Hamid R Hoveyda

Summary

Publications

  1. ncbi Discovery of 3-aryl-5-acylpiperazinyl-pyrazoles as antagonists to the NK3 receptor
    Hamid R Hoveyda
    Euroscreen SA, 47 Rue Adrienne Bolland, Gosselies, Belgium
    Bioorg Med Chem Lett 21:1991-6. 2011
  2. ncbi Optimization of the potency and pharmacokinetic properties of a macrocyclic ghrelin receptor agonist (Part I): Development of ulimorelin (TZP-101) from hit to clinic
    Hamid R Hoveyda
    Tranzyme Pharma Inc, 3001, 12e Avenue Nord, Sherbrooke, QC J1H 5N4, Canada
    J Med Chem 54:8305-20. 2011
  3. ncbi Discovery of a new class of macrocyclic antagonists to the human motilin receptor
    Eric Marsault
    Tranzyme Pharma Inc, 3001, 12e Avenue Nord, Sherbrooke, PQ, Canada, J1H 5N4
    J Med Chem 49:7190-7. 2006
  4. ncbi Effect of the ghrelin receptor agonist TZP-101 on colonic transit in a rat model of postoperative ileus
    Graeme L Fraser
    Tranzyme Pharma, Sherbrooke, QC, Canada, J1H 5N4
    Eur J Pharmacol 604:132-7. 2009

Collaborators

Detail Information

Publications4

  1. ncbi Discovery of 3-aryl-5-acylpiperazinyl-pyrazoles as antagonists to the NK3 receptor
    Hamid R Hoveyda
    Euroscreen SA, 47 Rue Adrienne Bolland, Gosselies, Belgium
    Bioorg Med Chem Lett 21:1991-6. 2011
    ..Unexpected cytotoxicity was observed in such N-Me pyrazole structures as compounds 41-42...
  2. ncbi Optimization of the potency and pharmacokinetic properties of a macrocyclic ghrelin receptor agonist (Part I): Development of ulimorelin (TZP-101) from hit to clinic
    Hamid R Hoveyda
    Tranzyme Pharma Inc, 3001, 12e Avenue Nord, Sherbrooke, QC J1H 5N4, Canada
    J Med Chem 54:8305-20. 2011
    ..Compound 2 is 24% orally bioavailable in both rats and monkeys. Despite its potency, in vitro and in gastric emptying studies, 2 did not induce growth hormone (GH) release in rats, thus demarcating the GH versus GI pharmacology of GRLN...
  3. ncbi Discovery of a new class of macrocyclic antagonists to the human motilin receptor
    Eric Marsault
    Tranzyme Pharma Inc, 3001, 12e Avenue Nord, Sherbrooke, PQ, Canada, J1H 5N4
    J Med Chem 49:7190-7. 2006
    ..Rapid access to this novel class of macrocyclic target structures was made possible through two efficient and complementary solid-phase parallel synthetic approaches, both of which are reported herein...
  4. ncbi Effect of the ghrelin receptor agonist TZP-101 on colonic transit in a rat model of postoperative ileus
    Graeme L Fraser
    Tranzyme Pharma, Sherbrooke, QC, Canada, J1H 5N4
    Eur J Pharmacol 604:132-7. 2009
    ....