Yu Chi Hou

Summary

Publications

  1. pmc Acute and Chronic Administrations of Rheum palmatum Reduced the Bioavailability of Phenytoin in Rats: A New Herb-Drug Interaction
    Ying Chang Chi
    Institute of Pharmaceutical Chemistry, China Medical University, Taichung 40402, Taiwan
    Evid Based Complement Alternat Med 2012:701205. 2012
  2. pmc Pharmacokinetics and Relative Bioavailability of Flavonoids between Two Dosage Forms of Gegen-Qinlian-Tang in Rats
    Chung Ping Yu
    School of Pharmacy, China Medical University, 91 Hsueh Shih Road, Taichung 40402, Taiwan
    Evid Based Complement Alternat Med 2012:308018. 2012
  3. ncbi request reprint Liquorice reduced cyclosporine bioavailability by activating P-glycoprotein and CYP 3A
    Yu Chi Hou
    School of Pharmacy, China Medical University, Taichung 40402, Taiwan, ROC
    Food Chem 135:2307-12. 2012
  4. doi request reprint Steady-state pharmacokinetics and tissue distribution of anthraquinones of Rhei Rhizoma in rats
    Chi Sheng Shia
    School of Pharmacy, College of Pharmacy, China Medical University, Taichung, Taiwan
    J Ethnopharmacol 137:1388-94. 2011
  5. doi request reprint Pharmacokinetics and tissue distribution of resveratrol, emodin and their metabolites after intake of Polygonum cuspidatum in rats
    Shiuan Pey Lin
    School of Pharmacy, China Medical University, Taichung, Taiwan
    J Ethnopharmacol 144:671-6. 2012
  6. ncbi request reprint Life-threatening interaction between the root extract of Pueraria lobata and methotrexate in rats
    Hsiu Mei Chiang
    Institute of Pharmaceutical Chemistry, China Medical University, Taichung, Taiwan, ROC
    Toxicol Appl Pharmacol 209:263-8. 2005
  7. ncbi request reprint Influence of honey on the gastrointestinal metabolism and disposition of glycyrrhizin and glycyrrhetic acid in rabbits
    Hui Ching
    Graduate Institute of Chinese Pharmaceutical Sciences, China Medical College, Taichung, Taiwan, ROC
    Biol Pharm Bull 25:87-91. 2002
  8. doi request reprint Flavonoid pharmacokinetics and tissue distribution after repeated dosing of the roots of Scutellaria baicalensis in rats
    Yu Chi Hou
    School of Pharmacy, College of Pharmacy, China Medical University, Taichung, Taiwan
    Planta Med 77:455-60. 2011
  9. doi request reprint Metabolism and pharmacokinetics of anthraquinones in Rheum palmatum in rats and ex vivo antioxidant activity
    Chi Sheng Shia
    Institute of Pharmaceutical Chemistry, China Medical University, Taichung, Taiwan, ROC
    Planta Med 75:1386-92. 2009
  10. ncbi request reprint Significant decrease of cyclosporine bioavailability in rats caused by a decoction of the roots of Scutellaria baicalensis
    Miao Ying Lai
    Graduate Institute of Chinese Pharmaceutical Sciences, China Medical University, Taichung, Taiwan, ROC
    Planta Med 70:132-7. 2004

Collaborators

  • Shih Hua Fang
  • Chun Hsu Yao
  • Yun Lian Lin
  • Hsin Ling Yang
  • Yann Lii Leu
  • Weng Cheng Chang
  • You Cheng Hseu
  • Pei Dawn Lee Chao
  • Shang Yuan Tsai
  • Shiuan Pey Lin
  • Chi Sheng Shia
  • Shin Hun Juang
  • Chung Ping Yu
  • Su Lan Hsiu
  • Ying Chang Chi
  • Miau Hwa Ko
  • Sheng Chu Kuo
  • Miao Ying Lai
  • Hsiu Mei Chiang
  • Pei Wen Hsu
  • Shih Ying Yang
  • Meng Ju Wang
  • Ping Ping Wu
  • Kuo Ching Wen
  • Hsien Tung Chen
  • Yao Horng Wang
  • Hui Ching
  • Tzu Yun Liao
  • Long Jung Kao
  • Wai Keung Chui
  • Meng Hao Wu
  • Pei Ming Chu
  • Lu Ching Ho
  • Govindan Suresh
  • Jung Chih Lin
  • Chiung Tong Chen
  • Yu Ching Huang
  • Pei Hsun Hsieh
  • Ming li Li
  • Ying Chen Chen
  • Wei Hong
  • Chen Kang Chang
  • Ching Lin Wu
  • Pei Hsun Huieh
  • Pei Hua Chang
  • Chang Chi Hsieh
  • Cherng Jyh Ke
  • Yueh Sheng Chen
  • Pei Dawn L Chao
  • Sang Yuan Tsai
  • Chung Chuan Chen
  • Tang Yen Huang
  • Der Hang Chin

Detail Information

Publications38

  1. pmc Acute and Chronic Administrations of Rheum palmatum Reduced the Bioavailability of Phenytoin in Rats: A New Herb-Drug Interaction
    Ying Chang Chi
    Institute of Pharmaceutical Chemistry, China Medical University, Taichung 40402, Taiwan
    Evid Based Complement Alternat Med 2012:701205. 2012
    ..It is recommended that caution should be exercised during concurrent use of RP and PHT...
  2. pmc Pharmacokinetics and Relative Bioavailability of Flavonoids between Two Dosage Forms of Gegen-Qinlian-Tang in Rats
    Chung Ping Yu
    School of Pharmacy, China Medical University, 91 Hsueh Shih Road, Taichung 40402, Taiwan
    Evid Based Complement Alternat Med 2012:308018. 2012
    ..In conclusion, the major flavonoids of GQT were extensively metabolized into sulfates/glucuronides and present as the major molecules in the circulation. TD of GQT revealed higher bioavailability of daidzin/daidzein than CP...
  3. ncbi request reprint Liquorice reduced cyclosporine bioavailability by activating P-glycoprotein and CYP 3A
    Yu Chi Hou
    School of Pharmacy, China Medical University, Taichung 40402, Taiwan, ROC
    Food Chem 135:2307-12. 2012
    ..In conclusion, liquorice significantly reduced the oral bioavailability of CsA through activating P-gp and CYP3A4...
  4. doi request reprint Steady-state pharmacokinetics and tissue distribution of anthraquinones of Rhei Rhizoma in rats
    Chi Sheng Shia
    School of Pharmacy, College of Pharmacy, China Medical University, Taichung, Taiwan
    J Ethnopharmacol 137:1388-94. 2011
    ..This study investigated the pharmacokinetics and tissue distribution of anthraquinones following seven-dose administration of RP decoction to rats...
  5. doi request reprint Pharmacokinetics and tissue distribution of resveratrol, emodin and their metabolites after intake of Polygonum cuspidatum in rats
    Shiuan Pey Lin
    School of Pharmacy, China Medical University, Taichung, Taiwan
    J Ethnopharmacol 144:671-6. 2012
    ..The rhizome of Polygonum cuspidatum SIEB. et ZUCC. (Polygonaceae, PC), a widely used Chinese medicine, is commonly prescribed for the treatments of amenorrhea, arthralgia, jaundice, abscess, scald and bruises...
  6. ncbi request reprint Life-threatening interaction between the root extract of Pueraria lobata and methotrexate in rats
    Hsiu Mei Chiang
    Institute of Pharmaceutical Chemistry, China Medical University, Taichung, Taiwan, ROC
    Toxicol Appl Pharmacol 209:263-8. 2005
    ..0 g/kg significantly increased the half-life by 53.9% and decreased the clearance by 47.9%. In conclusion, the coadministration of PLRD significantly decreased the elimination and resulted in markedly increased exposure of MTX in rats...
  7. ncbi request reprint Influence of honey on the gastrointestinal metabolism and disposition of glycyrrhizin and glycyrrhetic acid in rabbits
    Hui Ching
    Graduate Institute of Chinese Pharmaceutical Sciences, China Medical College, Taichung, Taiwan, ROC
    Biol Pharm Bull 25:87-91. 2002
    ..Therefore, honey might enhance the efficacy and adverse effects of glycyrrhizin...
  8. doi request reprint Flavonoid pharmacokinetics and tissue distribution after repeated dosing of the roots of Scutellaria baicalensis in rats
    Yu Chi Hou
    School of Pharmacy, College of Pharmacy, China Medical University, Taichung, Taiwan
    Planta Med 77:455-60. 2011
    ..In conclusion, the glucuronides/sulfates of baicalein and wogonin were exclusively present in the circulation, whereas their free forms appeared in the lung, liver, and kidney...
  9. doi request reprint Metabolism and pharmacokinetics of anthraquinones in Rheum palmatum in rats and ex vivo antioxidant activity
    Chi Sheng Shia
    Institute of Pharmaceutical Chemistry, China Medical University, Taichung, Taiwan, ROC
    Planta Med 75:1386-92. 2009
    ....
  10. ncbi request reprint Significant decrease of cyclosporine bioavailability in rats caused by a decoction of the roots of Scutellaria baicalensis
    Miao Ying Lai
    Graduate Institute of Chinese Pharmaceutical Sciences, China Medical University, Taichung, Taiwan, ROC
    Planta Med 70:132-7. 2004
    ..In order to ensure the efficacy and safety of cyclosporine, the coadministration of SR and its preparations with oral cyclosporine should be avoided...
  11. ncbi request reprint Comparison of metabolic pharmacokinetics of naringin and naringenin in rabbits
    Su Lan Hsiu
    Department of Pharmacy, China Medical College, Taichung, Taiwan, ROC
    Life Sci 70:1481-9. 2002
    ..Oral naringin resulted in latter Tmax, lower Cmax and longer MRT (mean residence time) for both naringenin and its conjugated metabolites than those after oral naringenin...
  12. ncbi request reprint Morin sulfates/glucuronides exert anti-inflammatory activity on activated macrophages and decreased the incidence of septic shock
    Shih Hua Fang
    Department of Microbiology, School of Medicine, China Medical University, Taichung 404, Taiwan
    Life Sci 74:743-56. 2003
    ..Therefore, morin could be a promising therapeutic candidate for inflammatory disease due to the strong activity of its metabolites...
  13. ncbi request reprint Interaction of rhubarb and methotrexate in rats: in vivo and ex vivo approaches
    Chi Sheng Shia
    School of Pharmacy, China Medical University, Taichung, Taiwan, Department of Pharmacy, China Medical University Hospital, Taichung, Taiwan
    Am J Chin Med 41:1427-38. 2013
    ..In conclusion, concomitant administration of RP markedly increased the systemic exposure of MTX via inhibiting MRP 2-mediated excretion. ..
  14. ncbi request reprint Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of Scutellariae Radix in humans
    Miao Ying Lai
    Graduate Institute of Chinese Pharmaceutical Sciences, China Medical College, Taichung 404, Taiwan, ROC
    Biol Pharm Bull 26:79-83. 2003
    ..6% of dose) were higher than that of baicalein (7.2% of dose). The baicalein sulfates was predominant than the corresponding glucuronides, whereas wogonin sulfates was comparable to the corresponding glucuronides...
  15. doi request reprint Glycyrrhizin and licorice significantly affect the pharmacokinetics of methotrexate in rats
    Shiuan Pey Lin
    Graduate Institute of Pharmaceutical Chemistry, School of Pharmacy, China Medical University, Taichung 40402, Taiwan
    J Agric Food Chem 57:1854-9. 2009
    ..The results revealed that the AUC and MRT of MTX were significantly increased by GZ and LD. In conclusion, the concurrent use of GZ or licorice with MTX should be with caution...
  16. doi request reprint Differences in pharmacokinetics and ex vivo antioxidant activity following intravenous and oral administrations of emodin to rats
    Chi Sheng Shia
    Institute of Pharmaceutical Chemistry, China Medical University, 40402 Taichung, Taiwan
    J Pharm Sci 99:2185-95. 2010
    ..We suggest biologists to redirect their targets to emodin glucuronide...
  17. doi request reprint St. John's wort significantly increased the systemic exposure and toxicity of methotrexate in rats
    Shih Ying Yang
    Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung, Taiwan
    Toxicol Appl Pharmacol 263:39-43. 2012
    ..In conclusion, coadministration of SJW significantly increased the systemic exposure and toxicity of MTX. The combined use of MTX with SJW would need to be with caution...
  18. doi request reprint Quercetin and rutin reduced the bioavailability of cyclosporine from Neoral, an immunosuppressant, through activating P-glycoprotein and CYP 3A4
    Chung Ping Yu
    School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan, Republic of China
    J Agric Food Chem 59:4644-8. 2011
    ..Transplant patients treated with Neoral should avoid concurrent consumption of quercetin or rutin to minimize the risk of allograft rejection...
  19. ncbi request reprint A deglucosylated metabolite of paeoniflorin of the root of Paeonia lactiflora and its pharmacokinetics in rats
    Su Lan Hsiu
    Department of Pharmacy, China Medical University, Taichung, ROC
    Planta Med 69:1113-8. 2003
    ..Rat and pig are appropriate models for investigating the metabolism and pharmacokinetics of paeoniflorin...
  20. doi request reprint Potential risk of mulberry-drug interaction: modulation on P-glycoprotein and cytochrome P450 3A
    Pei Wen Hsu
    School of Pharmacy, China Medical University, Taichung 404, Taiwan, Republic of China
    J Agric Food Chem 61:4464-9. 2013
    ..Mechanism studies indicated that mulberry significantly increased the activities of P-gp and CYP 3A. In conclusion, mulberry significantly reduced the bioavailability of CSP through activating the functions of P-gp and CYP 3A...
  21. ncbi request reprint Degradation of flavonoid aglycones by rabbit, rat and human fecal flora
    Ya Tze Lin
    Graduate Institute of Pharmaceutical Chemistry, China Medical College, Taipei, Taiwan, ROC
    Biol Pharm Bull 26:747-51. 2003
    ..In conclusion, wogonin and diosmetin were among the less degraded ones for all three feces tested. The presence of a methoxy group on the A or B ring of the flavonoid seems to protect the structure from bacterial degradation...
  22. ncbi request reprint Citrus grandis peel increases the bioavailability of cyclosporine and tacrolimus, two important immunosuppressants, in rats
    Shiuan Pey Lin
    School of Pharmacy, China Medical University, Taichung, Taiwan
    J Med Food 14:1463-8. 2011
    ..Ex vivo studies indicated that the interaction was mediated by the inhibition of CYP3A4. We suggest that CGP is contraindicated for transplant patients treated with cyclosporine or tacrolimus to minimize the risk of intoxication...
  23. ncbi request reprint Lethal quercetin-digoxin interaction in pigs
    Yao Horng Wang
    Institute of Pharmaceutical Chemistry, China Medical University, Taichung, Taiwan
    Life Sci 74:1191-7. 2004
    ..The results indicated that a very serious pharmacokinetic interaction occurred between quercetin and digoxin. The concomitant administration of digoxin and quercetin or quercetin-containing herbs and dietary supplement should be avoided...
  24. doi request reprint A Chinese herb formula decreases the monocarboxylate transporter-mediated absorption of valproic acid in rats
    Chung Ping Yu
    School of Pharmacy, China Medical University, Taichung 404, Taiwan, ROC
    Phytomedicine 20:648-53. 2013
    ..Mechanism study revealed that the MCT-mediated uptake of fluorescein was inhibited by HQT and each component herbs. In conclusion, the MCT-mediated absorption of VPA was significantly decreased by concomitant administration of HQT...
  25. doi request reprint A new herb-drug interaction of Polygonum cuspidatum, a resveratrol-rich nutraceutical, with carbamazepine in rats
    Ying Chang Chi
    Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung, 40402, Taiwan
    Toxicol Appl Pharmacol 263:315-22. 2012
    ..In conclusion, PC markedly increased the systemic exposure and brain concentration of CBZ and CBZE through inhibiting the activities of CYP 3A and MRP 2...
  26. doi request reprint The interactive effect of exercise and immunosuppressant cyclosporin A on immune function in mice
    Miau Hwa Ko
    Department of Anatomy, China Medical University, Taichung, Taiwan
    J Sports Sci 28:967-73. 2010
    ..However, whether this exercise-induced immunomodulatory effect is beneficial or detrimental to CsA-treated patients needs to be clarified...
  27. doi request reprint Metabolic transformation of sesamol and ex vivo effect on 2,2'-azo-bis(2-amidinopropane)dihydrochloride-induced hemolysis
    Yu Chi Hou
    School of Pharmacy, China Medical University, Taichung 40402, Taiwan
    J Agric Food Chem 56:9636-40. 2008
    ..The conjugated metabolites of sesamol warrant more bioactivity investigations to understand the in vivo effect of sesamol...
  28. doi request reprint Biotransformation and pharmacokinetics of 4-(3,4-dihydroxybenzoyloxymethyl)phenyl-O-beta-D-glucopyranoside, an antioxidant isolated from Origanum vulgare
    Shiuan Pey Lin
    Graduate Institute of Pharmaceutical Chemistry and School of Pharmacy, China Medical University, Taichung 40402, Taiwan
    J Agric Food Chem 56:2852-6. 2008
    ..The serum metabolites of OV-16 exhibited free radical scavenging activity. When oregano decoction was given, the glucuronides and sulfates of PCA were the major metabolites in blood...
  29. doi request reprint Suppression on metastasis by rhubarb through modulation on MMP-2 and uPA in human A549 lung adenocarcinoma: an ex vivo approach
    Chi Sheng Shia
    School of Pharmacy, China Medical University, Taichung 404, Taiwan
    J Ethnopharmacol 133:426-33. 2011
    ..The aim of this study is to determine and identify the possible molecular mechanisms of anti-cancer effect of rhubarb under the physiologically achievable concentrations by using an ex vivo approach...
  30. doi request reprint Antioxidant and anti-inflammatory potential of hesperetin metabolites obtained from hesperetin-administered rat serum: an ex vivo approach
    Hsin Ling Yang
    Institute of Nutrition, China Medical University, Taichung 40402, Taiwan
    J Agric Food Chem 60:522-32. 2012
    ..Hesperetin metabolites ex vivo showed potent antioxidant and anti-inflammatory activity in comparison with hesperidin/hesperetin...
  31. ncbi request reprint Pharmacokinetic and pharmacodynamic interactions of morin and cyclosporin
    Shih Hua Fang
    Department of Microbiology, School of Medicine, China Medical University, Taichung, Taiwan
    Toxicol Appl Pharmacol 205:65-70. 2005
    ..In conclusion, morin coadministration profoundly reduced CsA concentration but did not significantly alter the CsA-suppressed Th1 immune response in mice...
  32. pmc Metabolism and pharmacokinetics of san-huang-xie-xin-tang, a polyphenol-rich chinese medicine formula, in rats and ex-vivo antioxidant activity
    Chi Sheng Shia
    Institute of Pharmaceutical Chemistry, Taiwan
    Evid Based Complement Alternat Med 2011:721293. 2011
    ..The results indicated that metabolites of SHXXT exhibited significant free radical scavenging activity. We suggest that biologists redirect their focus to the bioactivity of the conjugated metabolites of these polyphenols...
  33. doi request reprint Pharmacokinetics, bioavailability, and tissue distribution of magnolol following single and repeated dosing of magnolol to rats
    Shiuan Pey Lin
    School of Pharmacy, China Medical University, Taichung, Taiwan
    Planta Med 77:1800-5. 2011
    ....
  34. pmc Different influences on tacrolimus pharmacokinetics by coadministrations of zhi ke and zhi shi in rats
    Shiuan Pey Lin
    School of Pharmacy, China Medical University, Taichung 40402, Taiwan
    Evid Based Complement Alternat Med 2011:751671. 2011
    ..Hence, we suggest that Zhi Shi be contraindicated for transplant patients treated with tacrolimus to reduce the risk of allograft rejection...
  35. doi request reprint Metabolism and pharmacokinetics of 3,3',4',7-tetrahydroxyflavone (fisetin), 5-hydroxyflavone, and 7-hydroxyflavone and antihemolysis effects of fisetin and its serum metabolites
    Chi Sheng Shia
    Institute of Pharmaceutical Chemistry and School of Pharmacy, China Medical University, Taichung, Taiwan
    J Agric Food Chem 57:83-9. 2009
    ..In conclusion, fisetin and 7-OH-flavone were rapidly and extensively biotransformed into their sulfate/glucuronide, whereas 5-OH-flavone was exclusively metabolized to glucuronide...
  36. doi request reprint Indoxyl sulfate, a uremic toxin, is biotransformed from indoxyl-beta-D-glucoside (indican) in rats
    Yu Chi Hou
    School of Pharmacy, China Medical University, No 91 Hsueh Shih Road, Taichung 40421, Taiwan, ROC
    Toxicon 52:440-4. 2008
    ..Because indoxyl sulfate is a harmful uremic toxin, we suggest that the content of indican in the aforementioned medicinal plants be quantitated and well controlled to ensure the safety for clinical use...
  37. doi request reprint Enhancing the bioavailability of magnolol in rabbits using melting solid dispersion with polyvinylpyrrolidone
    Shiuan Pey Lin
    School of Pharmacy, China Medical University, Taichung, Taiwan
    Drug Dev Ind Pharm 40:330-7. 2014
    ..Preparation of magnolol-loaded amorphous solid dispersion was investigated for improving the bioavailability...
  38. ncbi request reprint Effect of serum metabolites of Pueraria lobata in rats on peripheral nerve regeneration: in vitro and in vivo studies
    Hsien Tung Chen
    Laboratory of Biomaterials, Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan
    J Biomed Mater Res B Appl Biomater 84:256-62. 2008
    ..These results suggest that the serum metabolites of Pueraria lobata can be a potential nerve growth-promoting factor...