S L Hoti

Summary

Publications

  1. Chauhan N, Sharma R, Hoti S. Identification and biochemical characterization of macrophage migration inhibitory factor-2 (MIF-2) homologue of human lymphatic filarial parasite, Wuchereria bancrofti. Acta Trop. 2015;142:71-8 pubmed publisher
    ..Although the conserved CXXC oxido-reductase motif is absent in Wba-mif-2, the recombinant protein showed significant oxido-reductase activity in the insulin reduction assay, possibly because of the presence of vicinal cysteine residues. ..
  2. Chauhan N, Hoti S. Role of cysteine-58 and cysteine-95 residues in the thiol di-sulfide oxidoreductase activity of Macrophage Migration Inhibitory Factor-2 of Wuchereria bancrofti. Acta Trop. 2016;153:14-20 pubmed publisher
    ..The mutant proteins did not show any oxidoreductase activity in the insulin reduction assay, thus indicating that these two cysteine residues are vital for the catalytic activity of Wba-MIF-2. ..
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    Hoti S, Subramaniyan K, Das P. Detection of codon for amino acid 200 in isotype 1 beta-tubulin gene of Wuchereria bancrofti isolates, implicated in resistance to benzimidazoles in other nematodes. Acta Trop. 2003;88:77-81 pubmed
    ..bancrofti isolates from wide geographic areas of India had codon for Phe (TTC) at position 200 of the beta-tubulin isotype 1 gene suggesting that the parasite might be genetically sensitive to BZ. ..
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    Hoti S, Sridhar A, Das P. Presence of Wolbachia endosymbionts in microfilariae of Wuchereria bancrofti (Spirurida: Onchocercidae) from different geographical regions in India. Mem Inst Oswaldo Cruz. 2003;98:1017-9 pubmed
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    Karthikeyan S, Hoti S. Development of Fourth Generation ABC Inhibitors from Natural Products: A Novel Approach to Overcome Cancer Multidrug Resistance. Anticancer Agents Med Chem. 2015;15:605-15 pubmed
    ..Here, we briefly review the status of natural products for reversing MDR modulators, and discuss the long term goal of MDR strategies in current clinical settings. ..