S J Hosseinimehr

Summary

Publications

  1. doi request reprint Radioprotective effects of chlorogenic acid against mortality induced by gamma-irradiation in mice
    S J Hosseinimehr
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Methods Find Exp Clin Pharmacol 30:13-6. 2008
  2. doi request reprint Chemoprotective effects of Zataria multiflora against genotoxicity induced by cyclophosphamide in mice bone marrow cells
    Seyed Jalal Hosseinimehr
    Department of Radiopharmacy, Faculty of Pharmacy, Traditional and Complementary Medicine Research Center, Mazandaran University of Medical Sciences, Sari, Iran
    Integr Cancer Ther 9:219-23. 2010
  3. ncbi request reprint Radioprotective effects of 2-imino-3-[(chromone-2-yl)carbonyl] thiazolidines against gamma-irradiation in mice
    Seyed Jalal Hosseinimehr
    Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    J Radiat Res 43:293-300. 2002
  4. ncbi request reprint Radioprotective effects of hesperidin against gamma irradiation in mouse bone marrow cells
    S J Hosseinimehr
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandarn University of Medical Sciences, Sari, Iran
    Br J Radiol 79:415-8. 2006
  5. pmc Arginine increases genotoxicity induced by methyl methanesulfonate in human lymphocytes
    Seyed Jalal Hosseinimehr
    Department of Radiopharmacy, Faculty of Pharmacy, Traditional and Complementary Medicine Research Center, Mazandaran University of Medical Sciences, Sari, Iran
    Cytotechnology 65:379-84. 2013
  6. doi request reprint Hesperidin inhibits cyclophosphamide-induced tumor growth delay in mice
    Seyed Jalal Hosseinimehr
    Department of Radiopharmacy, Faculty of Pharmacy, Traditional and Complementary Medicine Research Center, Mazandaran University of Medical Sciences, Sari, Iran
    Integr Cancer Ther 11:251-6. 2012
  7. doi request reprint Radioprotective effects of Hawthorn against genotoxicity induced by gamma irradiation in human blood lymphocytes
    Seyed Jalal Hosseinimehr
    Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Research Center, Mazandaran University of Medical Sciences, Sari, Iran
    Radiat Environ Biophys 48:95-8. 2009
  8. doi request reprint Radioprotective effects of hesperidin against genotoxicity induced by gamma-irradiation in human lymphocytes
    Seyed Jalal Hosseinimehr
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Mutagenesis 24:233-5. 2009
  9. ncbi request reprint Radioprotective effects of kojic acid against mortality induced by gamma irradiation in mice
    Seyed J Hosseinimehr
    Department of Medicinal Chemistry, Faculty of Pharmacy, Pharmaceutical Research Center, Mazandaran University of Medical Sciences, Sari, Iran
    Saudi Med J 30:490-3. 2009
  10. doi request reprint Radioprotective effects of Daflon against genotoxicity induced by gamma irradiation in human cultured lymphocytes
    Seyed Jalal Hosseinimehr
    Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Research Center, Mazandaran University of Medical Sciences, Sari, Iran
    Environ Mol Mutagen 50:749-52. 2009

Collaborators

Detail Information

Publications34

  1. doi request reprint Radioprotective effects of chlorogenic acid against mortality induced by gamma-irradiation in mice
    S J Hosseinimehr
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Methods Find Exp Clin Pharmacol 30:13-6. 2008
    ..It appeared that chlorogenic acid with antioxidant activity reduced mortality induced by gamma-irradiation...
  2. doi request reprint Chemoprotective effects of Zataria multiflora against genotoxicity induced by cyclophosphamide in mice bone marrow cells
    Seyed Jalal Hosseinimehr
    Department of Radiopharmacy, Faculty of Pharmacy, Traditional and Complementary Medicine Research Center, Mazandaran University of Medical Sciences, Sari, Iran
    Integr Cancer Ther 9:219-23. 2010
    ..It appeared that ZM with antioxidative activity reduced the oxidative stress and genotoxicity induced by CP in mouse bone marrow cells...
  3. ncbi request reprint Radioprotective effects of 2-imino-3-[(chromone-2-yl)carbonyl] thiazolidines against gamma-irradiation in mice
    Seyed Jalal Hosseinimehr
    Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    J Radiat Res 43:293-300. 2002
    ..The most active compound has hydroxyl groups at the C-5 and C-7 positions of the chromone ring; it had a DRF of 1.48...
  4. ncbi request reprint Radioprotective effects of hesperidin against gamma irradiation in mouse bone marrow cells
    S J Hosseinimehr
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandarn University of Medical Sciences, Sari, Iran
    Br J Radiol 79:415-8. 2006
    ..Our study demonstrates that hesperidin has powerful protective effects on the radiation-induced DNA damage and on the decline in cell proliferation in mouse bone marrow...
  5. pmc Arginine increases genotoxicity induced by methyl methanesulfonate in human lymphocytes
    Seyed Jalal Hosseinimehr
    Department of Radiopharmacy, Faculty of Pharmacy, Traditional and Complementary Medicine Research Center, Mazandaran University of Medical Sciences, Sari, Iran
    Cytotechnology 65:379-84. 2013
    ..This enhancement of genotoxicity was reduced by NAME as NO inhibitor. It is thus cleared that an increase of DNA damage by arginine and MMS is related to NO production...
  6. doi request reprint Hesperidin inhibits cyclophosphamide-induced tumor growth delay in mice
    Seyed Jalal Hosseinimehr
    Department of Radiopharmacy, Faculty of Pharmacy, Traditional and Complementary Medicine Research Center, Mazandaran University of Medical Sciences, Sari, Iran
    Integr Cancer Ther 11:251-6. 2012
    ..These results imply that fruits containing hesperidin, such as citrus, might have side effects on the efficacy of cyclophosphamide in the treatment of patients with colon cancer...
  7. doi request reprint Radioprotective effects of Hawthorn against genotoxicity induced by gamma irradiation in human blood lymphocytes
    Seyed Jalal Hosseinimehr
    Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Research Center, Mazandaran University of Medical Sciences, Sari, Iran
    Radiat Environ Biophys 48:95-8. 2009
    ..These data suggest that it may be possible to use Hawthorn extracts in personnel exposed to radiation in order to protect lymphocytes from radiation effects...
  8. doi request reprint Radioprotective effects of hesperidin against genotoxicity induced by gamma-irradiation in human lymphocytes
    Seyed Jalal Hosseinimehr
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Mutagenesis 24:233-5. 2009
    ..These data have important application for the protection of human lymphocytes from the genetic damage and side effects induced by gamma-irradiation in patients undergoing radiotherapy...
  9. ncbi request reprint Radioprotective effects of kojic acid against mortality induced by gamma irradiation in mice
    Seyed J Hosseinimehr
    Department of Medicinal Chemistry, Faculty of Pharmacy, Pharmaceutical Research Center, Mazandaran University of Medical Sciences, Sari, Iran
    Saudi Med J 30:490-3. 2009
    ..To evaluate the protective effects of kojic acid on mortality induced by gamma irradiation in mice. The efficacy was compared with amifostine as a reference radioprotector...
  10. doi request reprint Radioprotective effects of Daflon against genotoxicity induced by gamma irradiation in human cultured lymphocytes
    Seyed Jalal Hosseinimehr
    Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Research Center, Mazandaran University of Medical Sciences, Sari, Iran
    Environ Mol Mutagen 50:749-52. 2009
    ..These findings suggest the possible application of Daflon for the protection of human lymphocytes from the genetic damage and side effects induced by gamma irradiation...
  11. doi request reprint Protective effects of hesperidin against genotoxicity induced by (99m)Tc-MIBI in human cultured lymphocyte cells
    Seyed Jalal Hosseinimehr
    Department of Radiopharmacy, Faculty of Pharmacy and Traditional and Complementary Medicine Research Center, Mazandaran University of Medical Sciences, Sari, Iran
    Nucl Med Biol 36:863-7. 2009
    ..The purpose of this study was to investigate the radioprotective effects of hesperidin as a flavonoid which protects against the genotoxic effects of (99m)Tc-MIBI in human cultured lymphocytes...
  12. doi request reprint The radiotracer (99m)Tc-MIBI is not genotoxic for human peripheral blood lymphocytes at diagnostic radioactive dose
    S J Hosseinimehr
    Department of Radiopharmacy, Faculty of Pharmacy and Pharmaceutical Research Center, Mazandaran University of Medical Sciences, Sari, Iran
    Genet Mol Res 8:923-8. 2009
    ..We concluded that there is no increased induction of micronuclei in lymphocytes incubated with (99m)Tc-MIBI at the radioactivity doses used for diagnostic purposes...
  13. doi request reprint Potential utility of radioprotective agents in the practice of nuclear medicine
    Seyed Jalal Hosseinimehr
    Department of Radiopharmacy, Faculty of Pharmacy, corrected Mazandaran University of Medical Sciences, corrected Sari, Iran
    Cancer Biother Radiopharm 24:723-31. 2009
    ..Second, radioprotective agents can reduce chromosomal aberration induced by gamma- or beta-rays and reduce the risk of tumors in personnel and patients...
  14. ncbi request reprint Effect of aloe cream versus silver sulfadiazine for healing burn wounds in rats
    Seyed Jalal Hosseinimehr
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Acta Dermatovenerol Croat 18:2-7. 2010
    ..The results of this study showed aloe cream to significantly increase reepithelialization in burn wounds as compared with silver sulfadiazine...
  15. doi request reprint 125I-labeled quercetin as a novel DNA-targeted radiotracer
    Seyed Jalal Hosseinimehr
    Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, 17 Kilometers Khazar abad Boulevard, Sari, Iran
    Cancer Biother Radiopharm 26:469-75. 2011
    ..These findings provide for using of (125)I-labeled quercetin as a carrier of Auger electron emitting radionuclide to the cell nuclei for targeted radiotherapy...
  16. doi request reprint Flavonoids and genomic instability induced by ionizing radiation
    Seyed Jalal Hosseinimehr
    Department of Radiopharmacy, Faculty of Pharmacy, Traditional and Complementary Medicine Research Center, Mazandaran University of Medical Sciences, Sari, 48175 861, Iran
    Drug Discov Today 15:907-18. 2010
    ..This review describes the molecular effects of IR on DNA structure and mechanisms by which flavonoids exert their effect on ionizing-radiation-induced genomic instability...
  17. ncbi request reprint Captopril protects mice bone marrow cells against genotoxicity induced by gamma irradiation
    Seyed Jalal Hosseinimehr
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Cell Biochem Funct 25:389-94. 2007
    ..It appears that captopril, due to its free radical scavenging properties, protects mice bone marrow cells from radiation-induced DNA damage and genotoxicity...
  18. ncbi request reprint Oral oxymetholone reduces mortality induced by gamma irradiation in mice through stimulation of hematopoietic cells
    Seyed Jalal Hosseinimehr
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Mol Cell Biochem 287:193-9. 2006
    ..These results demonstrate that oxymetholone stimulates myelopoiesis and thrombocytopenia and enhances survival in mice after ionizing radiation...
  19. ncbi request reprint Chemoprotective effects of captopril against cyclophosphamide-induced genotoxicity in mouse bone marrow cells
    S J Hosseinimehr
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Arch Toxicol 79:482-6. 2005
    ..2 mM. It appears that CAP, due to its antioxidant activity and by increasing GSH levels, can modulate the reduced cellular thiol content induced by CP and reduce the genotoxicity of CP in bone marrow cells...
  20. ncbi request reprint Citrus extract modulates genotoxicity induced by cyclophosphamide in mice bone marrow cells
    Seyed Jalal Hosseinimehr
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    J Pharm Pharmacol 57:505-9. 2005
    ..It appeared that citrus extract, particularly flavonoids constituents with antioxidative activity, may return the GSH level to normal in stress conditions and reduces genotoxicity induced by cyclophosphamide in bone marrow cells...
  21. ncbi request reprint Radioprotective effects of hawthorn fruit extract against gamma irradiation in mouse bone marrow cells
    Seyed Jalal Hosseinimehr
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    J Radiat Res 48:63-8. 2007
    ..It appeared that hawthorn extract with antioxidant activity reduced the genotoxicity induced by gamma irradiation in bone marrow cells...
  22. ncbi request reprint Radioprotective effects of citrus extract against gamma-irradiation in mouse bone marrow cells
    Seyed Jalal Hosseinimehr
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Tehran, Iran
    J Radiat Res 44:237-41. 2003
    ..Therefore fruits and vegetables contain flavonoids to be useful as protective effects under such stress conditions as irradiation...
  23. ncbi request reprint 5,7-Dihydroxychromone-2-carboxylic acid and it's transition-metal (Mn and Zn) chelates as non-thiol radioprotective agents
    Seyed Jalal Hosseinimehr
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Eur J Med Chem 43:557-61. 2008
    ..Amifostine provides effective radiation protection when administrated immediately prior to radiation exposure, but administration of DHCCA, even 24 h prior to gamma irradiation, provides a significant protection...
  24. ncbi request reprint Trends in the development of radioprotective agents
    Seyed Jalal Hosseinimehr
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Drug Discov Today 12:794-805. 2007
    ..Although recent agents have lower efficacy, they have lower toxicity, more favourable administration routes and improved pharmacokinetics compared to the older thiol compounds...
  25. ncbi request reprint Diospyros lotus L. fruit extract protects G6PD-deficient erythrocytes from hemolytic injury in vitro and in vivo: prevention of favism disorder
    M Azadbakht
    Department of Pharmacognosy, Faculty of Pharmacy, Traditional and Complementary Medicine Research Center, Mazandaran University of Medical Sciences, Sari, Iran
    Eur Rev Med Pharmacol Sci 15:1270-81. 2011
    ..The aim of this study was to evaluate the protective effect of Diospyros lotus L. fruit extract against the hemolytic damage induced by Vicia faba beans extract in both G6PD enzyme-deficient human and rat erythrocyte in vitro and in vivo...
  26. doi request reprint Chemoprotective effects of hesperidin against genotoxicity induced by cyclophosphamide in mice bone marrow cells
    Amirhosein Ahmadi
    Student Research Committee, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Arch Pharm Res 31:794-7. 2008
    ..It is obvious that hesperidin, may with antioxidative activity, reduced the oxidative stress and genotoxicity induced by cyclophosphamide in mouse bone marrow cells...
  27. doi request reprint Aloe versus silver sulfadiazine creams for second-degree burns: a randomized controlled study
    Ghasemali Khorasani
    Department of Surgery, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
    Surg Today 39:587-91. 2009
    ..We conducted this clinical study to evaluate the efficacy of aloe vera cream for partial thickness burn wounds and compare its results with those of silver sulfadiazine (SSD)...
  28. ncbi request reprint The alteration of plasma's zinc and copper levels in patients with burn injuries and the relationship to the time after burn injuries
    G Khorasani
    Department of Surgery, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
    Singapore Med J 49:627-30. 2008
    ..In this study, zinc (Zn) and copper (Cu) levels in plasma of burned patients and their relationship with the burn surface area and time-related pattern are determined in the admitted patients after burn injury...
  29. ncbi request reprint Kojic acid and its manganese and zinc complexes as potential radioprotective agents
    Saeed Emami
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Bioorg Med Chem Lett 17:45-8. 2007
    ..The results of in vivo radioprotection showed that these compounds exhibited significant radioprotective effects against lethal dose of gamma-irradiation in mice...
  30. ncbi request reprint The effect of saffron (Crocus sativus) extract for healing of second-degree burn wounds in rats
    Ghasemali Khorasani
    Department of Surgery, Faculty of Medicine, Mazandaran University of Medical Sciences, 18 Kilometer Khazar Boulevard, Sari, Iran
    Keio J Med 57:190-5. 2008
    ..The results of this study raise the possibility of potential efficacy of saffron in accelerating wound healing in burn injuries...
  31. ncbi request reprint Radioprotective effects of 2-iminothiazolidine derivatives against lethal doses of gamma radiation in mice
    S J Hosseinimehr
    Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    J Radiat Res (Tokyo) 42:401-8. 2001
    ..05). 2-Imino-3-(benzoylmethyl)thiazolidine derivatives showed different radioprotective effects when injected at different times before irradiation, but were not statistically significant from each other (P > 0.05)...
  32. doi request reprint Effects of Aloe vera cream on posthemorrhoidectomy pain and wound healing: results of a randomized, blind, placebo-control study
    Fariborz Eshghi
    Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
    J Altern Complement Med 16:647-50. 2010
    ..This study assessed the effects of Aloe vera cream in reducing postoperative pain, postdefection pain, and its promotion of wound healing after open hemorrhoidectomy...
  33. ncbi request reprint In vitro antioxidant activity of Polygonium hyrcanicum, Centaurea depressa, Sambucus ebulus, Mentha spicata and Phytolacca americana
    Seyed Jalal Hosseinimehr
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Pak J Biol Sci 10:637-40. 2007
    ..This result indicates that P. hyrcanium contains high levels of phenolic compounds that may contribute to higher free radical scavenging activity compared to the other extracts of the plants in this study...
  34. ncbi request reprint Spectrophotometric determination of captopril with DTNB reagent in pharmaceutical formulation
    S J Hosseinimehr
    Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Boll Chim Farm 143:249-51. 2004
    ..It was not statistically, significant difference between Ellman's and HPLC method. This proposed method can be successfully applied to the determination of captopril in water and its dosage form and can use instead HPLC...