Paludan S, Reinert L, Hornung V. DNA-stimulated cell death: implications for host defence, inflammatory diseases and cancer. Nat Rev Immunol. 2019;: pubmed publisher
..In this article, we review the emerging literature on the pathways governing DNA-stimulated cell death and the current knowledge on how these processes shape immune responses to exogenous and endogenous challenges. ..
Chauhan D, Bartok E, Gaidt M, Bock F, Herrmann J, Seeger J, et al
. BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages. Cell Rep. 2018;25:2354-2368.e5 pubmed publisher
..These results establish the ripoptosome/caspase-8 complex as a pro-inflammatory checkpoint that senses the perturbation of mitochondrial integrity. ..
Linder A, Hornung V. Mitochondrial dsRNA: A New DAMP for MDA5. Dev Cell. 2018;46:530-532 pubmed publisher
..Now, a recent study in Nature by Dhir et al. (2018) identifies mitochondrial dsRNA as an immunogenic ligand, adding another intriguing aspect to the role of mitochondria in innate immunity. ..
Roers A, Hiller B, Hornung V. Recognition of Endogenous Nucleic Acids by the Innate Immune System. Immunity. 2016;44:739-54 pubmed publisher
..Furthermore, we emphasize disease mechanisms initiated by failure to discriminate self from non-self in nucleic acid detection. ..
Schmid Burgk J, Chauhan D, Schmidt T, Ebert T, Reinhardt J, Endl E, et al
. A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation. J Biol Chem. 2016;291:103-9 pubmed publisher
..Although the mechanism of Nek7 functioning upstream of Nlrp3 yet remains elusive, these studies provide a first genetic handle of a component that specifically functions upstream of Nlrp3. ..
van den Boorn J, Jakobs C, Hagen C, Renn M, Luiten R, Melief C, et al
. Inflammasome-Dependent Induction of Adaptive NK Cell Memory. Immunity. 2016;44:1406-21 pubmed publisher
Gaidt M, Hornung V. Alternative inflammasome activation enables IL-1Î² release from living cells. Curr Opin Immunol. 2017;44:7-13 pubmed publisher
Mankan A, Müller M, Witte G, Hornung V. Cyclic Dinucleotides in the Scope of the Mammalian Immune System. Handb Exp Pharmacol. 2017;238:269-289 pubmed publisher
..In this regard, our main focus is the role of the cGAS-STING axis in the context of microbial infection and sterile inflammation and its implications for therapeutic applications. ..
Gaidt M, Ebert T, Chauhan D, Ramshorn K, Pinci F, Zuber S, et al
. The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3. Cell. 2017;171:1110-1124.e18 pubmed publisher
..We conclude that targeting the cGAS-STING-LCD-NLRP3 pathway will ameliorate pathology in inflammatory conditions that are associated with cytosolic DNA sensing. ..