independent datasets are needed to confirm this suggestion and to reveal its potential significance. ..
  2. pmc Hand washing with soap and water together with behavioural recommendations prevents infections in common work environment: an open cluster-randomized trial
    Carita Savolainen-Kopra
    National Institute for Health and Welfare THL, Department of Infectious Disease Surveillance and Control, Intestinal Viruses Unit, PO Box 30, FIN 00271 Helsinki, Finland
    Trials 13:10. 2012
    ..We explored whether guided hand hygiene together with transmission-limiting behaviour reduces infection episodes and lost days of work in a common work environment in an open cluster-randomized 3-arm intervention trial...
  3. pmc STOPFLU: is it possible to reduce the number of days off in office work by improved hand-hygiene?
    Carita Savolainen-Kopra
    National Institute for Health and Welfare THL, Department of Infectious Disease Surveillance and Control, Gastrointestinal Infections Unit, Helsinki, Finland
    Trials 11:69. 2010
    ....
  4. doi Role of environmental poliovirus surveillance in global polio eradication and beyond
    T Hovi
    National Institute for Health and Welfare, Mannerheimintie 166, Helsinki, Finland
    Epidemiol Infect 140:1-13. 2012
    ..In this paper we review the feasibility of using ENV to monitor wild PV and vaccine-derived PV circulation in human populations, based on global experiences in defined epidemiological situations...
  5. ncbi Molecular epidemiology of coxsackievirus B4 and disclosure of the correct VP1/2A(pro) cleavage site: evidence for high genomic diversity and long-term endemicity of distinct genotypes
    M N Mulders
    Department of Virology, Enterovirus Laboratory and Department of Infectious Disease Epidemiology, HIV Laboratory, National Public Health Institute KTL, Mannerheimintie 166, 00300 Helsinki, Finland
    J Gen Virol 81:803-12. 2000
    ..The VP4/VP2 region is less reliable for genetic serotyping and genotyping, although the primers are able to amplify many different serotypes...
  6. ncbi Mechanisms of coxsackievirus-induced damage to human pancreatic beta-cells
    M Roivainen
    Enterovirus Laboratory, National Public Health Institute, Helsinki, Finland
    J Clin Endocrinol Metab 85:432-40. 2000
    ..Coxsackie B viruses cause functional impairment and beta-cell death characterized by nuclear pyknosis. Apoptosis appears to play a minor role during a productive CBV infection in beta-cells...
  7. ncbi Enterovirus infection in human pancreatic islet cells, islet tropism in vivo and receptor involvement in cultured islet beta cells
    P Ylipaasto
    Enterovirus Laboratory, National Public Health Institute, Helsinki, Finland
    Diabetologia 47:225-39. 2004
    ..We sought evidence for this through autopsy studies and by investigating known enterovirus receptors in cultured human islets...
  8. ncbi Several different enterovirus serotypes can be associated with prediabetic autoimmune episodes and onset of overt IDDM. Childhood Diabetes in Finland (DiMe) Study Group
    M Roivainen
    Department of Virology, National Public Health Institute, Helsinki, Finland
    J Med Virol 56:74-8. 1998
    ....
  9. ncbi Coxsackievirus immunization delays onset of diabetes in non-obese diabetic mice
    B Davydova
    Enterovirus Laboratory, National Public Health Institute KTL, Helsinki, Finland
    J Med Virol 69:510-20. 2003
    ....
  10. ncbi Expression of Coxsackievirus B4 proteins VP0 and 2C in Escherichia coli and generation of virus protein recognizing antisera
    T Harkonen
    Enterovirus Laboratory, National Public Health Institute, Helsinki, Finland
    J Virol Methods 69:147-58. 1997
    ..In addition, cross-reactivity with CAV-9 and CBV-5 capsid proteins was observed. Anti-GST-2C antisera precipitated viral 2C protein in CBV-4-infected GMK cells, showing that the antibodies recognize the corresponding natural antigen...
  11. ncbi Genetic and phenotypic diversity of echovirus 30 strains and pathogenesis of type 1 diabetes
    A Paananen
    Enterovirus Laboratory, National Public Health Institute, Helsinki, Finland
    J Med Virol 79:945-55. 2007
    ..This finding does not support a previous proposition of aberrant antibody responses to E-30 in diabetic patients. It is concluded that identification of the genetic counterparts of pathogenicity of E-30 strains requires further studies...
  12. ncbi Picornavirus proteins share antigenic determinants with heat shock proteins 60/65
    T Harkonen
    Enterovirus Laboratory, National Public Health Institute, Helsinki, Finland
    J Med Virol 62:383-91. 2000
    ....
  13. ncbi Screening enteroviruses for beta-cell tropism using foetal porcine beta-cells
    M Roivainen
    Enterovirus Laboratory, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    J Gen Virol 82:1909-16. 2001
    ..Therefore, foetal porcine beta-cells cannot be used for systematic screening of human EV strains and isolates for beta-cell tropism, but they might provide a useful model for detailed studies on the interaction of CVBs with beta-cells...
  14. pmc Surveillance of patients with acute flaccid paralysis in Finland: report of a pilot study
    T Hovi
    Department of Virology, National Public Health Institute, Helsinki, Finland
    Bull World Health Organ 78:298-304. 2000
    ..Active feedback did not increase the proportion of virologically investigated patients to an acceptable level in all age groups. It is clear that other approaches must be used to quantify the circulation of poliovirus in Finland...
  15. ncbi Induction of neutralizing antibodies by synthetic peptides representing the C terminus of coxsackievirus A9 capsid protein VP1
    T Pulli
    Enterovirus Laboratory, National Public Health Institute, Helsinki, Finland
    J Gen Virol 79:2249-53. 1998
    ..Neutralization of the virus was observed with all three antipeptide antisera in A549 cells and with two antisera in RD cells...
  16. ncbi Highly divergent neurovirulent vaccine-derived polioviruses of all three serotypes are recurrently detected in Finnish sewage
    M Roivainen
    National Institute for Health and Welfare, Helsinki, Finland
    Euro Surveill 15:pii/19566. 2010
    ..While the source of the VDPV is unknown, characteristics of the viruses resemble those of strains isolated from immunodeficient, persistently infected persons. No cases of suspected poliomyelitis have been reported in Finland since 1985...
  17. ncbi Site-saturation mutagenesis of the PALTAVETG motif in coxsackievirus A9 capsid protein VP1 reveals evidence of conservation of a periodic hydrophobicity profile
    A Airaksinen
    National Public Health Institute KTL, Enterovirus Laboratory, Helsinki, Finland
    J Gen Virol 80:1919-27. 1999
    ..The constraints observed on the ranges of acceptable amino acids presumably reflect the structural-functional requirements that have resulted in the conservation of the motif...
  18. pmc Poliovirus surveillance by examining sewage specimens. Quantitative recovery of virus after introduction into sewerage at remote upstream location
    T Hovi
    Enterovirus Laboratory, WHO Collaborating Centre for Reference and Research on Poliomyelitis, National Public Health Institute (KTL, Helsinki, Finland
    Epidemiol Infect 127:101-6. 2001
    ..It is concluded that environmental surveillance is a sensitive approach to monitor silent poliovirus circulation in populations served by a sewage network...
  19. ncbi Age- and dose-interval-dependent antibody responses to inactivated poliovirus vaccine
    H Sormunen
    Department of Virology, National Public Health Institute (KTL, Helsinki, Finland
    J Med Virol 63:305-10. 2001
    ..It is concluded that three doses of IPV given in widely variable schedules may result in satisfactory immune responses in children but, for optimal results, very early onset of the program and short dosage intervals should be avoided...
  20. ncbi Entry of coxsackievirus A9 into host cells: specific interactions with alpha v beta 3 integrin, the vitronectin receptor
    M Roivainen
    Enterovirus Laboratory and Molecular Biology Program, National Public Health Institute, Helsinki, Finland
    Virology 203:357-65. 1994
    ..Of several other related viruses studied, only echovirus 22, which also has an RGD motif in the VP1 capsid protein, was found to compete for cell surface binding with CAV-9...
  21. ncbi Etiology of measles- and rubella-like illnesses in measles, mumps, and rubella-vaccinated children
    I Davidkin
    National Public Health Institute, Helsinki University Central Hospital, Helsinki, Finland
    J Infect Dis 178:1567-70. 1998
    ..Each suspected vaccine failure requires laboratory confirmation to maintain reliable surveillance and control and to establish the specific etiology of the disease...
  22. ncbi Poliovirus-specific intestinal antibody responses coincide with decline of poliovirus excretion
    S Valtanen
    Department of Biochemistry, National Public Health Institute, Helsinki, Finland
    J Infect Dis 182:1-5. 2000
    ..These results are in agreement with the view that an intestinal antibody response, mainly consisting of IgA, may be involved in the ceasing of a primary poliovirus excretion...
  23. ncbi Molecular epidemiology of enteroviruses with special reference to their potential role in the etiology of insulin-dependent diabetes mellitus (IDDM). A review
    T Hovi
    Enterovirus Laboratory, National Public Health Institute, Helsinki, Finland
    Clin Diagn Virol 9:89-98. 1998
    ..In such a situation it would be important to know which serotypes and strains are the most important ones, and whether there would be differences between the strains as regards the pathogenetic mechanisms involved...
  24. ncbi Genetic and phylogenetic clustering of enteroviruses
    T Pöyry
    Enterovirus Laboratory, National Public Health Institute, Helsinki, Finland
    J Gen Virol 77:1699-717. 1996
    ..Although the BEV-like viruses formed a separate cluster in all genomic regions, in the coding region they seem to be phylogenetically related to the CAV16-like viruses...
  25. ncbi Isolation of escape mutants of a hybrid poliovirus with the aid of insert-specific polyclonal antibodies
    T Hovi
    Enterovirus Laboratory and Molecular Biology Programme, National Public Health Institute, Helsinki, Finland
    J Gen Virol 76:1861-5. 1995
    ..These results indicate that, with the use of recombinant cDNA technology, it may be possible to study molecular interactions of defined regions of virus capsid proteins with neutralizing polyclonal antibodies...
  26. ncbi Molecular epidemiology of echovirus 30 in Europe: succession of dominant sublineages within a single major genotype
    C Savolainen
    Department of Virology, Enterovirus Laboratory, National Public Health Institute (KTL, Helsinki, Finland
    Arch Virol 146:521-37. 2001
    ..Interestingly, despite the low nucleotide variability, maximum amino acid sequence variability in VP1 was surprisingly high, 8.0%, suggesting possible antigenical differences...
  27. ncbi A Sabin vaccine-derived field isolate of poliovirus type 1 displaying aberrant phenotypic and genetic features, including a deletion in antigenic site 1
    M N Mulders
    Enterovirus Laboratory, Department of Virology, National Public Health Institute KTL, Helsinki, Finland
    J Gen Virol 80:907-16. 1999
    ..Likewise, replication of the virus under cell culture conditions was not affected by these mutations or by the deletion. Standard polio vaccination protects against this aberrant virus, and its epidemiological significance remains open...
  28. ncbi Poliomyelitis outbreaks in Africa and Asia: importation of infections a serious risk for polio-free countries with low vaccine coverage
    T Hovi
    WHO Collaborating Centre for Poliovirus Surveillance and Enterovirus Research, National Public Health Institute KTL, Helsinki, Finland
    Euro Surveill 11:E060309.2. 2006
  29. ncbi Association between prenatal exposure to poliovirus infection and adult schizophrenia
    J Suvisaari
    National Public Health Institute, Department of Mental Health and Alcohol Research, Helsinki, Finland
    Am J Psychiatry 156:1100-2. 1999
    ..The authors' goal was to determine whether there is an association between prenatal exposure to poliovirus infection and later development of schizophrenia...
  30. ncbi Inactivated poliovirus vaccine and the final stages of poliovirus eradication
    T Hovi
    The Enterovirus Laboratory, National Public Health Institute KTL, Mannerheimintie 166, 00300, Helsinki, Finland
    Vaccine 19:2268-72. 2001
    ..Our recent results suggest that locally excreted IgA might have a role in the elimination of poliovirus infection in the intestinal tissues...
  31. ncbi The efficiency and reliability of polio surveillance
    T Hovi
    National Public Health Institute (KTL, Enterovirus Laboratory, Helsinki, Finland
    Dev Biol (Basel) 105:21-31. 2001
    ..However, by applying all these approaches optimally, we may eventually reach a probability level allowing the safe cessation of immunisation...
  32. ncbi Variation in liposome binding among enteroviruses
    A Airaksinen
    Enterovirus Laboratory, National Public Health Institute KTL, Mannerheimintie 166, Helsinki, FIN 00300, Finland
    Virology 279:539-45. 2001
    ..The results follow the new classification of enteroviruses, as CAV21 is a member of the human enterovirus C species, which is genetically close to the poliovirus species...
  33. ncbi Functional impairment and killing of human beta cells by enteroviruses: the capacity is shared by a wide range of serotypes, but the extent is a characteristic of individual virus strains
    M Roivainen
    Enterovirus Laboratory, National Public Health Institute, Helsinki, Finland
    Diabetologia 45:693-702. 2002
    ..We extended these studies to additional enterovirus serotypes including several echoviruses, some of which have been associated clinically with the development of Type I (insulin-dependent) diabetes mellitus...
  34. ncbi A randomized study on donor immunization with tetanus-diphtheria, Haemophilus influenzae type b and inactivated poliovirus vaccines to improve the recipient responses to the same vaccines after allogeneic bone marrow transplantation
    T Parkkali
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Bone Marrow Transplant 39:179-88. 2007
    ..Especially patients whose donors have low-specific antibody concentrations may benefit from donor vaccination with protein and conjugate vaccines...
  35. ncbi Epidemiology of documented viral respiratory infections and acute otitis media in a cohort of children followed from two to twenty-four months of age
    S Vesa
    Department of Vaccines, National Public Health Institute, Helsinki, Finland
    Pediatr Infect Dis J 20:574-81. 2001
    ..Although rhinoviruses were definitely the most frequently found viruses in NPA specimens, the association of RS virus with concurrent AOM was relatively higher than that of any other virus...
  36. pmc Modified base compositions at degenerate positions of a mutagenic oligonucleotide enhance randomness in site-saturation mutagenesis
    A Airaksinen
    National Public Health Institute KTL, Enterovirus Laboratory, Mannerheimintie 166, FIN 00300, Helsinki, Finland
    Nucleic Acids Res 26:576-81. 1998
    ..Based on these results, we suggest levels to which different phosphoramidites should be reduced when synthesizing oligonucleotides for site-saturation mutagenesis...
  37. ncbi Enterovirus, mycoplasma and other infections as predictors for myocardial infarction
    A Reunanen
    Department of Health and Functional Capacity, National Public Health Institute, Helsinki, Finland
    J Intern Med 252:421-9. 2002
    ..To study antibodies against five infectious agents for their prediction of major coronary events in men with and without evidence of coronary heart disease at baseline...
  38. ncbi Enterovirus infection can induce immune responses that cross-react with beta-cell autoantigen tyrosine phosphatase IA-2/IAR
    T Harkonen
    Enterovirus Laboratory, National Public Health Institute, Helsinki, Finland
    J Med Virol 66:340-50. 2002
    ..The results obtained with human paired sera, collected during enterovirus infection, indicated that enterovirus infection in humans may also occasionally induce a humoral response that cross-reacts with IA-2/IAR...
  39. ncbi Risk of Guillain-Barré syndrome after measles-mumps-rubella vaccination
    A Patja
    Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland
    J Pediatr 138:250-4. 2001
    ..Respiratory or gastrointestinal tract infection predated the onset of GBS by 3 to 30 days in 20 (83%) of the 24 patients. CONCLUSIONS: No causal association seems to prevail between MMR vaccination and GBS...